Title:
CYTOTOXICITY-INDUCING THERAPEUTIC AGENT FOR USE IN TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2023/054421
Kind Code:
A1
Abstract:
The present disclosure provides: an anti-cancer agent that contains multispecific antigen-binding molecules, said anti-cancer agent being capable of effectively and selectively mobilizing T cells to target cancer cells, i.e. to cells that express CLDN6 such as cancer cells, and treating cancer through the cytotoxic activity of T cells on target cancer tissue containing cells that express CLDN6; a combination therapy that involves said anti-cancer agent and at least one other anti-cancer agent; and a medicinal composition for use in said combination therapy.
Inventors:
ISHII SHINYA (JP)
KAMIKAWA TAKAYUKI (JP)
KIMURA NAOKI (JP)
KODAMA TATSUSHI (JP)
KAMIKAWA TAKAYUKI (JP)
KIMURA NAOKI (JP)
KODAMA TATSUSHI (JP)
Application Number:
PCT/JP2022/036060
Publication Date:
April 06, 2023
Filing Date:
September 28, 2022
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K39/395; A61P35/00; A61P43/00
Domestic Patent References:
| WO2019111871A1 | 2019-06-13 | |||
| WO2019135404A1 | 2019-07-11 | |||
| WO2020168059A1 | 2020-08-20 | |||
| WO2020191344A1 | 2020-09-24 | |||
| WO2020067399A1 | 2020-04-02 | |||
| WO2020067419A1 | 2020-04-02 |
Foreign References:
| JP2016500059A | 2016-01-07 | |||
| JP2021168648A | 2021-10-28 |
Other References:
FABER MATTHEW S., LEE SUNG-HYUNG, KIM YOON KYUNG, QI JING, AVERY KENDRA N., NGUYEN DUC-HANH T., RASHID RUMANA, EIVAZI ARAZ, CHU SE: "Abstract 1860: Bispecific claudin-6 x CD3 antibodies in a 2 + 1 format demonstrate selectivity and activity on human ovarian cancer cells", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 81, no. 13_Supplement, 1 July 2021 (2021-07-01), US, pages 1860 - 1860, XP093054819, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2021-1860
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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