Title:
CYCLOALKYLAMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/021351
Kind Code:
A1
Abstract:
Disclosed is a therapeutic agent for hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like, which has a CaSR activating (agonistic) activity. Specifically disclosed is a compound represented by general formula (1) [wherein Ar which is a partial structure in general formula (1) represents a phenyl group, or a naphtyl group; R1a and R1b independently represent a hydrogen atom, a halogeno group, or the like; R2a and R2b independently represent a hydrogen atom, a halogeno group, or the like; A represents a single bond, an oxygen atom, or the like; B represents a single bond, a C1-C4 alkanediyl group, or the like; Z represents a carboxyl group, or a tetrazolyl group; and m represents an integer of 1 to 3] or a pharmacologically acceptable salt thereof.
Inventors:
MARUMOTO SHINJI
NISHIMATA TOYOKI
EBISAWA MASAYUKI
ASOH YUSUKE
FUKUSHIMA YASUO (JP)
KATO MIKIO (JP)
NISHIMATA TOYOKI
EBISAWA MASAYUKI
ASOH YUSUKE
FUKUSHIMA YASUO (JP)
KATO MIKIO (JP)
Application Number:
PCT/JP2009/064542
Publication Date:
February 25, 2010
Filing Date:
August 20, 2009
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
MARUMOTO SHINJI
NISHIMATA TOYOKI
EBISAWA MASAYUKI
ASOH YUSUKE
FUKUSHIMA YASUO (JP)
KATO MIKIO (JP)
MARUMOTO SHINJI
NISHIMATA TOYOKI
EBISAWA MASAYUKI
ASOH YUSUKE
FUKUSHIMA YASUO (JP)
KATO MIKIO (JP)
International Classes:
C07C229/46; A61K31/196; A61K31/198; A61K31/216; A61K31/41; A61P3/14; A61P5/18; A61P13/12; A61P43/00; C07C217/54; C07C229/16; C07C237/36; C07C323/52; C07D257/04
Domestic Patent References:
| WO2009065406A2 | 2009-05-28 | |||
| WO1994018959A1 | 1994-09-01 | |||
| WO1996012697A2 | 1996-05-02 | |||
| WO2005115975A1 | 2005-12-08 | |||
| WO2009065406A2 | 2009-05-28 |
Foreign References:
| JPH11130737A | 1999-05-18 | |||
| JP2003531187A | 2003-10-21 | |||
| EP0291172A1 | 1988-11-17 |
Other References:
See also references of EP 2341044A4
N. NAGANO, PHARMACOL. THER., vol. 109, no. 3, March 2006 (2006-03-01), pages 339 - 365
T. W. GREEN; G.M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS, INC.
T. W. GREEN; P.G.M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS, INC.
T. DESMOND ET AL., SYNTH. COMM., vol. 24, 1994, pages 887 - 890
HARTWIG ET AL., J. AM. CHEM. SOC., vol. 124, 2002, pages 12557 - 12565
MARYANOFF ET AL., CHEM. REV., vol. 89, 1989, pages 863 - 927
THOMPSON ET AL.: "Comprehensive Organic Synthesis", vol. 3, 1991, PERGAMON, pages: 1015 - 1043
CHEM. REV., vol. 95, 1995, pages 2457 - 2483
D. W. C. MACMILLAN ET AL., J. AM. CHEM. SOC., vol. 128, 2006, pages 12662 - 12663
HAYASHI ET AL., J. AM. CHEM. SOC., vol. 124, 2002, pages 5052 - 5058
J. JACQUES: "Enantiomers, Racemates and Resolution", JOHN WILEY AND SONS, INC.
"Handbook of Pharmaceutical Excipients", 1994
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING CO.
W. ADCOCK ET AL., J. AM. CHEM. SOC., vol. 98, 1976, pages 1701 - 1711
ENDOCRINOLOGY, vol. 137, 1996, pages 3842 - 3848
N. NAGANO, PHARMACOL. THER., vol. 9, no. 3, 10 March 2006 (2006-03-10), pages 339 - 365
N. NAGANO, PHARMACOL. THER., vol. 109, no. 3, March 2006 (2006-03-01), pages 339 - 365
T. W. GREEN; G.M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS, INC.
T. W. GREEN; P.G.M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS, INC.
T. DESMOND ET AL., SYNTH. COMM., vol. 24, 1994, pages 887 - 890
HARTWIG ET AL., J. AM. CHEM. SOC., vol. 124, 2002, pages 12557 - 12565
MARYANOFF ET AL., CHEM. REV., vol. 89, 1989, pages 863 - 927
THOMPSON ET AL.: "Comprehensive Organic Synthesis", vol. 3, 1991, PERGAMON, pages: 1015 - 1043
CHEM. REV., vol. 95, 1995, pages 2457 - 2483
D. W. C. MACMILLAN ET AL., J. AM. CHEM. SOC., vol. 128, 2006, pages 12662 - 12663
HAYASHI ET AL., J. AM. CHEM. SOC., vol. 124, 2002, pages 5052 - 5058
J. JACQUES: "Enantiomers, Racemates and Resolution", JOHN WILEY AND SONS, INC.
"Handbook of Pharmaceutical Excipients", 1994
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING CO.
W. ADCOCK ET AL., J. AM. CHEM. SOC., vol. 98, 1976, pages 1701 - 1711
ENDOCRINOLOGY, vol. 137, 1996, pages 3842 - 3848
N. NAGANO, PHARMACOL. THER., vol. 9, no. 3, 10 March 2006 (2006-03-10), pages 339 - 365
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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