Title:
CYTOKINE FUSION PROTEIN
Document Type and Number:
WIPO Patent Application WO/2024/014808
Kind Code:
A1
Abstract:
The present invention relates to a cytokine fusion protein comprising an immune cell targeting domain and a cytokine action domain that can specifically induce the proliferation and/or activation of immune cells. Specifically, the present invention relates to a fusion protein that specifically delivers a cytokine (e.g., IL-2 or IL-15) to depleted immune cells (e.g., exhausted T cells) in a tumor to induce and increase the activation of immune cells. The fusion protein of the present invention can selectively deliver the cytokine that promote the proliferation or activation of immune cells to effector T cells in a tumor microenvironment, thereby inducing a strong immune-enhancing and anti-cancer response within the tumor, as well as significantly reducing systemic toxicity or side effects caused by the cytokine by means of a unique structure of the cytokine action domain.
Inventors:
PARK HEUNG ROK (KR)
BAE DONG GOO (KR)
SHIN HYUN SOO (KR)
CHOI EUN JU (KR)
PARK SOO BONG (KR)
LEE KWANG HYUN (KR)
KIM JUNE MYOUNG (KR)
BAE DONG GOO (KR)
SHIN HYUN SOO (KR)
CHOI EUN JU (KR)
PARK SOO BONG (KR)
LEE KWANG HYUN (KR)
KIM JUNE MYOUNG (KR)
Application Number:
PCT/KR2023/009763
Publication Date:
January 18, 2024
Filing Date:
July 10, 2023
Export Citation:
Assignee:
GENUV INC (KR)
International Classes:
C07K16/28; A61K39/00; A61P35/00; C07K14/54; C07K14/55; C07K14/715; C12N15/62
Domestic Patent References:
| WO2020057646A1 | 2020-03-26 | |||
| WO2018044105A1 | 2018-03-08 |
Foreign References:
| KR20190060821A | 2019-06-03 | |||
| KR20220012256A | 2022-02-03 | |||
| KR20220032569A | 2022-03-15 |
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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