Title:
DENDRITIC CELL-MIMICKING FUNCTIONAL NANOSTRUCTURE COMPRISING αCTLA-4 AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2023/113546
Kind Code:
A1
Abstract:
The present invention relates to a dendritic cell-mimicking nanostructure for inhibiting immune checkpoints and a method for preparing same, the nanostructure comprising: a nanoparticle core; and a shell including a cell membrane of a lipid molecule derived from a dendritic cell, wherein the shell contains an αCTLA-4 monoclonal antibody. The present invention can provide an excellent effect of immune-anticancer treatment by increasing the immune response by means of strong activation of cytotoxic T cells through the inhibitory activity of the immune checkpoints.
Inventors:
HA SANG-JUN (KR)
MOON CHAE-WON (KR)
KIM DA-HAE (KR)
HONG JINKEE (KR)
KIM TAIHYUN (KR)
LEE YOOJIN (KR)
MOON CHAE-WON (KR)
KIM DA-HAE (KR)
HONG JINKEE (KR)
KIM TAIHYUN (KR)
LEE YOOJIN (KR)
Application Number:
PCT/KR2022/020604
Publication Date:
June 22, 2023
Filing Date:
December 16, 2022
Export Citation:
Assignee:
FORTUGA BIO INC (KR)
International Classes:
A61K9/51; A61K39/00; A61K47/54; A61P35/00; C07K16/28
Foreign References:
| CN112755182A | 2021-05-07 | |||
| EP3636269A1 | 2020-04-15 | |||
| CN112716912A | 2021-04-30 |
Other References:
LIU WEN-LONG, ZOU MEI-ZHEN, LIU TAO, ZENG JIN-YUE, LI XUE, YU WU-YANG, LI CHU-XIN, YE JING-JIE, SONG WEN, FENG JUN, ZHANG XIAN-ZHE: "Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP055939119, DOI: 10.1038/s41467-019-11157-1
WEIWEI GAO; CHE‐MING J. HU; RONNIE H. FANG; BRIAN T. LUK; JING SU; LIANGFANG ZHANG: "Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 25, no. 26, 27 May 2013 (2013-05-27), DE , pages 3549 - 3553, XP071870256, ISSN: 0935-9648, DOI: 10.1002/adma.201300638
SUN ZHIHONG, ET AL: "NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy", CHEMRXIV, 26 June 2020 (2020-06-26), XP055809069, DOI: 10.26434/chemrxiv.12546698.v2
WEIWEI GAO; CHE‐MING J. HU; RONNIE H. FANG; BRIAN T. LUK; JING SU; LIANGFANG ZHANG: "Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 25, no. 26, 27 May 2013 (2013-05-27), DE , pages 3549 - 3553, XP071870256, ISSN: 0935-9648, DOI: 10.1002/adma.201300638
SUN ZHIHONG, ET AL: "NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy", CHEMRXIV, 26 June 2020 (2020-06-26), XP055809069, DOI: 10.26434/chemrxiv.12546698.v2
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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