CYCLIC SINGLE STRAND TRISPECIFIC ANTIBODY

Title:

CYCLIC SINGLE STRAND TRISPECIFIC ANTIBODY

Document Type and Number:

WIPO Patent Application WO/2002/083738

Kind Code:

A1

Abstract:

The invention provides a cyclic single strand trispecific anti-tumor antibody. The antibody is combined by anti-tumor Fab, single strand antibody and modified anti-human CD3 or CD28 Fab. The present invention also provided the DNA sequence that codes for the antibody. The expression vector containing the DNA and the corresponding host cell containing the vector are also disclosed.

Inventors:

HUANG HUA-LIANG (CN)
CHENG JU-LONG (CN)
WANG XIANG-BIN (CN)
SONG LI-PING (CN)
ZHANG ZHONG (CN)
LIN QING (CN)
GU YING (CN)

Application Number:

PCT/CN2002/000252

Publication Date:

October 24, 2002

Filing Date:

April 10, 2002

Export Citation:

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Assignee:

INST OF GENETICS CAS (CN)
BEIJING ABT GENETIC ENGINEERIN (CN)
HUANG HUA-LIANG (CN)
CHENG JU-LONG (CN)
WANG XIANG-BIN (CN)
SONG LI-PING (CN)
ZHANG ZHONG (CN)
LIN QING (CN)
GU YING (CN)

International Classes:

C12N15/09; A61K39/395; A61P35/00; C07K7/64; C07K16/18; C07K16/28; C07K16/30; C07K16/32; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/63; (IPC1-7): C07K16/18; A61K39/395; A61P35/00; C12N15/13

Domestic Patent References:

WO2000018806A1	2000-04-06
WO1991003493A1	1991-03-21

Foreign References:

EP0885614B1	2000-09-27
US5601819A	1997-02-11

Other References: