Title:
CYTOTRIENINS, PROCESS FOR PREPARING THE SAME, AND ANTITUMOR AGENT
Document Type and Number:
WIPO Patent Application WO/1998/023594
Kind Code:
A1
Abstract:
An antitumor agent comprising cytotrienin (I), (II), (III), or (IV) as the active ingredient, characterized by being produced by culturing a bacterium capable of producing cytotrienin (I), (II), (III), or (IV) represented by general formulae (I), (II), (III) and (IV) and Streptomyces strain 95-74 in a medium to produce and accumulate cytotrienin (I), (II), (III), or (IV) in the medium and harvesting the product.
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Inventors:
OSADA HIROYUKI (JP)
KAKEYA HIDEAKI (JP)
ZHANG HUI-PING (JP)
KOBINATA KIMIE (JP)
KAKEYA HIDEAKI (JP)
ZHANG HUI-PING (JP)
KOBINATA KIMIE (JP)
Application Number:
PCT/JP1997/004374
Publication Date:
June 04, 1998
Filing Date:
December 01, 1997
Export Citation:
Assignee:
RIKAGAKU KENKYUSHO (JP)
OSADA HIROYUKI (JP)
KAKEYA HIDEAKI (JP)
ZHANG HUI PING (JP)
KOBINATA KIMIE (JP)
OSADA HIROYUKI (JP)
KAKEYA HIDEAKI (JP)
ZHANG HUI PING (JP)
KOBINATA KIMIE (JP)
International Classes:
A61K31/395; A61P35/00; C07D225/06; C12P17/10; C12R1/465; (IPC1-7): C07D225/06; A61K31/395; C12P17/10
Other References:
TETRAHEDRON LETTERS, (1997), Vol. 38, No. 10, HUI-PING ZHANG et al., "Novel Triene-Ansamycins, Cytotrienins A and B, Inducing Apoptosis on Human Leukemia HL-60 Cells", p. 1789-1792.
THE JOURNAL OF ANTIBIOTICS, (1997), Vol. 50, No. 4, HIDEAKI KAKEYA et al., "Cytotrienin A, a Novel Apoptosis Inducer In Human Leukemia HL-60 Cells", p. 370-372.
THE JOURNAL OF ANTIBIOTICS, (1993), Vol. 46, No. 11, NAOKI ABE et al., "Novel Cytocidal Compounds, Oxopropalines from Streptomyces Sp. G324 Producing Lavendamycin", p. 1678-1686.
THE JOURNAL OF ANTIBIOTICS, (1981), Vol. 34, No. 11, DANA J. WARNICK-PICKLE et al., "Fredericamycin A, A New Antitumor Antibiotic", p. 1402-1407.
THE JOURNAL OF ANTIBIOTICS, (1997), Vol. 50, No. 4, HIDEAKI KAKEYA et al., "Cytotrienin A, a Novel Apoptosis Inducer In Human Leukemia HL-60 Cells", p. 370-372.
THE JOURNAL OF ANTIBIOTICS, (1993), Vol. 46, No. 11, NAOKI ABE et al., "Novel Cytocidal Compounds, Oxopropalines from Streptomyces Sp. G324 Producing Lavendamycin", p. 1678-1686.
THE JOURNAL OF ANTIBIOTICS, (1981), Vol. 34, No. 11, DANA J. WARNICK-PICKLE et al., "Fredericamycin A, A New Antitumor Antibiotic", p. 1402-1407.
Attorney, Agent or Firm:
Nakamura, Minoru (Room 646 3-1, Marunouchi 3-chom, Chiyoda-ku Tokyo 100, JP)
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