Title:
CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF- alpha CONVERTING ENZYME (TACE)
Document Type and Number:
WIPO Patent Application WO2003024899
Kind Code:
A3
Abstract:
The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from 0, N, NR<1>, and S(O)p, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP) , TNF-a converting enzyme (TACE) , aggrecanase or a combination thereof, pharmaceutical compositions containing the same, and methods of using the same.
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Inventors:
OTT GREGORY (US)
CHEN XIAO-TAO (US)
DUAN JINGWU (US)
LU ZHONGHUI (US)
CHEN XIAO-TAO (US)
DUAN JINGWU (US)
LU ZHONGHUI (US)
Application Number:
PCT/US2002/029685
Publication Date:
November 27, 2003
Filing Date:
September 16, 2002
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
OTT GREGORY (US)
CHEN XIAO-TAO (US)
DUAN JINGWU (US)
LU ZHONGHUI (US)
OTT GREGORY (US)
CHEN XIAO-TAO (US)
DUAN JINGWU (US)
LU ZHONGHUI (US)
International Classes:
C07D209/08; C07D215/12; C07D235/06; C07D235/08; C07D235/10; C07D235/24; C07D279/16; C07D401/12; C07D403/12; C07D405/12; C07D405/14; C07D407/12; C07D413/12; C07D417/12; C07D417/14; C07D471/04; C07D475/08; C07D491/04; (IPC1-7): A61K31/38; A61K31/335; A61K31/415; A61K31/44; A61K31/47; A61K31/535; A61K31/54; C07D209/02; C07D209/36; C07D235/02; C07D265/30; C07D279/00
Foreign References:
| US5663187A | 1997-09-02 | |||
| US5663186A | 1997-09-02 | |||
| US5236943A | 1993-08-17 | |||
| US5210079A | 1993-05-11 |
Other References:
DATABASE CA [online] OTT G.R. ET AL.: "Preparation of spiro-cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteinases and TNF-alpha converting enzyme (TACE)", XP002963506, accession no. STN Database accession no. 137:262960
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