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Title:
DEGRADABLE BIOMEDICAL MAGNESIUM ALLOY DRUG-ELUTING VASCULAR STENT AND PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2023/151343
Kind Code:
A1
Abstract:
A degradable biomedical magnesium alloy drug-eluting vascular stent and a preparation method. With the total weight of a magnesium alloy being 100% for calculation, the magnesium alloy comprises the following components in percentage by weight: 3.0-6.0% of Gd, 2.5-5.5% of Y, 1.0-3.0% of Li, 0.3-1.0% of Zn, 0.2-1.0% of Zr, and the balance being Mg. The stent has good radial support strength and strain dispersion capability by means of finite element design. After a protective coating is used, the corrosion resistance of the magnesium alloy stent is greatly improved. An arsenic trioxide/rapamycin and tacrolimus composite drug sustained-release system is used to fully adapt to the damage repair process of blood vessels. An implantation result of large animals shows that the vascular stent system has a good anti-restenosis treatment effect.

Inventors:
REN HEFEI (CN)
SHEN XIN (CN)
HAO DONGYUN (CN)
LI YANAN (CN)
SHE JIA (CN)
HE FUGUI (CN)
MA XIAOYI (CN)
ZHOU LIFENG (CN)
Application Number:
PCT/CN2022/133109
Publication Date:
August 17, 2023
Filing Date:
November 21, 2022
Export Citation:
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Assignee:
AMSINOMED MEDICAL CO LTD (CN)
International Classes:
A61F2/915
Foreign References:
CN114159197A2022-03-11
CN105671391A2016-06-15
CN113116595A2021-07-16
CN107088110A2017-08-25
CN101214396A2008-07-09
CN108315618A2018-07-24
CN108289747A2018-07-17
CN107630157A2018-01-26
US20070135908A12007-06-14
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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