Title:
DEGRADABLE NEAR-INFRARED PHOTOSENSITIZER, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/020631
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of photosensitizers. Disclosed are a degradable near-infrared photosensitizer, and a preparation method therefor and the use thereof. The degradable near-infrared photosensitizer is any one of a porphyrin compound, and a pharmaceutically acceptable salt, a solvate, a noncovalent-bond compound, a complex and a prodrug thereof, wherein the structure of the porphyrin compound is as shown in formula (1). Disclosed in the present invention are a preparation method for and the use of the degradable near-infrared photosensitizer. The degradable near-infrared photosensitizer of the present invention can be degraded while generating active oxygen under illumination, and after illumination ends, the photosensitizer is completely converted into a low-toxicity substance without photoactivity, such that the problem in the prior art of photosensitizer residues is effectively solved.
Inventors:
ZHANG JUNLONG (CN)
ZHU MENGLIANG (CN)
ZHANG HANG (CN)
YANG ZISHU (CN)
WANG BINGWU (CN)
ZHU MENGLIANG (CN)
ZHANG HANG (CN)
YANG ZISHU (CN)
WANG BINGWU (CN)
Application Number:
PCT/CN2022/124995
Publication Date:
February 23, 2023
Filing Date:
October 13, 2022
Export Citation:
Assignee:
BEIJING INST OF COLLABORATIVE INNOVATION (CN)
GUANGDONG GBA INST OF COLLABORATIVE INNOVATION (CN)
GUANGDONG GBA INST OF COLLABORATIVE INNOVATION (CN)
International Classes:
C07D498/22; A61K41/00; A61P35/00
Foreign References:
| CN112279862A | 2021-01-29 | |||
| BR102012018491A2 | 2016-03-29 | |||
| CN103127953A | 2013-06-05 | |||
| CN114014875A | 2022-02-08 |
Attorney, Agent or Firm:
KEYCOM PARTNERS, P.C. (CN)
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