Title:
CYCLOSPORIN ANALOG AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/147624
Kind Code:
A1
Abstract:
The present invention provides a cyclosporin analog and use thereof, and in particular relates to a compound and use thereof as a mitochondrial protective agent for storing a donated organ. The compound is a compound of formula 1 or a salt thereof, wherein n is 2-5, and R1 and R2 are independently selected from H or C1-C4 alkyl, wherein R1 and R2 can be linked together to form a C3-C5 heteroalkyl ring.
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Inventors:
MAK CHING PONG (CN)
ZENG LI (CN)
YU SHENGQIANG (CN)
PEEL MICHAEL ROBERT (GB)
FLIRI HANS GEORG (GB)
ZENG LI (CN)
YU SHENGQIANG (CN)
PEEL MICHAEL ROBERT (GB)
FLIRI HANS GEORG (GB)
Application Number:
PCT/CN2020/070852
Publication Date:
July 23, 2020
Filing Date:
January 08, 2020
Export Citation:
Assignee:
FARSIGHT MEDICAL TECH SHANGHAI CO LTD (CN)
International Classes:
A01N1/02; A61K38/12; A61K38/13; C07K7/56; C07K7/64
Domestic Patent References:
| WO2019016572A1 | 2019-01-24 | |||
| WO2010076329A1 | 2010-07-08 | |||
| WO2014053834A1 | 2014-04-10 |
Foreign References:
| CN1305493A | 2001-07-25 | |||
| CN106902347A | 2017-06-30 | |||
| US6583265B1 | 2003-06-24 | |||
| EP0484281A2 | 1992-05-06 | |||
| EP0194972A2 | 1986-09-17 |
Other References:
DEVINDER SINGH, VIKAS CHANDER ,KANWALJIT CHOPRA: "Cyclosporine Protects Against Ischemia/Reperfusion Injury in Rat Kidneys", TOXICOLOGY, vol. 207, no. 3, 28 February 2005 (2005-02-28), pages 339 - 347, XP004722809, ISSN: 0300-483X, DOI: 10.1016/j.tox.2004.09.018
TANG, JIAN: "Using Calcineurin Inhibitor in Donor Preconditioning Reduce Ischemia-Reperfusion Injury in Rat Renel Transplantation and the Mechanisms", CHINA MEDICAL HERALD, no. 25, 30 September 2012 (2012-09-30), pages 8 - 10, XP055829073, ISSN: 1673-7210
QUESNIAUX ET AL., EUR. J IMMUNOL., vol. 17, 1987, pages 1359 - 1365
JANKOWSKI ET AL., ANAL. BIOCHEM., vol. 252, 1997, pages 299 - 307
BLATTNER ET AL., ANALYTICAL BIOCHEM, vol. 295, 2001, pages 220
See also references of EP 3915366A4
TANG, JIAN: "Using Calcineurin Inhibitor in Donor Preconditioning Reduce Ischemia-Reperfusion Injury in Rat Renel Transplantation and the Mechanisms", CHINA MEDICAL HERALD, no. 25, 30 September 2012 (2012-09-30), pages 8 - 10, XP055829073, ISSN: 1673-7210
QUESNIAUX ET AL., EUR. J IMMUNOL., vol. 17, 1987, pages 1359 - 1365
JANKOWSKI ET AL., ANAL. BIOCHEM., vol. 252, 1997, pages 299 - 307
BLATTNER ET AL., ANALYTICAL BIOCHEM, vol. 295, 2001, pages 220
See also references of EP 3915366A4
Attorney, Agent or Firm:
JIN MAO LAW FIRM (CN)
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