Title:
CYCLOHEXADIIMIDE DERIVATIVE SUBSTITUTED BY FUSED HETEROCYCLYL, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/148358
Kind Code:
A1
Abstract:
The present disclosure relates to a cyclohexadiimide derivative substituted by fused heterocyclyl, and a preparation method therefor and a pharmaceutical application thereof. Specifically, the present disclosure relates to a cyclohexadiimide derivative substituted by fused heterocyclyl and represented by general formula (I), a preparation method therefor, and a pharmaceutical composition comprising the derivative and a use thereof as a treatment agent, and particularly a use as a Cereblon adjustment agent in the field of multiple myeloma treatment.
Inventors:
JIA MINQIANG (CN)
TANG HUANYU (CN)
YANG FANGLONG (CN)
HE FENG (CN)
TAO WEIKANG (CN)
TANG HUANYU (CN)
YANG FANGLONG (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2022/070210
Publication Date:
July 14, 2022
Filing Date:
January 05, 2022
Export Citation:
Assignee:
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/496; A61P35/00
Foreign References:
| CN102822165A | 2012-12-12 | |||
| CN111989322A | 2020-11-24 | |||
| CN101679380A | 2010-03-24 | |||
| CN111285850A | 2020-06-16 | |||
| CN110963994A | 2020-04-07 | |||
| CN109912655A | 2019-06-21 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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