CYCLIC PEPTIDE PRODUCTION METHOD

Title:

CYCLIC PEPTIDE PRODUCTION METHOD

Document Type and Number:

WIPO Patent Application WO/2020/262590

Kind Code:

A1

Abstract:

The objective of the invention is to provide a cyclic peptide production method whereby multimerized impurity by-products that are generated during a cyclization reaction are eliminated effectively, the purity of the obtained cyclic peptide is improved, and the load on the purification step may be reduced. The cyclic peptide production method includes step (1) and step (2):　(1) a step of cyclizing a linear peptide; and (2) a step wherein, from a mixture of cyclic peptides and multimerized impurities obtained in the previous step, the multimerized impurities are filtered out as insoluble matter by adding a poor solvent, and the cyclic peptides are obtained.

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Inventors:

TAKAHASHI DAISUKE (JP)
INOMATA TATSUJI (JP)

Application Number:

PCT/JP2020/025157

Publication Date:

December 30, 2020

Filing Date:

June 26, 2020

Export Citation:

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Assignee:

AJINOMOTO KK (JP)

International Classes:

C07K1/00; C07K1/06; C07K1/14; C07K7/52

Domestic Patent References:

WO2018081367A1

2018-05-03

Foreign References:

JPS5818345A

1983-02-02

Attorney, Agent or Firm:

TAKASHIMA, Hajime (JP)

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