Title:
CUCURBITANE TRITERPENOID SAPONINS, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/079921
Kind Code:
A1
Abstract:
The present invention relates to the pharmaceutical field and discloses cucurbitane triterpenoid saponins extracted from Momordica charantia, a pharmaceutical composition containing them and their preparation. The invention also discloses the use of such compounds in preparation of medicaments for the treatment of diabetes, obesity and hyperlipaemia. The saponins disclosed in the invention are represented by formula I.
Inventors:
YE YANG (CN)
JAMES DAVID E (AU)
LENG YING (CN)
TAN MINJIA (CN)
YE JIMING (AU)
LIU XIAO (CN)
KE CHANGQIANG (CN)
FENG YING (CN)
CHEN TONG (CN)
LI XIQIANG (CN)
JAMES DAVID E (AU)
LENG YING (CN)
TAN MINJIA (CN)
YE JIMING (AU)
LIU XIAO (CN)
KE CHANGQIANG (CN)
FENG YING (CN)
CHEN TONG (CN)
LI XIQIANG (CN)
Application Number:
PCT/CN2008/001955
Publication Date:
July 02, 2009
Filing Date:
December 01, 2008
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
GARVAN INST OF MEDICAL RES AUS (AU)
YE YANG (CN)
JAMES DAVID E (AU)
LENG YING (CN)
TAN MINJIA (CN)
YE JIMING (AU)
LIU XIAO (CN)
KE CHANGQIANG (CN)
FENG YING (CN)
CHEN TONG (CN)
LI XIQIANG (CN)
GARVAN INST OF MEDICAL RES AUS (AU)
YE YANG (CN)
JAMES DAVID E (AU)
LENG YING (CN)
TAN MINJIA (CN)
YE JIMING (AU)
LIU XIAO (CN)
KE CHANGQIANG (CN)
FENG YING (CN)
CHEN TONG (CN)
LI XIQIANG (CN)
International Classes:
C07J9/00; A61K31/575; A61K36/42; A61P3/04; A61P3/06; A61P3/10
Foreign References:
| JP2007145782A | 2007-06-14 | |||
| CN1528785A | 2004-09-15 |
Other References:
MATSUDA, H. ET AL.: "Structures of new cucurbitane-type triterpenes and glycosides, karavilagenins D and E, and karavilosides VI, VII, VIII, IX, X, and XI, from the fruit ofMomordica charantia", HETEROCYCLES, vol. 71, no. 2, February 2007 (2007-02-01), pages 331 - 341
MURAKAMI T. ET AL.: "Medicinal foodstuffs. XXI. Structures of new cucurbitane-type triterpene glycosides, goyaglycosides-a, -b, -c, -d, -e, -f, -g, and -h, and new oleanane-type triterpene saponins, goyasaponins I, II, and III, from the fresh fruit ofjapanese Momordica charantia L.", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 49, no. 1, 2001, pages 54 - 63
NAKAMURA S. ET AL.: "Structures of new cucurbitane-type triterpenes and glycosides, karavilagenins and karavilosides, from the dried fruit ofMomordica charantia L. in Sri Lanka", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 54, no. 11, 2006, pages 1545 - 1550
NAKANO S. ET AL.: "Cucurbita-5,23-diene-3beta,25-diol from Sicana odorifera", FITOTERAPIA, vol. 75, no. 6, 2004, pages 609 - 611, XP004553673, DOI: doi:10.1016/j.fitote.2004.05.004
GOVINDACHARI, T. R ET AL.: "Structure of litsomentol, a new tetracyclic triterpene", TETRAHEDRON, vol. 27, no. 20, 1971, pages 4991 - 5009
ZHU, Z. J. ET AL.: "Active constituents of seeds of Momordica charantia L", ACTA PHARMACEUTICA SINICA, vol. 25, no. 12, 1990, pages 898 - 903
TAN, M.-J. ET AL.: "Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway", CHEMISTRY & BIOLOGY, vol. 15, no. 3, March 2008 (2008-03-01), pages 263 - 273
MURAKAMI T. ET AL.: "Medicinal foodstuffs. XXI. Structures of new cucurbitane-type triterpene glycosides, goyaglycosides-a, -b, -c, -d, -e, -f, -g, and -h, and new oleanane-type triterpene saponins, goyasaponins I, II, and III, from the fresh fruit ofjapanese Momordica charantia L.", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 49, no. 1, 2001, pages 54 - 63
NAKAMURA S. ET AL.: "Structures of new cucurbitane-type triterpenes and glycosides, karavilagenins and karavilosides, from the dried fruit ofMomordica charantia L. in Sri Lanka", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 54, no. 11, 2006, pages 1545 - 1550
NAKANO S. ET AL.: "Cucurbita-5,23-diene-3beta,25-diol from Sicana odorifera", FITOTERAPIA, vol. 75, no. 6, 2004, pages 609 - 611, XP004553673, DOI: doi:10.1016/j.fitote.2004.05.004
GOVINDACHARI, T. R ET AL.: "Structure of litsomentol, a new tetracyclic triterpene", TETRAHEDRON, vol. 27, no. 20, 1971, pages 4991 - 5009
ZHU, Z. J. ET AL.: "Active constituents of seeds of Momordica charantia L", ACTA PHARMACEUTICA SINICA, vol. 25, no. 12, 1990, pages 898 - 903
TAN, M.-J. ET AL.: "Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway", CHEMISTRY & BIOLOGY, vol. 15, no. 3, March 2008 (2008-03-01), pages 263 - 273
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (Block B Kingsound International Center, 116 Zizhuyuan Road, Haidian District, Beijing 7, CN)
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