Title:
CYCLIC PHOSPHONATE-MODIFIED NUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2023/241587
Kind Code:
A1
Abstract:
The present invention provides an oligonucleotide having a cyclic phosphonate modification. The oligonucleotide of the present invention exhibits one or more among enhanced stability, reduced off-target toxicity, and enhanced effectiveness.
Inventors:
HUANG JINYU (CN)
ZOU HAO (CN)
LIU JUNKAI (CN)
ZOU HAO (CN)
LIU JUNKAI (CN)
Application Number:
PCT/CN2023/099987
Publication Date:
December 21, 2023
Filing Date:
June 13, 2023
Export Citation:
Assignee:
SHANGHAI RONA THERAPEUTICS CO LTD (CN)
International Classes:
C07H21/02; A61K31/713; C07H19/20
Foreign References:
| CN109526222A | 2019-03-26 | |||
| US20160046939A1 | 2016-02-18 |
Other References:
LI, WENMING ET AL.: "Highly Substituted Cyclopentane−CMP Conjugates as Potent Sialyltransferase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, 25 September 2015 (2015-09-25), XP093117712
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
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