Title:
CYCLOPROPYLGLYCINE DERIVATIVES AND METABOLIC-REGULATION TYPE L-GLUTAMATE RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/1998/000391
Kind Code:
A1
Abstract:
Novel cyclopropylglycine derivatives represented by general formula (I) and intermediates for synthesizing the same, wherein R?1� and R?2� represent each independently hydroxy or C�1?-C�6? alkoxy; R?3� and R?4� represent each independently hydrogen or C�1?-C�6? alkyl; and X?1� and X?2� represent each independently halogeno. The derivatives serve as a metabolic-regulation type L-glutamate receptor agonist having a high selectively and excellent characteristics as compared with known ones.
Inventors:
SHINOZAKI HARUHIKO (JP)
TAGUCHI TAKEO (JP)
ISHIDA MICHIKO (JP)
TAGUCHI TAKEO (JP)
ISHIDA MICHIKO (JP)
Application Number:
PCT/JP1996/003849
Publication Date:
January 08, 1998
Filing Date:
December 27, 1996
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
SHINOZAKI HARUHIKO (JP)
TAGUCHI TAKEO (JP)
ISHIDA MICHIKO (JP)
SHINOZAKI HARUHIKO (JP)
TAGUCHI TAKEO (JP)
ISHIDA MICHIKO (JP)
International Classes:
C07C229/46; (IPC1-7): C07C229/46; A61K31/16; A61K31/215; C07D209/52
Foreign References:
| JPH0624970A | 1994-02-01 | |||
| JPH0193563A | 1989-04-12 |
Other References:
TETRAHEDRON, 52(1), (1996), SHIBUYA, AKIRA; KURISHITA, MASAHITO; AGO, CHIZURU; TAGUCHI, TAKEO, "A Highly Diastereoselective Synthesis of Trans-3,4-(Difluoromethano) Glutamic Acid", p. 271-278.
See also references of EP 0913389A4
See also references of EP 0913389A4
Attorney, Agent or Firm:
Yanagawa, Yasuo (2-14 Yotsuy, Shinjuku-ku Tokyo 160, JP)
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