Title:
CYCLIC PEPTIDE AND IMAGING COMPOUND COMPOSITIONS AND USES FOR TARGETED IMAGING AND THERAPY
Document Type and Number:
WIPO Patent Application WO2005019247
Kind Code:
A3
Abstract:
The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf) NIR imaging compositions and novel cyclic HWGFTL polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.
Inventors:
LI CHUN (US)
KE SHI (US)
WANG WEI (US)
KE SHI (US)
WANG WEI (US)
Application Number:
PCT/US2004/026220
Publication Date:
May 19, 2005
Filing Date:
August 13, 2004
Export Citation:
Assignee:
UNIV TEXAS (US)
LI CHUN (US)
KE SHI (US)
WANG WEI (US)
LI CHUN (US)
KE SHI (US)
WANG WEI (US)
International Classes:
A61K49/00; A61K51/08; C07K7/56; C07K14/81; (IPC1-7): C07K7/64; A61K51/08
Domestic Patent References:
| WO2002076451A1 | 2002-10-03 | |||
| WO1999047550A1 | 1999-09-23 | |||
| WO1993012819A1 | 1993-07-08 |
Other References:
E. KOIVUNEN ET AL: "Tumor targeting with a selective gelatinase inhibitor", NATURE BIOTECHNOLOGY, vol. 17, August 1999 (1999-08-01), pages 768 - 774, XP002309023
OULA PENATE MEDINA ET AL: "Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 61, 15 May 2001 (2001-05-15), pages 3978 - 3985, XP002954535, ISSN: 0008-5472
OULA PENATE MEDINA ET AL: "Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 61, 15 May 2001 (2001-05-15), pages 3978 - 3985, XP002954535, ISSN: 0008-5472
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