Cyclic depsipeptide sulfonylation, sulfenylation and phosphorylation process

WIPO Patent Application WO1996011945

A3

PCT No. PCT/EP95/03926 Sec. 371 Date Apr. 10, 1997 Sec. 102(e) Date Apr. 10, 1997 PCT Filed Oct. 5, 1995 PCT Pub. No. WO96/11945 PCT Pub. Date Apr. 25, 1996The present invention relates to a process for the aromatic sulfonylation, sulfenylation, thiocyanation and phosphorylation of cyclic depsipeptides having 6 to 24 ring atoms which are synthesized from alpha -hydroxycarboxylic acids and alpha -amino acids and contain at least one phenyl radical, characterized in that these cyclic depsipeptides are reacted with sulfonylating, sulfenylating, thiocyanating or phosphorylating agents, optionally in the presence of catalysts, auxiliaries and/or diluents, to novel thus-obtained compounds, and to their use as endoparasiticides.

SCHERKENBECK JUERGEN (DE)
PLANT ANDREW (DE)
JESCHKE PETER (DE)
HARDER ACHIM (DE)
MENCKE NORBERT (DE)

PCT/EP1995/003926

July 25, 1996

October 05, 1995

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BAYER AG (DE)
SCHERKENBECK JUERGEN (DE)
PLANT ANDREW (DE)
JESCHKE PETER (DE)
HARDER ACHIM (DE)
MENCKE NORBERT (DE)

A61K31/38; A61K31/395; A61K31/495; A61K31/535; A61P33/00; C07D273/00; C07D295/26; C07D413/12; C07D413/14; C07F9/6527; C07K11/02; (IPC1-7): C07K11/02; C07D273/00

EP0626376A1	1994-11-30
EP0382173A2	1990-08-16

YU.A.OVCHINNIKOV: "Recent Findings in the Structural and Functional Aspects of the Peptide Ionophores", PROCEEDINGS OF NOBEL SYMPOSIUM, vol. 34, 1976, STOCKHOLM, pages 345 - 372, XP002005330
Y.SHIMOHIGASHI ET AL.: "Cyclic Peptides", INT.J.PEPTIDE PROTEIN RES., vol. 12, 1978, COPENHAGEN, pages 7 - 16, XP002005331

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