Title:
DETECTION METHOD FOR CHRONIC ACTIVE Epstein-Barr VIRUS (CAEBV)
Document Type and Number:
WIPO Patent Application WO/2023/182460
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel detection method for chronic active Epstein-Barr virus (CAEBV) and a novel therapeutic pharmaceutical composition for CAEBV. The present invention provides a detection method for CAEBV that includes a step for measuring the amount or concentration of Flt3-L in a biological sample from a subject. The present invention also provides a therapeutic pharmaceutical composition for CAEBV that includes an Flt3 inhibitor. The present invention is advantageous for simply and accurately detecting CAEBV. The present invention is also advantageous for providing a novel therapeutic agent for CAEBV that targets Flt3.
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Inventors:
ARAI AYAKO (JP)
OHASHI AYAKA (JP)
UEMURA YU (JP)
IMADOME KEN-ICHI (JP)
OHASHI AYAKA (JP)
UEMURA YU (JP)
IMADOME KEN-ICHI (JP)
Application Number:
PCT/JP2023/011650
Publication Date:
September 28, 2023
Filing Date:
March 23, 2023
Export Citation:
Assignee:
UNIV SCHOOL ST MARIANNA MEDICINE (JP)
NAT CT CHILD HEALTH & DEV (JP)
NAT CT CHILD HEALTH & DEV (JP)
International Classes:
G01N33/68; A61K45/00; A61P43/00; C12Q1/6813; C12Q1/6851; C12Q1/686; C12Q1/6869
Domestic Patent References:
| WO2009034945A1 | 2009-03-19 |
Foreign References:
| JP2017131218A | 2017-08-03 | |||
| JP2009534397A | 2009-09-24 | |||
| CN114921540A | 2022-08-19 |
Other References:
CEN OSMAN, KANNAN KARUPPIAH, HUCK SAPPAL JESSICA, YU JIE, ZHANG MENGKUN, ARIKAN MUZAFFER, UCUR ALI, USTEK DURAN, CEN YETER, GORDON: "Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma", MSPHERE, vol. 3, no. 4, 29 August 2018 (2018-08-29), XP093095140, DOI: 10.1128/mSphereDirect.00378-18
KANNO, HIROYUKI: "Epstein-Barr Virus (EBV) Infection and EBV-Related Diseases", SHINSHU MEDICAL JOURNAL - SHINSHU IGAKU ZASSHI, SHINSHU UNIVERSITY, SCHOOL OF MEDICINE, NAGANO, JP, vol. 64, no. 4, 10 August 2016 (2016-08-10), JP , pages 173 - 181, XP009549658, ISSN: 0037-3826, DOI: 10.11441/shinshumedj.64.173
SUZUKI, RITSURO: "Epstein-Barr Virus Associated Lymphoproliferative Disorders: Disease Concept and Treatment", NIHON NAIKA GAKKAI ZASSHI - JOURNAL OF THE JAPANESE SOCIETY OFINTERNAL MEDICINE, NIHON NAIKA GAKKAI, TOKYO, JP, vol. 102, no. 4, 30 November 2012 (2012-11-30), JP , pages 979 - 985, XP009549660, ISSN: 0021-5384, DOI: 10.2169/naika.102.979
OHASHI AYAKA, UEMURA YU, YOSHIMORI MAYUMI, WADA NAOMI, IMADOME KEN-ICHI, YUDO KAZUO, KOYAMA TAKATOSHI, SHIMIZU NORIO, NISHIO MIWAK: "The Plasma Level of Interleukin-1β Can Be a Biomarker of Angiopathy in Systemic Chronic Active Epstein–Barr Virus Infection", FRONTIERS IN MICROBIOLOGY, vol. 13, XP093095144, DOI: 10.3389/fmicb.2022.874998
KANNO, HIROYUKI: "Epstein-Barr Virus (EBV) Infection and EBV-Related Diseases", SHINSHU MEDICAL JOURNAL - SHINSHU IGAKU ZASSHI, SHINSHU UNIVERSITY, SCHOOL OF MEDICINE, NAGANO, JP, vol. 64, no. 4, 10 August 2016 (2016-08-10), JP , pages 173 - 181, XP009549658, ISSN: 0037-3826, DOI: 10.11441/shinshumedj.64.173
SUZUKI, RITSURO: "Epstein-Barr Virus Associated Lymphoproliferative Disorders: Disease Concept and Treatment", NIHON NAIKA GAKKAI ZASSHI - JOURNAL OF THE JAPANESE SOCIETY OFINTERNAL MEDICINE, NIHON NAIKA GAKKAI, TOKYO, JP, vol. 102, no. 4, 30 November 2012 (2012-11-30), JP , pages 979 - 985, XP009549660, ISSN: 0021-5384, DOI: 10.2169/naika.102.979
OHASHI AYAKA, UEMURA YU, YOSHIMORI MAYUMI, WADA NAOMI, IMADOME KEN-ICHI, YUDO KAZUO, KOYAMA TAKATOSHI, SHIMIZU NORIO, NISHIO MIWAK: "The Plasma Level of Interleukin-1β Can Be a Biomarker of Angiopathy in Systemic Chronic Active Epstein–Barr Virus Infection", FRONTIERS IN MICROBIOLOGY, vol. 13, XP093095144, DOI: 10.3389/fmicb.2022.874998
Attorney, Agent or Firm:
FIELDS IP ATTORNEYS PPC (JP)
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