CYCLIC DIAMINE COMPOUND HAVING FIVE−MEMBERED CYCLIC GROUP

Title:

CYCLIC DIAMINE COMPOUND HAVING FIVE−MEMBERED CYCLIC GROUP

Document Type and Number:

WIPO Patent Application WO/2003/002540

Kind Code:

A1

Abstract:

A compound represented by the following general formula (1): (1) (wherein A represents a single bond, C ≡ C, CONH, or NHCO&semi W represents carbon or nitrogen&semi X represents CH, nitrogen, oxygen, or sulfur&semi Y represents CH, CHR¹, nitrogen, oxygen, sulfur, or NR²&semi Z represents nitrogen, oxygen, sulfur, CH, or NR³&semi m is 1 or 2&semi n is a number of 1 to 5&semi and R¹, R², and R³ each represents hydrogen, lower alkyl, lower alkyl substituted by hydroxy, lower alkyl substituted by lower alkoxy, aryl, lower alkyl substituted by aryl, or lower alkyl substituted by heteroaryl&semi provided that one or two of W, X, Y, and Z are heteroatoms), an acid addition salt of the compound, or a hydrate of either&semi and a medicine containing any of these. The compound (1) has inhibitory activity against cell adhesion and cell infiltration. It is useful for allergy, asthma, rheumatism, arteriosclerosis, inflammation, etc.

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Inventors:

KODAMA TATSUHIKO
TAMURA MASAHIRO
ODA TOSHIAKI
YAMAZAKI YUKIYOSHI
NISHIKAWA MASAHIRO
DOI TAKESHI
KYOTANI YOSHINORI

Application Number:

PCT/JP2002/006488

Publication Date:

January 09, 2003

Filing Date:

June 27, 2002

Export Citation:

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Assignee:

KOWA CO (JP)

International Classes:

A61P9/10; A61P11/06; A61P29/00; A61P37/08; A61P43/00; C07D231/12; C07D233/54; C07D261/08; C07D263/32; C07D277/28; C07D277/46; C07D333/20; C07D401/14; C07D403/14; C07D409/14; C07D413/14; C07D417/14; (IPC1-7): C07D231/12; C07D277/28; C07D417/14; C07D403/14; C07D401/14; C07D413/14; C07D263/32; C07D409/14; C07D333/20; A61K31/496; A61K31/551; A61P11/06; A61P37/08; A61P29/00; A61P9/10; A61P43/00

Foreign References:

EP0774257A2	1997-05-21
JPH1192382A	1999-04-06
JP2000086641A	2000-03-28

Other References: