Title:
CYANOPHENYL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2000/017163
Kind Code:
A1
Abstract:
Novel piperazino-substituted cyanophenyl derivatives in which a substituted carbamoyl or sulfamoyl group bearing an optionally substituted aryl or heterocyclic group or the like is bonded to the nitrogen atom constituting the piperazine ring. These derivatives exhibit antiandrogen activities and are therefore useful in the prevention or treatment of prostatic cancer, prostatic hypertrophy and so forth.
Inventors:
TANIGUCHI NOBUAKI (JP)
KINOYAMA ISAO (JP)
KAMIKUBO TAKASHI (JP)
TOYOSHIMA AKIRA (JP)
SAMIZU KIYOHIRO (JP)
KAWAMINAMI EIJI (JP)
IMAMURA MASAKAZU (JP)
MORITOMO HIROYUKI (JP)
MATSUHISA AKIRA (JP)
HIRANO MASAAKI (JP)
MIYAZAKI YOJI (JP)
NOZAWA EISUKE (JP)
OKADA MINORU (JP)
KOUTOKU HIROSHI (JP)
OHTA MITSUAKI (JP)
KINOYAMA ISAO (JP)
KAMIKUBO TAKASHI (JP)
TOYOSHIMA AKIRA (JP)
SAMIZU KIYOHIRO (JP)
KAWAMINAMI EIJI (JP)
IMAMURA MASAKAZU (JP)
MORITOMO HIROYUKI (JP)
MATSUHISA AKIRA (JP)
HIRANO MASAAKI (JP)
MIYAZAKI YOJI (JP)
NOZAWA EISUKE (JP)
OKADA MINORU (JP)
KOUTOKU HIROSHI (JP)
OHTA MITSUAKI (JP)
Application Number:
PCT/JP1999/005149
Publication Date:
March 30, 2000
Filing Date:
September 21, 1999
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
TANIGUCHI NOBUAKI (JP)
KINOYAMA ISAO (JP)
KAMIKUBO TAKASHI (JP)
TOYOSHIMA AKIRA (JP)
SAMIZU KIYOHIRO (JP)
KAWAMINAMI EIJI (JP)
IMAMURA MASAKAZU (JP)
MORITOMO HIROYUKI (JP)
MATSUHISA AKIRA (JP)
HIRANO MASAAKI (JP)
MIYAZAKI YOJI (JP)
NOZAWA EISUKE (JP)
OKADA MINORU (JP)
KOUTOKU HIROSHI (JP)
OHTA MITSUAKI (JP)
TANIGUCHI NOBUAKI (JP)
KINOYAMA ISAO (JP)
KAMIKUBO TAKASHI (JP)
TOYOSHIMA AKIRA (JP)
SAMIZU KIYOHIRO (JP)
KAWAMINAMI EIJI (JP)
IMAMURA MASAKAZU (JP)
MORITOMO HIROYUKI (JP)
MATSUHISA AKIRA (JP)
HIRANO MASAAKI (JP)
MIYAZAKI YOJI (JP)
NOZAWA EISUKE (JP)
OKADA MINORU (JP)
KOUTOKU HIROSHI (JP)
OHTA MITSUAKI (JP)
International Classes:
C07D213/85; C07D233/88; C07D241/08; C07D295/192; C07D295/205; C07D295/215; C07D295/26; (IPC1-7): C07D213/74; C07D213/84; C07D233/88; C07D215/38; C07D401/04; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D295/18; C07D295/22; C07D243/08; C07D243/06; A61K31/415; A61K31/47; A61K31/55; A61K31/495; A61K31/54
Domestic Patent References:
| WO1997003054A1 | 1997-01-30 | |||
| WO1995017471A1 | 1995-06-29 |
Foreign References:
| JPS6344572A | 1988-02-25 | |||
| EP0023569A1 | 1981-02-11 |
Other References:
RAVI R., SIVARAMAKRISHNAN H., NAGARAJAN K.: "Nucleophilic Substitutions on 3-Chloro-4-fluoronitrobenzene", INDIAN. J. CHEM., SECT B: ORG. CHEM. INCL. MED. CHEM., vol. 36B, no. 4, 1997, pages 347 - 348, XP002925891
OGAWA H. ET AL.: "Studies on Positive Inotropic Agents. VI. Synthesis of 1-Aromatic Ring Substituted 4-(3,4-Dimethoxybenzoyl)-piperazine derivatives", CHEM. PHARM. BULL., vol. 36, no. 7, 1988, pages 2401 - 2409, XP002925892
MIYAMOTO T., EGAWA H., MATSUMOTO J.: "Pyridonecarboxylic Acids as Antibacterial Agents. VIII. An Alternative Synthesis of Enoxacin via Fluoronicotinic Acid Derivatives", CHEM. PHARM. BULL., vol. 35, no. 6, 1987, pages 2280 - 2285, XP002925893
AGRAWAL V.K., SHARMA S.: "Studies in Potential Filaricides: Part XV-Synthesis of 1- Acyl/aryl-4-substituted-piperazines as Diethylcarbamazine analogs", INDIAN. J. CHEM., SECT. B: ORG. CHEM. INCL. MED. CHEM., vol. 23B, no. 7, 1984, pages 650 - 654, XP002925894
CHEMICAL ABSTRACTS, vol. 97, 1982, Columbus, Ohio, US; abstract no. 97:109953S, ZHANG X., LI G., DAI Z., QIAN Y., CHEN L.: "Studies on antimalarials. III. Synthesis and Antimalarial Effects of some Derivatives of 2,4-Diamino-6-Substituted Piperazinylquinazolines" page 608; XP002925895
OGAWA H. ET AL.: "Studies on Positive Inotropic Agents. VI. Synthesis of 1-Aromatic Ring Substituted 4-(3,4-Dimethoxybenzoyl)-piperazine derivatives", CHEM. PHARM. BULL., vol. 36, no. 7, 1988, pages 2401 - 2409, XP002925892
MIYAMOTO T., EGAWA H., MATSUMOTO J.: "Pyridonecarboxylic Acids as Antibacterial Agents. VIII. An Alternative Synthesis of Enoxacin via Fluoronicotinic Acid Derivatives", CHEM. PHARM. BULL., vol. 35, no. 6, 1987, pages 2280 - 2285, XP002925893
AGRAWAL V.K., SHARMA S.: "Studies in Potential Filaricides: Part XV-Synthesis of 1- Acyl/aryl-4-substituted-piperazines as Diethylcarbamazine analogs", INDIAN. J. CHEM., SECT. B: ORG. CHEM. INCL. MED. CHEM., vol. 23B, no. 7, 1984, pages 650 - 654, XP002925894
CHEMICAL ABSTRACTS, vol. 97, 1982, Columbus, Ohio, US; abstract no. 97:109953S, ZHANG X., LI G., DAI Z., QIAN Y., CHEN L.: "Studies on antimalarials. III. Synthesis and Antimalarial Effects of some Derivatives of 2,4-Diamino-6-Substituted Piperazinylquinazolines" page 608; XP002925895
Attorney, Agent or Firm:
Nagai, Shozo (Patent Dept. 17-, Hasune 3-chome Itabashi-ku Tokyo, JP)
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