Title:
CYCLIC N-HYDROXY IMIDES AS INHIBITORS OF FLAP ENDONUCLEASE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2006014647
Kind Code:
A3
Abstract:
Acylic n-hydroxy imides and their use in pharmaceutical compositions and in the inhibition of flap endonuclease are disclosed.
Inventors:
TUMEY LAWRENCE N (US)
BENNANI YOUSSEF (US)
HUCK BAYARD (US)
BOM DAVID C (US)
BENNANI YOUSSEF (US)
HUCK BAYARD (US)
BOM DAVID C (US)
Application Number:
PCT/US2005/025592
Publication Date:
July 27, 2006
Filing Date:
July 20, 2005
Export Citation:
Assignee:
ATHERSYS INC (US)
TUMEY LAWRENCE N (US)
BENNANI YOUSSEF (US)
HUCK BAYARD (US)
BOM DAVID C (US)
TUMEY LAWRENCE N (US)
BENNANI YOUSSEF (US)
HUCK BAYARD (US)
BOM DAVID C (US)
International Classes:
C07D495/04; A61K31/519; C07D491/048
Other References:
HENNEKE G. ET AL.: "Flap endonuclease 1: a novel tumour suppresser protein", TRENDS IN BIOCHEMICAL SCIENCES, vol. 28, no. 7, July 2003 (2003-07-01), pages 384 - 390, XP004440371
HENNEKE G. ET AL.: "Multiple roles for kinases in DNA replication", EMBO REP., vol. 4, no. 3, 2003, pages 252 - 256, XP003001062
HENNEKE G. ET AL.: "Multiple roles for kinases in DNA replication", EMBO REP., vol. 4, no. 3, 2003, pages 252 - 256, XP003001062
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