Title:
CYCLIC BISBENZYL TETRAHYDROISOQUINOLINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/104213
Kind Code:
A1
Abstract:
The present invention provides a cyclic bisbenzyl tetrahydroisoquinoline compound as represented by formula (I), and a pharmaceutically acceptable salt, an enantiomer, a diastereoisomer, a racemate, a crystalline hydrate, and a solvate thereof, wherein R1 and R2 are as defined in the description.
The present invention further provides a method for preparing the compound and the use of the compound for the preparation of an inhibitor for inhibiting viruses, inflammation, fibrosis and abnormal differentiation of T cells and/or for the preparation of a drug for preventing and/or treating related diseases caused by viruses, such as respiratory tract infections and pneumonia, inflammation-related diseases, fibrosis-related diseases and autoimmune diseases.
Inventors:
SHEN JINGSHAN (CN)
GAO ZHAOBING (CN)
XIAO GENGFU (CN)
LI JIA (CN)
YANG FEIPU (CN)
ZHANG LEIKE (CN)
XIA BINGQING (CN)
JIANG XIANGRUI (CN)
HE YANG (CN)
JIANG HUALIANG (CN)
GAO ZHAOBING (CN)
XIAO GENGFU (CN)
LI JIA (CN)
YANG FEIPU (CN)
ZHANG LEIKE (CN)
XIA BINGQING (CN)
JIANG XIANGRUI (CN)
HE YANG (CN)
JIANG HUALIANG (CN)
Application Number:
PCT/CN2022/138457
Publication Date:
June 15, 2023
Filing Date:
December 12, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCIENCE (CN)
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCIENCE (CN)
International Classes:
C07D491/18; A61K31/4748; A61P9/00; A61P11/00; A61P17/00; A61P19/10; A61P25/00; A61P27/00; A61P31/12; A61P31/14; A61P43/00
Foreign References:
| JP2021075469A | 2021-05-20 | |||
| JPH11180873A | 1999-07-06 | |||
| US5607693A | 1997-03-04 | |||
| CN114375293A | 2022-04-19 |
Other References:
JOSHI TANUJA, BHAT SUNAULLAH, PUNDIR HEMLATA, CHANDRA SUBHASH: "Identification of Berbamine, Oxyacanthine and Rutin from Berberis asiatica as anti-SARS-CoV-2 compounds: An in silico study", JOURNAL OF MOLECULAR GRAPHICS AND MODELLING, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 109, 1 December 2021 (2021-12-01), US , pages 108028, XP093071116, ISSN: 1093-3263, DOI: 10.1016/j.jmgm.2021.108028
IVANOVSKA N, PHILIPOV S: "Study on the anti- inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, ELMSFORD,NY, US, vol. 18, no. 10, 1 January 1996 (1996-01-01), US , pages 553 - 561, XP002212064, ISSN: 0192-0561, DOI: 10.1016/S0192-0561(96)00047-1
NAWAWI AS'ARI, C MA, N NAKAMURA, M HATTORI, M KUROKAWA, K SHIRAKI, N KASHIWABA, M ONO: "Anti-herpes simplex virus activity of alkaloids isolated from Stephania cepharantha", BIOLOGICAL PHARMACEUTICAL BULLETIN., vol. 22, no. 3, 1 March 1999 (1999-03-01), pages 268 - 274, XP093071123, DOI: 10.1248/bpb.22.268
IVANOVSKA N, PHILIPOV S: "Study on the anti- inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, ELMSFORD,NY, US, vol. 18, no. 10, 1 January 1996 (1996-01-01), US , pages 553 - 561, XP002212064, ISSN: 0192-0561, DOI: 10.1016/S0192-0561(96)00047-1
NAWAWI AS'ARI, C MA, N NAKAMURA, M HATTORI, M KUROKAWA, K SHIRAKI, N KASHIWABA, M ONO: "Anti-herpes simplex virus activity of alkaloids isolated from Stephania cepharantha", BIOLOGICAL PHARMACEUTICAL BULLETIN., vol. 22, no. 3, 1 March 1999 (1999-03-01), pages 268 - 274, XP093071123, DOI: 10.1248/bpb.22.268
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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