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Title:
DEACETYLATION MODIFIED BAF155 PROTEIN AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/236863
Kind Code:
A1
Abstract:
The present invention provides a deacetylation modified BAF155 protein and a pharmaceutical use thereof. The present invention provides a deacetylation modified BAF155 protein or an active fragment thereof. Compared with a wild-type BAF155 protein, the deacetylation modified BAF155 protein comprises an amino acid sequence as shown in SEQ ID NO: 1, and the lysine is deacetylated. The present invention further provides a use of the deacetylation modified BAF155 protein or the active fragment thereof in preparation of a drug for preventing or treating cardiac remodeling. The applicant finds that BAF155 interacts with a BRCT domain of PARP1, a deacetylated state of the BAF155 activates E3 ubiquitin ligase WWP2, then the K948 site of the PARP1 is subjected to ubiquitination degradation, and the BAF155 and SIRT2 act synergistically to prevent cardiac remodeling, thereby providing a new idea and research direction for treatment and prevention of cardiovascular diseases.

Inventors:
SUN YINGXIAN (CN)
ZHANG NAIJIN (CN)
ZHANG YING (CN)
Application Number:
PCT/CN2023/098023
Publication Date:
December 14, 2023
Filing Date:
June 02, 2023
Export Citation:
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Assignee:
SUN YINGXIAN (CN)
ZHANG NAIJIN (CN)
ZHANG YING (CN)
International Classes:
C07K14/47; A61K38/17; A61K38/50; A61P9/00; A61P9/04; C12N9/80
Foreign References:
CN107173817A2017-09-19
CN113383018A2021-09-10
US20200239532A12020-07-30
Other References:
ZHANG NAIJIN, ZHANG YING, WU BOQUAN, WU SHAOJUN, YOU SHILONG, LU SAIEN, LIU JINGWEI, HUANG XINYUE, XU JIAQI, CAO LIU, SUN YINGXIAN: "Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury", REDOX BIOLOGY, ELSEVIER, NL, vol. 47, 1 November 2021 (2021-11-01), NL , pages 102141, XP093091362, ISSN: 2213-2317, DOI: 10.1016/j.redox.2021.102141
Attorney, Agent or Firm:
SHENYANG PATENT & TRADEMARK AGENCY ACADEMIA SINICA (CN)
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