Title:
CUSTOMMUNE: A WEB TOOL FOR DESIGNING PERSONALIZED AND POPULATION-TARGETED PEPTIDE VACCINES
Document Type and Number:
WIPO Patent Application WO/2021/176352
Kind Code:
A3
Abstract:
Computational prediction of immunogenic epitopes is a promising platform for designing therapeutic and preventive vaccines. A potential target is, for example, the human immunodeficiency virus (HIV-1) for which, despite decades of efforts, no vaccine is available. Indeed, due to the enormous variability of the virus, a single formulation effective against all or most HIV strains might not be achievable. Moreover, upon infecting host cells, HIV-1 can integrate in the host genome and form long lasting latent reservoirs that are not susceptible to common antiretroviral treatments. Therefore, a therapeutic vaccine designed to eliminate infected cells might represent a key component of strategies aimed at curing the infection. We herein introduce an automated algorithm to produce personalized and population-based vaccines.
Inventors:
TAREK MOHAMMAD (EG)
SHYTAJ IART LUCA (BR)
ELHEFNAWI MAHMOUD (EG)
SAVARINO ANDREA (IT)
DIAZ RICARDO SOBHIE (BR)
SHYTAJ IART LUCA (BR)
ELHEFNAWI MAHMOUD (EG)
SAVARINO ANDREA (IT)
DIAZ RICARDO SOBHIE (BR)
Application Number:
PCT/IB2021/051732
Publication Date:
March 10, 2022
Filing Date:
March 02, 2021
Export Citation:
Assignee:
TAREK MOHAMMAD (EG)
SHYTAJ IART LUCA (BR)
ELHEFNAWI MAHMOUD (EG)
SAVARINO ANDREA (IT)
DIAZ RICARDO SOBHIE (BR)
SHYTAJ IART LUCA (BR)
ELHEFNAWI MAHMOUD (EG)
SAVARINO ANDREA (IT)
DIAZ RICARDO SOBHIE (BR)
International Classes:
A61K39/00; A61P31/18; C12Q1/6886
Foreign References:
| US20040072249A1 | 2004-04-15 |
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