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Title:
DEGRADABLE, POROUS, MAGNESIUM-CONTAINING CALCIUM PHOSPHATE-CALCIUM SULFATE COMPOSITE BIOLOGICAL STENT
Document Type and Number:
WIPO Patent Application WO/2017/219654
Kind Code:
A1
Abstract:
A degradable, porous, magnesium-containing calcium phosphate-calcium sulfate composite biological stent. A calcined bovine cancellous bone mineral porous stent is subject to a three-part system comprising a magnesium-source, sulfur-source, and phosphorus-source for processing, and is then retrieved, dried, and subject to high temperature calcination. The degradable, porous, magnesium-containing calcium phosphate-calcium sulfate composite biological stent has an excellent three-dimensional, interconnected porous structure, bone conductivity, and degradability as well as improved mechanical strength and biocompatibility. A pore of the stent has a calcium sulfate crystal whisker growth with a larger length-to-diameter ratio, and can thus be used to increase the specific surface area of a material and improve cellular adhesion. Effective addition of an osteogenic magnesium ion and of calcium sulfate, wherein the calcium sulfate generates a calcium-rich local environment when degraded, provides a potential osteoinductive property to the composite biological stent. The composite biological stent can better meet the ideal properties for a bone grafting material or a bone tissue engineering stent material.

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Inventors:
LI YAPING (CN)
LI SANG (CN)
MAO HAIJIAO (CN)
TANG TINGTING (CN)
FU JUN (CN)
XIONG HANFENG (CN)
NIE LEI (CN)
ZHENG JIANMIN (CN)
ZHANG GUOFENG (CN)
Application Number:
PCT/CN2017/000100
Publication Date:
December 28, 2017
Filing Date:
January 04, 2017
Export Citation:
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Assignee:
LI YAPING (CN)
International Classes:
A61L27/36; A61L27/40
Domestic Patent References:
WO2012101428A12012-08-02
Foreign References:
CN105597158A2016-05-25
CN105582574A2016-05-18
CN105169482A2015-12-23
US20050184418A12005-08-25
CN102106765A2011-06-29
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