Title:
CYCLIZED AMIDE DERIVATIVES FOR TREATING OR PREVENTING NEURONAL DAMAGE
Document Type and Number:
WIPO Patent Application WO2001002358
Kind Code:
A3
Abstract:
The present invention relates to cyclized amide derivatives of formula (I) for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
Inventors:
LAUFFER DAVID (US)
MULLICAN MICHAEL (US)
LEDFORD BRIAN (US)
MULLICAN MICHAEL (US)
LEDFORD BRIAN (US)
Application Number:
PCT/US2000/018418
Publication Date:
July 12, 2001
Filing Date:
July 05, 2000
Export Citation:
Assignee:
VERTEX PHARMA (US)
LAUFFER DAVID (US)
MULLICAN MICHAEL (US)
LEDFORD BRIAN (US)
LAUFFER DAVID (US)
MULLICAN MICHAEL (US)
LEDFORD BRIAN (US)
International Classes:
A61K31/4015; A61K31/45; A61K31/4545; A61K31/55; A61K31/5513; A61K38/27; A61P19/08; A61P21/04; A61P25/00; C07D243/12; A61P25/02; A61P25/16; A61P25/28; C07D207/273; C07D211/76; C07D223/12; C07D223/16; C07D243/14; C07D243/24; C07D401/06; C07D401/14; C07D207/26; (IPC1-7): C07D401/14; C07D413/14; C07D417/14; C07D207/26; C07D211/72; C07D223/12; C07D243/14; A61K31/554; A61P25/00
Domestic Patent References:
WO1998011075A1 | 1998-03-19 | |||
WO1999032453A1 | 1999-07-01 | |||
WO1998028268A2 | 1998-07-02 |
Other References:
WITIAK ET AL.: "3,4-Methylenedioxyphenyl-, isopropylidenedioxyphenyl-, and benzyl-substituted chiral 2-aminosuccinimides and 3-aminopyrrolidines. Stereoselective investigations of potential anti-parkinsonian, antipsychotic, and anticonvulsant activities.", J. MED. CHEM., vol. 20, no. 6, 1977, pages 801 - 5, XP002156597
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