Title:
CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS
Document Type and Number:
WIPO Patent Application WO/2022/234853
Kind Code:
A1
Abstract:
The present inventors found a cyclic compound and an oligopeptide compound that selectively inhibit KRAS. The present inventors further found an oligopeptide compound and a non-natural amino acid that are useful for producing the cyclic compound. The present inventors furthermore found that the cyclic compound and the oligopeptide compound interact with a KRAS-specific amino acid residue.
Inventors:
KAWADA HATSUO (JP)
TAKANO KOJI (JP)
KOTAKE TOMOYA (JP)
KAGE MIRAI (JP)
HASHIMOTO SATOSHI (JP)
TAMIYA MINORU (JP)
WAKAMIYA YUMA (JP)
HAYASHI RYUJI (JP)
MORITA YUYA (JP)
TAKANO KOJI (JP)
KOTAKE TOMOYA (JP)
KAGE MIRAI (JP)
HASHIMOTO SATOSHI (JP)
TAMIYA MINORU (JP)
WAKAMIYA YUMA (JP)
HAYASHI RYUJI (JP)
MORITA YUYA (JP)
Application Number:
PCT/JP2022/019544
Publication Date:
November 10, 2022
Filing Date:
May 06, 2022
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61P43/00; A61K38/06; A61K38/12; C07K5/083; C07K7/54
Domestic Patent References:
WO2020122182A1 | 2020-06-18 | |||
WO2013100132A1 | 2013-07-04 | |||
WO2018225864A1 | 2018-12-13 | |||
WO2018225851A1 | 2018-12-13 | |||
WO2021090855A1 | 2021-05-14 | |||
WO2013100132A1 | 2013-07-04 | |||
WO2018225864A1 | 2018-12-13 | |||
WO2018225851A1 | 2018-12-13 |
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NAT. REV. DRUG DISCOV., vol. 13, no. 12, December 2014 (2014-12-01), pages 928 - 942
NAT. REV. DRUG DISCOV., vol. 15, no. 11, November 2016 (2016-11-01), pages 771 - 785
FUTURE MED. CHEM., vol. 1, 2009, pages 1289 - 1310
CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 13, no. 7, 2013, pages 821 - 836
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 484, 2017, pages 605 - 611
BIOORG. MED. CHEM. LETT., vol. 27, 2017, pages 2757 - 2761
ACS MED. CHEM. LETT., vol. 8, 2017, pages 732 - 736
J. APPL. CRYST., vol. 40, 2007, pages 658 - 674
ACTA CRYST., vol. D67, 2011, pages 355 - 467
MANDEL, M.HIGA, A., JOURNAL OF MOLECULAR BIOLOGY, vol. 53, 1970, pages 158 - 162
HANAHAN, D., JOURNAL OF MOLECULAR BIOLOGY, vol. 166, 1983, pages 557 - 580
ORGANIC LETTERS, vol. 16, 2014, pages 4944 - 4947
ORGANIC LETTERS, vol. 10, 2008, pages 4815 - 4818
NATURE PROTOCOLS, vol. 7, 2012, pages 432 - 444
ORGANIC LETTERS, vol. 12, 2010, pages 4928 - 4931
TETRAHEDRON LETTERS, vol. 44, 2003, pages 3863 - 3865
JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, 2011, pages 4815 - 4830
JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, 2014, pages 159 - 170
HUIHUI ET AL., J. AM. CHEM. SOC., vol. 138, no. 15, 2016, pages 5016 - 5019
NATURE PROTOCOLS, vol. 6, 2011, pages 761 - 771
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 4130 - 4133
FREIDINGER ET AL., J. ORG. CHEM., vol. 48, no. 22, 1983, pages 4155 - 4156
NGUYEN ET AL., SYNTHESIS, vol. 12, 2009, pages 1991
KING ET AL., TETRAHEDRON LETTERS, vol. 43, no. 11, 2002, pages 1987 - 1990
BORCH ET AL., J. ORG. CHEM., vol. 37, no. 10, 1972, pages 1673 - 1674
REEVES ET AL., ADVANCED SYNTHESIS & CATALYSIS, vol. 355, no. 1, 2013, pages 47 - 52
HE, ORG. LETT., vol. 16, no. 24, 2014, pages 6488 - 6491
ISHIYAMA ET AL., J. AM. CHEM. SOC., vol. 124, no. 3, 2002, pages 390 - 391
LINDNER ET AL., CHEM. EUR. J., vol. 22, 2016, pages 13218 - 13235
MITSUNOBU ET AL., SYNTHESIS, vol. 1, 1981, pages 1 - 28
WILLIAMSON ET AL., LIEBIGS ANN. CHEM., vol. 1851, no. 77, pages 37 - 49
LEE ET AL., BIOORG. MED. CHEM. LETT., vol. 19, no. 17, 2009, pages 4887 - 5274
SHENDAGE ET AL., EUR. J. ORG. CHEM., 2005, pages 719 - 727
TETRAHEDRON LETTERS, vol. 39, 1998, pages 8357 - 8360
JOURNAL OF PEPTIDE RESEARCH, vol. 56, 2000, pages 115 - 120
CAS , no. 1616099-24-1
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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