Title:
DEGRADATION INDUCER
Document Type and Number:
WIPO Patent Application WO/2023/054549
Kind Code:
A1
Abstract:
The present invention provides a novel compound that induces selective degradation of a non-receptor tyrosine kinase (and especially a tyrosine kinase that constitutes the JAK family), or a pharmaceutically acceptable salt thereof. Provided is a compound represented by formula I [formula 1] (In the formula, R1 is a hydrogen atom or a C1-3 alkyl group that may be substituted with one or more deuterium atoms; R2 is CONHR3 (in the formula, R3 is a C1-3 alkyl group that may be substituted with one or more OH groups) or a triazole group that may be substituted with one or more C1-3 alkyl groups; A is a pyridyl group or a pyridazinyl group; B is represented by [Formula 2]; and n is an integer between 0 and 12), or a pharmaceutically acceptable salt thereof.
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Inventors:
KATO JUN-YA (JP)
KORENAGA SHIGERU (JP)
IWAKURA MASARU (JP)
KORENAGA SHIGERU (JP)
IWAKURA MASARU (JP)
Application Number:
PCT/JP2022/036353
Publication Date:
April 06, 2023
Filing Date:
September 29, 2022
Export Citation:
Assignee:
ASKA PHARM CO LTD (JP)
International Classes:
C07K5/06; A61K38/05; A61P17/00; A61P17/14; A61P29/00; A61P31/14; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07K5/02; C07K5/062; C12N9/12
Domestic Patent References:
| WO2020200291A1 | 2020-10-08 | |||
| WO2020069117A1 | 2020-04-02 | |||
| WO2020086616A1 | 2020-04-30 | |||
| WO2022100710A1 | 2022-05-19 |
Attorney, Agent or Firm:
SUZUKI Mamoru et al. (JP)
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