Title:
D-AMINO ACID PEPTIDES
Document Type and Number:
WIPO Patent Application WO2005021494
Kind Code:
A3
Abstract:
The present invention provides compounds of the formula X-R1-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)-R3(Y)-NR4R5; or R1(X)-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)-R3(Y)-NR4R5, in which X is a hard acid cation chelator, a soft acid cation chelator or Ac-, R1, R2 and R3 are independently selected from a covalent bond or one or more D-amino acids that can be the same or different, Y is a hard acid cation chelator, a soft acid cation chelator or absent, Z is a hard acid cation chelator, a soft acid cation chelator or absent, and A and B are haptens or hard acid cation chelators and can be the same or different, and R4 and R5 are independently selected from the group consisting of hard acid cation chelators, soft acid cation chelators, enzymes, therapeutic agents, diagnostic agents and H. The present invention also provides methods of using these compounds and kits containing the compounds.
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Inventors:
MCBRIDE WILLIAM J (US)
GOLDENBERG DAVID M (US)
GOLDENBERG DAVID M (US)
Application Number:
PCT/US2004/018646
Publication Date:
October 20, 2005
Filing Date:
June 14, 2004
Export Citation:
Assignee:
IMMUNOMEDICS INC (US)
MCBRIDE WILLIAM J (US)
GOLDENBERG DAVID M (US)
MCBRIDE WILLIAM J (US)
GOLDENBERG DAVID M (US)
International Classes:
A61K49/00; C07K5/10; A61K38/00; (IPC1-7): C07K38/12
Foreign References:
| US20020006379A1 | 2002-01-17 |
Other References:
See also references of EP 1633773A4
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