Title:
CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/1997/047622
Kind Code:
A1
Abstract:
Cytokine production inhibitors containing compounds represented by general formula (I), novel triazepine compounds, and intermediates for producing these triazepine compounds. The compounds (I) inhibit the production of cytokines such as IL-6, TNF-'alpha', IL-8, IFN'gamma', IL-2 and GM-CSF and are useful as cytokine production inhibitors and antiinflammatory drugs. In formula (I), R1 represents aryl or heteroaryl; B represents formula (a) or (b), (wherein R2 represents hydrogen, hydroxy, halogeno, etc.; R4 represents hydrogen or halogeno, or R2 and R4 may together form carbonyl; R3 represents lower alkoxy, cycloalkyl, aryl, heteroaryl, -X-Y {wherein X represents -(CH2)m-, -CO-, -COCH2-, -NHCH2-, -CH2NH-, -OCH2-, etc.; and Y represents halogeno, cycloalkyl, aryl or heteroaryl}, etc.; R51 represents -NHCONHR57 etc.; and R52 represents hydrogen or -COOR53); and A represents a benzene or thiophene ring.
Inventors:
YAMAMOTO YOSHIHISA (JP)
SHINDO MSANORI (JP)
NAKAMURA TAKESHI (JP)
SHINDO MSANORI (JP)
NAKAMURA TAKESHI (JP)
Application Number:
PCT/JP1997/002016
Publication Date:
December 18, 1997
Filing Date:
June 11, 1997
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
YAMAMOTO YOSHIHISA (JP)
SHINDO MSANORI (JP)
NAKAMURA TAKESHI (JP)
YAMAMOTO YOSHIHISA (JP)
SHINDO MSANORI (JP)
NAKAMURA TAKESHI (JP)
International Classes:
C07D255/04; C07D471/14; C07D487/04; C07D487/20; C07D495/04; C07D495/14; (IPC1-7): C07D487/04; C07D487/14; C07D495/12; A61K31/55
Domestic Patent References:
| WO1996016062A1 | 1996-05-30 |
Foreign References:
| JPS51115498A | 1976-10-12 | |||
| US4144233A | 1979-03-13 | |||
| JPH08225546A | 1996-09-03 |
Other References:
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, Vol. 14, No. 2, 1992, M.P. CHANG et al., "Mechanism of Immunosuppressive Effect of Alprazolam: Alprazolam Suppresses T-Cell Proliferation by Selectively Inhibiting the Production of IL2 But Not Acquisition of IL2 Receptor", pp. 227-237.
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