Title:
CYCLIC COMPOUND HAVING DOPAMINE D3 RECEPTOR ANTAGONISM
Document Type and Number:
WIPO Patent Application WO/2019/146740
Kind Code:
A1
Abstract:
Provided is a novel compound which has D3 receptor antagonism.
A compound represented by formula (I) (wherein: ring A represents a non-aromatic heterocycle, etc. substituted by an optionally substituted aromatic heterocyclic group, etc.; R2a to R2d independently represent a hydrogen atom, etc.; n is an integer of 0-3; ring B represents a non-aromatic carbon ring, etc.; R3s independently represent a halogen, etc.; r is an integer of 0-4; -L- represents -N(R10)-C(=O), etc. wherein R10 represents a hydrogen atom, etc.; and R4 represents an optionally substituted aromatic heterocyclic group, etc.) or a pharmaceutically acceptable salt thereof.
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Inventors:
ICHIHASHI YUSUKE (JP)
INAGAKI MASANAO (JP)
MASUDA KOJI (JP)
INAGAKI MASANAO (JP)
MASUDA KOJI (JP)
Application Number:
PCT/JP2019/002397
Publication Date:
August 01, 2019
Filing Date:
January 25, 2019
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D401/14; A61K31/422; A61K31/4245; A61K31/427; A61K31/433; A61K31/435; A61K31/437; A61K31/4439; A61K31/454; A61K31/4709; A61K31/496; A61K31/506; A61P1/08; A61P1/14; A61P3/04; A61P15/00; A61P15/10; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P43/00; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04
Domestic Patent References:
| WO2002079151A1 | 2002-10-10 |
Foreign References:
| JP2014513109A | 2014-05-29 | |||
| JP2012502944A | 2012-02-02 | |||
| US20100075979A1 | 2010-03-25 | |||
| US20090143398A1 | 2009-06-04 | |||
| JP2010523642A | 2010-07-15 | |||
| JP5502733B2 | 2014-05-28 | |||
| JP2014503519A | 2014-02-13 | |||
| EP0431580A2 | 1991-06-12 | |||
| JP2014506905A | 2014-03-20 |
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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