Title:
CYCLIC AMINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2010/074088
Kind Code:
A1
Abstract:
Provided are novel low-molecular compounds which exhibit calcium receptor antagonist activity, and which are highly safe and orally administrable, namely, compounds having general formula (I) or pharmacologically acceptable salts thereof. In the general formula, R1, R2a, and R2b are each a hydrogen atom or the like; R3 is methyl, ethyl, or the like; Z is carboxyl or the like; Ar is phenyl or the like; A is a single bond or the like; B is a single bond or the like; n is 0 or 1; and m is an integer of 0 to 6.
Inventors:
NAKAO AKIRA
GOTANDA KENTOKU
AOKI KAZUMASA
HIRANO SHIMPEI
HIRUMA YOSHIHARU
SHIIKI TAKESHI
GOTANDA KENTOKU
AOKI KAZUMASA
HIRANO SHIMPEI
HIRUMA YOSHIHARU
SHIIKI TAKESHI
Application Number:
PCT/JP2009/071338
Publication Date:
July 01, 2010
Filing Date:
December 22, 2009
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
NAKAO AKIRA
GOTANDA KENTOKU
AOKI KAZUMASA
HIRANO SHIMPEI
HIRUMA YOSHIHARU
SHIIKI TAKESHI
NAKAO AKIRA
GOTANDA KENTOKU
AOKI KAZUMASA
HIRANO SHIMPEI
HIRUMA YOSHIHARU
SHIIKI TAKESHI
International Classes:
C07D205/04; A61K31/397; A61K31/40; A61K31/41; A61P1/02; A61P3/14; A61P5/18; A61P19/00; A61P19/02; A61P19/10; A61P29/00; A61P35/00; C07D207/08; C07D207/10; C07D207/12; C07D403/12
Domestic Patent References:
| WO2004106295A2 | 2004-12-09 | |||
| WO2005115975A1 | 2005-12-08 | |||
| WO2004106280A1 | 2004-12-09 | |||
| WO2004094362A1 | 2004-11-04 | |||
| WO2004106295A2 | 2004-12-09 | |||
| WO2002014259A1 | 2002-02-21 | |||
| WO2004106280A1 | 2004-12-09 | |||
| WO2005077886A1 | 2005-08-25 | |||
| WO2004106280A1 | 2004-12-09 | |||
| WO2001049649A1 | 2001-07-12 | |||
| WO2008025509A1 | 2008-03-06 | |||
| WO2004094362A1 | 2004-11-04 | |||
| WO2009010530A1 | 2009-01-22 |
Foreign References:
| JP2003012616A | 2003-01-15 | |||
| US20040259860A1 | 2004-12-23 | |||
| US20070167506A1 | 2007-07-19 |
Other References:
ENDOCRINOLOGICAL REVIEW, vol. 13, 1992, pages 66 - 80
"Principles of Bone Biology", 1996, ACADEMIC PRESS, pages: 87 - 102
ENDOCRINOLOGICAL REVIEW, vol. 17, 1996, pages 308 - 332
AMERICAN JOURNAL OF PHYSIOLOGY, vol. 260, 1991, pages C1315 - C1324
ENDOCRINOLOGY, vol. 110, 1982, pages 506 - 512
ENDOCRINOLOGY, vol. 132, 1993, pages 823 - 831
BROWN, E. M.: "Homeostatic mechanisms regulating extracellular and intracellular calcium metabolism in the parathyroids", 1994, RAVEN PRESS, pages: 19
NATURE, vol. 366, 1993, pages 575 - 580
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Drugs", pages: 163 - 198
CAMILLE GEORGES WERMUTH: "The Practice of Medicinal Chemistry", 1996, ACADEMIC PRESS
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS, INC.
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
T. W. GREENE, P.G. WUTS: "Protective groups in Organic Synthesis", 1999
ZHOU, HETEROATOM CHEMISTRY, vol. 14, 2003, pages 603 - 606
MULZER, J. ORG. CHEM., vol. 51, 1986, pages 5294 - 5299
"Organic Synthesis", 1999
YANG, BIOORG. MED. CHEM. LETT., vol. 15, 2005, pages 1225 - 1228
KUNISHIMA, TETRAHEDRON, vol. 55, 1999, pages 13159 - 13170
J. ORG. CHEM., vol. 25, 1960, pages 1016 - 1020
TETRAHEDRON LETT., vol. 36, 1995, pages 881 - 884
EUR. J. MED. CHEM., vol. 35, 2000, pages 979 - 988
CHIRALITY, vol. 17, 2005, pages 476 - 480
See also references of EP 2374794A4
"Principles of Bone Biology", 1996, ACADEMIC PRESS, pages: 87 - 102
ENDOCRINOLOGICAL REVIEW, vol. 17, 1996, pages 308 - 332
AMERICAN JOURNAL OF PHYSIOLOGY, vol. 260, 1991, pages C1315 - C1324
ENDOCRINOLOGY, vol. 110, 1982, pages 506 - 512
ENDOCRINOLOGY, vol. 132, 1993, pages 823 - 831
BROWN, E. M.: "Homeostatic mechanisms regulating extracellular and intracellular calcium metabolism in the parathyroids", 1994, RAVEN PRESS, pages: 19
NATURE, vol. 366, 1993, pages 575 - 580
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Drugs", pages: 163 - 198
CAMILLE GEORGES WERMUTH: "The Practice of Medicinal Chemistry", 1996, ACADEMIC PRESS
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS, INC.
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
T. W. GREENE, P.G. WUTS: "Protective groups in Organic Synthesis", 1999
ZHOU, HETEROATOM CHEMISTRY, vol. 14, 2003, pages 603 - 606
MULZER, J. ORG. CHEM., vol. 51, 1986, pages 5294 - 5299
"Organic Synthesis", 1999
YANG, BIOORG. MED. CHEM. LETT., vol. 15, 2005, pages 1225 - 1228
KUNISHIMA, TETRAHEDRON, vol. 55, 1999, pages 13159 - 13170
J. ORG. CHEM., vol. 25, 1960, pages 1016 - 1020
TETRAHEDRON LETT., vol. 36, 1995, pages 881 - 884
EUR. J. MED. CHEM., vol. 35, 2000, pages 979 - 988
CHIRALITY, vol. 17, 2005, pages 476 - 480
See also references of EP 2374794A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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