The invention also relates to processes for the preparation of the above derivatives of 1,3-diones and their use as herbicides for the control of weeds in agricultural crops.

Various derivatives of 1,3-diones substituted in position 1 and 2 by aromatic and/or heteroaromatic groups are described in J. Indian. Chem. Soc. (1961), vol. 38, pages 343-345, J. Org. Chem. (1962), vol.

27, pages 1899-1901 and Tetrahedron (1963), vol. 19, pages 413-418.

A herbicidal activity has never been described for any of these compounds.

The Applicant has now surprisingly found that derivatives of 1, 3-dines, in which the substituents in position 1 and 2 represent suitably substituted aryl, heteroaryl or heterocyclic groups, have a high herbicidal activity with respect to weeds in crops of agrarian interest.

An object of the present invention therefore relates to derivatives of 1,3-diones having general formula (I):

wherein: - A represents: an aryl group optionally substituted by one or more substituents selected from halogen, NO2, CN, CHO, OH, linear or branched C1-C6 alkyl, linear or branched C1- C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched C1-C6 haloalkoxyl, Cl-C6 cyanoalkyl, C2-C6 <BR> <BR> alkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6<BR> <BR> alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6<BR> <BR> haloalkoxyalkyl, C2-C6 haloalkylthioalkyl, C2-C6 haloalkylsulfinylalkyl, C2-C6 haloalkylsulfonylalkyl, C2-C6 alkoxyalkoxyl or C2-C6 haloalkoxyalkoxyl optionally substituted with a group selected from Cl- C4 alkoxyl or C1-C4 haloalkoxyl, C2-C6 alkylthioalkoxyl, C2-C6 haloalkylthioalkoxyl, C3-C12 dialkoxyalkyl, C3-C12 dialkylthioalkyl, C3-C12 dialkylthioalkoxyl, C3-C12 dialkoxyalkoxyl, C2-C6 <BR> <BR> haloalkoxyhaloalkoxyl, C3-Clo alkoxyalkoxyalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyloxy, C2-C6

haloalkenyloxy, C3-C8 alkenyloxyalkoxyl, C3-C8 haloal kenyloxyalkoxyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyloxy, C2-C6 haloalkynyloxy, C3-C8 alkynyloxyalkoxyl, C3-C8 haloalkynyloxyalkoxyl, Cl-ci acylaminoalkoxy, C2-C8 alkoxyiminoalkyl, C2-C8 <BR> <BR> <BR> <BR> <BR> haloal koxyiminoalkyl, C3-Cg alkenyloxyiminoalkyl, C3- C8 haloalkenyloxyiminoalkyl, Cs-Cg alkynyloxyiminoalkyl, C3-C8 haloalkynyloxyiminoalkyl, C5-C1o C10 alkoxyalkynyloxyl, C6-C12 <BR> <BR> <BR> <BR> <BR> cycloalkylideneiminooxyalkyl, C6-C12 dialkylideneiminooxyalkyl, -S(O)mR1, -OS(O)tR1, -SO2NR2R3, -CO2R4, -COR5, -CONR6R7, -CSNR8R9, -NR10R11, -NR12COR13, -NR14CO2R15, -NR16CONR17R18, -PO(R19)2, -Q, -ZQ1, -(CR20R21)pQ2, -Z(CR22R23)pQ3, - (CR24R25) pZQ4,- (CR26R27) pZ (CR28R29) qQ5r - (CR30R31) pZ (CR32R33) qZlQ6,-Z2 (CR34R35) p (C=Y) T, -Z3(CR36R37)v(CR38R39=CR40R41) (C=Y) T ; or it represents a heterocyclic group selected from pyridyl, pyrimidyl, quinolinyl, pyrazolyl, thiazolyl, oxazolyl, thienyl, furyl, benzothienyl, dihydrobenzothienyl, benzofuranyl, dihydrobenzofuranyl, benzoxazolyl, benzoxazolonyl, benzothiazolyl, benzothiazolonyl, benzoimidazolyl, benzoimidazolonyl, benzotriazolyl, chromanonyl, chromanyl, thiochromanonyl, thiochromanyl, 3a, 4-

dihydro-3H-indeno [1, 2-c] isoxazolyl, 3a, 4-dihydro-3H- chromeno [4,3-c] isoxazolyl, 5,5-dioxide-3a, 4-dihydro- 3H-thiochromeno [4, 3-c] isoxazolyl, 2,3, 3a, 4- tetrahydrochromeno [4,3-c] pyrazolyl, 6,6-dioxide-2, 3- dihydro-5H- [1, 4] dithiino [2,3-c] thiochromenyl, 5,5- dioxide-2, 3,3a, 4-tetrahydrothiochromeno [4,3- c] pyrazolyl, 1', 1'-dioxide-2', 3'-dihydrospiro [1, 3- dioxolano-2,4'-thiochromen]-yl, 1, 1,4, 4-tetraoxide- 2, 3-dihydro-1, 4-benzodithiin-6-yl, 4,4-dioxide-2, 3- dihydro-1, 4-benzoxathiin-7-yl, 1, 1-dioxide-3-oxo-2, 3- dihydro-1, 2-benzoisothiazol-5-yl, 4- (alkoxyimino)- 1, 1-dioxide-3, 4-dihydro-2H-thiochromen-6-yl, 1, 1- dioxide-4-oxo-3, 4-dihydro-2H-thiochromen-6-yl, 2,3- dihydro-1, 4-benzoxathiin-7-yl, with said groups optionally substituted by one or more substituents selected from halogen, N02, CN, CHO, OH, linear or branched C1-C6 alkyl, linear or branched C1-C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched C1-C6 haloalkoxyl, Cl-C6 <BR> <BR> <BR> <BR> cyanoalkyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, C2-Ce alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6 haloalkoxyalkyl, C2-C6 haloalkylthioalkyl, C2-C6 haloalkylsulfinylalkyl, C2-C6 haloalkylsulfonylalkyl, C2-C6 alkoxyalkoxyl or C2-C6 haloalkoxyalkoxyl optionally substituted with a group selected from C1-

C4 alkoxyl or Cl-C4 haloalkoxyl, CZ-C6 alkylthioalkoxyl, C2-C6 haloalkylthioalkoxyl, C3-C12 dialkoxyalkyl, C3-C12 dialkylthioalkyl, C3-C12 dialkylthioalkoxyl, C3-C12 dialkoxyalkoxyl, C2-C6 haloalkoxyhaloalkoxyl, C3-C10 alkoxyalkoxyalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C3-C8 alkenyloxyalkoxyl, C3-C8 haloalkenyloxyalkoxyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyloxy, C2-C6 haloalkynyloxy, C3-C8 alkynyloxyalkoxyl, C3-Cg haloalkynyloxyalkoxyl, C3-C12 acylaminoalkoxy, C2-C8 alkoxyiminoalkyl, C2-C8 haloalkoxyiminoalkyl, C3-C8 alkenyloxyiminoalkyl, C3- C8 haloalkenyloxyiminoalkyl, C3-Cs alkynyloxyiminoalkyl, C3-C8 haloalkynyloxyiminoalkyl, C5-C10 alkoxyalkynyloxyl, C6-C12 cycloalkylideneiminooxyalkyl, C6-C12 dialkylideneiminooxyalkyl, -S(O)mR1, -OS(O)tR1, -SO2NR2R3, -CO2R4, -COR5, -CONR6R7, -CSNR8R9, -NR10R11, -NR12COR13, -NR14CO2R15, -NR16CONR17R18, -PO(R19)2, -Q, -ZQ1, -(CR20R21)pQ2, -Z(CR22R23)pQ3, - (CR24R25) pZQ4 r- (CR26R27) pZ (CR28R29) qQ5 r - (CR30R31)pZ(CR32R33)qZ1Q6, -Z2(CR34R35)p(C=Y)T, -Z3(CR36R37)v(CR38R39=CR40R41)(C=Y)T; - B represents a D- (Rx)n group;

- represents a hydrogen atom, a linear or branched C1-C6 alkyl group, a linear or branched C1-C6 haloalkyl group, a C3-C6 cycloalkyl or C4-C12 cyclo- alkylalkyl group optionally substituted with halogen atoms or Cl-C6 alkyl or Ci-C6 thioalkyl or C1-C6 alkoxyl or C2-C6 alkoxycarbonyl groups, C2-C6 alkenyl groups, C2-C6 alkynyl groups, the latter two groups, in turn, optionally substituted with halogen atoms, a C5-C6 cycloalkenyl group optionally substituted with halogen atoms or Cl-C6 alkyl groups, an aryl or arylalkyl group optionally substituted ; - R1 and Ri9 represent a Cl-C6 alkyl group or a Cl-C6 haloalkyl group, a C3-C6 cycloalkyl group, an aryl group optionally substituted by one or more substituents selected from halogen, NO2, CN, CHO, linear or branched Cl-C6 alkyl, linear or branched Cl- C6 haloaLkyl, linear or branched Cl-C6 alkoxyl, linear or branched Cl-C6 haloalkoxyl, C1-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl ; - m is equal to 0,1 or 2; - t is equal to 1 or 2 ; - R2, R3, R6, R7, R8, R9, R10, R11, R17 and R18, the same or different, represent a hydrogen atom, a linear or branched Cl-C6 alkyl group in turn optionally substituted with halogen atoms, a Cl-C6 alkoxyl

group, a C3-C6 cycloalkyl group, an arylalkyl group or an aryl group, said arylalkyl and aryl groups also optionally substituted by one or more substituents selected from halogen, N02, CN, CHO, linear or branched C1-C6 alkyl, linear or branched C1-C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched Cl-C6 haloalkoxyl, Cl-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl, or they jointly represent a C2- C5 alkylene group; - R4, R5 and R42 represent a hydrogen atom, a linear or branched Cl-C6 alkyl group in turn optionally substituted with halogen atoms, a C3-C6 alkenyl group in turn optionally substituted with halogen atoms, a Q7 group, an arylalkyl group optionally substituted by one or more substituents selected from halogen, NO2, CN, CHO, linear or branched Cl-C6 alkyl, linear or branched Cl-C6 haloalkyl, linear or branched Cl-C6 alkoxyl, linear or branched Cl-C6 haloalkoxyl, Cl-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl; - R12, R14 and Rig represent a hydrogen atom, a linear or branched Cl-C6 alkyl group in turn optionally substituted with halogen atoms, a C3-C6 cycloalkyl group, a C1-C6 alkoxyl group, a C1-C6 haloalkoxyl group;

- R13 and R15 represent a hydrogen atom, a linear or branched C1-C6 alkyl group in turn optionally substituted with halogen atoms, a C3-C6 alkenyl group in turn optionally substituted with halogen atoms, a Q7, NH2, NHCN, NHNH2, NHOH group, an arylalkyl group optionally substituted by one or more substituents selected from halogen, NO2, CN, CHO, linear or branched C1-C6 alkyl, linear or branched C1-C6 haloalkyl, linear or branched Ci-C6 alkoxyl, linear or branched Cl-C6 haloalkoxyl, C1-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl ; - R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40 and R4l, the same or different, represent a hydrogen atom, a linear or branched Cl-C6 alkyl group in turn optionally substituted with halogen atoms, a Cl-C6 alkoxyl group, or the two groups attached to the same carbon atom can be joined to each other by C2-C5 alkylene groups, the alkylene groups can in turn be substituted with Cl-C3 alkyl groups; - Q, Q1, Q2, Q3, Q4, Q5, Q6 and Q7 represent an aryl group, a C3-C6 cycloalkyl group, a C5-C6 cycloalkenyl group, a heterocyclic group selected from triazolyl, triazolonyl, pyrazolyl, imidazolyl, imidazolidinonyl, tetrazolyl, tetrazolonyl, isoxazolyl, furyl, thienyl,

pyrrolyl, pyrrolidinyl, pyrrolidinonyl, pyridyl, pyrimidinyl, pyrimidinonyl, pyrazinyl, pyridazinyl, oxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, isothiazolyl, benzoxazolyl, benzothiazolyl, isoxazolinyl, 1,3-dioxanyl, 1,4-dioxanyl, 1, 3- dioxolanyl, tetrahydropyranyl, oxethanyl, oxyranyl, thiazolidinyl, oxazolidinyl, piperidinyl, piperidinonyl, piperazinyl, morpholinyl, thiazinyl, tetrahydrofuranyl, dioxazolyl, <BR> <BR> <BR> <BR> tetrahydrofuroisoxazolyl, 2-oxa-3- azabicyclo [3.1. 0] hex-3-enyl, said groups optionally substituted by one or more substituents selected from halogen, NO2, OH, CN, CHO, linear or branched C1-C6 alkyl, linear or branched C1- C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched Cl-C6 haloalkoxyl, Cl-C6 cyanoalkyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, Cs-Cg <BR> <BR> <BR> <BR> alkylsulfinylalkyl, C2 C6 alkylsulfonylalkyl, C2-C6 haloalkoxyalkyl, C2-C6 haloalkylthioalkyl, C2-C6 <BR> <BR> <BR> <BR> haloalkylsulfinylalkyl, C2-C6 haloalkylsulfonylalkyl, C2-C6 alkoxyalkoxyl or C2-C6 haloalkoxyalkoxyl optionally substituted with a group selected from C1- C4 alkoxyl or Ci-C4 haloalkoxyl, C2-C6 alkylthioalkoxyl, C2-C6 haloalkylthioalkoxyl, C3-C12 dialkoxyalkyl, C3-C12 dialkylthioalkyl, C3-C12

dialkylthioalkoxyl, C3-Ci2 dialkoxyalkoxyl, C2-C6 <BR> <BR> <BR> <BR> haloalkoxyhaloalkoxyl, C3-C1o alkoxyalkoxyalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C3-C8 alkenyloxyalkoxyl, C3-C8 haloalkenyloxyalkoxyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyloxy, C2-C6 haloalkynyloxy, C3-C8 alkynyloxyalkoxyl, C3-C8 haloalkynyloxyalkoxyl, C3-C12 acylaminoalkoxy, C2'-'Ce alkoxyiminoalkyl, C2-C8 haloalkoxyiminoalkyl, C3-C8 alkenyloxyiminoalkyl, C3- Cs haloalkenyloxyiminoalkyl, C3-C8 alkynyloxyiminoalkyl, C3-C8 haloalkynyloxyiminoalkyl, <BR> <BR> <BR> <BR> C5-Cso alkoxyalkynyloxyl, C6-Cl2 cycloalkylideneiminooxyalkyl, C6-C12 dialkylideneiminooxyalkyl, aryl optionally substituted, -S(O)mR1, -OS(O)tR1, -SO2NR2R3, -CO2R4, -COR5, -CONR6R7, -CSNR8R9, -NR10R11, -NR12COR13, -NR14CO2R15, -NR16CONR17R18, -PO(R19)2, -Z2(CR34R35) p (C=Y) T, -Z3 (CR36R37)v(CR38R39=CR40R41)(C=Y)T; - Z, Z1, Z2 = O, S (0) r; - Y = O, S; - r is equal to 0, 1 or 2; - p, q are equal to 1,2, 3 or 4; - v is equal to 0 or 1; - Z3 = O, S or a direct bond;

- T represents a hydrogen atom, a Z4R42 group, a - NR43R44 group, an aryl group or a heterocyclic group selected from triazolyl, triazolonyl, pyrazolyl, imidazolyl, imidazolidinonyl, tetrazolyl, tetrazolonyl, pyrrolyl, pyrrolidinyl, pyrrolidinonyl, pyridyl, pyrimidinyl, piperidinyl, piperidinonyl, piperazinyl, morpholinyl, said groups optionally substituted by one or more substituents selected from halogen, NO2, OH, CN, CHO, linear or branched Ci-Ce alkyl, linear or branched Cl-C6 haloalkyl, C3-C6 cycloalkyl, C5-C6 cycloalkenyl, linear or branched Cl- C6 alkoxyl, linear or branched Ci-C6 haloalkoxyl, C1- C6 cyanoalkyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6 haloalkoxyalkyl, C2-C6 haloalkylthioalkyl, C2-C6 haloalkylsulfinylalkyl, C2- C6 haloalkylsulfonylalkyl,-S (O) Rl ; - Z4 = 0, S or a direct bond; - R43 and R44, the same or different, represent a hydrogen atom, a linear or branched C1-C6 alkyl group in turn optionally substituted with halogen atoms, a C3-C6 alkenyl group in turn optionally substituted with halogen atoms, a Q7 group, an arylalkyl group optionally substituted by one or more substituents selected from halogen, NO2, CN, CHO, linear or

branched C1-C6 alkyl, linear or branched Ci-C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched C1-C6 haloalkoxyl, C1-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl, or they jointly represent a C2- C5 alkylene chain; - D represents: a heterocyclic group of the heteroaryl or heterocyclic type, in all the above cases the heterocycle can be mono or polycyclic and can be connected to the rest of the structure either through one of its carbon atoms or, when possible, through one of its nitrogen atoms ; or it represents a mono or polycyclic aryl group, in this latter case, the group can also be partially saturated ; - Rx represents a substituent selected from hydrogen, halogen, NO2, CN, CHO, OH, linear or branched C1-C6 alkyl, linear or branched C1-C6 haloalkyl, linear or branched Ci-Ce alkoxyl, linear or branched C1-C6 haloalkoxyl, C1-C6 cyanoalkyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 <BR> <BR> <BR> <BR> alkylsulfonylalkyl, C2-C6 haloalkoxyalkyl, C2-C6 haloalkylthioalkyl, C2-C6 haloalkylsulfinylalkyl, C2- C6 haloalkylsulfonylalkyl, C2-C6 alkoxyalkoxyl or C2- C6 haloalkoxyalkoxyl optionally substituted with a

group selected from C1-C4 alkoxyl or C-C4 haloalkoxyl, C2-C6 haloalkylthioalkoxyl, C3-C12 dialkoxyalkyl, C3-C12 dialkylthioalkyl, C3-C12 dialkylthioalkoxyl, C3-C12 dialkoxyalkoxyl, C2-C6 haloalkoxyhaloalkoxyl, C3-C10 alkoxyalkoxyalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C3-C8 alkenyloxyalkoxyl, C3-C8 haloalkenyloxyalkoxyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyloxy, C2-C6 haloalkynyloxy, C3-CB alkynyloxyalkoxyl, C3-C8 haloalkynyloxyalkoxyl, C3-C12 acylaminoalkoxy, C2-C8 alkoxyiminoalkyl, C2-C8 <BR> <BR> <BR> <BR> <BR> haloalkoxyiminoalkyl, C3-C8 alkenyloxyiminoalkyl, C3- C8 haJLoalkenyloxyiminoalkyI, Cs-Cg alkynyloxyiminoalkyl, C3-C8 haloalkynyloxyiminoalkyl, C5-C10 alkoxyalkynyloxyl, C6-C12 <BR> <BR> <BR> <BR> <BR> cycloalkylidene iminooxyalkyl, C6-C12 dialkylideneiminooxyalkyl,-S (O) mRi,-OS (O) tRl, - SO2NR2R3, -CO2R4, -COR5, -CONR6R7, -CSNR8R9, -NR10R11, -NR12COR13, -NR14CO2R15, -NR16CONR17R18, -PO(R19)2, -Q, -ZQ1, -(CR20R21)pQ2, -Z(CR22R23)pQ3, - (CR24R25)pZQ4, -(CR26R27)pZ(CR28R29)qQ5, - (CR30R31)pZ(CR32R33)qZ1Q6, -Z2(CR34R35) p (C=Y) T, - Z3 (CR36R37) v (CR38R39=CR4oR4l) (C=Y) T ; if several Rx groups are present, these can be the same or different ;

- n = 1-9; excluding the following compounds having general formula (I) wherein A, B and R have the following meanings : A=4-chlorophenyl, B=1-methylimidazol-2-yl, R=H ; A=4-nitrophenyl, B=1- (2-hydroxyethyl)-5- nitroimidazol-2-yl, R=H ; A=phenyl, B=lH-benzimidazol-2-yl, R=C2H5 ; A=phenyl, B=4H-1-benzopyran-4-yl, R=CH3 ; A=4-nitrophenyl, B=3- (4-methylphenyl)-1, 2,4- oxadiazol-5-yl, R=CH3 ; A=phenyl, B=4-chloro-2,5-dioxo-2, 5-dihydro-lH-pyrrol- 3-yl, R=CH3 ; A=phenyl, B=2-acetyl-1, 2,3, 4-tetrahydroisoquinolin-1- yl, R=C2H5 ; A=2-hydroxy-4-methoxyphenyl, B=thiazol-4-yl, R=CH3 ; A=phenyl, B=2, 5-diphenyl-1, 3-oxathiol-2-yl, R=CH3 ; A=4-nitrophenyl, B=4,6-bis (dimethylamino)-1, 3,5- triazin-2-yl, R=CH3 ; A=phenyl, B=furan-2-yl, R=CH3 ; A=phenyl, B=1, 3-dithian-2-yl, R=CH3; A=phenyl, B=4-chlorothien-2-yl, R=H; A=phenyl, B=5-bromothien-2-yl, R=H; A=phenyl, B=5-methylthien-2-yl, R=H; A=phenyl, B=6-phenylpyrazin-2-yl, R=CH3 ;

A=phenyl, B=3, 4-dihydro-3-methyl-2-oxo-2H-1, 3-benzo- oxazin-4-yl, R=CH3 ; A=phenyl, B=benzothiazol-2-yl, R=CH3 ; <BR> <BR> <BR> <BR> A=2-hydroxy-4-methoxyphenyl, B=2-phenylthiazol-4-yl, R=CH3; A=phenyl, B=5-methylfuran-2-yl, R=CH3; A=phenyl, B=3- (4-methylphenyl)-1, 2,4-oxadiazol-5-yl, R=CH3 ; A=phenyl, B=tetrahydrofuran-2-yl, R=CH3; A=phenyl, B=2, 3-dihydro-3-hydroxy-2-oxo-lH-indol-3- yl, R=CH3, A=phenyl, B=4-chloro-1-methyl-2, 5-dioxo-2,5-dihydro- pyrrol-3-yl, R=CH3 ; A=phenyl, B=2-trifluoroacetyl-1, 2,3, 4-tetrahydroiso- quinolin-1-yl, R=C2H5 ; A=phenyl, B=2-acetyl-1, 2,3, 4-tetrahydroisoquinolin-1- yl, R=CH3; A=4-nitrophenyl, B=2- (4-nitrophenyl)-3, 5,6-triphenyl- pyridin-4-yl, R=CH3 ; A=phenyl, B=4,6-bis (dimethylamino)-1, 3,5-triazin-2- yl, R=CH3; <BR> <BR> <BR> <BR> A=phenyl, B=4-methoxy-5-tert-butoxycarbonyl-1H-pyrro- 2-yl, R=CH3 ; A=phenyl, B=1, 3-dihydro-3-oxo-isobenzofuran-1-yl, R=CH3 ;

A=phenyl, B= (5-methoxycarbonylmethyl) thien-2-yl, R=H ; A=phenyl, B=4-methylthien-2-yl, R=H; A=phenyl, B=1, 4-dihydro-1-methyl-3-nitroquinolin-4- yl, R=H; A=phenyl, B=thien-2-yl, R=H ; A=phenyl, B=6-methylbenzothiazol-2-yl, R=CH3 ; A=2-methoxycarbonylphenyl, B=phenyl, R=CH3; A=2-benzyloxy-4-methoxyphenyl, B=2,3, 4- trimethoxyphenyl, R=H; A=4,5-dimethoxy-2-nitrophenyl, B=3,4-dimethoxyphenyl, R=H ; A=2-nitrophenyl, B=phenyl, R=H ; A=2,4, 5-trimethoxyphenyl, B=4-methoxyphenyl, R=H ; A=4-bromophenyl, B=phenyl, R=H; A=4-bromophenyl, B=2,4-dinitrophenyl, R=CH3; A=4-chlorophenyl, B=phenyl, R=H; A=2, 4-dibenzyloxy-5-methoxyphenyl, B=1, 3-benzodioxol- 5-yl, R=H ; A=2,4-dibenzyloxyphenyl, B=1, 3-benzodioxol-5-yl, R=H ; A=4-methoxyphenyl, B=2-carboxyphenyl, R=H ; A=4-methylphenyl, B=2,4-dinitrophenyl, R=CH3; A=4-hydroxy-3-methoxyphenyl, B=4-hydroxy-3- methoxyphenyl, R=H; A=2-nitrophenyl, B=4-methylphenyl, R=H ; A=4-chlorophenyl, B=4-chlorophenyl, R=H;

A=2, 4-diacetoxyphenyl, B=phenyl, R=CH3 ; A=3-methoxyphenyl, B=phenyl, R=C2R5 ; A=4-nitrophenyl, B=phenyl, R=H; A=2-nitrophenyl, B=4-n-butoxyphenyl, R=H ; A=2-nitro-4-chlorophenyl, B=4-methylphenyl, R=H; A=phenyl, B=8-carboxynaphthalenyl, R=CH3; A=2,5-dimethoxyphenyl, B=2-hydroxyphenyl, R=C2R5 ; A=4-fluorophenyl, B=2-nitro-4-trifluoromethylphenyl, R=CH3; A=3-chloro-4-methylphenyl, B=2,4-dinitrophenyl, R=CH3; A=2-nitro-4-chlorophenyl, B=phenyl, R=H; A=4,5-dimethoxy-2-nitrophenyl, B=4-methylphenyl, R=H; A=2-carboxy-6-nitrophenyl, B=phenyl, R=CH3; A=2, 4,5-trimethoxyphenyl, B=3-methoxyphenyl, R=H ; A=phenyl, B=4-bromophenyl, R=H ; A=6-benzyloxy-2, 3, 4-trimethoxyphenyl, B=1, 3- benzodioxol-5-yl, R=H ; A=4,5-dimethoxy-2-nitrophenyl, B=4-methoxyphenyl, R=H; A=4,5-dimethoxy-2-nitrophenyl, B=4-chlorophenyl, R=H ; A=2, 4-dibenzyloxyphenyl, B=4-methoxyphenyl, R=H; A=4-methylphenyl, B=4-methylphenyl, R=H; A=4-dimethylaminophenyl, B=phenyl, R=H ; A=4-methoxyphenyl, B=phenyl, R=H;

A=4, 5-dichloro-2-nitrophenyl, B=4-chlorophenyl, R=H; A=2-nitrophenyl, B=4-methoxyphenyl, R=H ; A=phenyl, B=2, 5-dimethoxycarbonylaminophenyl, R=CH3i A=4-hydroxy-4-methoxyphenyl, B=2-methoxyphenyl, R=H; A=phenyl, B=4-methylphenyl, R=H; A=2-nitrophenyl, B=4-ethoxyphenyl, R=H ; A=2-nitro-4-chlorophenyl, B=4-methoxyphenyl, R=H ; A=4-chlorophenyl, B=phenyl, R=C2H5 ; A=2-t-butoxycarbonyl-5-ethyl-4-methoxyphenyl, B=2,3- dihydro-7-methyl-1, 4-benzodioxin-6-yl, R=t-butyl ; A=phenyl, B=2-nitro-4-trifluoromethylphenyl, R=CH3; A=3, 4-dichlorophenyl, B=2,4-dinitrophenyl, R=CH3 ; A=4, 5-dichloro-2-nitrophenyl, B=4-methoxyphenyl, R=H; A=4-methoxy-2-nitrophenyl, B=4-methylphenyl, R=H ; A=phenyl, B=anthracene-9-yl, R=CH3 ; A=phenyl, B=4-methoxyphenyl, R=H ; A=2, 4, 5-trimethoxyphenyl, B=phenyl, R=H; A=2,4-diacetoxyphenyl, B=2,4, 5-trimethoxyphenyl, R=CH3; A=2-hydroxyphenyl, B=phenyl, R=H; A=4-methoxy-2-nitrophenyl, B=phenyl, R=H; A=4, 5-dimethoxy-2-nitrophenyl, B=phenyl, R=H ; A=2, 4-dinitrophenyl, B=phenyl, R=CH3 ; A=phenyl, B=phenyl, R=CH3 ; A=phenyl, B=4-dimetlaylaminophenyl, R=H ;

A=phenyl, B=2, 4-dinitrophenyl, R=CH3 ; A=4, 5-dichloro-2-nitrophenyl, B=4-methylphenyl, R=H; A=4-bromophenyl, B=phenyl, R=CH3 ; A=2- (4-methylphenylsulfonyloxy)-6-methoxyphenyl, B=phenyl, R=H ; A=4-methylsulfonylphenyl, B=2-methoxyphenyl, R=CH3; A=4-methoxyphenyl, B=4-methoxyphenyl, R=CH3 ; A=phenyl, B=4-chlorophenyl, R=H ; A=2-nitrophenyl, B=4-nitrophenyl, R=H; A=phenyl, B=phenyl, R=H ; A=2,4-dimethoxyphenyl, B=4-methoxyphenyl, R=H ; A=2-nitrophenyl, B=4-n-hexyloxyphenyl, R=H ; A=4-methoxy-2-nitrophenyl, B=4-methoxyphenyl, R=H; A=phenyl, B=9-carboxyphenanthren-10-yl, R=CH3 ; A=phenyl, B=phenyl, R=CH3 ; A=3,4-dimethoxyphenyl, B=3, 4-dimethoxyphenyl, R=H ; A=2,4-dimethoxyphenyl, B=phenyl, R=H; A=phenyl, B=2-hydroxy-3,4, 6-trimethyl-5- methoxyphenyl, R=CH3 ; A=4-chloro-2-nitrophenyl, B=4-chlorophenyl, R=H ; A=2-nitrophenyl, B=4-chlorophenyl, R=H; A=2,4, 5-trimethoxyphenyl, B=3,4-dimethoxyphenyl, R=H ; A=4-chlorophenyl, B=2,4-dinitrophenyl, R=CH3 ; A=4, 5-dichloro-2-nitrophenyl, B=phenyl, R=H ; A=4-methoxyphenyl, B=phenyl, R=CH3 ;

A=2, 4-dibenzyloxyphenyl, B=3,4-dimethoxyphenyl, R=H; A=4-methylthiophenyl, B=4-methoxyphenyl, R=CH3; A=phenyl, B=phenyl, R=C2H5 ; A=4-methoxyphenyl, B=2,4-dinitrophenyl, R=CH3; A=2-nitrophenyl, B=3-chlorophenyl, R=H; A=2-nitrophenyl, B=3, 4-dimethoxyphenyl, R=H ; A=4-methoxyphenyl, B=4-methoxyphenyl, R=H ; A=2-hydroxyphenyl, B=4-methoxyphenyl, R=H; A=phenyl, B=2,5-bis (phenacylamino) phenyl, R=CH3; A=4-nitrophenyl, B=4-methylphenyl, R=H; A=2-nitrophenyl, B=4-n-pentyloxyphenyl, R=H ; A=4-methoxy-2-nitrophenyl, B=4-chlorophenyl, R=H; A=phenyl, B=2-carboxynaphthalen-1-yl, R=CH3.

A further object of the present invention relates to the use of derivatives of 1, 3-diones having general formula (I) (I) wherein: - A represents: an aryl group possibly substituted by one or more substituents selected from halogen, N02, CN, CHO, OH,

linear or branched Cl-C6 alkyl, linear or branched C1- C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched C1-C6 haloalkoxyl, C1-C6 cyanoalkyl, C2-C6 alkoxyalkyl, Cz-Cg alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6 haloalkoxyalkyl, C2-C6 haloalkylthioalkyl, C2-C6 haloalkylsulfinylalkyl, C2-C6 haloalkylsulfonylalkyl, C2-C6 alkoxyalkoxyl or C2-C6 haloalkoxyalkoxyl possibly substituted with a C1-C4 alkoxyl or C1-C4 haloalkoxyl group, C2-C6 alkylthioalkoxyl, C2-C6 haloalkylthioalkoxyl, C3-C12 dialkoxyalkyl, C3-C12 dialkylthioakyl, C3-C12 dialkylthioalkoxyl, 3-012 dialkoxyalkoxyl, C2-C6 haloalkoxyhaloalkoxyl, C3-C10 alkoxyalkoxyalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C3-C8 alkenyloxyalkoxyl, C3-C8 haloalkenyloxyalkoxyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyloxy, Cz-Cg haloalkynyloxy, C3-CB alkynyloxyalkoxyl, C3-CB haloalkynyloxyalkoxyl, C3-C12 acylaminoalkoxy, C2-C8 alkoxyiminoalkyl, C2-C8 haloalkoxyiminoalkyl, C3-C8 alkenyloxyiminoalkyl, C3-C8 haloalkenyloxyiminoalkyl, C3-CB alkynyloxyiminoalkyl, C3-C8 haloalkynyloxyiminoalkyl, C5-C1o alkoxyalkynyloxyl, C6-C12 cycloalkylideneiminooxyalkyl, Cl-ci <BR> <BR> <BR> dialkylideneiminooxyalkyl,-S (O) mRl,-OS (O) tRl.-

S02NR2R3,-C02R4,-COR5,-CONR6R7,-CSNR8R9,-NRloRl, -NR12COR13, -NR14CO2R15, -NR16CONR17R18, -PO(R19)2, -Q, - ZQ1, -(CR20R21)rQ2, -Z(CR22R23)pQ3, -(CR24R25)pZQ4, - (CR26R27)pZ(CR28R29)qQ5, -(CR30R31)pZ(CR32R33)qZ1Q6, -Z2 (CR34R35) p (C=Y) T,-Z3 (CR36R39=CR4oR4l) (C=Y) T ; or represents a heterocyclic group selected from pyridyl, pyrimidyl, quinolinyl, pyrazolyl, thiazolyl, oxazolyl, thienyl, furyl, benzothienyl, dihydrobenzothienyl, benzofuranyl, dihydrobenzofuranyl, benzoxazolyl, benzoxazolonyl, benzothiazolyl, benzothiazolonyl, benzoimidazolyl, benzoimidazolonyl, benzotriazolyl, chromanonyl, chromanyl, thiochromanonyl, thiochromanyl, 3a, 4- dihydro-3H-indeno [1, 2-c] isoxazolyl, 3a, 4-dihydro-3H- chromeno [4, 3-c] isoxazolyl, 5,5-dioxide-3a, 4-dihydro- 3H-thiochromeno [4,3-c] isoxazolyl, 2,3, 3a, 4- tetrahydrochromeno [4, 3-c] pyrazolyl, 6,6-dioxide-2, 3- dihydro-5H- [1, 4] dithiino [2,3-c] thiochromenyl, 5,5- dioxide-2,3, 3a, 4-tetrahydrothiochromeno [4,3- c] pyrazolyl, 1', 1'-dioxide-2', 3'-dihydrospiro [1, 3- dioxolane-2, 4'-thiochromen]-yl, 1,1, 4,4-tetraoxide- 2, 3-dihydro-1, 4-benzodithiin-6-yl 4, 4-dioxide-2,3- dihydro-1, 4-benzoxathiin-7-yl, 1, 1-dioxide-3-oxo-2, 3- dihydro-1, 2-benzoisothiazol-5-yl, 4- (alkoxyimino)- 1, 1-dioxide-3, 4-dihydro-2H-thiochromen-6-yl, 1,1-

dioxide-4-oxo-3, 4-dihydro-2H-thiochromen-6-yl, 2,3- dihydro-1, 4-benzoxathiin-7-yl, with all these groups possibly substituted by one or more substituents selected from halogen, NO2, CN, CHO, OH, linear or branched C1-C6 alkyl, linear or branched Ci-C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched C1-C6 haloalkoxyl, Cl-C6 cyanoalkyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6 haloalkoxyalkyl, C2-C6 haloalkylthioalkyl, C2-C6 haloalkylsulfinylalkyl, C2-C6 haloalkylsulfonylalkyl, C2-C6 alkoxyalkoxyl or C2-C6 haloalkoxyalkoxyl, possibly substituted with a C1-C4 alkoxyl or C1-C4 haloalkoxyl group, C2-C6 alkylthioalkoxyl, C2-C6 haloalkylthioalkoxyl, C3-C12 dialkoxyalkyl, C3-C12 dialkylthioalkyl, C3-C12 dialkylthioalkoxyl, C3-C12 dialkoxyalkoxyl, C2-C6 haloalkoxyhaloalkoxyl, C3-C10 alkoxyalkoxyalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, Cs-Cg alkenyloxyalkoxyl, C3-C8 haloalkenyloxyalkoxyl, CZ-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyloxy, C2-C6 haloalkynyloxy, C3-C8 alkynyloxyalkoxyl, C3-C8 haloalkynyloxyalkoxyl, C3-C12 acylaminoalkoxy, C2-C8 alkoxyiminoalkyl, C2-C8 haloalkoxyiminoalkyl, C3-C8 alkenyloxyiminoalkyl, C3-

C8 haloalkenyloxyiminoalkyl, Cg-Cg alkynyloxyiminoalkyl, C3-C8 haloalkynyloxyiminoalkyl, C5-C10 alkoxyalkynyloxyl, C6-C12 cycloalkylideneiminooxyalkyl, C6-C12 dialkylideneiminooxyalkyl,-S (0) mRl,-OS (O) tRl, -SO2NR2R3, -CO2R4, -COR5, -CONR6R7, -CSNR8R9, -NR10R11, -NR12COR13, -NR14CO2R15, -NR16CONR17R18, -PO(R19)2, -Q, - ZQ1, -(CR20R21)pQ2, -Z(CR22R23)pQ3, -(CR24R25)pZQ4, - (CR26R27) pZ (CR28R29)pQ5, -(CR30R31)pZ(CR32R33)pZ1Q6, - (CR34R35) p (C=Y)T, -Z(CR36R37)v(CR38R39=CR40R41) (C=Y)T; - B represents a D- (Rx)n group; - R represents a hydrogen atom, a linear or branched C1-C6 alkyl group, a linear or branched C1-C6 haloalkyl group, a C3-C6 cycloalkyl group or a C4-Cl2 cycloalkylalkyl group possibly substituted with halogen atoms or C1-C6 alkyl or C1-C6 thioalkyl or C1- C6 alkoxyl or C2-C6 alkoxycarbonyl groups, alkenyl C2- C6 groups, alkynyl C2-C6 groups, the latter two groups, in turn, possibly substituted with halogen atoms, a C5-C6cycloalkenyl group possibly substituted with halogen atoms or C1-C6 alkyl groups, an aryl or arylalkyl group optionally substituted ; Ri and R19, represent a C1-6 alkyl or C1-C6 haloalkyl group, a C3-C6 cycloalkyl group, an aryl group optionally substituted by one or more

substituents selected from halogen, NO2, CN, CHO, linear or branched C1-C6 alkyl, linear or branched C1- C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched Cl-C6 haloalkoxyl, Cl-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl ; - m is equal to 0,1 or 2; - t is equal to 1 or 2; - R2, R3, R6, R7, R8, R9, R10, R11, R17 and R18, the same or different, represent a hydrogen atom, a linear or branched Ci-Ce alkyl group in turn possibly substituted with halogen atoms, a C1-C6 alkoxyl group, a C3-C6 cycloalkyl group, an arylalkyl group or an aryl group, said arylalkyl or aryl groups also optionally substituted with one or more substituents selected from halogen, NO2, CN, CHO, linear or branched Ci-Ce alkyl, linear or branched C1-C6 haloalkyl, linear or branched Ci-Ce alkoxyl, linear or branched Ci-Ce haloalkoxyl, C1-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl or, together, represent a C2-C5 alkylenic chain; -R4, R5 and R42, represent a hydrogen atom, a linear or branched C1-C6 alkyl group in turn possibly substituted with halogen atoms, a C3-C6 alkenyl group in turn possibly substituted with halogen atoms, a Q7 group, an arylalkyl group possibly substituted with

one or more substituents selected from halogen, N02, CN, CHO, linear or branched C1-C6 alkyl, linear or branched C1-C6 haloalkyl, linear or branched Cl-C6 alkoxyl, linear or branched Cl-C6 haloalkoxyl, C1-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl; - R12, R14 and R16, represent a hydrogen atom, a linear or branched C1-C6 alkyl group in turn possibly substituted with halogen atoms, a C3-C6 cycloalkyl group, a Ci-C6 alkoxyl group, a Cl-C6 haloalkoxyl group ; - R13 and R15, represent a hydrogen atom, a linear or branched C1-C6 alkyl group in turn possibly substituted with halogen atoms, a C3-C6 alkenyl group, in turn possibly substituted with halogen atoms, a Q7 group, NH2, NHCN, NHNH2, NHOH, an arylalkyl group possibly substituted with one or more substituents selected from halogen, NO2, CN, CHO, linear or branched C1-C6 alkyl, linear or branched C1- C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched C1-C6 haloalkoxyl, C1-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl ; - R20, R21, R22, R23, R24, R25, R26, R27, R28 R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40 and R41, the same or different, represent a hydrogen atom, a linear or branched Cl-C6 alkyl group in turn possibly

substituted with halogen atoms, a C1-C6 alkoxyl group, or the two groups bound to the same carbon atom can be joint by C2-C5 alkylene groups, the alkylene groups can be, in turn, substituted with Cl- C3 alkyl groups; - Q, Q1, Q2, Q3, Q4, Q5, Q6 and Q7 represent an aryl group, a C3-C6 cycloalkyl group, C5-C6 cycloalkenyl, a heterocyclic group selected from triazolyl, triazolonyl, pyrazolyl, imidazolyl, imidazolydinonyl, tetrazolyl, tetrazolonyl, isoxazolyl, furyl, thienyl, pyrrolyl, pyrrolidinyl, pyrrolidinonyl, pyridyl, pyrimidinyl, pyrimidinonyl, pyrazinyl, pyridazinyl, oxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, isothiazolyl, benzoxazolyl, benzothiazolyl, isoxazolinyl, 1,3-dioxanyl, 1,4-dioxanyl, 1,3- dioxolanyl, tetrahydropyranyl, oxethanyl, oxyranyl, thiazolidinyl, oxazolidinyl, piperidinyl, piperidinonyl, piperazinyl, morpholinyl, thiazinyl, tetrahydrofuranyl, dioxazolyl, tetrahydrofuroisoxazolyl, 2-oxa-3- azabicyclo [3.1. 0] hex-3-enyl, said groups optionally substituted by one or more substituents selected from halogen, N02, CN, CHO, linear or branched C1-C6 alkyl, linear or branched C1- C6 haloalkyl, linear or branched Cl-C6 alkoxyl, linear

or branched Cl-C6 haloalkoxyl, Cl-C6 cyanoalkyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, Cz-Cg haloalkoxyalkyl, C2-C6 haloalkylthioalkyl, C2-C6 haloalkylsulfinylalkyl, Cz-Cg haloalkylsulfonylalkyl, C2-C6 alkoxyalkoxyl or C2-C6 haloalkoxyalkoxyl optionally substituted with a group selected from C1- C4 alkoxyl or C1-C4 haloalkoxyl, C2-C6 alkylthioalkoxyl, C2-C6 haloalkylthioalkoxyl, C3-C12 dialkoxyalkyl, C3-Cl2 dialkylthioalkyl, C3-C12 dialkylthioalkoxyl, C3-Cl2 dialkoxyalkoxyl, C2-C6 haloalkoxyhaloalkoxyl, C3-Clo alkoxyalkoxyalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C3-C8 alkenyloxyalkoxyl, C3-C8 haloalkenyloxyalkoxyl, Cz-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyloxy, C2-C6 haloalkynyloxy, C3-C8 alkynyloxyalkoxyl, C3-C8 haloalkynyloxyalkoxyl, C3-Cl2 acylaminoalkoxy, C2-C8 alkoxyiminoalkyl, C2-C8 haloalkoxyiminoalkyl, C3-C8 alkenyloxyiminoalkyl, C3- CB haloalkenyloxyiminoalkyi, Cs-Cg alkynyloxyiminoalkyl, C3-C8 haloalkynyloxyiminoalkyl, C5-C10 alkoxyalkynyloxyl, C6-C12 <BR> <BR> <BR> <BR> <BR> cycloalkylideneiminooxyalkyl, C6-C12 dialkylideneiminooxyalkyl, aryl optionally <BR> <BR> <BR> substituted, -S (0) mRl,-OS (O) tRl,-SO2NR2R3,-

CO2R4, -COR5, -CONR6R7, -CSNR8R9, -NR10R11, - NR12COR13, -NR14CO2R15, -NR15CONR17R18, -PO(R19)2, - Z2 (CR34R3s) p (C=Y)T, -Z3(CR36R37) v (CR38R39=CR40R1) (C=Y)T; - Z, Z1, Z2 = O, S (O)r; - Y = O, S; - r is equal to 0,1 or 2; - p, q are equal to 1, 2,3 or 4; - v is equal to 0 or 1 ; - Z3 = 0, S or a direct bond ; - T represents a hydrogen atom, a Z4R42 group, a- NR43R44 group, an aryl group or a heterocyclic group selected from triazolyl, triazolonyl, pyrazolyl, imidazolyl, imidazolidinonyl, tetrazolyl, tetrazolonyl, pyrrolyl, pyrrolidinyl, pyrrolidinonyl, pyridyl, pyrimidinyl, piperidinyl, piperidinonyl, piperazinyl, morpholinyl, said groups optionally substituted by one or more substituents selected from halogen, N02, OH, CN, CHO, linear or branched Cl-C6 alkyl, linear or branched Cl-C6 haloalkyl, C3-C6 cycloalkyl, C5-C6 cycloalkenyl, linear or branched C1- C6 alkoxyl, linear or branched Cl-C6 haloalkoxyl, Cl- C6 cyanoalkyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6 haloalkoxyalkyl, C2-C6

haloalkylthioalkyl, C2-C6 haloalkylsulfinylalkyl, C2- C6 haloalkylsulfonylalkyl,-S (0) mRl ; - Z4 = O, S or a direct bond; - R43 and R44, the same or different, represent a hydrogen atom, a linear or branched C1-C6 alkyl group in turn optionally substituted with halogen atoms, a C3-C6 alkenyl group in turn optionally substituted with halogen atoms, a Q7 group, an arylalkyl group optionally substituted by one or more substituents selected from halogen, NO2, CN, CHO, linear or branched C1-C6 alkyl, linear or branched C1-C6 haloalkyl, linear or branched Cl-C6 alkoxyl, linear or branched Cl-C6 haloalkoxyl, Cl-C6 alkylsulfonyl, C2-C6 alkoxycarbonyl, or they jointly represent a C2- C5 alkylene chain; - D represents: a heterocyclic group of the heteroaryl or heterocyclic type, in all the above cases the heterocycle can be mono or polycyclic and can be connected to the rest of the structure either through one of its carbon atoms or, when possible, through one of its nitrogen atoms; or it represents a mono or polycyclic aryl group, in this latter case, the group can also be partially saturated;

- Rx represents a substituent selected from hydrogen, halogen, NO2, CN, CHO, OH, linear or branched C1-C6 alkyl, linear or branched C1-C6 haloalkyl, linear or branched C1-C6 alkoxyl, linear or branched C1-C6 haloalkoxyl, C1-C6 cyanoalkyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6 haloalkoxyalkyl, C2-C6 haloalkylthioalkyl, C2-C6 haloalkylsulfinylalkyl, C2- C6 haloalkylsulfonylalkyl, C2-C6 alkoxyalkoxyl or C2- C6 haloalkoxyalkoxyl optionally substituted with a group selected from C1-C4 alkoxyl or C1-C4 haloalkoxyl, C2-C6 alkylthioalkoxyl, C2-C6 haloalkylthioalkoxyl, C3-C12 dialkoxyalkyl, C3-C12 dialkylthioalkyl, C3-C12 dialkylthioalkoxyl, C3-C12 dialkoxyalkoxyl, C2-C6 haloalkoxyhaloalkoxyl, C3-C10 alkoxyalkoxyalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C3-C8 alkenyloxyalkoxyl, C3-C8 haloalkenyloxyalkoxyl, C2-Cg alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyloxy, C2-C6 haloalkynyloxy, C3-C8 alkynyloxyalkoxyl, C3-C8 haloalkynyloxyalkoxyl, C3-C12 acylaminoalkoxy, Cz-Cg alkoxyiminoalkyl, Cz-Cg haloalkoxyiminoalkyl, Cg-Cg alkenyloxyiminoalkyl, C3-CB haloalkenyloxyiminoalkyl, C3-C8 alkynyloxyiminoalkyl, C3-C8 haloalkynyloxyiminoalkyl, C5-C10 alkoxyalkynyloxyl,

C6-C12 cycloalkylideneiminooxyalkyl, C6-C12 dialkylideneiminooxyalkyl,-S (0) mR1, -OS (O) tR1, - SO2NR2R3, -CO2R4, -COR5, -CONR6R7, -CSNR8R9, - NR10R11, -NR12COR13, -NR14CO2R15, -NR16CONR17R18, - PO (Rlg) 2, -Q, -ZQ1, -(CR20R21)pQ2, -Z(CR22R23)pQ3, - <BR> <BR> <BR> (CR24R25) pZQ4,- (CR2eR27) pZ (CR28R29) qQ5, (CR30R31)pZ(CR32R33)qZ1Q6, - Z2 (CR34R35) p (C=Y) T, -Z3(CR36R37)v(CR38R39=CR40R41) (C=Y)T; if several Rx groups are present, these can be the same or different; - n = 1-9; and of the relevant salts having agronomical compatibility, as herbicides.

The use of derivatives of 1, 3-dines having general formula (I) is a further object of the present invention: (I) wherein: - A, B and R have the above-defined meanings, and of relevant salts pharmaceutically acceptable as medicament.

Examples of D groups include: pyrrolyl, pyrrolidinonyl, thienyl, furyl, pyrazolyl, imidazolyl, imidazolidinonyl, triazolyl, triazolonyl, tetrazolyl, tetrazolonyl, thiazolyl, isothiazolyl, dithiol, oxathiol, isoxazolyl, isoxazolinyl, oxazolyl, oxadiazolyl, thiadiazolyl, oxatriazolyl, dioxazolyl, oxathiazolyl, pyridyl, N-oxidopyridyl, pyrimidyl, pyrimidinonyl, pyridazinyl, pyrazinyl, triazinyl, tetrazinyl, piperazinyl, oxazinyl, oxathiazinyl, morfolinyl, benzofuranyl, isobenzofuranyl, benzothienyl, isobenzothienyl, indolyl, isoindolyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, benzopyrazolyl, benzotriazolyl, benzoxadiazolyl, benzothiadiazolyl, quinolinyl, quinazolinyl, quinoxalinyl, pyridopyrimidinyl, oxazolepyridinyl, chromenyl, thiochromenyl, purine, phenyl, naphthyl.

A C1-C6 alkyl group means a linear or branched C1-C6 alkyl group.

Examples of these groups are: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl.

A C1-C6 haloalkyl group means a linear or branched C1-C6 alkyl group, substituted with one or more halogen atoms, the same or different.

Examples of this group are: fluoromethyl, chlorodifluoromethyl, difluoromethyl, trifluoromethyl, dichloromethyl, trichloromethyl, 2,2, 2-trifluoroethyl, 2,2, 2-trichloroethyl, 1,1, 2,2, 2-pentafluoroethyl, 1,1, 2, 2-tetrafluoroethyl, 1,2, 2,2-tetrafluoroethyl, 2,2, 3, 3-tetrafluoropropyl, 2,2, 3,3, 3-pentafluoropropyl.

A C2-C6 alkenyl group means a linear or branched C2-C6 alkenyl group.

Examples of this group are: ethenyl, propenyl, butenyl.

A C2-C6 haloalkenyl group means a linear or branched C2-C6 alkenyl group, substituted by one or more halogen atoms, the same or different.

Example of this group are: 3, 3-dichloroprop-2- enyl, 3,3-difluoroprop-2-enyl, 3,3, 3- trifluoropropenyl.

Example of Cg-Cg alkynyl groups are: ethynyl, propargyl.

A C2-C6 haloalkynyl group means a linear or branched C2-C6 alkynyl group, substituted by one or more halogen atoms, the same or different.

Example of this group are: 3-chloropropynyl, 3- iodopropynyl.

Halogen atom means a halogen atom selected from fluorine, chlorine, bromine or iodine.

A C3-C6 cycloalkyl group means a cycloalkyl group consisting of 3 to 6 carbon atoms, possibly substituted by one or more substituents the same or different.

Examples of this group are: cyclopropyl, cyclopentyl.

Examples of alkoxy groups are: methoxy, ethoxy.

Examples of haloalkoxyl groups are: difluoromethoxy, trifluoromethoxy, 1,1, 2,2- tetrafluoroethoxy, 1,1, 2,3, 3, 3-hexafluoropropoxy.

A heterocyclic group, of the heteroarylic or heterocyclic type, means a ring which can be unsaturated, partially saturated or completely saturated, and can consist of from three to eighteen units containing at least one heteroatom selected from nitrogen, oxygen and sulphur; this group can be condensed with other rings of the heterocyclic or carbocyclic type, which, in turn, can be of the aromatic type, partially saturated or completely saturated.

Mono or polycyclic aryl group means a ring that can be aromatic or partially saturated and consisting exclusively of carbon atoms.

Examples of these groups are: phenyl, naphthyl, tetrahydronaphthalenyl.

The compounds having general formula (I) can exist in different tautomeric and/or isomeric forms, as shown hereinafter:

Both the tautomeric and/or isomeric forms of compounds (I) and the mixtures of the same in any possible proportions, are considered included in the present patent application.

If the particular groups A, B and R allow the existence of other tautomeric and/or isomeric forms, these forms are definitely included within the scope of the present invention.

The salts of compounds (I) which have agronomical compatibility are also considered within the spirit of this patent.

As stated before, the derivatives of 1,3-diones having general formula (I) have a high herbicidal activity.

Specific examples of compounds having general formula (I) of interest for their activity are shown in table 1 : A B R 2-NO2-4-SO2MePh 1, 2, 4-oxadiazol-5-yl H 2-NO2-4-SO2MePh 1,2,4-oxadiazol-5-yl methyl 2-N02-4-S02MePh 1,2, 4-oxadiazol-5-yl i-propyl 2 NO2-4-S02MePh 1, 2, 4-oxadiazol-5-yl cyclopropyl 2-NO2-4-SO2MePh 1, 2, 4-oxadiazol-5-yl CF3 2-NO2-4-S02MePh 3-methyl-1, 2, 4-oxadiazol-5-yl H 2-NO2-4-SO2MePh 3-methyl-1, 2, 4-oxadiazol-5-yl methyl 2-N02-4-S02MePh 3-methyl-1, 2, 4-oxadiazol-5-yl i-propyl 2-N02-4-S02MePh 3-methyl-1,2,4-oxadiazol-5-yl cyclopropyl 2-NO2-4-SO2MePh 3-methyl-1, 2, 4-oxadiazol-5-yl CF3 2-N02-4-S02MePh 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl H 2-NO2-4-SO2MePh 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl methyl 2-N02-4-S02MePh 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl i-propyl 2-NO2-4-SO2MePh 3-trifluoromethyl-1, 2, 4-oxadiazol-5- cyclopropyl 2-N02-4-S02MePh 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl CF3 2-NO2-4-SO2MePh 1,2,4-oxadiazol-3-yl H 2-NO2-4-SO2MePh 1, 2, 4-oxadiazol-3-yl methy 2-N02-4-S02MePh 1, 2, 4-oxadiazol-3-yl i-propyl 2-NO2-4-SO2MePh 1, 2, 4-oxadiazol-3-yl cyclopropyl 2-NO2-4-SO2MePh 1, 2, 4-oxadiazol-3-yl CF3 2-N02-4-S02MePh 5-methyl-1, 2, 4-oxadiazol-3-yl H 2-N02-4-S02MePh 5-methyl-1, 2, 4-oxadiazol-3-yl methyl 2-NO2-4-SO2MePh 5-methyl-1,2,4-oxadiazol-3-yl i-propyl 2-NO2-4-SO2MePh 5-methyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 2-N02-4-S02MePh 5-methyl-1, 2, 4-oxadiazol-3-yl CF3 2-NO2-4-SO2MePh 5-trifluoromethyl-1, 2,4-oxadiazol-3-yl H 2-NO2-4-S02MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl methyl 2-NO2-4-SO2MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 2-NO2-4-S02MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 2-N02-4-S02MePh 5-trifluoromethyl-1,2,4-oxadiazol-3-yl CF3 2-NO2-4-SOzMePh 5-chloro-1, 2, 4-oxadiazol-3-yl H 2-NO2-4-SO2MePh 5-chloro-1, 2, 4-oxadiazol-3-yl methyl 2-NO2-4-S02MePh 5-chloro-1, 2, 4-oxadiazol-3-yl i-propyl 2-N0z-4-SO2MePh 5-chloro-1,2,4-oxadiazol-3-yl cyclopropyl 2-NO2-4-SO2MePh 5-chloro-1, 2, 4-oxadiazol-3-yl CF3 2-NO2-4-S02MePh 1, 3,4-oxadiazol-2-yl H 2-NO2-4-S02MePh 1, 3, 4-oxadiazol-2-ylmethyl 2-NO2-4-SO2MePh 1, 3, 4-oxadiazol-2-yl i-propyl 2-NO2-4-SO2MePh 1, 3, 4-oxadiazol-2-yl cyclopropyl 2-NO2-4-SO2MePh 1, 3, 4-oxadiazol-2-yl CF3 2-NO2-4-SO2MePh 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl H A B R 2-NO2-4-SO2MePh 5-methylsulfonyl-1,3,4-oxadiazol-2-yl methyl 2-NO2-4-SO2MePh 5-methylsulfonyl-1,3,4-oxadiazol-2-yl i-propyl 2-NO2-4-SO2MePh 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 2-NO2-4-SO2MePh 5-methylsulfonyl-1, 3, 4-oxadiazol-2- CE3 2-N02-4-S02MePh 5-methyl-l, 3, 4-oxadiazol-2-yl H 2-NO2-4-SO2MePh 5-methyl-1,3,4-oxadiazol-2-yl methyl 2-N02-4-S02MePh 5-methyl-1, 3, 4-oxadiazol-2-yl i-propyl 2-NO2-4-SO2MePh 5-mthyl-1,3,4-oxadiazol-2-yl cyclopropyl 2-N02-4-S02MePh 5-methyl-1, 3, 4-oxadiazol-2-yl CF3 2-N02-4-S02MePh 5-txifluoromethyl-1, 3, 4-oxadiazol-2-yl H 2-NO2-4-SO2MePh 5-trifluoromethyl-1,3,4-oxadiazol-2-yl methyl 2-NO2-4-SO2MePh 5-trifluoromethyl-1,3,4-oxadiazol-2-yl i-propyl 2-NO2-4-SO2MePh 5-trifluoromethyl-1, 3, 4-oxadiazol-- 1 c clo ro 1 2-NO2-4-S02MePh 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl CF3 2-NO2-4-SO2MePh 1, 2, 3-triazol-4-yl H 2-NO2-4-SO2MePh 1, 2, 3-triazol-4-yl methyl 2-NO2-4-SO2MePh 1, 2, 3-triazol-4-yl i-propyl 2-N02-4-S02MePh 1, 2, 3-triazol-4-yl cyclopropyl 2-NO2-4-SO2MePh 1, 2, 3-triazol-4-yl CF3 2-NO2-4-SO2MePh 1-methyl-1,2,3-triazol-4-yl H 2-N02-4-S02MePh 1-methyl-1, 2, 3-triazol-4-yl methyl 2-N02-4-S02MePh l-methyl-1, 2, 3-triazol-4-yl i-propyl 2-NO2-4-SO2MePh 1-methyl-1, 2, 3-triazol-4-yl cyclopropyl 2-NO2-4-S02MePh 1-methyl-1, 2, 3-triazol-4-yl CF3 2-NO2-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl H 2-NO2-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl methyl 2-NO2-4-S02MePh 2-methyl-1,2,3-triazol-4-yl i-propyl 2-N02-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl cyclopropyl 2-NO2-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl CF3 2-N02-4-S02MePh 1,2, 3-triazol-1-yl H 2-N02-4-S02MePh 1,2, 3-triazol-1-yl methyl 2-NO2-4-S02MePh 1,2, 3-triazol-1-yl i-propyl 2-N02-4-S02MePh 1,2, 3-triazol-1-yl cyclopropyI 2-N02-4-S02MePh 1,2, 3-triazol-1-yl CF3 2-N02-4-S02MePh 1, 2, 3-triazol-2-yl H 2-NO2-4-S02MePh 1, 2, 3-triazol-2-yl methyl 2-NO2-4-SO2MePh 1, 2, 3-triazol-2-yl i-propyl 2-NO2-4-SO2MePh 1, 2, 3-triazol-2-yl cyclopropyl 2-NO2-4-S02MePh 1, 2, 3-triazol-2-yl CF3 2-NO2-4-S02MePh 1, 2, 4-triazol-1-yl H 2-NO2-4-S02MePh 1,2, 4-triazol-1-yl methyl 2-NO2-4-SO2MePh 1,2,4-triazol-1-yl i-propyl 2-N02-4-S02MePh 1,2, 4-triazol-1-yl cyclopropyl 2-N02-4-S02MePh 1,2, 4-triazol-1-yl CF3 2-NO2-4-SO2MePh imidazol-2-yl H 2-N02-4-SO2MePh imidazol-2-yl methyl A B R 2-NO2-4-SO2MePh imidazol-2-yl i-propyl 2-NO2-4-SO2MePh imidazol-2-yl cyclopropyl 2-NO2-4-SO2MePh imidazol-2-yl CF3 2-NO2-4-S02MePh imidazol-1-yl H 2-NO2-4-SO2MePh imidazol-1-yl methyl 2-NO2-4-SO2MePh imidazol-1-yl i-propyl 2-N02-4-S02MePh imidazol-1-yl cyclopropyl 2-NO2-4-SO2MePh imidazol-1-yl CF3 2-N02-4-SO2MePh imidazol-4-yl H 2-NO2-4-SO2MePh imidazol-4-yl methyl 2-NO2-4-SO2MePh imidazol-4-yl i-propyl 2-NO2-4-S02MePh imidazol-4-yl cyclopropyl 2-NO2-4-SO2MePh imidazol-4-yl CF3 2-N02-4-S02MePh thiazol-2-yl H 2-NO2-4-SO2MePh thiazol-2-yl methyl 2-N02-4-SO2MePh thiazol-2-yl i-propyl 2-NO2-4-SO2MePh thiazol-2-yl cyclopropyl 2-NO2-4-S02MePh thiazol-2-yl CF3 2-N02-4-S02MePh 4-methylthiazol-2-yl H 2-NO2-4-SO2MePh 4-methylthiazol-2-yl methyl 2-NO2-4-SO2MePh 4-methylthiazol-2-yl i-propyl 2-NO2-4-SO2MePh 4-methylthiazol-2-yl ccyclopropyl 2-N02-4-S02MePh 4-methylthiazol-2-yl CF3 2-N02-4-S02MePh oxazol-2-yl H 2-NO2-4-SO2MePh oxazol-2-yl methyl 2-N02-4-SO2MePh oxazol-2-yl i-propyl 2-NO2-4-SO2MePh oxazol-2-yl cyclopropyl 2-NO2-4-SO2MePh oxazol-2-yl CF3 2-N02-4-S02MePh 4, 5-dimethyloxazol-2-yl H 2-N02-4-SO2MePh 4, 5-dimethyloxazol-2-yl methyl 2-NO2-4-SO2MePh 4,5-dimethyloxazol-2-yl i-propyl 2-NO2-4-SO2MePh 4, 5-dimethyloxazol-2-yl cyclorpopyl 2-N02-4-S02MePh 4, 5-dimethyloxazol-2-yl CF3 2-NO2-4-SO2MePh 2-oxazolin-2-yl H 2-NO2-4-SO2MePh 2-oxazolin-2-yl methyl 2-NO2-4-SO2MePh 2-oxazolin-2-yl i-propyl 2-NO2-4-SO2MePh 2-oxazolin-2-yl cyclopropyl 2-NO2-4-SO2MePh 2-oxazolin-2-yl CF3 2-NO2-4-SO2MePh 4, 4-dimethyl-2-oxazolin-2-yl H 2-NO2-4-SO2MePh 4, 4-dimethyl-2-oxazolin-2-yl methyl 2-NO2-4-S02MePh 4, 4-dimeth 1-2-oxazolin-2-1 i-ro 1 2-N02-4-S02MePh 4, 4-dimethyl-2-oxazolin-2-yl cyclopropyl 2-N02-4-S02MePh 4, 4-dimethyl-2-oxazolin-2-yl CF3 2-N02-4-S02MePh 1, 2, 4-thiadiazol-5-yl H 2-NO2-4-SO2MePh 1, 2, 4-thiadiazol-5-yl methyl . 2-N02-4-S02MePh 1,2, 4-thiadiazol-5-yl i-propyl ABR 2-NO2-4-SO2MePh 1,2,4-thiadiazol-5-yl cyclopropyl 2-NO2-4-SO2MePh 1,2,4-thiadiazol-5-yl CF3 2-NO2-4-SO2MePh 3-methyl-1,2,4-thiadiazol-5-yl H 2-NO2-4-SO2MePh 3-methyl-1, 2, 4-thiadiazol-5-ylmethyl 2-NO2-4-SO2MePh 3-methyl-1, 2, 4-thiadiazol-5- I i-ro 1 2-NO2-4-SO2MePh 3-methyl-1,2,4-thiadiazol-5-yl cyclopropyl 2-NO2-4-SO2MePh 3-methyl-1,2,4-thiadiazol-5-yl CF3 2-NO2-4-SO2MePh 3-trifluoromethyl-1,2,4-thiadiazol-5-yl H 2-N02-4-S02MePh 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl methyl 2-NO2-4-SO2MePh 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl i-propyl 2-NO2-4-SO2MePh 3-trifluoromethyl-1,2,4-thiadiazol-5-yl cyclopropyl 2-NO2-4-SO2MePh 3-trifluoromethyl-1,2,4-thiadiazol-5-yl CF3 2-NO2-4-S02MePh 1, 2, 4-thiadiazol-3-yl H 2-NO2-4-SO2MePh 1, 2, 4-thiadiazol-3-yl methyl 2-NO2-4-SO2MePh 1,2,4-thiadiazol-3-yl i-propyl 2-NO2-4-SO2MePh 1,2,4-thiadiazol-3-yl cyclopropyl 2-NO2-4-SO2MePh 1, 2, 4-thiadiazol-3-yl CF3 2-NO2-4-SO2MePh 5-methyl-1,2,4-thiadiazol-3-yl H 2-NO2-4-SO2MePh 5-methyl-1, 2, 4-thiadiazol-3-yl methyl 2-N02-4-SO2MePh 5-methyl-1, 2, 4-thiadiazol-3-yl i-pro l 2-N02-4-SO2MePh 5-methyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 2-N02-4-S02MePh 5-methyl-1,2,4-thiadiazol-3-yl CF3 2-NO2-4-SO2MePh 5-trifluoromethyl-1,2,4-thiadiazol-3-yl H 2-N02-4-SO2MePh 5-trifluoromethyl-1., 2, 4-thiadiazol-3-yl methyl 2-NO2-4-SO2MePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-l i-propyl 2-NO2-4-SO2MePh 5-trifluoromethyl-1, 2,4-thiadiazol-3-yl cyclopropyl 2-NO2-4-SO2MePh 5-trifluoromethyl-1,2,4-thiadiazol-3-yl CF3 2-NO2-4-SO2MePh 1,3,4-thiadiazol-2-yl H 2-N02-4-S02MePh 1, 3, 4-thiadiazol-2-yl methyl 2-N02-4-S02MePh 1, 3, 4-thiadiazol-2-yl i-propyl 2-N02-4-S02MePh 1, 3, 4-thiadiazol-2-yl cyclopropyl 2-N02-4-S02MePh 1, 3, 4-thiadiazol-2-yl CF3 2-NO2-4-SO2MePh 5-methylsulfonyl-1, 3,4-thiadiazol-2-yl H 2-N02-4-S02MePh 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl methyl 2-N02-4-S02MePh 5-methylsulfonyl-1,3,4-thiadiazol-2-yl i-propyl 2-NO2-4-SO2MePh 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl cyclopropyl 2-NO2-4-SO2MePh 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl CF3 2-NO2-4-SO2MePh 5-methyl-1, 3, 4-thiadiazol-2-yl H 2-N02-4-S02MePh 5-methyl-1, 3, 4-thiadiazol-2-yl methyl 2-NO2-4-SO2MePh 5-methyl-1, 3, 4-thiadiazol-2-yl i-propyl 2-NO2-4-S02MePh 5-methyl-1, 3, 4-thiadiazol-2-yl cyclopro yl 2-NO2-4-SO2MePh 5-methyl-1, 3, 4-thiadiazol-2-yl CF3 2-N02-4-SO2MePh benzoxazol-2-yl H 2-NO2-4-SO2MePh benzoxazol-2-yl methyl 2-N02-4-SO2MePh benzoxazol-2-yl i-propyl 2-NO2-4-SO2MePh benzoxazol-2-1 cyclopropyl 2-NO2-4-SO2MePh benzoxazol-2-yl CF3 A B R 2-NO2-4-S02MePh 6-methylbenzoxazol-2-yl H 2-NO2-4-SO2MePh 6-methylbenzoxazol-2-yl methyl 2-NO2-4-SO2MePh 6-methylbenzoxazol-2-yl i-orpoyl 2-NO2-4-SO2MePh 6-methylbenzoxazol-2-yl cyclopropyl 2-N02-4-S02MePh 6-methylbenzoxazol-2-yl CF3 2-NO2-4-SO2MePh benzothiazol-2-yl H 2-N02-4-SO2MePh benzothiazol-2-l methyl 2-NO2-4-SO2MePh benzothiazol-2-yl i-propyl 2-NO2-4-SO2MePh benzothiazol-2-yi cyclopropy, 2-N02-4-S02MePh benzothiazol-2-yl CF3 2-N02-4-S02MePh yrazol-1-yl H 2-NO2-4-SO2MePh pyrazol-1-yl methyl 2-N02-4-S02MePh pyrazol-1-yl i-propyl 2-NO2-4-SO2MePh pyrazol-1-yl cyclopropyl 2-NO2-4-SO2MePh pyrazol-1-yl CF3 2-N02-4-S02MePh pyrazol-3-l H 2-NO2-4-SO2MePh azol-3-yl methyl 2-NO2-4-SO2MePh pyrazol-3-yl i-propyl 2-N02-4-SO2MePh azol-3-yl cyclopropyl 2-NO2-4-SO2MePh pyrazol-3-yl CF3 2-NO2-4-SO2MePh 1-methylpyrazol-3-yl H 2-NO2-4-SO2MePh 1-methylpyrazol-3-yl methyl 2-N02-4-S02MePh 1-methylpyrazol-3-yl i-propyl 2-NO2-4-SO2MePh 1-methylpyrazol-3-yl cyclopropyl 2-N02-4-SO2MePh 1-methylpyrazol-3-yl CF3 2-NO2-4-SO2MePh tetrazol-1-yl H 2-NO2-4-SO2MePh tetrazol-1-yl methyl 2-NO2-4-SO2MePh tetrazol-1-yl i-propyl 2-N02-4-SO2MePh tetrazol-1-yl cyclopropyl 2-N02-4-S02MePh tetrazol-1-yl CF3 2-N02-4-S02MePh 5-methyltetrazol-1-yl H 2-N02-4-S02MePh 5-methyltetrazol-1-yl methyl 2-NO2-4-SO2MePh 5-methyltetrazol-1-yl i-propyl 2-NO2-4-SO2MePh 5-methyltetrazol-1-yl cyclopropyl 2-NO2-4-SO2MePh 5-methyltetrazol-1-yl CF3 2-N02-4-S02MePh tetrazol-2-yl H 2-NO2-4-SO2MePh tetrazol-2-yl methyl 2-NO2-4-SO2MePh tetrazol-2-yl. i-propyl 2-NO2-4-S02MePh tetrazol-2-yl cyclopropyl 2-NO2-4-SO2MePh tetrazol-2-yl CF3 2-NO2-4-SO2MePh 5-methyltetrazol-2-yl H 2-N02-4-SO2MePh 5-methyltetrazol-2-yl methyl 2-NO2-4-SO2MePh 5-methyltetrazol-2-yl i-propyl 2-NO2-4-SOMePh 5-methyltetrazol-2-yl cyclopropyl 2-N02-4-S02MePh 5-methyltetrazol-2-yl CF3 2-NO2-4-SO2MePh 1-methyltetrazol-5-yl H A B R 2-NO2-4-SO2MePh 1-methyltetrazol-5-yl methyl 2-NO2-4-SO2MePh 1-methyltetrazol-5-yl i-propyl 2-NO2-4-SO2MePh 1-methyltetrazol-5-yl cyclopropyl 2-NO2-4-SO2MePh 1-methyltetrazol-5-yl CF3 2-NO2-4-SOMePh 2-methyltetrazol-5-yl H 2-N02-4-S02MePh 2-methyltetrazol-5-yl methyl 2-NO2-4-SO2MePh 1-methyltetrazol-5-yl i-propyl 2-NO2-4-SO2MePh 1-methyltetrazol-5-yl cyclopropyl 2-N02-4-S02MePh 2-methyltetrazol-5-l CF3 2-NO2-4-SO2MePh pyridin-2-yl H 2-NO2-4-S02MePh pyridin-2-yl methyl 2-N02-4-SO2MePh pyridin-2-l i-propyl 2-N02-4-S02MePh pyridin-2-ylcyclopropyi 2-NO2-4-SO2MePh pyridin-2-yl CF3 2-NO2-4-SO2MePh pyridin-4-yl H 2-N02-4-S02MePh pyridin-4-yl methyl 2-NO2-4-SO2MePh pyridin-4-yl i-propyl 2-NO2-4-SO2MePh pyridin-4-yl cyclopropyl 2-NO2-4-SO2MePh pyridin-4-yl CF3 2-N02-4-S02MePh pyridin-3-yl H 2-N02-4-SO2MePh idin-3-l methyl 2-NO2-4-SO2MePh pyridin-3-yl i-propyl 2-NO2-4-SO2MePh pyridin-3-yl cyclopropyl 2-NO2-4-SO2MePh pyridin-3-yl CF3 2-NO2-4-SO2MePh 3-nitropyridin-4-yl H 2-NO2-4-SO2MePh 3-nitropyridin-4-yl methyl 2-NO2-4-SO2MePh 3-nitropyridin-4-yl i-propyl 2-NO2-4-S02MePh 3-nitropyridin-4-yl cyclopropyl 2-NO2-4-SO2MePh 3-nitropyridin-4-yl CF3 2-NO2-4-SO2MePh 5-cyanopyridin-2-yl H 2-NO2-4-SO2MePh 5-cyanopyridin-2-yl methyl 2-NO2-4-SO2MePh 5-cyanopyridin-2-yl i-propyl 2-NO2-4-SO2MePh 5-cyanopyridin-2-y cyclopropyl 2-N02-4-SO2MePh 5-cyanopyridin-2-yl CF3 2-N02-4-S02MePh 5-trifluoromethylpyridin-2-yl H 2-NO2-4-SO2MePh 5-trifluoromethylpyridin-2-yl methyl 2-NO2-4-SO2MePh 5-trifluoromethylpyridin-2-yl i-propyl 2-NO2-4-SO2MePh 5-trifluoromethylpyridin-2-yl cyclopropyl 2-NO2-4-SO2MePh 5-trifluoromethylpyridin-2-yl CF3 2-N02-4-S02MePh pyrimidin-2-yl H 2-NO2-4-SO2MePh pyrimidin-2-yl methyl 2-NO2-4-SO2MePh yrimidin-2-yl i-propyl 2-NO2-4-SO2MePh pyrimidin-2-yl cyclopropyl 2-NO2-4-SO2MePh pyrimidin-2-yl CF3 2-NO2-4-S02MePh rimidin-4-yl H 2-NO2-4-SO2MePh pyrimidin-4-yl methyl A B R 2-NO2-4-SO2MePh pyrimidin-4-yl i-propyl 2-NO2-4-SO2MePh yrimidin-4-yl cyclopro 2-NO2-4-SO2MePh pyrimidin-4-yl CFs 2-NO2-4-SO2MePh 6-chloropyrimidin-4-yl methyl 2-NO2-4-SO2MePh 6-chloropyrimidin-4-yl i-propyl 2-NO2-4-SO2MePh 6-chloropyrimidin-4-yl cyclopropyl 2-NO2-4-SO2MePh 6-chloropyrimidin-4-yl CF3 2-NO2-4-SO2MePh pyridazin-3-yl H 2-N02-4-SO2MePh pyridazin-3-yl methyl 2-NO2-4-SO2MePh pyridazin-3-yl i-propyl 2 pyridazin-3-yl cyclopropyl 2 N02-4-SOMePh pyridazin-3-yl CF3 2-NO2-4-SO2MePh 6-chloropyridazin-3-l methyl 2-NO2-4-SO2MePh 6-chloropyridazin-3-yl i-propyl 2-NO2-4-SO2MePh 6-chloropyridazin-3-yl cyclopropyl 2-NO2-4-SO2MePh 6-chloropyridazin-3-yl CF3 2-NO2-4-SO2MePh pyrazin-2-yl methyl 2-NO2-4-SO2MePh pyrazin-2-yli-propyi 2-NO2-4-SO2MePh pyrazin-2-yl cyclopropyl 2-NO2-4-SO2MePh pyrazin-2-yl CF3 2-NO2-4-SO2MePh triazin-2-yl methyl 2-N02-4-S02MePh triazin-2-yl i-propyl 2-NO2-4-SO2MePh triazin-2-yl cyclopropyl 2-NO2-4-SO2MePh triazin-2-yl CF3 2-N02-4-SO2MePh uinolin-2-yl methyl 2-NO2-4-SO2MePh quinolin-2-yl i-propyl 2-N02-4-S02MePh quinolin-2-yl cyclopropyl 2-N02-4-S02MePh quinolin-2-yl CF3 2-NO2-4-S02MePh 4,4,6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl H 2-N02-4-S02MePh 4,4,6-trimethyl-5,6-dihydro-1, 3 (4H0-oxazin-2-yl methyl 2-NO2-4-SO2MePh 4, 4,6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl i-propyl 2-NO2-4-S02MePh 4,4, 6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl cyclopropyl 2-NO2-4-SO2MePh 4,4, 6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl CF3 2-N02-4-S02MePh 2-oxazolidinon-3-l H 2-NO2-4-SO2MePh 2-oxazolidinon-3-yl methyl 2-N02-4-S02MePh 2-oxazolidinon-3-yl i-propyl 2-NO2-4-SO2MePh 2-oxazolidinon-3-yl cyclopropyl 2-NO2-4-SO2MePh 2-oxazolidinon-3-yl CF3 2-NO2-4-SO2MePh 2-pyrrolidinon-1-yl methyl 2-NO2-4-SO2MePh 2-pyrrolidinon-1-yl i-propyl 2-NO2-4-SO2MePh 2-pyrrolidinon-1-yl cyclopropyl 2-NO2-4-SO2MePh 2-pyrrolidinon-1-yl CF3 2-NO2-4-SO2MePh 3-methylisoxazol-5-yl methyl 2-NO2-4-SO2MePh 3-methylisoxazol-5-yl i-propyl 2-NO2-4-SO2MePh 3-methylisoxazol-5-yl cyclopropyl 2-NO2-4-SO2MePh 3-methylisoxazol-5-yl CF3 A B R 2-NO2-4-SO2MePh 2-NO2-4-SO2MePh H 2-NO2-4-SO2MePh 2 N02-4-S02MePh methyl 2-NO2-4-SO2MePh 2-NO2-4-SO2MePh i-propyl 2-N02-4-S02MePh 2-NO2-4-S02MePh cyclopropyl 2-NO2-4-SO2MePh 2-No2-4-SO2MePh CF3 2-NO2-4-SO2MePh 2-Cl-4-SO2MePh H 2-NO2-4-SO2MePh 2-Cl-4-SO2MePh methyl 2-NO2-4-SO2MePh 2-Cl-4-SO2MePh i-propyl 2-NO2-4-SO2MePh 2-Cl-4-SQ2MePh cyclopropyl 2-NO2-4-SO2MePh 2-Cl-4-So2MePh CF3 2-N02-4-SO2MePh 2-NO2-4-CF3Ph H 2-N02-4-S02MePh 2-N02-4-CF3Phmethyl 2-NO2-4-SO2MePh 2-No2-4-CF3Ph i-propyl 2-NO2-4-SO2MePh 2-NO2-4-CF3Ph cyclopropyl 2-NO2-4-SO2MePh 2-NO2-4-CF3Ph CF3 2-NO2-4-SO2MePh 2-NO2-4-ClPh H 2-NO2-4-SO2MePh 2-NO2-4-ClPh methyl 2-NO2-4-SO2MePh 2-NO2-4-ClPh i-propyl 2-NO2-4-SO2MePh 2-NO24-CIPh cyclopropyl 2-NO2-4-CIPh CF3 2-NO2-4-SO2MePh 2-Cl-4-NO2Ph H 2-NO2-4-SO2MePh 2-Cl-4-NO2Ph methyl 2-NO2-4-SO2MePh 2-Cl-4-NO2Ph i-propyl 2-NO2-4-SO2MePh 2-Cl-4-NO2Ph cyclopropyl 2-NO2-4-SO2MePh 2-Cl-4-NO2Ph CF3 2-NO2-4-SO2MePh 2,4-(NO2)2Ph H 2-NO2-4-SO2MePh 2, 4-(NO2) 2Ph methyl 2-NO2-4-SO2MePh 2, 4-(NO2)2Ph i-propyl 2-NO2-4-SO2MePh 2, 4-(NO2) 2Ph cyclopropyl 2-NO2-4-SO2MePh 2, 4- (NO2) Rh CF3 2-NO2-4-SO2MePh 4-F-3-NO2Ph H 2-NO2-4-SO2MePh 4-F-3-NO2Ph methyl 2-NO2-4-SO2MePh 4-F-3-NO2Ph i-propyl 2-NO2-4-SO2MePh 4-F-3-NO2Ph cyclopropyl 2-NO2-4-SOzMePh 4-F-3-NO2Ph CF3 2-NO2-4-SO2MePh 3, 5-(CF3)2Ph H 2-NO2-4-SO2MePh 3,5- (CF3) 2Ph methyl 2-NO2-4-SO2MePh 3,5-(CF3)2Ph i-propyl 2-NO2-4-SO2MePh 3, 5-(CF3)2Ph cyclopropyl 2-NO2-4-SO2MePh 3, 5-(CF3)2Ph CF3 2-NO2-4-SO2MePh 2-SO2Me-4-CF3Ph H 2-NO2-4-SO2MePh 2-SO2Me-4-CF3Ph methyl 2-NO2-4-SO2MePh 2-SO2Me-4-CF3Ph i-propyl 2-NO2-4-SO2MePh 2-SO2Me-4-CF3Ph cyclopropyl 2-NO2-4-SO2MePh 2-SO2Me-4-CF3Ph CF3 A B R 2-Cl-4-SO2MePh 1, 2, 4-oxadiazol-5-yl H 2-Cl-4-SO2MePh 1, 2, 4-oxadiazol-5-yl methyl 2-Cl-4-SO2MePh 1,2,4-oxadiazol-5-yl i-propyl 2-Cl-4-SO2MePh 1, 2, 4-oxadiazol-5-yl cyclopropyl 2-Cl-4-SO2MePh 1, 2, 4-oxadiazol-5-yl CF3 2-Cl-4-SO2MePh 3-methyl-1,2,4-oxadiazol-5-yl H 2-Cl-4-SO2MePh 3-methyl-1, 2, 4-oxadiazol-5-yl methyl 2-Cl-4-SO2MePh 3-methyl-1,2,4-oxadiazol-5-yl i-propyl 2-Cl-4-SO2MePh 3-methyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 2-Cl-4-SO2MePh 3-methyl-1, 2, 4-oxadiazol-5-yl CF3 2-Cl-4-SO2MePh 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl H 2-Cl-4-SO2MePh 3-trifluoromethyl-1,2,4-oxadiazol-5-yl methyl 2-Cl-4-SO2MePh 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl i-propyl 2-Cl-4-SO2MePh 3-trifluoromethyl-1,2,4-oxadiazol-5-yl cyclopropyl 2-Cl-4-SO2MePh 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl CF3 2-Cl-4-SO2MePh 1, 2, 4-oxadiazol-3-yl H 2-Cl-4-SO2MePh 1, 2, 4-oxadiazol-3-yl methyl 2-Cl-4-SO2MePh 1, 2, 4-oxadiazol-3-yl i-propyl 2-Cl-4-SO2MePh 1, 2, 4-oxadiazol-3-yl cyclopropyl 2-Cl-4-SO2MePh 1, 2, 4-oxadiazol-3-yl CF3 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-oxadiazol-3-yl H 2-Cl-4-SO2MePh 5-methyl-1,2,4-oxadiazol-3-yl methyl 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 2-Cl-4-SO2MePh 5-methyl-1,2,4-oxadiazol-3-yl cyclopropyl 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-oxadiazol-3-yl CF3 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl H 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl methyl 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2,4-oxadiazol-3-yl CF3 2-Cl-4-SO2MePh 5-chloro-1, 2, 4-oxadiazol-3-yl H 2-Cl-4-SO2MePh 5-chloro-1,2, 4-oxadiazol-3-yl methyl 2-Cl-4-SO2MePh 5-chloro-1,2,4-oxadiazol-3-yl i-propyl 2-Cl-4-SO2MePh 5-chloro-1, 2, 4-oxadiazol-3-yl cyclopropyl 2-Cl-4-SO2MePh 5-chloro-1, 2, 4-oxadiazol-3-yl CF3 2-Cl-4-SO2MePh 1, 3, 4-oxadiazol-2-yl H 2-Cl-4-SO2MePh _ _ methyl 2-Cl-4-SO2MePh 1, 3, 4-oxadiazol-2-yl i-propyl 2-Cl-4-SO2MePh 1,3, 4-oxadiazol-2-yl cyclopropyl 2-Cl-4-SO2MePh 1, 3,4-oxadiazol-2-yl CF3 2-Cl-4-SO2MePh 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl H A B R 2-Cl-4-SO2MePh 5-methylsulfonyl-1, 3,4-oxadiazol-2-yl methyl 2-Cl-4-SO2MePh 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl i-propyl 2-Cl-4-SO2MePh h 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 2-Cl-4-SOMePh 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl CF3 2-Cl-4-SO2MePh 5-methyl-1, 3, 4-oxadiazol-2-yl H 2-Cl-4-SO2MePh 5-methyl-1,3,4-oxadiazol-2-yl methyl 2-Cl-4-SO2MePh 5-methyl-1,3,4-oxadiazol-2-yl i-propyl 2-Cl-4-SO2MePh 5-methyl-1,3,4-oxadiazol-2-yl cyclopropyl 2-cl-4-SO2MePh 5-methyl-1, 3, 4-oxadiazol-2-yl CF3 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl H 2-Cl-4-SO2MePh 5-trifluoromethyl-1,3,4-oxadiazol-2-yl methyl 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 3,4-oxadiazol-2-yl i-propyl 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl CF3 2-Cl-4-SO2MePh 1, 2, 3-triazol-4-yl H 2-Cl-4-SO2MePh 1, 2, 3-triazol-4-yl methyl 2-Cl-4-SO2MePh 1, 2, 3-triazol-4-yl H 2-CI-4-SOZMePh 3-triazol-4-yl methyl 2, 3-triazol-4-yl cyclopropyl 2-Cl-4-SO2MePh 1,2,3-triazol-4-yl CF3 2-Cl-4-SO2MePh 1-methyl-1, 2, 3-triazol-4-yl H 2-Cl-4-SO2MePh 1-methyl-1, 2, 3-triazol-4-yl methyl 2-Cl-4-SO2MePh 1-methyl-1, 2, 3-triazol-4-yl i-propyl 2-Cl-4-SO2MePh 1-methyl-1, 2, 3-triazol-4-yl cyclopropyl 2-Cl-4-S02MePh 1-methyl-1, 2, 3-triazol-4-yl CF3 2-Cl-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl H 2-Cl-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl methyl 2-Cl-4-SO2MePh 2-methyl-1,2,3-triazol-4-yl i-propyl 2-Cl-4-SO2MePh 2-methyl-1,2,3-triazol-4-yl cyclopropyl 2-Cl-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl CF3 2-Cl-4-SO2MePh 1, 2, 3-triazol1-yl H 2-CI-4-SOzMePh 1,2, 3-triazol-1-yl methyl 2-Cl-4-SO2MePh 1,2, 3-triazol-1-yl i-propyl 2-Cl-4-SO2MePh 1,2, 3-triazol-1-yl cyclopropyl 2-Cl-4-SO2MePh 1,2, 3-triazol-1-yl CF3 2-Cl-4-SO2MePh 1, 2, 3-triazol-2-yl H 2-Cl-4-SO2MePh 1, 2, 3-tiazol-2-yl methyl 2-Cl-4-SO2MePh 1, 2, 3-triazol-2-yl i-propyl 2-Cl-4-SO2MePh 1, 2, 3-triazol-2-yl cyclopropyl 2-Cl-4-SO2MePh 1, 2, 3-triazol-2-yl CF3 2-Cl-4-SO2MePh 1, 2, ,4-triazol-1-yl H 2-Cl-4-SO2MePh 1,2, 4-triazol-1-yl methyl 2-Cl-4-SO2MePh 1,2, 4-triazol-1-yl i-propyl 2-CI-4-SO2MePh 1,2, 4-triazol-1-yl cyclopropyl 2-CI4-SO2MePh 1,2, 4-triazol-1-yl CF3 2-Cl-4-SO2MePh imidazol-2-yl H 2-Cl-4-SO2MePh imidazol-2-yl methyl A B R 2-Cl-4-SO2MePh imidazol-2-yl i-propyl 2-Cl-4-SO2MePh imidazol-2-yl cyclopropyl 2-Cl-4-SO2MePh imidazol-2-yl CF3 2-Cl-4-SO2MePh imidaz [ 2-Cl-4-SO2MePh imidazol-1-ylmethyl 2-Cl-4-SO2MePh imidazol-1-yl i-propyl 2-Cl-4-SO2MePh imidazol-1-yl cyclopropyl 2-Cl-4-SO2MePh imidazol-1-yl CF3 2-Cl-4-SO2MePh imidazol-4-yl H 2-Cl-4-SO2MePh imidazol-4-yl methyl 2-Cl-4-SO2MePh imidazol-4-yl i-propyl 2-Cl-4-SO2MePh imidazol-4-yl cyclopropyl 2-Cl-4-SO2MePh imidazol-4-yl CF3 2-Cl-4-SO2MePh thiazol-2-yi H 2-Cl-4-SO2MePh thiazol-2-1 methyl 2-Cl-4-SO2MePh thiazol-2-yl i-propyl 2-Cl-4-SO2MePh thiazol-2-yl cyclopropyl 2-Cl-4-SO2MePh thiazol-2-yl CF3 2-Cl-4-SO2MePh 4-methylthiazol-2-yl H 2-Cl-4-SO2MePh 4-methylthiazol-2-yl methyl 2-Cl-4-SO2MePh 4-methylthiazol-2-yl i-propyl 2-Cl-4-SO2MePh 4-methylthiazol-2-yl cyclopropyl 2-Cl-4-SO2MePh 4-methylthiazol-2-yl CF3 2-Cl-4-SO2MePh oxazol-2-yl H 2-Cl-4-SO2MePh oxazol-2-yl methyl 2-Cl-4-SO2MePh oxazol-2-yl i-propyl 2-Cl-4-SO2MePh oxazol-2-yl cyclopropyl 2-Cl-4-SO2MePh oxazol-2-yl CF3 2-Cl-4-SO2MePh 4,5-dimethyloxazol-2-yl H 2-Cl-4-SO2MePh 4, 5-dimethyloxazol-2-yl methyl 2-Cl-4-SO2MePh 4, 5-dimethyloxazol-2-yl i-propyl 2-Cl-4-SO2MePh 4, 5-dimethyloxazol-2-yl cyclopropyl 2-Cl-4-SO2MePh 4, 5-dimethyloxazol-2-yl CFs 2-Cl-4-SO2MePh 2-oxazolin-2-yl H 2-Cl-4-SO2MePh 2-oxazolin-2-yl methyl 2-Cl-4-SO2MePh 2-oxazolin-2-yl i-propyl 2-Cl-4-SO2MePh 2-oxazolin-2-yl cyclopropyl 2-Cl-4-SO2MePh 2-oxazolin-2-yl CF3 2-Cl-4-SO2MePh 4, 4-dimethyl-2-oxazolin-2-l H 2-Cl-4-S02MePh 4, 4-dimethyl-2-oxazolin-2-yl methyl 2-Cl-4-SO2MePh 4, 4-dimethyl-2-oxazolin-2-yl i-propyl 2-Cl-4-SO2MePh 4, 4-dimethyl-2-oxazolin-2-yl cyclopropyl 2-Cl-4-SO2MePh 4, 4-dimethyl-2-oxazolin-2-yl CF3 2-Cl-4-SO2MePh 1, 2, 4-thiadiazol-5-yl H 2-Cl-4-SO2MePh 1,2,4-thiadiazol-5-yl methyl 2-Cl-4-SO2MePh 1,2,4-thiadiazol-5-yl i-propyl A B R 2-Cl-4-SO2MePh 1, 2, 4-thiadiazol-5-yl cyclopropyl 2-Cl-4-SO2MePh 1, 2, 4-thiadiazol-5-yl CF3 2-CI-4-S02MePh 3-methyl-1, 2, 4-thiadiazol-5-yl H 2-Cl-4-SO2MePh 3-methyl-1,2,4-thiadiazol-5-yl methyl 2-Cl-4-SO2MePh 3-methyl-1, 2, 4-thiadiazol-5-yl i-propyl 2-Cl-4-S02MePh 3-methyl-1,3,4-thiadiazol-5-yl cyclopropyl 2-Cl-4-SO2MePh 3-methyl-1,2,4-thiadiazol-5-yl CF3 2-Cl-4-SO2MePh 3-trifluoromethyl-1,2,4-thiadiazol-5-yl H 2-Cl-4-SO2MePh 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl methyl 2-Cl-4-SO2MePh 3-trifluoromethyl-1,2,4-thiadiazol5-yl i-propyl 2-Cl-4-SO2MePh 3-trifluoromethyl-1, 2, 4-thiadiazol-5- cyclopropyl 2-Cl-4-SO2MePh 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl CF3 2-Cl4-SO2MePh 1, 2, 4-thiadiazol-3- 1 H 2-Cl-4-SO2MePh 1, 2, 4-thiadiazol-3-yl methyl 2-Cl-4-SO2MePh 1, 2, 4-thiadiazol-3-yl i-propyl 2-Cl-4-SO2MePh 1, 2, 4-thiadiazol-3-yl cyclopropyl 2-Cl-4-SO2MePh 1, 2, 4-thiadiazol-3-yl CF3 2-CI-4-S02MePh 5-methyl-1, 2, 4-thiadiazol-3-yl H 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-thiadiazol-3-yl methyl 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-thiadiazol-3-yl i-propyl 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 4-Cl-4-SO2MePh 5-methyl-1, 2, 4-thiadiazol-3-yl CF3 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl H 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl methyl 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl i-propyl 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl CF3 2-Cl-4-SO2MePh 1, 3, 4-thiadiazol-2-yl H 2-Cl-4-SO2MePh 1, 3, 4-thiadiazol-2-yl methyl 2-Cl-4-SO2MePh 1, 3,4-thiadiazol-2-yl i-propyl 2-Cl-4-S02MePh 1, 3, 4-thiadiazol-2-yl cyclopropyl 2-Cl-4-SOzMePh 1, 3, 4-thiadiazol-2-yl CF3 2-Cl-4-SO2MePh 5-methylsulfonyl-1, 3,4-thiadiazol-2-yl H 2-Cl-4-SO2MePh 5-methylsulfonyl-1,3,4-thiadiazol-2-yl methyl 2-Cl-4-SO2MePh 5-methylsulfonyl-1,3,4-thiadiazol-2-yl i-propyl 2-Cl-4-SO2MePh 5-methylsulfonyl-1,3,4-thiadiazol-2-yl cyclopropyl 2-Cl-4-SO2MePh 5-methylsulfonyl-1,3,4-thiadiazol-2-yl CF3 2-Cl-4-SO2MePh 5-methyl-1, 3, 4-thiadiazol-2-yl H 2-Cl-4-S02MePh 5-methyl-1, 3, 4-thiadiazol-2-yl met 2-Cl-4-SO2MePh 5-methyl-1,3,4-thiadiazol-2-yl i-propyl 2-Cl-4-SO2MePh 5-methyl-1,3,4-thiadiazol-2-yl cyclopropyl 2-Cl-4-SO2MePh 5-methyl-1, 3, 4-thiadiazol-2-yl CF3 2-Cl-4-SO2MePh benzoxazol-2-yl H 2-Cl-4-SO2MePh benzoxazol-2-yl methyl 2-Cl-4-SO2MePh benzoxazol-2-yl i-propyl 2-Cl-4-SO2MePh benzoxazol-2-yl cyclopropyl 2-Cl-4-SO2MePh benzoxazol-2-yl CF3 ABR 2-GI-4-SOzMePh 6-methylbenzoxazol-2-yl H 2-Cl-4-SO2MePh 6-methylbenzoxazol-2-yl methyl 2-Cl-4-SO2MePh 6-methylbenzoxazol-2-yl i-propyl 2-Cl-4-SO2MePh 6-methylbenzoxazol-2-yl cyclopropyl 2-Cl-4-SO2MePh 6-methylbenzoxazol-2-yl CF3 2-Cl-4-SO2MePh benzothiazol-2-yl H 2-Cl-4-SO2MePh benzothiazol-2-yl methyl 2-Cl-4-SO2MePh benzothiazol-2-yl i-propyl 2-Cl-4-SO2MePh beD2 cyclopropyl 2-Cl-4-SO2MePh benzothiazol-2-yl CF3 2-Cl-4-SOzMePh yrazol-1-yl H 2-Cl-4-SO2MePh azol-1-yl methyl 2-CI-4-Sa2MePh pyrazol-1-yl i-propyl 2-Cl-4-SO2MePh pyrazol-1-yl cyclopropyl 2-Cl-4-SO2MePh pyrazol-1-yl CF3 2-Cl-4-SO2MePh yrazol-3-yl H 2-Cl-4-SO2MePh pyrazol-3-yl methyl 2-Cl-4-SO2MePh pyrazol-3-yl i-propyl 2-Cl-4-SO2MePh pyrazol-3-yl cyclopropyl 2-Cl-4-SO2MePh pyrazol-3-yl CF3 2-Cl-4-SO2MePh 1-methylpyrazol-3-yl H 2-Cl-4-SO2MePh 1-methylpyrazol-3-yl methyl 2-Cl-4-SO2MePh 1-methylpyrazol-3-yl i-propyl 2-Cl-4-SO2MePh 1-methylpyrazol-3-yl cyclopropyl 2-Cl-4-SO2MePh 1-methylpyrazol-3-yl CF3 2-Cl-4-SO2MePh tetrazol-1-yl H 2-CI-4-SOzMePh tetrazol-1-yl methyl 2-Cl-4-SO2MePh tetrazol-1-yl i-propyl 2-Cl-4-SO2MePh tetrazol-1-yl cyclopropyl 2-Cl-4-SO2MePh tetrazol-1-yl CF3 2-Cl-4-SO2MePh 5-methyltetrazol-1-yl H 2-Gl-4-SOaMePh 5-methyltetrazol-1-yl methyl 2-Cl-4-SO2MePh 5-methyltetrazol-1-yl i-propyl 2-Cl-4-SO2MePh 5-methyltetrazol-1-yl cyclopropyl 2-CI-4-SOzMePh 5-methyltetrazol-1-yl CF3 2-Cl-4-SO2MePh tetrazol-2-yl H 2-Cl-4-S02MePh tetrazol-2-1 methyl 2-Cl-4-SO2MePh tetrazol-2-yl i-propyl 2-Cl-4-SO2MePh tetrazol-2-yl cyclopropyl 2-Cl-4-SO2MePh tetrazol-2-yl CF3 2-Cl-4-SO2MePh 5-methyltetrazol-2-yl H 2-Cl-4-SO2MePh 5-methyltetrazol-2-yl methyl 2-Cl-4-SO2MePh 5-methyltetrazol-2-yl i-propyl 2-Cl-4-SO2MePh 5-methyltetrazol-2-yl cylopropyl 2-Cl-4-SO2MePh 5-methyltetrazol-2-yl CF3 2-Cl-4-SO2MePh 1-methyltetrazol-5-yl H A B R 2-Cl-4-SO2MePh 1-methyltetrazol-5-yl methyl 2-Cl-4-SO2MePh 1-methyltetrazol-5-yl i-propyl 2-Cl-4-SO2MePh 1-methyltetrazol-5-yl cyclopropyl 2-Cl-4-SO2MePh 1-methyltetrazol-5-yl CF3 2-Cl-4-SO2MePh 2-methyltetrazol-5-yl t-butile 2-Cl-4-SO2MePh 2-methyltetrazol-5-yl methyl 2-Cl-4-SO2MePh 2-methyltetrazol-5-yl i-propyl 2-Cl-4-SO2MePh 2-methyltetrazol-5-yl cyclopropyl 2-Cl-4-SO2MePh 2-methyltetrazol-5-yl CF3 2-Cl-4-SO2MePh pyridin-2-yl H 2-Cl-4-SO2MePh pyridin-2-yl methyl 2-Cl-4-SO2MePh pyridin-2-yl i-propyl 2-Cl-4-SO2MePh pyridin-2-yl cyclopropyl 2-Cl-4-SO2MePh pyridin-2-yl CF3 2-Cl-4-SO2MePh pyridin-4-yl H 2-Cl-4-SO2MePh pyridin-4-yl methyl 2-Cl-4-SO2MePh pyridin-4-yl i-propyl 2-Cl-4-SO2MePh pyridin-4-yl cyclopropyl 2-Cl-4-SO2MePh idin-4-yl CF3 2-Cl-4-SO2MePh pyridin-3-yl R 2-Cl-4-SO2MePh pyridin-3-yl methyl 2-Cl-4-SO2MePh pyridin-3-yl i-propyl 2-Cl-4-SO2MePh pyridin-3-yl cyclopropyl 2-Cl-4-SO2MePh pyridin-3-yl CF3 2-Cl-4-SO2MePh 3-nitropyridin-4-yl H 2-Cl-4-SO2MePh 3-nitropyridin-4-yl methyl 2-Cl-4-SO2MePh 3-nitropyridin-4-yl i-propyl 2-Cl-4-SO2MePh 3-nitropyridin-4-yl cyclopropyl 2-Cl-4-SO2MePh 3-nitropyridin-4-yl CF3 2-Cl-4-SO2MePh 5-cyanopyridin-2-yl H 2-Cl-4-SO2MePh 5-cyanopyridin-2-yl methyl 2-Cl-4-SO2MePh 5-cyanopyridin-2-yl i-propyl 2-Cl-4-SO2MePh 5-cyanopyridin-2-yl cyclopropyl 2-Cl-4-SO2MePh 5-cyanopyridin-2-yl CF3 2-Cl-4-SO2MePh 5-trifluoromethylpyridin-2-yl H 2-Cl-4-SOzMePh 5-trifluoromethylpyridin-2-yl methyl 2-Cl-4-SO2MePh 5-trifluoromethylpyridin-2-yl i-propyl 2-Cl-4-SO2MePh 5-trifluoromethylpyridin-2-yl cyclopropyl 2-CI-4-SO2MePh 5-trifluoromethylpyridin-2-yl CF3 2-Cl-4-SO2MePh pyrimidin-2-yl H 2-Cl-4-SO2MePh pyrimidin-2-yl methyl 2-Cl-4-SO2MePh pyrimidin-2-yl i-propyl 2-Cl-4-SO2MePh pyrimidin-2-yl cyclopropyl 2-Cl-4-SO2MePh pyrimidin-2-yl CF3 2-Cl-4-SO2MePh pyrimidin-4-yl H 2-Cl-4-SO2MePh pyrimidin-4-yl methyl A B R 2-Cl-4-SO2MePh pyrimidin-4-yl i-propyl 2-Cl-4-SO2MePh yrimidin-4-yl cyclopropyl 2-Cl-4-SO2MePh pyrimidin-4-yl CF3 2-Cl-4-SO2MePh 6-chloropyrimidin-4-yl methyl 2-Cl-4-SO2MePh 6-chloropyrimidin-4-yl i-propyl 2-Cl-4-SO2MePh 6-chloropyrimidin-4-yl cyclopropyl 2-Cl-4-SO2MePh 6-chloropyrimidin-4-yl CF3 2-Cl-4-SO2MePh idazin-3-yl H 2-Cl-4-SO2MePh pyridazin-3-yl methyl 2-Cl-4-SO2MePh pyridazin-3-yl i-propyl 2-Cl-4-SO2MePh pyridazin-3-yl cyclopropyl 2-Cl-4-SO2MePh pyridazin-3-yl CF3 2-Cl-4-SO2MePh 6-chloropyridazin-3-yl methyl 2-CI-4-SO2MePh 6-chloropyridazin-3-yl i-propyl 2-Cl-4-SOMePh 6-chloropyridazin-3-yl cyclopropyl _2-Ci-4-SO2MePh 6-chloropyridazin-3-yl CF3 2-Cl-4-SO2MePh pyrazin-2-yl methyl 2-Cl-4-SO2MePh pyrazin-2-yl i-propyl 2-Cl-4-SO2MePh pyrazin-2-yl-cyclopropy, 2-Cl-4-SO2MePh pyrazin-2-yl CF3 2-Cl-4-SO2MePh triazin-2-yl methyl 2-Cl-4-SO2MePh triazin-2-yl i-propyl 2-Cl-4-SO2MePh triazin-2-yl cyclopropyl 2-Cl-4-SO2MePh triazin-2-yl CF3 2-Cl-4-SO2MePh quinolin-2-yl methyl 2-Cl-4-SO2MePh quinolin-2-yl i-propyl 2-Cl-4-SO2MePh uinolin-2-yl cyclopropyl 2-Cl-4-SO2MePh uinolin-2-yl CFs 2-Cl-4-SO2MePh 4, 4,6-trimethy;-5,6-dihydro-1, 3 (4H)-oxazin-2-yl H 2-CI-4-SOaMePh 4,4, 6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl methyl 2-Cl-4-SO2MePh 4,4, 6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl i-propyl 2-Cl-4-SO2MePh 4,4, 6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl cyclopropyl 2-Cl-4-SO2MePh 4, 4, 6-trimethyl-5, 6-dihydro-l, 3 (4H)-oxazin-2-yl CF3 2-Cl-4-SO2MePh 2-oxazolidinon-3-yl H 2-Cl-4-SO2MePh 2-oxazolidinon-3-yl methyl 2-Cl-4-SO2MePh 2-oxazolidinon-3-yl i-propyl 2-Cl-4-SO2MePh 2-oxazolidinon-3-yl cyclopropyl 2-Cl-4-SO2MePh 2-oxazolidinon-3-yl CF3 2-Cl-4-SO2MePh 2-pyrrolidinon-l-yl methyl 2-Cl-4-SO2MePh 2-pyrrolidinon-1-yl i-propyl 2-Cl-4-SO2MePh 2-pyrrolidinon-1-yl cyclopropyl 2-Cl-4-SO2MePh 2-pyrrolidinon-l-yl CF3 2-Cl-4-SO2MePh 3-methylisoxazol-5-yl methyl 2-Cl-4-SO2MePh 3-methylisoxazol-5-yl i-propyl 2-Cl-4-SO2MePh 3-methylisoxazol-5-yl cyclopropyl 2-Cl-4-SO2MePh 3-methylisoxazol-5-yl CF3 A B R 2-Cl-4-SO2MePh 2-NO2-4-SO2MePh H 2-Cl-4-SO2MePh 2-NO2-4-SO2MePh methyl 2-Cl-4-SO2MePh 2-NO2-4-SO2MePh i-propyl 2-Cl-4-SO2MePh 2-NO2-4-SO2MePh cyclopropyl 2-Cl-4-SO2MePh 2-NO2-4-SO2MePh CF3 2-Cl-4-S02MePh 2-Cl-4-SO2MePh H 2-Cl-4-SO2MePh 2-Cl-4-SO2MePh methyl 2-CI-4-SOzMePh 2-Cl-4-SO2MePh i-propyl 2-Cl-4-SO2MePh 2-Cl-4-SO2MePh cyclopropyl 2-Cl-4-SO2MePh 2-Cl-4-SO2MePh CF3 2-Cl-4-SO2MePh 2-NO2-4-CF3Ph H 2-Cl-4-SO2MePh 2-NO2-4-CF3Ph methyl 2-Cl-4-SO2MePh 2-NO2-4-CF3Ph i-propyl 2-Cl-4-SO2MePh 2-NO2-4-CF3Ph cyclopropyl 2-Cl-4-SO2MePh 2-NO2-4-CF3Ph CF3 2-Cl-4-SO2MePh 2-NO2-4-CIPh H 2-Cl-4-SO2MePh 2-NO2-4-ClPh methyl 2-Cl-4-SO2MePh 2-NO2-4-ClPh i-propyl 2-Cl-4-SO2MePh 2-NO2-4-ClPh cyclopropyl 2-Cl-4-SO2MePh 2-NO2-4-ClPh CF3 2-Cl-4-SO2MePh 2-Cl-4-N02Ph H 2-Cl-4-SO2MePh 2-Cl-4-NO2Ph methyl 2-Cl-4-SO2MePh 2-Cl-4-No2Ph i-propyl 2-Cl-4-SO2MePh 2-Cl-4-NO2Ph cyclopropyl 2-Cl-4-SO2MePh 2-Cl-4-NO2Ph CF3 2-Cl-4-SO2MePh 2, 4- (NO2) 2Ph H 2-Cl-4-SO2MePh 2,4-(NO2)2Ph methyl 2-Cl-4-SO2MePh 2, 4-(NO2)2Ph i-propyl 2-Cl-4-SO2MePh 2, 4-(NO2)2Ph cyclopropyl 2-Cl-4-SO2MePh 2, 4-(NO2)2Ph CF3 2-CI-4-SOzMePh 4-F-3-NO2Ph H 2-Cl-4-SO2MePh 4-F-3-NO2Ph methyl 2-Cl-4-SO2MePh 4-F-3-NO2Ph i-propyl 2-Cl-4-SO2MePh 4-F-3-NO2Ph cyclopropyl 2-CI-4-SOZMePh 4-F-3-NO2Ph CF3 2-Cl-4-SO2MePh 3, 5- (CF3) 2Ph H 2-Cl-4-SO2MePh 3, 5-(CF3)2Ph methyl 2-Cl-4-SO2MePh 3, 5- 2Ph i-propyl 2-Cl-4-SO2MePh 3, 5-(CF3)2Ph cyclopropyl 2-Cl-4-SO2MePh 3, 5-(CF3)2Ph CF3 2-Cl-4-SO2MePh 2-SO2Me-4-CF3Ph H 2-Cl-4-SO2MePh 2-SO2Me-4-CF3Ph methyl 2-Cl-4-SO2MePh 2-SO2Me-4-CF3Ph i-propyl 2-Cl-4-SO2MePh 2-SO2Me-4-CF3Ph cyclopropyl 2-Cl-4-SO2MePh 2-SO2Me-4-CF3Ph CF3 A B R 4-Cl-2-NO2Ph 1, 2, 4-oxadiazol-5-yl H 4-Cl-2-NO2Ph 1, 2, 4-oxadiazol-5-yl methyl 4-Cl-2-NO2Ph 1,2,4-oxadiazol-5-yl i-propyl 4-Cl-2-NO2Ph 1,2,4-oxadiazol-5-yl cyclopropyl 4-Cl-2-N02Ph 1, 2, 4-oxadiazol-5-yl CF3 4-Cl-2-NO2Ph 3-methyl-1, 2, 4-oxadiazol-5-yl H 4-Cl-2-NO2Ph 3-methyl-1, 2, 4-oxadiazol-5-yl methyl 4-Cl-2-NO2Ph 3-methyl-1,2,4-oxadiazol-5-yl i-propyl 4-Cl-2-NO2Ph 3-methyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 4-Cl-2-NO2Ph 3-methyl-1, 2, 4-oxadiazol-5-yl CF3 4-Cl-2-NO2Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl H 4-Cl-2-N02Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl methyl 4-Cl-2-NO2Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl i-propyl 4-Cl-2-NO2Ph 3-trifluoromethyl-1,2,4-oxadiazol-5-yl cyclopropyl 4-Cl-2-NO2Ph 3-trifluoromethyl-1,2, 4-oxadiazol-5-yl CFs 4-Cl-2-NO2Ph 1, 2, 4-oxadiazol-3-yl H 4-Cl-2-NO2Ph 1,2,4-oxadiazol-3-yl methyl 4-Cl-2-NO2Ph 1,2,4-oxadiazol-3-yl i-propyl 4-Cl-2-NO2Ph 1,2,4-oxadiazol-3-yl cyclopropyl 4-Cl-2-NO2Ph 1, 2, 4-oxadiazol-3-yl CF3 4-Cl-2-NO2Ph 5-methyl-1, 2, 4-oxadiazol-3-yl H 4-Cl-2-NO2Ph 5-methyl-1,2,4-oxadiazol-3-yl methyl 4-Cl-2-NO2Ph 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 4-Cl-2-NO2Ph 5-methyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 4-Cl-2-NO2Ph 5-methyl-1, 2, 4-oxadiazol-3-yl CF3 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl H 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl methyl 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 4-CI-2-NO2Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 4-Cl-2-NO2Ph 5-chloro-1, 2, 4-oxadiazol-3-yl H 4-Cl-2-N02Ph 5-chloro-1, 2, 4-oxadiazol-3-yl methyl 4-Cl-2-NOzPh 5-chloro-1, 2, 4-oxadiazol-3-yl i-propyl 4-Cl-2-NO2Ph 5-chloro-1, 2, 4-oxadiazol-3-yl cyclopropyl 4-Cl-2-NO2Ph 5-chloro-1, 2, 4-oxadiazol-3-yl CF3 4-Cl-2-NO2Ph 1, 3, 4-oxadiazol-2-yl H 4-Cl-2-NO2Ph 1, 3, 4-oxadiazol-2-yl methyl 4-Cl-2-NO2Ph 1,3,4-oxadiazol-2-yl i-propyl 4-Cl-2-NO2Ph 1, 3, 4-oxadiazol-2-yl cyclopropyl 4-Cl-2-N02Ph 1, 3, 4-oxadiazol-2-yl CF3 4-Cl-2-NO2Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl H A B R 4-Cl-2-NO2Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl methyl 4-Cl-2-NO2Ph 5-methylsulfonyl-1, 3,4-oxadiazol-2-yl i-propyl 4-Cl-2-NO2Ph 5-methylsulfonyl-1,3,4-oxadiazol-2-yl cyclopropyl 4-Cl-2-NO2Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl CF3 4-Cl-2-NO2Ph 5-methyl-1, 3, 4-oxadiazol-2-yl H 4-C-2-N02Ph 5-methyl-1, 3, 4-oxadiazol-2-yl methyl 4-Cl-2-NO2Ph 5-methyl-1, 3, 4-oxadiazol-2-yl i-propyl 4-Cl-2-NO2Ph 5-methyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 4-Cl-2-NO2Ph 5-methyl-1, 3, 4-oxadiazol-2-yl CF3 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl H 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl methyl 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl i-propyl 4-Cl-2-NO2Ph 5-trifluoromethyl-1,3,4-oxadiazol-2-yl cyclopropyl 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl CF3 4-Cl-2-NO2Ph 1, 2,3-triazol-4-yl H 4-Cl-2-NO2Ph 1, 2, 3-triazol-4-yl methyl 4-Cl-2-NO2Ph 1, 2, 3-triazol-4-yl i-propyl 4-Cl-2-NO2Ph 1, 2, 3-triazol-4-yl cyclopropyl 4-Cl-2-NO2Ph 1, 2,3-triazol-4-yl CF3 4-Cl-2-NO2Ph 1-methyl-1,2,3-triazol-4-yl H 4-Cl-2-NO2Ph 1-methyl-l, 2, 3-triazol-4-yl methyl 4-Cl-2-NO2Ph 1-methyl-1,2,3-triazol-4-yl i-propyl 4-Cl-2-NO2Ph 1-methyl-1, 2, 3-triazol-4-yl cyclopropyl 4-Cl-2-N02Ph 1-methyl-1, 2, 3-triazol-4-yl CF3 4-Cl-2-NO2Ph 2-methyl-1, 2, 3-triazol-4-yl H 4-Cl-2-NO2Ph 2-methyl-1, 2, 3-triazol-4-yl methyl 4-Cl-2-NO2Ph 2-methyl-1, 2, 3-triazol-4-yl i-propyl 4-Cl-2-NO2Ph 2-methyl-1, 2, 3-triazol-4-yl cyclopropyl 4-Cl-2-NO2Ph 2-methyl-1, 2, 3-triazol-4-yl CF3 4-Cl-2-NO2Ph 1, 2, 3-triazol-1-yl H 4-Cl-2-NO2Ph 1,2,3-triazol-1-yl methyl 4-Cl-2-NO2Ph 1, 2, 3-triazol-1-yl i-propyl 4-Cl-2-NO2Ph 1,2,3-triazol-1-yl cyclopropyl 4-Cl-2-NO2Ph 1,2, 3-triazol-1-yl CF3 4-Cl-2-NO2Ph 1,2,3-triazol-2-yl H 4-Cl-2-NO2Ph 1, 2, 3-triazol-2-yl methyl 4-Cl-2-NO2Ph 1, 2, 3-triazol-2-yl i-propyl 4-Cl-2-NO2Ph 1, 2, 3-triazol-2-yl cyclopropyl 4-Cl-2-N02Ph 1, 2, 3-triazol-2-yl CF3 4-Cl-2-NO2Ph 1, 2, 4-triazol-1-yl H 4-Cl-2-NO2Ph 1,2, 4-triazol-1-yl methyl 4-Cl-2-NO2Ph 1,2, 4-triazol-1-yl i-propyl 4-Cl-2-NO2Ph 1,2, 4-triazol-1-yl cyclopropyl 4-Cl-2-NO2Ph 1,2, 4-triazol-1-yl CF3 4-Cl-2-NO2Ph imidazol-2-yl H 4-Cl-2-NO2Ph imidazol-2-yl methyl A B R 4-Cl-2-NO2Ph imidazol-2-yl i-propyl 4-Cl-2-NO2Ph imidazol-2-yl cyclopropyl 4-Cl-2-NO2Ph imidazol-2-yl CF3 4-Cl-2-NO2Ph imidazol-1-yl H 4-Cl-2-NO2Ph imidFl methyl 4-Cl-2-NO2Ph imidazol-1-yl i-propyl 4-Cl-2-NO2Ph imidazol-1-yl cyclopropyl 4-Cl-2-NO2Ph imidazl-1-yl CF3 4-Cl-2-NO2Ph imidazol-4-yl H 4-Cl-2-NO2Ph imidazol-4-yl methyl 4-Cl-2-NO2Ph imidazol-4-yl i-propyl 4-Cl-2-NO2Ph imidazol-4-yl cyclopropyl 4-Cl-2-N02Ph imidazol-4-l CF3 4-Cl-2-N02Ph thiazol-2-yl H 4-Cl-2-NO2Ph thiazol-2-yl methyl 4-Cl-2-NO2Ph thiazol-2-yli-propyi 4-Cl-2-NO2Ph thiazol-2-yl cyclopropyl 4-Cl-2-NO2Ph thiazol-2-yl CF3 4-Cl-2-NO2Ph 4-methylthiazol-2-yl H 4-Cl-2-NO2Ph 4-methylthiazol-2-yl methyl 4-Cl-2-NO2Ph 4-methylthiazol-2-yl i-propyl 4-Cl-2-NO2Ph 4-methylthiazol-2-yl cyclopropyl 4-Cl-2-NO2Ph 4-methylthiazol-2-yl CF3 4-Cl-2-NO2Ph oxazol-2-yl H 4-Cl-2-NO2Ph oxazol-2-yl methyl 4-Cl-2-NO2Ph oxazol-2-yl i-propyl 4-Cl-2-NO2Ph oxazol-2-yl cyclopropyl 4-Cl-2-NO2Ph oxazol-2-yl CF3 4-Cl-2-NO2Ph 4, 5-dimethyloxazol2-yl H 4-Cl-2-NO2Ph 4, 5-dimethyloxazol-2-yl methyl 4-Cl-2-NO2Ph 4,5-dimethyloxazol-2-yl i-propyl 4-Cl-2-NO2Ph 4,5-dimethyloxazol-2-yl cyclopropyl 4-Cl-2-NO2Ph 4,5-dimethyloxazol-2-yl CF3 4-Cl-2-NO2Ph 2-oxazolin-2-yl H 4-Cl-2-NO2Ph 2-oxazolin-2-yl methyl 4-Cl-2-NO2Ph 2-oxazolin-2-yl i-propyl 4-Cl-2-NO2Ph 2-oxazolin-2-yl cyclopropyl 4-Cl-2-NO2Ph 2-oxazolin-2-yl CF3 4-Cl-2-NO2Ph 4, 4-dimethyl-2-oxazolin-2-yl H 4-Cl-2-NO2Ph 4, 4-dimethyl-2-oxazolin-2-yl methyl 4-Cl-2-NO2Ph 4,4-dimethyl-2-oxazolin-2-yl i-propyl 4-Cl-2-NO2Ph 4,4-dimethyl-2-oxazolin-2-yl cyclopropyl 4-Cl-2-NO2Ph 4, 4-dimethyl-2-oxazolin-2-yl CF3 4-Cl-2-NO2Ph 1 2, 4-thiadiazol-5-yl H 4-Cl-2-NO2Ph 1, 2, 4-thiadiazol-5-yl methyl 4-Cl-2-NO2Ph 1, 2, 4-thiadiazol-5-yl i-propyl A B R 4-CI-2-N42Ph 1,2,4-thiadiazol-5-yl cyclopropyl 4-Cl-2-NO2Ph 1,2,4-thiadiazol-5-yl CF3 4-Cl-2-NO2Ph 3-methyl-1,2,4-thiadiazol-5-yl H 4-Cl-2-NO2Ph 3-methyl-1, 2, 4-thiadiazol-5-yl methyl 4-Cl-2-NO2Ph 3-methyl-1, 2, 4-thiadiazol-5-yl i-propyl 4-Cl-2-NO2Ph 3-methyl-1,2,4-thiadiazol-5-yl cyclopropyl 4-Cl-2-NO2Ph 3-methyl-1,2,4-thiadiazol-5-yl CF3 4-Cl-2-NO2Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl H 4-Cl-2-NO2Ph 3-trifluoromethyl-1, 2,4-thiadiazol-5-yl methyl 4-Cl-2-NO2Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl i-propyl 4-Cl-2-N02Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl cyclopropyl 4-Cl-2-NO2Ph 3-trifluoromethyl-1,2,4-thiadiazol-5-yl CF3 4-Cl-2-NO2Ph 1,2,4-thiadiazol-3-yl H 4-Cl-2-NO2Ph 1, 2, 4-thiadiazol-3-yl methyl 4-Cl-2-NO2Ph 1, 2, 4-thiadiazol-3-yl i-propyl 4-CI-2-N02Ph 1, 2, 4-thiadiazol-3-yl cyclopropyl 4-Cl-2-NO2Ph 1, 2, 4-thiadiazol-3-yl CF3 4-Cl-2-NO2Ph 5-methyl-1, 2, 4-thiadiazol-3-yl H 4-Cl-2-NO2Ph 5-methyl-1, 2, 4-thiadiazol-3-yl methyl 4-Cl-2-NO2Ph 5-methyl-1, 2, 4-thiadiazol-3-yl i-propyl 4-Cl-2-NO2Ph 5-methyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 4-Cl-2-NO2Ph 5-methyl-1,2,4-thiadiazol-3-yl CF3 4-Cl-2-NO2Ph 5-trifluoromethyl-1,2,4-thiadiazol-3-yl H 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 2, 4 thiadiazol-3-1 methyl 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl i-propyl 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 4-Cl-2-N02Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3- CF3 4-Cl-2-NO2Ph 1, 3, 4-thiadiazol-2-yl H 4-Cl-2-NO2Ph 1, 3, 4-thiadiazol-2-yl methyl 4-Cl-2-NO2Ph 1, 3, 4-thiadiazol-2-yl i-propyl 4-Cl-2-NO2Ph 1,3,4-thiadiazol-2-yl cyclopropyl 4-Cl-2-N02Ph 1, 3, 4-thiadiazol-2-yl CF3 4-Cl-2-NO2Ph 5-methylsulfonyl-1,3,4-thiadiazol-2-yl H 4-Cl-2-NO2Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl methyl 4-Cl-2-NO2Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl i-ropyl 4-Cl-2-NO2Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl cyclopropyl 4-Cl-2-NO2Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl CF3 4-Cl-2-NO2Ph 5-methyl-1,3,4-thiadiazol-2-yl H 4-Cl-2-N02Ph 5-methyl-1,3,4-thiadiazol-2-yl methyl 4-Cl-2-NO2Ph 5-methyl-1, 3, 4-thiadiazol-2-yl i-propyl 4-Cl-2-NO2Ph 5-methyl-1, 3, 4-thiadiazol-2-yl cyclopropyl 4-Cl-2-NO2Ph 5-methyl-1, 3, 4-thiadiazol-2-yl CF3 4-Cl-2-NO2Ph benzoxazol-2-yl H 4-Cl-2-NO2Ph benzoxazol-2-yl methyl 4-Cl-2-NO2Ph benzoxazol-2-yl i-ropyl 4-CI-2-NO2Ph benzoxazol-2-yl cyclopropyl 4-Cl-2-N02Ph benzoxazol-2-l. CF3 A B R 4-Cl-2-NO2Ph 6-methylbenzoxazol-2-yl H 4-Cl-2-NO2Ph 6-methylbenzoxazol-2-yl methyl 4-Cl-2-NO2Ph 6-methylbenzoxazol-2-yl i-propyl 4-Cl-2-NO2Ph 6-methylbenzoxazol-2-yl cyclopropyl 4-Cl-2-NO2Ph 6-methylbenzoxazol-2-yl CF3 4-Cl-2-NO2Ph benzothiazol-2-yl H 4-Cl-2-NO2Ph benzothiazol-2-yl methyl 4-Cl-2-NO2Ph benzothiazol-2-yl i-propyl 4-Cl-2-N02Ph benzothiazol-2-yl cyclopropyl 4-Cl-2-NO2Ph benzothiazol-2-yl CF3 4-Cl-2-NO2Ph pyrazol-1-yl H 4-Cl-2-NO2Ph 'hrazol-1-l methyl 4-Cl-2-NO2Ph pyrazol-1-yl i-propyl 4-Cl-2-NO2Ph pyrazol-1-yl cyclopropyl 4-Cl-2-NO2Ph pyrazol-1-yl CF3 4-Cl-2-NO2Ph pyrazol-3-yl H 4-Cl-2-NO2Ph pyrazol-3-yl methyl 4-Cl-2-NO2Ph pyrazol-3-yl i-propyl 4-Cl-2-NO2Ph pyrazol-3-yl cyclopropyl 4-Cl-2-NO2Ph pyrazol-3-yl CF3 4-Cl-2 1-methylpyrazol-3-yl H 4-Cl-2-NO2Ph 1-methylpyrazol-3-yl methyl 4-Cl-2-NO2Ph 1-methylpyrazol-3-yl i-propyl 4-Cl-2-NO2Ph 1-methylpyrazol-3-yl cyclopropyl 4-Cl-2-NO2Ph 1-methylpyrazol-3-yl CF3 4-Cl-2-NO2Ph tetrazol-1-yl H 4-Cl-2-N02Ph tetrazol-1-l methyl 4-Cl-2-NO2Ph tetrazol-1-yl i-propyl 4-Cl-2-NO2Ph tetrazol-1-yl cyclopropyl 4-Cl-2-NO2Ph tetrazol-1-yl CF3 4-Cl-2-N02Ph 5-methyltetrazol-1-yl H 4-Cl-2-NO2Ph 5-methyltetrazol-1-yl methyl 4-Cl-2-NO2Ph 5-methyltetrazol-1-yl i-propyl 4-Cl-2-NO2Ph 5-methyltetrazol-1-yl cyclopropyl 4-Cl-2-NO2Ph 5-methyltetrazol-1-yl CF3 4-Cl-2-NO2Ph tetrazol-2-yl H 4-Cl-2-NO2Ph tetrazol-2-yl methyl 4-Cl-2-NO2Ph tetrazol-2-yl i-propyl 4-CI-2-NO2Ph tetrazol-2-yl cyclopropyl 4-Cl-2-NO2Ph tetrazol-2-yl CF3 4-Cl-2-NO2Ph 5-methyltetrazol-2-yl H 4-Cl-2-NO2Ph 5-methyltetrazol-2-yl methyl 4-Cl-2-NO2Ph 5-methyltetrazol-2-yl i-propyl 4-Cl-2-NO2Ph 5-methyltetrazol-2-yl cyclopropyl 4-Cl-2-NO2Ph 5-methyltetrazol-2-yl CF3 4-Cl-2-NO2Ph 1-methyltetrazol-5-yl H A B R 4-Cl-2-NO2Ph 1-methyltetrazol-5-yl methyl 4-Cl-2-NO2Ph 1-methyltetrazol-5-yl i-propyl 4-Cl-2-NO2Ph 1-methyltetrazol-5-yl cyclopropyl 4-Cl-2-NO2Ph 1-methyltetrazol-5-yl CF3 2-Cl-4-NO2Ph 2-methyltetrazol-5-yl cyclopropyl 4-Cl-2-NO2Ph 2-methyltetrazol-5-yl methyl 4-Cl-2-NO2Ph 2-methyltetrazol-5-yl i-propyl 4-Cl-2-NO2Ph 2-methyltetrazol-5-yl cyclopropyl 4-Cl-2-NO2Ph 2-methyltetrazol-5-yl CF3 2, 4-(NO2)2Ph 2-methyltetrazol-5-yl cyclopropyl 4-Cl-2-NO2Ph pyridin-2-yl methyl 4-Cl-2-NO2Ph pyridin-2-yl i-propyl 4-CI-2-NO2Ph pyridin-2-yl cyclopropy, 4-Cl-2-NO2Ph pyridin-2-yl CF3 4-Cl-2-NO2Ph pyridin-4-yl H 4-Cl-2-NO2Ph pyridin-4-yl methyl 4-Cl-2 -NO2Ph pyridin-4-yl i-propyl 4-Cl-2-NO2Ph pyridin-4-yl cyclopropyl 4-Cl-2 pyridin-4-yl CF3 4-Cl-2-NO2Ph pyridin-3-yl H 4-Cl-2-NO2Ph pyridin-3-yl methyl 4-CI-2-NO2Ph pyridin-3-yl i-ropyl 4-Cl-2-NO2Ph pyridin-3-yl cyclopropyl 4-Cl-2 -NO2Ph pyridin-3-yl CF3 4-Cl-2-NO2Ph 3-nitropyridin-4-yl H 4-Cl-2-NO2Ph 3-nitropyridin-4-yl methyl 4-Cl-2-NO2Ph 3-nitropyridin-4-yl i-propyl 4-Cl-2-NO2Ph 3-nitropyridin-4-yl cyclopropyl 4-Cl-2-NO2Ph 3-nitropyridin-4-yl CF3 4-CI-2-NO2Ph 5-cyanopyridin-2-yl H 4-CI-2-NO2Ph 5-cyanopyridin-2-yl methyl 4-CI-2-NO2Ph 5-cyanopyridin-2-yl i-propyl 4-Cl-2-NO2Ph 5-cyanopyridin-2-yl cyclopropyl 4-Cl-2-NO2Ph 5-cyanopyridin-2-yl CF3 4-Cl-2-NO2Ph 5-trifluoromethylpyridin-2-yl H 4-Cl-2-NO2Ph 5-trifluoromethylpyridin-2-yl methyl 4-Cl-2-NO2Ph 5-trifluoromethylpyridin-2-yl i-propyl 4-Cl-2-NO2Ph 5-trifluoromethylpyridin-2-yl cyclopropyl 4-CI-2-NOzPh 5-trifluoromethylpyridin-2-yl CF3 4-Cl-2-NO2Ph pyrimidin-2-yl H 4-Cl-2-NO2Ph pyrimidin-2-yl methyl 4-Cl-2-NO2Ph pyrimidin-2-yl i-propyl 4-Cl-2-NO2Ph pyrimidin-2-yl cyclopropyl 4-Cl-2-NO2Ph pyrimidin-2-yl CF3 4-Cl-2-NO2Ph pyrimidin-2-yl H 4-CI-2-NO2Ph pyrimidin-4-yl methyl A B R 4-Cl-2-NO2Ph pyrimidin-4-yl i-propyl 4-Cl-2-NO2Ph pyrimidic-4-ylcyclopropyi 4-Cl-2-NO2Ph pyrimidin-4-yl CF3 4-Cl-2-NO2Ph 6-chloropyrimidin-4-yl methyl 4-Cl-2-NO2Ph 6-chloropyrimidin-4-yl i-propyl 4-Cl-2-NO2Ph 6-chloropyrimidin-4-yl cyclopropyl 4-Cl-2-NO2Ph 6-chloropyrimidin-4-yl CF3 2, 4- C1)2Ph 1-methyltetrazol-5-yl t-butil 4-Cl-2-NO2Ph pyridazin-3-yl methyl 4-Cl-2-NO2Ph pyridazin-3-yl i-propyl 4-Cl-2-NO2Ph pyridazin-3-yl cyclopropyl 4-Cl-2-NO2Ph pyridazin-3-yl CF3 4-Cl-2-NO2Ph 6-chloropyridazin-3-yl methyl 4-Cl-2-NO2Ph 6-chloropyridazin-3-yl i-propyl 4-Cl-2-NO2Ph 6-chloropyridazin-3-yl cyclopropyl 4-Cl-2-NO2Ph 6-chloropyridazin-3-yl CF3 4-Cl-2-NO2Ph pyrazin-2-yl methyl 4-Cl-2-NO2Ph pyrazin-2-yl i-propyl 4-Cl-2-NO2Ph pyrazin-2-yl cyclopropyl 4-Cl-2-NO2Ph azin-2-yl CF3 4-Cl-2-NO2Ph tnazin-2-yl methyl 4-Cl-2-NO2Ph triazin-2-yl i-propyl 4-Cl-2-NO2Ph triazin-2-yl cyclopropyl 4-Cl-2-NO2Ph triazin-2-yl CF3 4-Cl-2-NO2Ph quinolin-2-yl methyl 4-Cl-2-NO2Ph quinolin-2-yl i-propyl 4-Cl-2-NO2Ph quinolin-2-yl cyclopropyl 4-Cl-2-NO2Ph quinolin-2-yl CF3 4-Cl-2-NO2Ph 4,4,6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl H 4-Cl-2-NO2Ph 4,4, 6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl methyl 4-CI-2-NOZPh 4, 4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl i-propyl 4-Cl-2-NO2Ph 4,4, 6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl cyclopropyl 4-Cl-2-N02Ph 4, 4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl 4-Cl-2-NO2Ph 2-oxazolidinon-3-yl H 4-Cl-2-NO2Ph 2-oxazolidinon-3-yl methyl 4-Cl-2-NO2Ph 2-oxazolidinon-3-yl i-propyl 4-Cl-2-NO2Ph 2-oxazolidinon-3-yl cyclopropyl 4-Cl-2-NO2Ph 2-oxazolidinon-3-yl CF3 4-Cl-2-NO2Ph 2-pyrrolidinon-1-yl methyl 4-Cl-2-NO2Ph 2-pyrrolidinon-1-yl i-propyl 4-Cl-2-NO2Ph 2-pyrrolidinon-1-yl cyclopropyl 4-Cl-2-NO2Ph 2-pyrrolidinon-1-yl CF3 4-Cl-2-NO2Ph 3-methylisoxazol-5-yl methyl 4-Cl-2-NO2Ph 3-methylisoxazol-5-yl i-propyl 4-Cl-2-NO2Ph 3-methylisoxazol-5-yl cyclopropyl 4-Cl-2-NO2Ph 3-methylisoxazol-5-yl CF3 A B R 4-Cl-2-NO2Ph 2-NO2-4-SO2MePh H 4-CI-2-NO2Ph 2-NO2-4-SO2MePh methyl 4-Cl-2-NO2Ph 2-NO2-4-SO2MePh i-propyl 4-Cl-2-NO2Ph 2-NO2-4-SO2MePh cyclopropyl 4-Cl-2-NO2Ph 2-NO2-4-SO2MePh CF3 4-Cl-2-NO2Ph 2-Cl-4-SO2MePh H 4-Cl-2-NO2Ph 2-Cl-4-SO2MePh methyl 4-Cl-2-NO2Ph 2-Cl-4-SO2MePh i-propyl 4-Cl-2-NO2Ph 2-Cl-4-SO2MePh cyclopropyl 4-Cl-2-NO2Ph 2-Cl-4-SO2MePh CF3 4-Cl-2-NO2Ph 2-NO2-4-CF3Ph H 4-Cl-2-NO2Ph 2-NO2-4-CF3Ph methyl 4-Cl-2-NO2Ph 2-NO2-4-CF3Ph i-propyl 4-CI-2-NO2Ph 2-NO2-4-CF3Ph cyclopropyl 4-Cl-2-NO2Ph 2-NO2-4-CF3Ph CF3 4-Cl-2-NO2Ph 2-NO2-4-ClPh H 4-Cl-2-NO2Ph 2-NO2-4-CIPh methyl 4-Cl-2-NO2Ph 2-NO2-4-ClPh i-propyl 4-Cl-2-NO2Ph 2-NO2-4-ClPh cyclopropyl 4-Cl-2-NO2Ph 2-NO2-4-ClPh CF3 4-Cl-2-NO2Ph 2-Cl-4-NO2Ph H 4-Cl-2-NO2Ph 2-Cl-4-NO2Ph methyl 4-Cl-2-N02Ph 2-Cl-4-NO2Ph i-propyl 4-Cl-2-NO2Ph 2-Cl-4-NO2Ph cyclopropyl 4-Cl-2-NO2Ph 2-Cl-4-NO2Ph CF3 4-Cl-2-NO2Ph 2, 4-(NO2)2Ph H 4-Cl-2-NO2Ph 2, 4-(NO2)2Ph methyl 4-Cl-2-NO2Ph 2,4-(NO2)2Ph i-propyl 4-Cl-2-NO2Ph 2, 4-(NO2)2Ph cyclopropyl 4-Cl-2-NO2Ph 2, 4-(NO2)2Ph CF3 4-Cl-2-NO2Ph 4-F-3-NO2Ph H 4-Cl-2-NO2Ph 4-F-3-NO2Ph methyl 4-Cl-2-NO2Ph 4-F-3-NO2Ph i-propyl 4-Cl-2-NO2Ph 4-F-3-NO2Ph cyclopropyl 4-Cl-2-NO2Ph 4-F-3-NO2Ph CF3 4-Cl-2-NO2Ph 3,5-(CF3)2Ph H 4-Cl-2-NO2Ph 3, 5-(CF3) 2Ph methyl 4-Cl-2-NO2Ph 3,5-(CF3)2Ph i-propyl 4-Cl-2-NO2Ph 3, 5- CF3 2Ph cyclopropyl 4-Cl-2-N02Ph 3, 5-(CF3)2Ph CF3 4-Cl-2-NO2Ph 2-SO2Me-4-CF3Ph H 4-Cl-2-NO2Ph 2-SO2Me-4-CF3Ph methyl 4-Cl-2-NO2Ph 2-SO2Me-4-CF3Ph i-propyl 4-Cl-2-N02Ph 2-SO2Me-4-CF3Ph cyclopropyl 4-Cl-2-NO2Ph 2-SO2Me-4-CF3Ph CF3 A B R 2-SO2Me-4-CF3Ph 1, 2, 4-oxadiazol-5-yl H 2-SO2Me-4-CF3Ph 1, 2,4-oxadiazol-5-yl methyl 2-SO2Me-4-CF3Ph 1, 2, 4-oxadiazol-5-yl i-propyl 2-SO2Me-4-CF3Ph 1,2,4-oxadiazol-5-yl cyclopropyl 2-SO2Me-4-CF3Ph 1, 2, 4-oxadiazol-5-yl CF3 2-SO2Me-4-CF3Ph 3-methyl-l, 2, 4-oxadiazol-5-yl H 2-SO2Me-4-CF3Ph 3-methyl-l, 2, 4-oxadiazol-5-yl methyl 2-SO2Me-4-CF3Ph 3-methyl-1, 2, 4-oxadiazol-5-yl i-propyl 2-SO2Me-4-CF3Ph 3-methyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 2-SO2Me-4-CF3Ph 3-methyl-1, 2, 4-oxadiazol-5-yl CF3 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl H 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1,2,4-oxadiazol-5-yl methyl 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1,2,4-oxadiazol-5-yl i-propyl 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl CFs 2-SO2Me-4-CF3Ph 1, 2, 4-oxadiazol-3-yl H 2-SO2Me-4-CF3Ph 1, 2, 4-oxadiazol-3-yl methyl 2-SO2Me-4-CF3Ph 1, 2, 4-oxadiazol-3-yl i-propyl 2-SO2Me-4-CF3Ph 1, 2, 4-oxadiazol-3-yl cyclopropyl 2-SO2Me-4-CF3Ph 1, 2, 4-oxadiazol-3-ylCFs 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-oxadiazol-3-yl H 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-oxadiazol-3-yl methyl 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-oxadiazol-3-yl CF3 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl H 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl methyl 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1,2,4-oxadiazol-3-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 2-SO2Me-4-CF3Ph 5-chloro-1, 2, 4-oxadiazol-3-yl H 2-SO2Me-4-CF3Ph 5-chloro-1, 2, 4-oxadiazol-3-yl methyl 2-SO2Me-4-CF3Ph 5-chloro-1, 2, 4-oxadiazol-3-yl i-propyl 2-SO2Me-4-CF3Ph 5-chloro-1,2, 4-oxadiazol-3-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-chloro-1, 2, 4-oxadiazol-3-yl CF3 2-SO2Me-4-CF3Ph 1, 3, 4-oxadiazol-2-yl H 2-SO2Me-4-CF3Ph 1, 3, 4-oxadiazol-2-yl methyl 2-SO2Me-4-CF3Ph 1, 3, 4-oxadiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 1, 3, 4-oxadiazol-2-yl cyclopropyl 2-S02Me-4-CF3Ph 1,3,4-oxadiazol-2-yl CF3 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl H A B R 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1,3,4-oxadiazol-2-yl methyl 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1,3,4-oxadiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl CF3 2-SO2Me-4-CF3Ph 5-methyl-1, 3, 4-oxadiazol-2-yl H 2-SO2Me-4-CF3Ph 5-methyl-1,3,4-oxadiazol-2-yl methyl 2-S02Me-4-CF3Ph S-methyl-1, 3, 4-oxadiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 5-methyl-1,3,4-oxadiazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-methyl-1, 3, 4-oxadiazol-2-yl CF3 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl H 2-S02Me-4-CF3Ph 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl methyl 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1,3,4-oxadiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1,3,4-oxadiazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1,3,4-oxadiazol-2-yl CF3 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-4-yl H 2-SO2Me-4-CF3Ph 1,2, 3-triazol-4-yl methyl 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-4-yl i-propyl 2-SO2Me-4-CF3Ph 1, 2,3-triazol-4-yl cyclopropyl 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-4-yl CF3 2-SO2Me-4-CF3Ph 1-methyl-1, 2, 3-triazol-4-yl H 2-SO2Me-4-CF3Ph 1-methyl-1, 2, 3-triazol-4-yl methyl 2-SO2Me-4-CF3Ph 1-methyl-1, 2, 3-triazol-4-yl i-propyl 2-SO2Me-4-CF3Ph 1-methyl-1, 2, 3-triazol-4-yl cyclopropyl 2-SO2Me-4-CF3Ph 1-methyl-1, 2, 3-triazol-4-yl CF3 2-SO2Me-4-CF3Ph 2-methyl-1, 2, 3-triazol-4-yl H 2-SO2Me-4-CF3Ph 2-methyl-1, 2, 3-triazol-4-yl methyl 2-SO2Me-4-CF3Ph 2-methyl-1, 2, 3-triazol-4-yl i-propyl 2-SO2Me-4-CF3Ph 2-methyl-1,2,3-triazol-4-yl cyclopropyl 2-SO2Me-4-CF3Ph 2-methyl-1, 2, 3-triazol-4-yl CF3 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-1-yl H 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-1-yl methyl 2-SO2Me-4-CF3Ph 1,2, 3-triazol-1-yl i-propyl 2-SO2Me-4-CF3Ph 1,2, 3-triazol-1-yl cyclopropyl 2-S02Me-4-CF3Ph 1, 2, 3-triazol-1-yl CF3 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-2-yl H 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-2-yl methyl 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 1,2,3-triazol-2-yl CF3 2-SO2Me-4-CF3Ph 1, 2, 4-triazol-1-yl H 2-SO2Me-4-CF3Ph 1,2, 4-triazol-1-yl methyl 2-SO2Me-4-CF3Ph 1, 2, 4-triazol-1-yl i-propyl 2-SO2Me-4-CF3Ph 1,2, 4-triazol-1-yl cyclopropyl 2-SO2Me-4-CF3Ph 1, 2,4-triazol-1-yl CF3 2-SO2Me-4-CF3Ph imidazol-2-yl H 2-SO2Me-4-CF3Ph imidazol-2-yl methyl A B R 2-SO2Me-4-CF3Ph imidazol-2-yl i-propyl 2-SO2Me-4-CF3Ph imidazol-2-yl cyclopropyl 2-SOzMe-4-CF3Ph imidazol-2-yl CF3 2-SO2Me-4-CF3Ph imidazol-1-yl H 2-SO2Me-4-CF3Ph imidazol-1-yl methyl 2-SO2Me-4-CF3Ph imidazol-1-yl i-propyl 2-SO2Me-4-CF3Ph imidazol-1-yl cyclopropyl 2-SO2Me-4-CF3Ph imidazol-1-yl CF3 , 2-SO2Me-4-CF3Ph imidazol-4-yl H 2-S02Me-4-CF3Ph imidazol-4-yl methyl 2-S02Me-4-CF3Ph imidazol-4-yl i-propyl 2-SO2Me-4-CF3Ph imidazol-4-yl cyclopropyl 2-SO2Me-4-CF3Ph imidazol-4-yl CF3 2-SO2Me-4-CF3Ph thiazol-2-yl H 2-SO2Me-4-CF3Ph thiazol-2-1 methyl 2-SO2Me-4-CF3Ph thiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph thiazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph thiazol-2-yl CF3 2-SO2Me-4-CF3Ph 4-methylthiazol-2-yl H 2-SO2Me-4-CF3Ph 4-methylthiazol-2-yl methyl 2-SO2Me-4-CF3Ph 4-methylthiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 4-methylthiazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 4-methylthiazol-2-yl CF3 2-SO2Me-4-CF3Ph oxazol-2-yl H 2-SO2Me-4-CF3Ph oxazol-2-yl methyl 2-SO2Me-4-CF3Ph oxazol-2-yl i-propyl 2-SO2Me-4-CF3Ph oxazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph oxazol-2-yl CF3 2-SO2Me-4-CF3Ph 4, 5-dimethyloxazol-2-yl H 2-SO2Me-4-CF3Ph 4, 5-dimethyloxazol-2-yl methyl 2-SO2Me-4-CF3Ph 4, 5-dimethyloxazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 4, 5-dimethyloxazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 4,5-dimethyloxazol-2-yl CF3 2-SO2Me-4-CF3Ph 2-oxazolin-2-yl H 2-SO2Me-4-CF3Ph 2-oxazolin-2-yl methyl 2-SO2Me-4-CF3Ph 2-oxazolin-2-yl i-propyl 2-SO2Me-4-CF3Ph 2-oxazolin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 2-oxazolin-2-yl CF3 2-SO2Me-4-CF3Ph 4, 4-dimethyl-2-oxazolin-2-yl H 2-SO2Me-4-CF3Ph 4, 4-dimethyl-2-oxazolin-2-yl methyl 2-SO2Me-4-CF3Ph 4, 4-dimethyl-2-oxazolin-2-yl i-propyl 2-SO2Me-4-CF3Ph 4, 4-dimethyl-2-oxazolin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 4, 4-dimethyl-2-oxazolin-2-yl CF3 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-5-yl H 2-S02Me-4-CF3Ph 1, 2, 4-thiadiazol-5-yl methyl 2-S02Me-4-CF3Ph 1,2, 4-thiadiazol-5-yl i-propyl A B R 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-5- l cyclopropyl 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-5-yl CF3 2-SO2Me-4-CF3Ph 3-methyl-1, 2, 4-thiadiazol-5-yl H 2-SO2Me-4-CF3Ph 3-methyl-1, 2, 4-thiadiazol-5-yl methyl 2-SO2Me-4-CF3Ph 3-methyl-1, 2, 4-thiadiazol-5-yl i-propyl 2-SO2Me-4-CF3Ph 3-methyl-1,2,4-thiadiazol-5-yl cyclopropyl 2-SO2Me-4-CF3Ph 3-methyl-1, 2, 4-thiadiazol-5-yl CF3 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl H 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl methyl 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl i-propyl 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl cyclopropyl 2-SO2Me-4-CF3Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl CF3 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-3-yl H 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-3-yl methyl 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-3-yl i-propyl 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-3-yl cyclopropyl 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-3-yl CF3 2-SO2Me-4-CF3Ph 5-methyl-1,2,4-thiadiazol-3-yl H 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-thiadiazol-3-yl methyl 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-thiadiazol-3-yl i-propyl 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-thiadiazol-3-yl CF3 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl H 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl methyl 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1,2,4-thiadiazol-3-yl i-propyl 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl CF3 2-SO2Me-4-CF3Ph 1, 3, 4-thiadiazol-2-yl H 2-SO2Me-4-CF3Ph 1, 3, 4-thiadiazol-2-yl methyl 2-SO2Me-4-CF3Ph 1, 3, 4-thiadiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 1, 3, 4-thiadiazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 1, 3, 4-thiadiazol-2-yl CF3 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl H 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl methyl 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl CF3 2-SO2Me-4-CF3Ph 5-methyl-1,3,4-thiadiazol-2-yl H 2-SO2Me-4-CF3Ph 5-methyl-1, 3, 4-thiadiazol-2-yl methyl 2-SO2Me-4-CF3Ph 5-methyl-1,3,4-thiadiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 5-methyl-1,3,4-thiadiazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-methyl-1,3,4-thiadiazol-2-yl CF3 2-SO2Me-4-CF3Ph benzoxazol-2-yl H 2-SO2Me-4-CF3Ph benzoxazol-2-yl methyl 2-SO2Me-4-CF3Ph benzoxazol-2-yl i-propyl 2-SO2Me-4-CF3Ph benzoxazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph benzoxazol-2-yl CF3 A B R 2-SO2Me-4-CF3Ph 6-methylbenzoxazol-2-yl H 2-SO2Me-4-CF3Ph 6-methylbenzoxazol-2-yl methyl 2-SO2Me-4-CF3Ph 6-methylbenzoxazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 6-methylbenzoxazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 6-methylbenzoxazol-2-yl CF3 2-SO2Me-4-CF3Ph benzothiazol-2-yl H 2-SO2Me-4-CF3Ph benzothiazol-2-yl methyl 2-SO2Me-4-CF3Ph benzothiazol-2-yl i-propyl 2-SO2Me-4-CF3Ph benzothiazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph benzothiazol-2-yl CF3 2-SO2Me-4-CF3Ph pyrazol-1-yl H 2-SO2Me-4-CF3Ph pyrazol-1-yl methyl 2-SO2Me-4-CF3Ph pyrazol-1-yl i-propyl 2-SO2Me-4-CF3Ph azol-1-yl cyclopropyl 2-SO2Me-4-CF3Ph pyrazol-1-yl CF3 2-SO2Me-4-CF3Ph pyrazol-3-yl H 2-SO2Me-4-CF3Ph azol-3-yl methyl 2-SO2Me-4-CF3Ph pyrazol-3-yl i-propyl 2-SO2Me-4-CF3Ph pyrazol-3-yl cyclopropyl 2-SO2Me-4-CF3Ph pyrazol-3-yl CF3 2-SO2Me-4-CF3Ph 1-methylpyrazol-3-yl H 2-SO2Me-4-CF3Ph 1-methylpyrazol-3-yl methyl 2-SO2Me-4-CF3Ph 1-methylpyrazol-3-yl i-propyl 2-SO2Me-4-CF3Ph 1-methylpyrazol-3-yl cyclopropyl 2-SO2Me-4-GF3Ph 1-methylpyrazol-3-yl CF3 2-SO2Me-4-CF3Ph tetrazol-1-yl H 2-SO2Me-4-CF3Ph tetrazol-1-yl methyl 2-SO2Me-4-CF3Ph tetrazol-1-yl i-propyl 2-SO2Me-4-CF3Ph tetrazol-1-yl cyclopropyl 2-SO2Me-4-CF3Ph tetrazol-1-yl CF3 2-SO2Me-4-CF3Ph 5-methyltetrazol-1-yl H 2-SO2Me-4-CF3Ph 5-methyltetrazol-1-yl methyl 2-SO2Me-4-CF3Ph 5-methyltetrazol-1-yl i-propyl 2-SO2Me-4-CF3Ph 5-methyltetrazol-1-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-methyltetrazol-I-yl CF3 2-SO2Me-4-CF3Ph tetrazol-2-yl H 2-SO2Me-4-CF3Ph tetrazol-2-yl methyl 2-SO2Me-4-CF3Ph tetrazol-2-yl i-propyl 2-SO2Me-4-CF3Ph tetrazol-2-yl cyclopropyl 2-SO2Me-4-CF3Ph tetrazol-2-yl CF3 2-SO2Me-4-CF3Ph 5-methyltetrazol-2-yl H 2-SO2Me-4-CF3Ph 5-methyltetrazol-2-yl methyl 2-SO2Me-4-CF3Ph 5-methyltetrazol-2-yl i-propyl 2-SO2Me-4-CF3Ph 5-methyltetrazol-Z-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-methyltetrazol-2-yl CF3 2-SO2Me-4-CF3Ph 1-methyltetrazol-5-yl H A B R 2-SO2Me-4-CF3Ph 1-methyltetrazol-5-yl methyl 2-SO2Me-4-CF3Ph 1-methyltetrazol-5-yl i-propyl 2-SO2Me-4-CF3Ph 1-methyltetrazol-5-yl cyclopropyl 2-SO2Me-4-CF3Ph 1-methyltetrazol-5-yl CF3 2-SO2Me-4-CF3Ph 2-methyltetrazol-5-yl H 2-SO2Me-4-CF3Ph 2-methyltetrazol-5-yl methyl 2-SO2Me-4-CF3Ph 2-methyltetrazol-5-yl i-propyl 2-S02M-4-CF3Ph 2-methyltetrazol-5-yl cyclopropyl 2-SO2Me-4-CF3Ph 2-methyltetrazol-5-yl CF3 2-SO2Me-4-CF3Ph pyridin-2-yl H 2-SO2Me-4-CF3Ph pyridm-2-ylmethyl 2-SO2Me-4-CF3Ph pyridin-2-yl i-propyl 2-SO2Me-4-CF3Ph pyridin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph pyridin-2-yl CF3 2-SO2Me-4-CF3Ph pyridin-4-yl H. 2-SO2Me-4-CF3Ph pyridin-4-yl methyl 2-SO2Me-4-CF3Ph pyridin-4-yl i-propyl 2-SO2Me-4-CF3Ph pyridin-4-yl cyclopropyl 2-SO2Me-4-CF3Ph pyridin-4-yl CF3 2-SO2Me-4-CF3Ph pyridin-3-yl H 2-SO2Me-4-CF3Ph pyridin-3-yl methyl 2-02Me-4-CF3Ph pyridin-3-yl i-propyl 2-SO2Me-4-CF3Ph pyridin-3-yl cyclopropyl 2-SO2Me-4-CF3Ph idin-3-yl CF3 2-SO2Me-4-CF3Ph 3-nitropyridin-4-yl H 2-SO2Me-4-CF3Ph 3-nitropyridin-4-yl methyl 2-SO2Me-4-CF3Ph 3-nitropyridin-4-yl i-propyl 2-SO2Me-4-CF3Ph 3-nitropyridin-4-yl cyclopropyl 2-SO2Me-4-CF3Ph 3-nitropyridin-4-yl CF3 2-SO2Me-4-CF3Ph 5-cyanopyridin-2-yl H 2-SO2Me-4-CF3Ph 5-cyanopyridin-2-yl methyl 2-SO2Me-4-CF3Ph 5-cycanopyridin-2-yl i-propyl 2-SO2Me-4-CF3Ph 5-cyanopyridin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-cyanopyridin-2-yl CF3 2-SO2Me-4-CF3Ph 5-trifluoromethylpyridin-2-yl H 2-SO2Me-4-CF3Ph 5-trifluoromethylpyridin-2-yl methyl 2-SO2Me-4-CF3Ph 5-trifluoromethylpyridin-2-yl i-propyl 2-SO2Me-4-CF3Ph 5-trifluoromethylpyridin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 5-trifluoromethylpyridin-2-yl CF3 2-SO2Me-4-CF3Ph pyrimidin-2-yl H 2-SO2Me-4-CF3Ph pyrimidin-2-yl methyl 2-SO2Me-4-CF3Ph pyrimidin-2-yl i-propyl 2-SO2Me-4-CF3Ph pyrimidin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph pyrimidin-2-yl CF3 2-SO2Me-4-CF3Ph din-4- 2-SO2Me-4-CF3Ph pyrimidin-4-yl methyl B R 2-SO2Me-4-CF3Ph pyrimidin-4-yl i-propyl 2-SO2Me-4-CF3Ph pyrimidin-4-yl cyclopropyl 2-SO2Me-4-CF3Ph pyrimidin-4-yl CF3 2-SO2Me-4-CF3Ph 6-chloropyrimidin-4-yl methyl 2-SO2Me-4-CF3Ph 6-chloropyrimidin-4-yl i-propyl 2-SO2Me-4-CF3Ph 6-chloropyrimidin-4-yl cyclopropyl 2-SO2Me-4-CF3Ph 6-chloropyrimidin-4-yl CF3 2-S02Me-4-CF3Ph CF3Ph pyridazin-3-yl H 2-SO2Me-4-CF3Ph pyridazin-3-yl methyl 2-SO2Me-4-CF3Ph pyridazin-3-yl i-propyl 2-SO2Me-4-CF3Ph pyridazin-3-yl cyclopropyl 2-SO2Me-4-CF3Ph pyridazin-3-yl CF3 2-SO2Me-4-CF3Ph 6-chloropyridazin-3-yl methyl 2-SO2Me-4-CF3Ph 6-chloropyridazin-3-yl i-propyl 2-SO2Me-4-CF3Ph 6-chloropyridazin-3-yl cyclopropyl 2-SO2Me-4-CF3Ph 6-chloropyridazin-3-yl CF3 2-SO2Me-4-CF3Ph pyrazin-2-yl methyl 2-SO2Me-4-CF3Ph pyrazin-2-yl i-propyl 2-SO2Me-4-CF3Ph pyrazin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph azin-2-yl CF3 2-SO2Me-4-CF3Ph triazin-2-yl methyl 2-SO2Me-4-CF3Ph triazin-2-yl i-propyl 2-SO2Me-4-CF3Ph triazin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph triazin-2-yl CF3 2-SO2Me-4-CF3Ph quinolin-2-yl methyl 2-SO2Me-4-CF3Ph quinolin-2-yl i-propyl 2-SO2Me-4-CF3Ph quinolin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph quinolin-2-yl CF3 2-SO2Me-4-CF3Ph 4,4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl H 2-SO2Me-4-CF3Ph 4,4,6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl methyl 2-S02Me-4-CF3Ph 4,4,6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl i-propyl 2-SO2Me-4-CF3Ph 4, 4, 6-trimethyl-5, 6-dihydro-1, 3 (4H)-oxazin-2-yl cyclopropyl 2-SO2Me-4-CF3Ph 4,4,6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl CF3 2-SO2Me-4-CF3Ph 2-oxazolidinon-3-yl H 2-SO2Me-4-CF3Ph 2-oxazolidinon-3-yl methyl 2-SO2Me-4-CF3Ph 2-oxazolidinon-3-yl i-propyl 2-SO2Me-4-CF3Ph 2-oxazolidinon-3-yl cyclopropyl 2-SO2Me-4-CF3Ph 2-oxazolidinon-3-yl CF3 2-SO2Me-4-CF3Ph 2-pyrrolidinon-1-yl methyl 2-SO2Me-4-CF3Ph 2-pyrrolidinon-1-yl i-propyl 2-SO2Me-4-CF3Ph 2-pyrrolidinon-1-yl cyclopropyl 2-SO2Me-4-CF3Ph 2-pyrrolidinon-1-yl CF3 2-SO2Me-4-CF3Ph 3-methylisoxazol-5-yl methyl 2-SO2Me-4-CF3Ph 3-methylisoxazol-5-yl i-propyl 2-S02Me-4-CF3Ph 3-methylisoxazol-5-yl cyclopropyl 2-SO2Me-4-CF3Ph 3-methylisoxazol-5-yl CF3 A B R 2-SO2Me-4-CF3Ph 2-NO2-4-SO2MePh H 2-SO2Me-4-CF3Ph 2-NO2-4-SO2MePh methyl 2-SO2Me-4-CF3Ph 2-NO2-4-SO2MePh i-propyl 2-SO2Me-4-CF3Ph 2-NO2-4-SO2MePh cyclopropyl 2-SO2Me-4-CF3Ph 2-NO2-4-SO2MePh CF3 2-SO2Me-4-CF3Ph 2-Cl-4-SO2MePh H 2-SO2Me-4-CF3Ph 2-Cl-4-SO2MePh methyl 2-SO2Me-4-CF3Ph 2-Cl-4-SO2MePh i-propyl 2-SO2Me-4-CF3Ph 2-Cl-4-SO2MePh cyclopropyl 2-SO2Me-4-CF3Ph 2-Cl-4-SO2MePh CF3 2-SO2Me-4-CF3Ph 2-NO2-4-CF3Ph H 2-SO2Me-4-CF3Ph 2-NO2-4-CF3Ph methyl 2-SO2Me-4-CF3Ph 2-NO2-4-CF3Ph i-propyl 2-SO2Me-4-CF3Ph 2-NO2-4-CF3Ph cyclopropyl 2-SO2Me-4-CF3Ph 2-NO2-4-CF3Ph CF3 2-SO2Me-4-CF3Ph 2-NO2-4-ClPh H 2-SO2Me-4-CF3Ph 2-N02-4-ClPh methyl 2-SO2Me-4-CF3Ph 2-NO2-4-ClPh i-propyl 2-SO2Me-4-CF3Ph 2-NO2-4-ClPh cyclopropyl 2-SO2Me-4-CF3Ph 2-NO2-4-ClPh CF3 2-SO2Me-4-CF3Ph 2-Cl-4-NO2Ph H 2-SO2Me-4-CF3Ph 2-Cl-4-NO2Ph methyl 2-SO2Me-4-CF3Ph 2-Cl-4-NO2Ph i-propyl 2-SO2Me-4-CF3Ph 2-Cl-4-No2Ph cyclopropyl 2-SO2Me-4-CF3Ph 2-Cl-4-NO2Ph CF3 2-SO2Me-4-CF3Ph 2, 4-(NO2)2Ph H 2-SO2Me-4-CF3Ph 2, 4-(NO2)2Ph methyl 2-SO2Me-4-CF3Ph 2, 4-(NO2)2Ph i-propyl 2-SO2Me-4-CF3Ph 2, 4-(N02) 2Ph cyclopropyl 2-S02Me-4-CF3Ph 2, 4- O2) 2Ph CF3 2-SO2Me-4-CF3Ph 4-F-3-NO2Ph H 2-SO2Me-4-CF3Ph 4-F-3-NO2Ph 2-SO2Me-4-CF3Ph 4-F-3-NO2Ph i-propyl 2-SO2Me-4-CF3Ph 4-F-3-NO2Ph cyclopropyl 2-SO2Me-4-CF3Ph 4-F-3-NO2Ph CF3 2-SO2Me-4-CF3Ph 3, 5-(CF3)2Ph H 2-SO2Me-4-CF3Ph 3, 5-(CF3)2Ph methyl 2-SO2Me-4-CF3Ph 3, 5-(CF3)2Ph i-propyl 2-SO2Me-4-CF3Ph 3,5-(CF3)2Ph cyclopropyl 2-SO2Me-4-CF3Ph 3, 5-(CF3)2Ph CF 2-S02Me-4-CF3Ph 2-SO2Me-4-CF3Ph H 2-SO2Me-4-CF3Ph 2-SO2Me-4-CF3Ph methyl 2-SO2Me-4-CF3Ph 2-SO2Me-4-CF3Ph i-propyl 2-SO2Me-4-CF3Ph 2-SO2Me-4-CF3Ph cyclopropyl 2-SO2Me-4-CF3Ph 2-SO2Me-4-CF3Ph CF3 A B R 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-oxadiazol-5-yl H 3-Cl-5-CF3Pyridin-2-yl 1,2, 4-oxadiazol-5-yl methyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-oxadiazol-5-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 1,. 2, 4-oxadiazol-S-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-oxadiazol-5-yl CF3 3-Cl-5-CF3Pyridin-2-yl 3-methyl-1, 2, 4-oxadiazol-5-yl H 3-Cl-5-CF3Pyridin-2-yl 3-methyl-1, 2, 4-oxadiazol-5-yl methyl 3-Cl-5-CF3Pyridin-2-yl 3-methyl-1, 2, 4-oxadiazol-5-yl i-propyl 3-Cl-5-CF3P'din-2-yl 3-methyl-1, 2, 4-oxadiazol-5-yl cycloprop 3-Cl-5-CF3Pyridin-2-yl 3-methyl-1, 2, 4-oxadiazol-5-yl CF3 3-Cl-5-CF3Pyridin-2-yl 3-trifluoromethyl-1,2,4-oxadiazol-5-yl H 3-Cl-5-CF3Pyridin-2-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl methyl 3-Cl-5-CF3Pyridin-2-yl 3-trifluoromethyl-1,2,4-oxadiazol-5-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 3-trifluoromethyl-1,2,4-oxadiazol-5-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-oxadiazol-3-yl H 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-oxadiazol-3-yl methyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-oxadiazol-3-yl i-propyl 3-CI-5-CF3Pyridin-2-yl 1, 2, 4-oxadiazol-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-oxadiazol-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-oxadiazol-3-yl H 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-oxadiazol-3-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-oxadiazol-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl 4-trifluoromethyl-1,2,4,-oxadiazol-3-yl H 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethyl-1,2,4-oxadiazol-3-yl methyl 3-Cl-5-CF3Pyriin-2-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-chloro-1, 2, 4-oxadiazol-3-yl H 3-Cl-5-CF3Pyridin-2-yl 5-chloro-1, 2, 4-oxadiazol-3-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-chloro-1, 2, 4-oxadiazol-3-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-chloro-1, 2, 4-oxadiazol-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-chloro-1,2,4-oxadiazol-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1,3,4-oxadiazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 1, 3, 4-oxadiazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 1, 3, 4-oxadiazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 1,3, 4-oxadiazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1,3,4-oxadiazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-methylsulfonyl-1,3,4-oxadiazol-2-yl H A B R 3-Cl-5-CF3Pyridin-2-yl 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-methylsulfonyl-1,3,4-oxadiazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 3-Cl-5-CF3P'din-2-y 5--methylsulfonyl-1, 3, 4-oxadiazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 3, 4-oxadiazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 3, 4-oxadiazol-2-yl methyl 3-CI-5-CF3P'din-2-yl 5-methyl-1, 3, 4-oxadiazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1 3,4-oxadiazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethyl-1,3,4-oxadiazol-2-yl H 3-Cl-5-CF3P'din-2-yl 5-trifluoromethyl-1,3,4-oxadiazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethyl-1,3,4-oxadiazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethyl-l, 3, 4-oxadiazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1,2,3-triazol-4-yl H 3-Cl-5-CF3Pyridin-2-yl 1,2,3-triazol-4-yl methyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 1,2,3-triazol-4-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 3-triazol-4-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 3-triazol-4-yl CF3 3-Cl-5-CF3P'din-2-yl 1-methyl-1, 2, 3-triazol-4-yl H 3-Cl-5-CF3Pyridin-2-yl 1-methyl-1, 2, 3-triazol-4-yl methyl 3-Cl-5-CF3Pyridin-2-yl 1-methyl-1, 2, 3-triazol-4-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl I-methyl-1, 2, 3-triazol-4-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1-methyl-1,2,3-triazol-4-yl CF3 3-Cl-5-CF3P'din-2-yl 2-methyl-1, 2, 3-triazol-4-yl H 3-Cl-5-CF3Pyridin-2-yl 2-methyl-1, 2, 3-triazol-4-yl methyl 3-Cl-5-CF3Pyridin-2-yl 2-methyl-1, 2, 3-triazol-4-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 2-methy-1, 2, 3-triazol-4-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2-methyl-1, 2, 3-triazol-4-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1,2,3-triazol-1-yl H 3-CI-5-CF3Pyridin-2-yl 1,2, 3-triazol-1-yl methyl 3-Cl-5-CF3P'din-2-yl 1, 2, 3-triazol-1-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 1,2, 3-triazol-1-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 3-triazol-1-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1, 2, 3-triazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 1, 2, 3-triazol-2-yl methyl 3-Cl-5-CF3P'din-2-yl 1, 2, 3-triazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 1,2,3-triazol-2-yl cyclopropyl 3-Cl-5-CF3P'din-2-yl 1, 2, 3-triazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1,2, 4-triazol-1-yl H 3-Cl-5-CF3Pyridin-2-yl 1,2, 4-triazol-1-yl methyl 3-Cl-5-CF3Pyridin-2-yl 1,2,4-triazol-1-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 1,2, 4-triazol-1-1 cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-triazol-1-yl CF3 3-Cl-5-CF3Pyiidin-2-yl imidazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl imidazol-2-yl methyl A B R 3-Cl-5-CF3Pyridin-2-yl imidazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl imidazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl imidazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl imidazol-1-yl H 3-Cl-5-CF3Pyridin-2-yl imidazol-1-yl methyl 3-Cl-5-CF3Pyridin-2-yl imidazol-1-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl imidazol-1-yl cyclo ropyl 3-Cl-5-CF3Pyridin-2-yl imidazol-1-yl CF3 3-C1-5-CF3Pyridin-2-yl imidazol-4-yl H 3-Cl-5-CF3Pyridin-2-yl imidazol-4-yl methyl 3-Cl-5-CF3Pyridin-2-yl imidazol-4-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl imidazol-4-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl imidazol-4-yl CF3 3-Cl-5-CF3Pyridin-2-yl thiazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl thiazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl thiazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl thiazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl thiazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 4-methylthiazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 4-methylthiazol-2-l methyl 3-Cl-5-CF3Pyridin-2-yl 4-methylthiazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 4-methylthiazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 4-methylthiazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl oxazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl oxazol-2-l methyl 3-Cl-5-CF3Pyridin-2-yl oxazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl oxazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl oxazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 4,5-dimethyloxazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 4,5-dimethyloxazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 4,5-dimethyloxazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 4, 5-dimethvoxazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 4, 5-dimethyloxazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 2-oxazolin-2-yl H 3-Cl-5-CF3Pyridin-2-yl 2-oxazolin-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 2-oxazolin-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 2-oxazolin-2-yl cyclopro 3-Cl-5-CF3Pyridin-2-yl 2-oxazolin-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 4, 4-dimethyl-2-oxazolin-2-l H 3-Cl-5-CF3Pyridin-2-yl 4, 4-dimethyl-2-oxazolin-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 4, 4-dimethyl-2-oxazolin-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 4, 4-dimethyl-2-oxazolin-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 4, 4-dimethyl-2-oxazolin-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-thiadiazol-5-yl H 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-thiadiazol-5-yl methyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-thiadiazol-5-yl i-propyl A B R 3-Cl-5-CF3Pyridin-2-yl 1,2,4-thiadiazol-5-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-thiadiazol-5-yl CF3 3-Cl-5-CF3Pyridin-2-yl 3-methyl-1, 2, 4-thiadiazol-5-yl H 3-Cl-5-CF3Pyridin-2-yl 3-methyl-l, 2, 4-thiadiazol-5-yl methyl 3-Cl-5-CF3Pyridin-2-yl 3-methyl-1,2,4-thiadiazol-5-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 3-methyl-1,2,4-thiadiazol-5-yl cyclopro 3-Cl-5-CF3Pyridin-2-yl 3-methyl-1,2,4-thiadiazol-5-yl CF3 3-Cl-5-CF3Pyridin-2-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl H 3-Cl-5-CF3Pyridin-2-yl 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl methyl 3-Cl-5-CF3Pyridin-2-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl i-propyl 3-Cl-5-CF3P'din-2-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl cyclopro 3-Cl-5-CF3Pyridin-2-yl 3-trifluoromethyl-l 2, 4-thiadiazol-5-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1,2,4-thiadiazol-3-yl H 3-Cl-5-CF3Pyridin-2-yl 1,2,4-thiadiazol-3-yl methyl 3-Cl-5-CF3Pyndin---yl 1, 2, 4-thiadiazol-3-yl i-propyl 3-Cl-5-CF3P'din-2-yl 1, 2, 4-thiadiazol-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-thiadiazol-3-yl C 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-thiadiazol-3-yl H 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-thiadiazol-3-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-thiadiazol-3-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1,2,4-thiaiiazol-3-yl CF3 3-CI-5-CF3Pyridin-2-yl 5-trifluoromethyl-1, 2,4-thiadiazol-3-yl H 3-CI-5-CF3Pyridin-2-yl 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl i-propyl 3-Cl-5-CF3Pylidin-2-yl 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl c 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethyl-1,2,4-thiadiazol-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1, 3, 4-thiadiazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 1, 3, 4-thiadiazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-l 1, 3, 4-thiadiazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 1, 3, 4 thiadiazol-2-yl cyclo ropyl 3-Cl-5-CF3Pyndin-2-yl 1, 3, 4-thiadiazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-methylsuflonyl-1, 3, 4-thiadiazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-methylsuflonyl-1, 3, 4-thiadiazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 3, 4-thiadiazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1,3,4-thiadiazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 3, 4-thiadiazol-2-yl i-propyl 3-Cl-5-CF3P'din-2-yl 5-methyl-1, 3, 4-thiadiazol-2-yl cyclopro 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 3, 4-thiadiazol-2-yl CF3 3-Cl-5-CF3P'din-2-yl benzoxazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl benzoxazol-2-yl methyl 3-Cl-S-CF3Pyridin-2-yl benzoxazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl benzoxazol-2-yl cyclopropyl 3-Cl-5-CFsPyridin-2-yl benzoxazol-2-yl CF3 A B R 3-Cl-5-CF3Pyridin-2-yl 6-methylbenzoxazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 6-methylbenzoxazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 6-methylbenzoxazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 6-methylbenzoxazol-2-yl cyclopropyl 3-Cl-5-CF3P'din-2-yl 6-methylbenzoxazol-2-l CFs 3-Cl-5-CF3Pyridin-2-yl benzothiazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl benzotbiazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl benzothiazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl benzothiazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl benzothiazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl pyrazol-1-yl H 3-Cl-5-CF3Pyridin-2-yl pyrazol-1-yl methyl 3-Cl-5-CF3Pyridin-2-yI pyrazol-1-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl pyrazol-1-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl pyrazol-1-yl CF3 3-Cl-5-CF3Pyridin-2-yl pyrazol-3-yl H 3-Cl-5-CF3Pyridin-2- pyrazol-3-yl methyl 3-CI-5-CF3Pyridin-2-yl azol-3-yl i-propyl 3-Cl-5-CF3Pyndin-2-yl azol-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl pyrazol-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1-methylpyrazol-3-yl H 3-Cl-5-CF3Pyridin-2-yl 1-methylpyrazol-3-yl methyl 3-Cl-5-CF3Pyridin-2-yl 1-methylpyrazol-3-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 1-methylpyrazol-3-yl cyclopropyl 3-Cl-5-CF3Pyndin-2-yl 1-methylpyrazol-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl tetrazol-1-yl H 3-Cl-5-CF3Pyridin-2-yl tetrazol-1-yl methyl 3-Cl-5-CF3Pyridin-2-yl tetrazol-1-l i-propyl 3-C1-5-CF3Pyridin-2-yl tetrazol-1-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl tetrazol-1-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-methyltetrazol-1-yl H 3-CI-5-CF3Pyndin-2-yl 5-methyltetrazol-1-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-methyltetrazol-1-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-methyltetrazol-1-yl cyclopropyl 3-CI-5-CF3Pyridin-2-yl 5-methyltetrazol-1-yl CF3 3-Cl-5-CF3Pydin-2-yl tetrazol-2-l H 3-Cl-5-CF3Pyridin-2-yl tetrazol-2-yl. methyl 3-Cl-5-CF3Pyridin-2-yl tetrazol-2-yl i-propyl 3-Ct-5-CF3Pyridin-2-yl tetrazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl tetrazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-methyltetrazol-2-yl H 3-Cl-5-CF3Pyridin-2-yl 5-methyltetrazol-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-methyltetrazol-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-methyltetrazol-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-methyltetrazol-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 1-methyltetrazol-5-yl H ABR A B R 3-Cl-5-CF3Pyridin-2-yl 1-methyltetrazol-5-yl methyl 3-Cl-5-CF3Pyridin-2-yl 1-methyltetrazol-5-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 1-methyltetrazol-5-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 1-methyltetrazol-5-yl CF3 3-Cl-5-CF3Pyridin-2-yl 2-methyltetrazol-5-yl H 3-Cl-5-CF3Pyridin-2-yl 2-methyltetrazol-5-yl methyl 3-Cl-5-CF3Pyridin-2-yl 2-methyltetrazol-5-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 2-methyltetrazol-5-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2-methyltetrazol-5-yl CF3 3-Cl-5-CF3Pyridin-2-yl pyridin-2-yl H 3-Cl-5-CF3Pyridin-2-yl pyridin-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl pyridin-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl pyridin-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl pyridin-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl pyridin-4-yl H 3-Cl-5-CF3Pyridin-2-yl pyridm-4-ylmethyl 3-Cl-5-CF3Pyridin-2-yl pyridin-4-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl pyridin-4-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl pyridin-4-yl CF3 3-Cl-S-CF3Pyridin-2-yl yridin-3-yl H 3-Cl-5-CF3Pyridin-2-yl pyridin-3-yl methyl 3-Cl-5-CF3Pyridin-2-yl pyridin-3-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl pyridin-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl pyridin-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl 3-nitropyridin-4-yl H 3-Cl-5-CF3Pyridin-2-yl 3-nitropyridin-4-yl methyl 3-Cl-5-CF3Pyndin-2-yl 3-nitropyridin-4-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 3-nitropyridin-4-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 3-nitropyridin-4-yl CF3 3-Cl-5-CF3Pyridin-2-yl 5-cyanopyridin-2-yl H 3-Cl-5-CF3Pyridin-2-yl 5-cyanopyridin-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-cyanopyridin-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-cyano idin-2-l cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-cyanopyridin-2-yl CF3 3-C1-5-CF3Pyridin-2-yl 5-trifluoromethylpyridin-2-yl H 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethylpyridin-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethylpyridin-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethylpyridin-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 5-trifluoromethylpyridin-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl pyrimidin-2-yl H 3-CI-5-CF3Pyridin-2-yl yrimidin-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl yrimidin-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl pyrimidin-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl yrimidin-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl pyrimidin-4-yl H 3-Cl-5-CF3Pyridin-2-yl pyrimidin-4-yl methyl A B R 3-Cl-5-CF3Pyridin-2-yl pyrimidin-4-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl pyrimidin-4-yl cyclopropyl 3-Cl-5-CF3Pyndin-2-yl pyrimidin-4-yl CFs 3-Cl-5-CF3Pyridin-2-yl 6-chloropyrimidin-4-yl methyl 3-Cl-5-CF3Pyridin-2-yl 6-chloropyrimidin-4-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 6-chloropyrimidin-4-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 6-chloropyrimidin-4-yl CF3 3-Cl-5-CF3Pyridin-2-yl pyridazin-3-yl H 3-Cl-5-CF3Pyridin-2-yl pyridazin-3-yl methyl 3-Cl-5-CF3Pyridin-2-yl pyridazin-3-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl pyridazin-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl pyridazin-3-yl CFs 3-Cl-5-CF3Pyridin-2-yl 6-chloropyridazin-3-yl methyl 3-CI-5-CF3Pyridin-2-yl 6-chloropyridazin-3-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 6-chloropyridazin-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 6-chloropyridazin-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl pyrazin-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl pyrazin-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl pyrazin-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl pyrazin-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl triazin-2-yl methyl 3-Cl-5-CF3Pyridin-2-yl triazin-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl triazin-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl triazin-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl quinolin-2-yl methyl 3-Gl-5-CF3Pyridin-2-yl quinolin-2-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl quinolin-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl quinolin-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 4, 4, 6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl H 3-Cl-5-CF3Pyridin-2-yl 4,4,6,-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl methyl 3-CI-5-CF3Pyridin-2-yl 4, 4, 6-trimethyl-5, 5hydro 1, 3 (4H)-oxazin-2-yl i-propyl 3-Cl-5-CF3Pyndin-2-l 4, 4, 64dmethyl-5, 6-dihydro-1, 3 (4H)-oxazin-2-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 4, 4, 6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl CF3 3-Cl-5-CF3Pyridin-2-yl 2-oxazolidinon-3-yl H 3-Cl-5-CF3Pyridin-2-yl 2-oxazolidinon-3-yl methyl 3-Cl-5-CF3Pyndin-2-yl 2-oxazolidinon-3-yl 3-Cl-5-CF3P'din-2-l 2-oxazolidinon-3-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2-oxazolidinon-3-yl CF3 3-Cl-5-CF3Pyridin-2-yl 2-pyrrolidinon-1-yl methyl 3-Cl-5-CF3Pyridin-2-yl 2-pyrrolidinon-1-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 2-pyrrolidinon-1-yl cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2-pyrrolidinon-1-yl CF3 3-Cl-5-CF3Pyridin-2-yl 3-methylisoxazol-5-yl methyl 3-Cl-5-CF3Pyridin-2-yl 3-methylisoxazol-5-yl i-propyl 3-Cl-5-CF3Pyridin-2-yl 3-methylisoxazol-5-yl cyclopropyl 3-Cl-5-CF3P'din-2-yl 3-methylisoxazol-5-l CFs ABR 3-Cl-S-CF3Pyndin-2-yl 2-NO2-4-S02MePh H 3-Cl-5-CF3Pyridin-2-yl $2-NO2-4-SO2MePh methyl 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-SO2MePh i-propyl 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-SO2MePh cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-SO2MePh CF3 3-Cl-5-CF3Pyridin-2-yl 2-Cl-4-SO2MePh H 3-Cl-5-CF3Pyridin-2-yl 2-Cl-4-SO2MePh methyl 3-Cl-5-CF3Pyridin-2-yl 2-Cl-4-SO2MePh i-propyl 3-CI-5-CF3Pyridin-2-yl 2-CI-4-SO2MePh cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2-Cl-4-SO2MePh CF3 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-CF3Ph H 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-CF3Ph methyl 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-CF3Ph i-propyl 3-Cl-5-CF3Pyridin-2-yl NO2-4-CF3Ph cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-CF3Ph CF3 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-ClPh H 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-CIPh methyl 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-ClPh i-propyl 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-ClPh cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2-NO2-4-ClPh CF3 3-Cl-5-CF3Pyridin-2-yl 2-Cl-4-NOzPh H 3-Cl-5-CF3P'din-2-yl 2-Cl-4-NO2Ph methyl 3-Cf-5-CF3Pyiidin-2-yl 2-CI-4-NO2Ph i-propy, 3-Cl-5-CF3Pyridin-2-yl 2-Cl-4-NO2Ph cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2-Cl-4-NO2Ph CF3 3-Cl-5-CF3Pyndin-2-yl 2, 4-(NO2)2Ph H 3-Cl-5-CF3Pyridin-2-yl 2, 4- (N02) 2Ph methyl 3-Cl-5-CF3Pyridin-2-yl 2, 4-(NO2)2Ph i-propyl 3-Cl-5-CF3Pyridin-2-yl 2, 4-(NO2)2Ph cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 2,4-(NO2)2Ph CF3 3-Cl-5-CF3Pyridin-2-yl 4-F-3-NO2Ph H 3-Cl-5-CF3Pyridin-2-yl 4-F-3-NO2Ph methyl 3-Cl-5-CF3Pyridin-2-yl 4-F-3-NO2Ph i-propyl 3-Cl-5-CF3Pyridin-2-yl 4-F-3-NO2Ph cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 4-F-3-NO2Ph CF3 3-Cl-5-CF3Pyridin-2-yl 3, 5- (CF3) 2Ph H 3-Cl-5-CF3Pyridin-2-yl 3, 5-(CF3)2Ph methyl 3-Cl-5-CF3Pyndin-2-yl 3, 5-(CF3)2Ph i-propyl 3-Cl-5-CF3Pyridin-2-yl 3, 5-(CF3)2Ph cyclopropyl 3-Cl-5-CF3Pyridin-2-yl 3, 5- (CF3) 2Ph CF3 3-Cl-5-CF3Pyridin-2-yl 2-SO2Me-4-CF3Ph H 3-Cl-5-CF3Pyridin-2-yl 2-SO2Me-4-CF3Ph methyl 3-Cl-5-CF3Pyridin-2-yl 2-SO2Me-4-CF3Ph i-propyl 3-Cl-5-CF3Pyridin-2-yl 2-SO2Me-4-CF3Ph cyclopro 3-Cl-5-CF3Pyridin-2-yl 2-SO2Me-4-CF3Ph CF3 A B R 2, 4-(Me)2Thiazol-5-yl 1, 2, 4-oxadiazol-5-yl H 2, 4-(Me)2Thiazol-5-yl 1,2,4-oxadiazol-5-yl methyl 2, 4- (Me) 2Thiazol-5-yl 1, 2, 4-oxadiazol-5-yl i-propyl 2, 4- (Me) 2Thiazol-5-yl 1, 2, 4-oxadiazol-5-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 1,2,4-oxadiazol-5-yl CF3 2, 4-(Me)2Thiazol-5-yl 3-methyl-1, 2, 4-oxadiazol-5-yl H 2,4-(Me)2Thiazol-5-yl 3-methyl-1,2,4-oxadiazol-5-yl methyl 2, 4-(Me)2thiazol-5-yl 3-methyl-1, 2, 4-oxadiazol-5-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 3-methyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 3-methyl-1, 2, 4-oxadiazol-5-yl CF3 2, 4-(Me)2Thiazol-5-yl 3-trifluoromethyl-1,2,4-oxadiazol-5-yl H 2, 4-(Me)2Thiazol-5-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl methyl 2, 4- e)2Thiazol-5-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl i-propyl 2, 4- (Me)2thiazol-5-yl 3-trifluoromethyl-1,2,4-oxadiazol-5-yl cyclopropyl 2, 4- e 2Thiazol-5-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl CF3 2, 4-(Me) 2Thiazol-5-yl 1, 2, 4-oxadiazol-3-yl H 2, 4-(Me) 2Thiazol-5-yl 1,2, 4-oxadiazol-3-yl methyl 2, 4-(Me)2Thiazol-5-yl 1,2,4-oxadiazol-3-yl i-propyl 2, 4- (Me) 2Thiazol-5-yl 1, 2, 4-oxadiazol-3-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 1, 2, 4-oxadiazol-3-yl CF3 2, 4-(Me) 2Thiazol-5-yl 5-methyl-1, 2, 4-oxadiazol-3-yl H 2, 4-(Me)2Thiazol-5-yl 5-methyl-1, 2, 4-oxadiazol-3-yl methyl 2, 4- 2Thiazol-5-yl 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl 5-methyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 2,4-(Me)2Thiazol-5-yl 5-methyl-1, 2, 4-oxadiazol-3-yl CF3 2, 4-(Me)2thiazol-5-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl H 2, 4-(Me)2Thiazol-5-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl methyl 2, 4-(Me) 2Thiazol-5-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 5-trifluoromethyl-1, 2,4-oxadiazol-3-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 5-trifluoromethyl-1,2,4-oxadiazol-3-yl CF3 2, 4- (Me) 2Thiazol-5-yl 5-chloro-1, 2, 4-oxadiazol-3-yl H 2, 4-(Me)2thiazol-5-yl 5-chloro-1, 2, 4-oxadiazol-3-yl methyl 2, 4-(Me)2Thiazol-5-yl 5-chloro-1, 2, 4-oxadiazol-3-yl i-propyl 2, 4-(Me)2thiazol-5-yl 5-chloro-1, 2, 4-oxadiazol-3-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 5-chloro-1, 2, 4-oxadiazol-3-yl CF3 2, 4-(Me) 2Thiazol-5-yl 1, 3, 4-oxadiazol-2-yl H 2, 4-(Me) 2Thiazol-5-yl 1, 3, 4-oxadiazol-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl 1, 3, 4-oxadiazol-2-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl 1, 3, 4-oxadiazol-2-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 1, 3, 4-oxadiazol-2-yl CF3 2, 4-(Me)2Thiazol-5-yl 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl H A B R 2, 4-(Me)2Thiazol-5-yl 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl methyl 2, 4-(Me)2Thiazol-5-yl 5-methylsulfonyl-1,3,4-oxadiazol-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 2, 4- e 2Thiazol-5-yl 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl CF3 2, 4-(Me)2Thiazol-5-yl 5-methyl-1, 3, 4-oxadiazol-2-yl H 2, 4-(Me)2Thiazol-5-yl 5-methyl-1, 3, 4-oxadiazol-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl 5-mefhyl-1, 3, 4-oxadiazol-2-yl i-propyl 2,4-(Me)2Thiazol-5-yl 5-methyl-1,3,4-oxadiazol-2-yl cyclopropyl 2,4-(Me)2Thiazol-5-yl 5-methyl-1,3,4-oxadiazol-2-yl CF3 2,4-(Me)2Thiazol-5-yl 5-trifluoromethyl-1,3,4-oxadiazol-2-yl H 2,4-(Me)2Thiazol-5-yl 5-trifluoromethyl-1,3,4-oxadiazol-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 2, 4-(Me) 2Thiazol-5-yI 5-trifluoromethyl-I, 3 4-oxadiazol-2-yl CF3 2, 4-(Me)2Thiazol-5-yl 1, 2, 3-triazol-4-yl H 2, 4-(Me)2Thiazol-5-yl 1,2,3-triazol-4-yl methyl 2, 4- (Me) 2Thiazol-5-yl 1, 2, 3-triazol-4-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 1,2,3-triazol-4-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 1,2,3-triazol-4-yl CF3 2, 4-(Me)2Thiazol-5-yl 1-methyl-1, 2, 3-triazol-4-yl H 2, 4-(Me)2Thiazol-5-yl 1-methyl-1,2,3-triazol-4-yl methyl 2, 4-(Me) 2Thiazol-5-yl 1-methyl-1, 2, 3-triazol-4-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl 1-methyl-I, 2, 3-triaaol-4-yl cyclo ro yl 2, 4-(Me)2Thiazol-5-yl 1-methyl-1,2,3-triazol-4-yl CF3 2, 4-(Me) 2Thiazol-5-yl 2-methyl-1, 2, 3-triazol-4-yl H 2, 4-(Me) 2Thiazol-5-yl 2-methyl-1, 2, 3-triazol-4-yl methyl 2, 4-(Me)2Thiazol-5-yl 2-methyl-1,2,3-triazol-4-yl i-propyl 2, 4- (Me) 2Tazol-5-yl 2-methyl-1, 2, 3-triazol-4-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 2-methyl-1, 2, 3-triazol-4-yl CF3 2, 4-(Me)2Thiazol-5-yl 1,2,3-triazol-1-yl H 2, 4-(Me)2Thiazol-5-yl 1,2, 3-triazol-1-yl methyl 2, 4-(Me)2Thiazol-5-yl 1,2, 3-triazol-1-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 1,2, 3-triazol-1-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 1,2, 3-triazol-1-yl CF3 2, 4-(Me)2thiazol-5-yl 1,2,3-triazol-2-yl H 2, 4- (Me) 2Thiazol-5-yl 1,2, 3-triazol-2-yl methyl 2, 4-(Me) 2Thiazol-5-yl 1, 2, 3-triazol-2-yl i-propyl 2, 4- (Me) 2Thiazol-5-yl 1,2, 3-triazol-2-yl cyclopropyl 2, 4-(Me) 2Thiazol-5-yl 1, 2, 3-triazol-2-yl CF3 2, 4- (Me) 2Thiazol-5-yl 1,2, 4-triazol-1-yl H 2, 4-(Me)2Thiazol-5-yl 1,2, 4-triazol-1-yl methyl 2, 4-(Me)2Thiazol-5-yl 1, 2, 4-triazol-1-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 1,2, 4-triazol-1-yl cyclopropyl 2, 4-(Me) 2Thiazol-5-yl 1, 2, 4-triazol-1-yl CF3 2, 4-(Me)2Thiazol-5-yl imidazol-2-yl H 2, 4-(Me)2Thiazol-5-yl imidazol-2-yl methyl A B R 2, 4-(Me)2Thiazol-5-yl imidazol-2-yl i-propyl "Y__ 2, 4- (Me) 2Thiazol-5-yl imidazol-2-yl c 2, 4- (Me) 2Thiazol-5-yl imidazol-2-yl CF3 2, 4-(Me)2Thiazol-5-yl imidazol-1-yl H 2, 4-(Me)2Thiazol-5-yl imidazol-1-yl methyl 2, 4-(Me)2Thiazol-5-yl imidazol-1-yl i-propyl 2, 4-(Me)2Thiazol-5-yl imidazol-1-yl cyclopropyl 2, 4-(Me) 2Thiazol-5-yl imidazol-1-yl _ CF3 2,4-(Me)2Thiazol-5-yl imidazol-4-yl H 2, 4-(Me)2Thiazol-5-yl imidazol-4-yl methyl 2,4-(Me)2Thiazol-5-yl imidazol-4-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl imidazol-4-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl imidazol-4-l CF3 2, 4- (Me) 2Thiazol-5-yI thiazol-2-1 H 2, 4-(Me)2Thiazol-5-yl thiazol-2-yl methyl 2, 4-(Me) 2Thiazol-5-yl thiazol-2-yl i-propyl 2,4-(Me)2Thiazol-5-yl thiazol-2-yl cyclopropyl 2,4-(Me)2Thiazol-5-yl thiazol-2-yl CF3 2, 4- (Me) 2Thiazol-5-yl 4-methylthiazol-2-yl H 2,4-(Me)2Thiazol-5-yl 4-methylthiazol-2-yl methyl 2,4-(Me)2Thiazol-5-yl 4-methylthiazol-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 4-methylthiazol-2-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yI 4-methylthiazol-2-yl GF3 2, 4- (Me) 2Thiazol-5-yl oxazol-2-yl H 2, 4-(Me)2Thiazol-5-yl oxazol-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl oxazol-2-yl i-propyl 2,4-(Me)2Thiazol-5-yl oxazol-2-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl oxazol-2-yl CF3 2, 4- (Me) 2Thiazol-5-yl 4, S-dimethyloxazol-2-yl H 2, 4- (Me) 2Thiazol-5-yl 4, 5-dimethyloxazol-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl 4, 5-dimethyloxazol-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 4, 5-dimethyloxazol-2-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 4, 5-dimethyloxazol-2-yl CF3 2, 4-(Me)2Thiazol-5-yl 2-oxazolin-2-yl H 2, 4-(Me)2Thiazol-5-yl 2-oxazolin-2-yl methyl 2, 4-(Me) 2Thiazol-5-yl 2-oxazolin-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 2-oxazolin-2-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 2-oxazolin-2-yl CF3 2, 4-(Me)2Thiazol-5-yl 4, 4-dimethyl-2-oxazolin-2-yl H 2, 4-(Me)2Thiazol-5-yl 4,4-dimethyl-2-oxazolin-2-yl methyl 2, 4-(Me)2Thiazol-5-yl 4, 4-dimethyl-2-oxazolin-2-yl i-propyl 2, 4- (Me) 2Thiazol-5-yl 4, 4-dimethyl-2-oxazolin-2-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 4, 4-dimethyl-2-oxazolin-2-yl CF3 2, 4-(Me)2Thiazol-5-yl 1, 2, 4-thiadiazol-5-yl H 2, 4-(Me)2Thiazol-5-yl 1, 2, 4-thiadiazol-5-yl methyl 2, 4-(Me)2Thiazol-5-yl 1, 2, 4-thiadiazol-5-yl i-propyl A B R 2,4-(Me)2Thiazol-5-yl 1,2,4-thiadiazol-5-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 1, 2, 4-thiadiazol-5-yl CF3 2, 4-(Me)2Thiazol-5-yl 3-methyl-1, 2, 4-thiadiazol-5-yl H 2,4-(Me)2Thiazol-5-yl 3-methyl-1,2,4-thiadiazol-5-yl methyl 2,4-(Me)2Thiazol-5-yl 3-methyl-1,2,4-thiadiazol-5-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 3-methyl-1, 2, 4-thiadiazol-5-yl cyclopropyl 2,4-(Me)2Thiazol-5-yl 3-methyl-1, 2, 4-thiadiazol-5-yl CF3 2,4-(Me)2Thiazol-5-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl H 2,4-(Me)2Thiazol-5-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl methyl 2, 4-(Me)2Thiazol-5-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl CF3 2, 4- (Me) 2Thiazol-S-l 1, 2, 4-thiadiazol-3-yl H 2, 4-(Me)2Thiazol-5-yl 1,2, 4-thiadiazol-3-ylmethyl 2, 4- (Me) 2Thiazol-5-yl 1, 2, 4-thiadiazol-3-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl 1, 2, 4-thiadiazol-3-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 1,2,4-thiadiazol-3-yl CF3 2, 4- (Me) 2Thiazol-5-yl 5-methyl-1, 2, 4-thiadiazol-3-yl H 2, 4- (Me) 2Thiazol-5-yl 5-methyl-1, 2, 4-thiadiazol-3-yl methyl 2, 4-(Me) 2Thiazol-5-yl 5-methyl-1, 2, 4-thiadiazol-3-yl H 2, 4-(Me) 2Thiazol-5-yl 5-methyl-1, 2, 4-(Me)2Thiazol-5-yl 2, 4-(Me) 2Thiazol-5-yl 5-methyl-1, 2, 4-thiadiazol-3-yl CF3 2, 4-(Me)2Thiazol-5-yl 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl H 2, 4- (Me) 2Thiazol-5-yl 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl methyl 2,4-(Me)2Thiazol-5-yl 5-trifluoromethyl-1, 2, 4-thiadiazol3-yl i-propyl 2, 4- (Me) 2Thiazol-5-yl 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl CF3 2, 4-(Me)2Thiazol-5-yl 1, 3, 4-thiadiazol-2-yl H 2, 4- (Me) 2Thiazol-5-yl 1, 3, 4-thiadiazol-2-yl methyl 2, 4-(Me)2Thiazol-5-yl 1, 3, 4-thiadiazol-2-yl i-prop1 2, 4- (Me) 2Thiazol-5-yl 1,3, 4-thiadiazol-2-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 1, 3, 4-thiadiazol-2-yl CF3 2, 4-(Me)2Thiazol-5-yl 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl H 2, 4- (Me) 2Thiazol-5-yl 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 5-methylsulfonyl-1,3,4-thiadiazol-2-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 5-methylsulfonyl-1,3,4-thiadiazol-2-yl CF3 2, 4-(Me)2Thiazol-5-yl 5-methyl-1,3,4-thiadiazol-2-yl H 2, 4-(Me)2Thiazol-5-yl 5-methyl-1, 3, 4-thiadiazol-2-yl methyl 2,4-(Me)2Thiazol-5-yl 5-methyl-1,3,4-thiadiazol-2-yl i-propyl 2,4-(Me)2Thiazol-5-yl 5-methyl-1,3,4-thiadiazol-2-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 5-methyl-1, 3, 4-thiadiazol-2-yl CF3 2, 4-(Me) 2Thiazol-5-yl benzoxazol-2-yl H 2, 4-(Me)2Thiazol-5-yl benzoxazol-2-yl methyl 2, 4-(Me)2Thiazol-5-yl benzoxazol-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl benzoxazol-2-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl benzoxazol-2-yl CF3 A B R 2, 4-(Me)2thiazol-5-yl 6-methylbenzoxazol-2-yl H 2, 4-(Me)2thiazol-5-yl 6-methylbenzoxazol-2-yl methyl A B R 2,4-(Me)2Thiazol-5-yl 6-methylbenzoxazol-2-yl i-propyl 2,4-(Me)2Thiazol-5-yl 6-methylbenzoxazol-2-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 6-methylbenzoxazol-2-1 CFs 2, 4- (Me) 2Thiazol-5-yl benzothiazol-2-yl H 2, 4- (Me) 2Thiazol-5-yl benzothiazol-2-l methyl 2, 4- (Me) 2Thiazol-5-yl benzothiazol-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl benzothiazol-2-yl cyclopro 2, 4-(Me) 2Thiazol-S-yl benzothiazol-2-yl CF3 2, 4- (Me) 2Thiazol-5-yl pyrazol-1-yl H 2, 4-(Me)2Thiazol-5-yl pyrazol-1-yl methyl 2, 4- (Me) 2Thiazol-5-yl pYrazol-1-yl i-propyl 2,4-(Me)2Thiazol-5-yl pyrazol-1-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl pyrazol-1-yl CF3 2, 4-(Me) 2Thiazol-5-yl pyrazol-3-yl H 2, 4-(Me)2Thiazol-5-yl pyrazol-3-yl methyl 2, 4-(Me)2Thiazol-5-yl pyrazol-3-yl i-propyl 2, 4-(Me)2Thiazol-5-yl pyrazol-3-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl pyrazol-3-yl CF3 2, 4-(Me)2Thiazol-5-yl 1-methylpyrazol-3-yl H 2, 4- (Me) 2Thiazol-5-yl 1-methylpyrazol-3-yl methyl 2, 4- (Me) 2Thiazol-5-yl 1-methylpyrazol-3-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 1-methylpyrazol-3-yl cyclopropyl 2, 4-(Me) 2Thiazol-5-yl 1-methylpyrazol-3-yl CF3 2, 4- (Me) 2Thiazol-5-yl tetrazol-1-yl H 2, 4- (Me) 2Thiazol-5-yl tetrazol-1-ylmethyl 2, 4-(Me) 2Thiazol-5-yl tetrazol-1-yl i-propyl 2v4-(Me) 2Thiazol-5-yl tetrazol-1-yl cyclopropyl 2, 4-(Me) 2Thiazol-5-yl tetrazol-1-yl CF3 2, 4-(Me)2Thiazol-5-yl 5-methyltetrazol-1-yl H 2, 4-(Me)2Thiazol-5-yl 5-methyltetrazol-1-yl methyl 2, 4-(Me)2Thiazol-5-yl 5-methyltetrazol-1-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 5-methyltetrazol-1-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 5-methyltetrazol-1-yl CF3 2, 4-(Me)2Thiazol-5-yl tetrazol-2-yl H 2, 4-(Me)2Thiazol-5-yl tetrazol-2-yl methyl 2, 4-(Me) 2Thiazol-5-yl tetrazol-2-yl i-propyl 2, 4-Ne32Thiazol-5-yl tetrazol-2-yl cyclopropyl 2,4- (Me) 2Thiazol-5-yl tetrazol-2-I CF3 2, 4-(Me)2Thiazol-5-yl 5-methyltetrazol-2-yl H 2, 4-(Me)2Thiazol-5-yl 5-methyltetrazol-2-yl methyl 2, 4-(Me)2Thiazol-5-yl 5-methyltetrazol-2-yl i-propyl 2, 4- (Me) 2Thiazol-5-yl 5-methyltetrazol-2-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-l 5-meth ltetrazol-2-l CF3 2, 4- (Me) 2Thiazol-5-yl 1-methyltetrazol-5-yl H ABR 2, 4-(Me)2Thiazol-5-yl 1-methyltetrazol-5-yl methyl 2, 4-(Me) 2Thiazol-5-yl 1-methyltetrazol-5-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 1-methyltetrazol-5-yl cyclopropyl 2,4-(Me)2Thiazol-5-yl 1-methyltetrazol-5-yl CF3 2, 4-(Me)2Thiazol-5-yl 2-methyltetrazol-5-yl H 2, 4-(Me)2Thiazol-5-yl 2-methyltetrazol-5-yl methyl 2, 4-(Me)2Thiazol-5-yl 2-methyltetrazol-5-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl 2-methyltetrazol-5-yl cyclopropyl 2,4-(Me)2Thiazol-5-yl 2-methyltetrazol-5-yl CF3 2, 4-(Me)2Thiazol-5-yl pyridin-2-yl H 2, 4-(Me)2Thiazol-5-yl pyridin-2-yl methyl 2, 4-(Me)2Thiazol-5-yl pyridin-2-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl pyridin-2-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl pyridin-2-yl CF3 2, 4-(Me)2Thiazol-5-yl pyridin-4-yl H 2, 4-(Me) 2Thiazol-5-yl pyridin-4-yl methyl 2, 4-(Me)2Thiazol-5-yl pyridin-4-yl i-propyl 2, 4- (Me)2Thiazol-5-yl pyridin-4-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl pyridin-4-yl CF3 2, 4- (Me) 2Thiazol-5-yl pyridin-3-yl H 2, 4-(Me) 2Thiazol-5-yl pyridin-3-yl methyl 2, 4-(Me) 2Thiazol-5-yl pyridin-3-yl i-propyl 2, 4-(Me)2Thiazol-5-yl pyridin-3-yl cyclopropyl 2, 4-(Me)2Thiazol-5-ylpyridin-3-yl CF3 2, 4-(Me)2Thiazol-5-yl 3-nitropyridin-4-yl H 2, 4-(Me)2Thiazol-5-yl 3-nitropyridin-4-yl methyl 2, 4-(Me) 2Thiazol-5-yl 3-nitropyridin-4-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 3-nitropyridin-4-yl cyclopropyl 2,4- (Me) 2Thiazol-5-yl 3-nitropyridin-4-yl CF3 2, 4- (Me) aThiazol-5-yl 5-cyanopyridin-2-yl H 2, 4-(Me)2Thiazol-5-yl 5-cyanopyridin-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl 5-cyanopyridin-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 5-cyanopyridin-2-yl cyclopropyl 2, 4-(Me) 2Thiazol-5-yl 5-cyanopyridin-2-yl CF3 2, 4- (Me) 2Thiazol-5-yl 5-trifluoromethylpyridin-2-yl H 2, 4- (Me) 2Thiazol-5-yl 5-iifluoromethylpyridin-2-l methyl 2, 4- (Me) 2Thiazol-5-yl 5--trifluoromethylpyridin-2-yl i-ropyl 2, 4- Me) 2Thiazol-5-yl 5-trifluoromethylpyridin-2-l cyclopropr 2, 4-(Me)2Thiazol-5-yl 5-trifluoromethylpyridin-2-yl CF3 2, 4-(Me)2Thiazol-5-yl pyrimidin-2-yl H 2, 4-(Me)2Thiazol-5-yl pyrimidin-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl pyrimidin-2-yli-propyi 2, 4-(Me)2Thiazol-5-yl pyrimidin-2-yl cyclopropyl 2, 4- 2Thiazol-5-yl pyrimidin-2-yl CF3 2, 4-(Me) 2Thiazol-5-yl pyrimidin-4-yl H 2, 4-(Me)2Thiazol-5-yl pyrimidin-4-yl methyl A B R 2, 4-(Me)2Thiazol-5-yl pyrimidin-4-yl i-propyl 2,4-(Me)2Thiazol-5-yl pyrimidin-4-yl i-propyl 2,4-(Me)2Thiazol-5-yl pyrimidin-4-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl pyrimidin-4-yl CF3 2,4-(Me)2Thiazol-5-yl 6-chloropyrimidin-4-yl methyl 2,4-(Me)2Thiazol-5-yl 6-chloropyrimidin-4-yl i-propyl 2, 4-(Me)2Thiazol-5-yl 6-chloropyrimidin-4-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 6-chloropyrimidin-4-yl CF3 2, 4- ( e) 2Thiazol-5-yl pyridazin-3-l H 2, 4-e) 2Thiazol-5-yl pyridazin-3-yl methyl 2, 4- (Me)2Thiazol-5-yl pyridazin-3-yl i-propyl 2, 4-(Me)2Thiazol-5-yl pyridazin-3-yl cyclopropyl 2,4-(Me)2Thiazol-5-yl pyridazin-3-yl CF3 2,4-(Me)2Thiazol-5-yl 6-chloropyridazin-3-yl methyl 2, 4-(Me) 2Thiazol-5-yl 6-chloropyridazin-3-yl i-propyl 2, 4- (Me 2Thiazol-S-yl 6-chloropyridazin-3-y c clo ropyl 2, 4-(Me) 2Thiazol-5-yl 6-chloropyridazin-3-yl CF3 2, 4- (Me) 2Thiazol-5-yl pyrazin-2-yl methyl 2, 4-(Me2)Thiazol-5-yl pyrazin-2-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl pyrazin-2-yl cyclopropyl 2,4-(Me)2Thiazol-5-yl pyrazin-2-yl CF3 2,4-(Me)2Thiazol-5-yl triazin-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl triazin-2-yl i-propyl 2, 4-(Me)2Thiazol-5-yl triazin-2-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl triazin-2-yl CF3 2, 4-(Me)2Thiazol-5-yl quinolin-2-yl methyl 2, 4- (Me) 2Thiazol-5-yl uinolin-2-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl quinolin-2-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl quinolin-2-yl CF3 2, 4- (Me) 2Thiazol-5-yl 4,4, 6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl H 2, 4-(Me)2Thiazol-5-yl 4, 4, 6-trimethyl-5, 6-dihydro-1, 3 (4H)-oxazm-2-yi methyl 2, 4- (Me) 2Thiazol-5-yl 4,4, 6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl 4, 4, 6-trimethyl-5, 6-dihydro-1, 3 (4H)-oxazin-2-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 4,4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl 2, 4-(Me)2Thiazol-5-yl 2-oxazolidinon-3-yl H 2, 4- (Me) 2Thiazol-5-yl 2-oxazolidinon-3-yl methyl 2, 4-(Me) 2Thiazol-5-yl 2-oxazolidinon-3-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl 2-oxazolidinon-3-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 2-oxazolidinon-3-yl CF3 2, 4-(Me)2Thiazol-5-yl 2-pyrrolidinon-1-yl methyl 2, 4- (Me) 2Thiazol-5-yl 2-pyrrolidinon-1-l i-propyl 2, 4-(Me)2Thiazol-5-yl 2-pyrrolidinon-1-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 2-pyrrolidinon-1-yl CF3 2, 4-(Me)2Thiazol-5-yl 3-methylisoxazol-5-yl methyl 2, 4-(Me)2Thiazol-5-yl 3-methylisoxazol-5-yl i-propyl 2, 4-(Me) 2Thiazol-5-yl 3-methylisoxazol-5-yl cyclopropyl 2, 4-(Me)2Thiazol-5-yl 3-methylisoxazol-5-yl CF3 A B 2, 4-(Me)2Thiazol-5-yl 2-NO2-4-SO2MePh H 2, 4-(Mei2Thiazol-5-yl 2-NO2-4-SO2MePh methyl 2, 4- (Me) 2Thiazol-5-yl 2-NO2-4-SO2MePh i-propyl 2, 4-(Me) 2Thiazol-5-el 2-NO2-4-SO2MePh cyclopropyl 2, 4-(Me)2Thiazol-5-yl 2-NO2-4-SO2MePh CF3 2, 4-(Me)2Thiazol-5-yl 2-Cl-4-SO2MePh H 2, 4-(Me)2Thiazol-5-yl 2-Cl-4-SO2MePh methyl 2, 4- (Me) 2Thiazol-5-'yl 2-Cl-4-S02MePhi-propyi 2, 4- (Me 2Thiazol-5-l 2-Cl-4-SO2MePh cyclopropyl 2,4-(Me)2Thiazol-5-yl 2-Cl-4-SO2MePh CF3 2, 4-(Me)2Thiazol-5-yl 2-NO2-4-CF3Ph H 2, 4-(Me) 2Thiazol-5-yl 2-NO2-4-CF3Ph methyl 2, 4-(Me)2Thiazol-5-yl 2-NO2-4-CF3Ph i-propyl 2,4-(Me 2Thiazol-5-yl 2-NO2-4-CF3Ph cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 2-NO2-4-CF3Ph CF3 2, 4-(Me)2Thiazol-5-yl 2-NO2-4-ClPh H 2, 4-Ie) 2Thiazol-5-yl 2-NO2-4-C3Ph methyl 2, 4-(Me)2Thiazol-5-yl 2-NO2-4-ClPh i-propyl 2, 4-(Me)2Thiazol-5-yl 2-NO2-4-ClPh cyclopropyl 2, 4-(Me)2Thiazol-5-yl 2-NO2-4-ClPh CF3 2, 4-(Me)2Thiazol-5-yl 2-Cl-4-NO2Ph H 2, 4-(Me)2Thiazol-5-yl 2-Cl-4-NO2Ph methyl 2, 4- (Me) 2Thiazol-5-yl 2-Ci-4-N02Ph i-propyI 2, 4-(Me) 2Thiazol-5-yl 2-a-4-NO2Ph cyclopropyl 2, 4-(Me)2Thiazol-5-yl 2-Cl-4-NO2Ph CF3 2, 4-(Me)2Thiazol-5-yl 2,4-(NO2)2Ph H 2, 4-(Me)2Thiazol-5-yl 2, 4-(NO2)2Ph methyl 2, 4-(Me)2thiazol-5-yl 2,4-(NO2)2Ph i-propyl 2, 4- (Me) 2Thiazol-5-yl 2, 4-(NQ2) 2Ph cyclopropyl 2, 4- e 2Thiazol-5-yl 2, 4-(NO2)2Ph CF3 2, 4- (Me) 2Thiazol-5-yl 4-F-3-NO2Ph H 2,4-(Me)2Thiazol-5-yl 4-F-3-NO2Ph methyl 2, 4-(Me)2Thiazol-5-yl 4-F-3NO2-Ph i-propyl 2,4-(Me)2Thiazol-5-yl 4-F-3-NO2Ph cyclopropyl 2,4-(Me)2Thiazol-5-yl 4-F-3-NO2Ph CF3 2, 4-(Me)2Thiazol-5-yl 3,5-(CF3)2Ph H 2, 4-(Me)2Thiazol-5-yl 3, 5- (CF3) 2Phmethyl 2, 4-(Me) 2Thiazol-5-yl 3, 5-(CF3) 2Ph i-propyl 2, 4-(Me) 2Thiazol-5-yl 3, 5-(CF3)2Ph cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 3, 5-(CF3)2Ph CF3 2, 4-(Me)2Thiazol-5-yl 2-SO2Me-4-CF3Ph H 2, 4-(Me)2Thiazol-5-yl 2-SO2Me-4-CF3Ph methyl 2, 4-(Me)2Thiazol-5-yl 2-SO2Me-4-CF3Ph i-propyl 2, 4- (Me 2Thiazol-5-yl 2-SO2Me-4-CF3Ph cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 2-SO2Me-4-CF3Ph CF3 ABR A B R 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-oxadiazol-5-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 1, 2, oxadiazol-5-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-oxadiazol-5-yl i-propyl 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph l, 2, 4-oxadiazol-5-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1, 2, 4-oxadiazol-5-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-methyl-1,2,4-oxadiazol-5-yl H 2-Me-4-SO2Me-3- (4,5-dihydroisoxazol-3-yl)Ph 3-methyl-1, 2, 4-oxadiazol-5-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-methyl-1,2,4-oxadiazol-5-yl i-pro 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-methyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-methyl-1,2,4-oxadiazol-5-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl)Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-trifluoromethyl-1,2,4-oxadiazol-5-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-trifluoromethyl-1,2,4-oxadiazol-5-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl Ph 3-trifluoromethyl-1,2,4-oxadiazol-5-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-trifluoromethyl-1,2,4-oxadiazol-5-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl)Ph 1,2,4-oxadiazol-3-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-oxadiazol-3-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3 Ph 1, 2, 4-oxadiazol-3-yl 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl)Ph 1,2,4-oxadiazol-3-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-oxadiazol-3-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-methyl-1, 2, 4-oxadiazol-3-yl H 2-Me-4-S02Me-3- (4, 5-dihydToisoxazol-3-yl) Ph 5-methyl-1, 2, 4-oxadiazol-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1,2,4-oxadiazol-3-yl cyclopropyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl)Ph 5-methyl-1,2,4-oxadiazol-3-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1,2,4-oxadiazol-3-yl H 2-Me-4-S02Me-3- (4, 5-dihydrflisoxazol-3-yl) Ph 5-trjuoromethyl-1, 2, 4-oxadiazol-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propy1 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1,2, 4-oxadiazol-3-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 2-Me4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-chloro-1, 2, 4-oxadiazol-3-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-chloro-1,2,4-oxadiazol-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-chloro-1,2,4-oxadiazol-3-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-chloro-1,2,4-oxadiazol-3-yl cyclopropyl 2-Me-4-SO2-Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-chloro-1,2, 4-oxadiazol-3-yl CF3 2-Me4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 3, 4-oxadiazol-2-yl H 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 3, 4-oxadiazol-2-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 3, 4-oxadiazol-2-yl i-propyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yI) Ph 1, 3, 4-oxadiazol-2-yl 1 cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1, 3, 4-oxadiazol-2-yl CF3 2 Me-4-SOzMe-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl H aber 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-5-yl)Ph 5-methylsulfonyl-1,3,4-oxadiazol-2-yl methyl 2-Me-4-S02Me-3- (4, 3-dihydroisoxazoI-3-yl) Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl CF3 2-Me-4-SOzMe-3- 4, 5-dihydroisoxazol-3-yl) Ph 5-methyl-1, 3, 4-oxadiazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1, 3, 4-oxadiazol-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1, 3, 4-oxadiazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1,3,4-oxadiazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1,3,4-oxadiazol-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1,3,4-oxadiazol-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1,3,4-oxadiazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1,3,4-oxadiazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1, 2, 3-triazol-4-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,3-triazol-4-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,3-triazol-4-yl i-propyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 3-triazol-; cyclopropyi 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 3-triazol-4-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1-methyl-1,2,3-triazol-4-yl H 2 Me-4-SOMe-3- (4, 5-dihydroisozol-3 yl) Ph l-meth 1-1, 2, 3-triazol-4-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1-methyl-1, 2, 3-triazol-4-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1-methyl-1, 2, 3-triazol-4-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 1-methyl-1, 2, 3-triazol-4-yl CF3 2-Me-4-SO2Me-3-(4, 5 dihydroisoxazol-3-yl) Ph 2-methyl-1, 2, 3-triazol-4-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-methyl-1, 2, 3-tiiazol-4-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 2-methyl-1, 2, 3-triazol-4-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-methyl-1, 2, 3-triazol-4-yl cyclopropyl 2-Me4-SO2Me-3. (4, 5-dihydroisoxazol-3-yl)Ph 2-methyl-1, 2, 3-ttiazol-4-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,3-triazol-1-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,3-triazol-1-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 3-triazol-l-yl i-propI 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 3-triazol-1-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,3-triazol-1-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,3-triazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 1, 2, 3-triazol methyl 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 3-triazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,3-triazol-2-yl cyclopropy; 2-Me-4.-S02Me-3- (4, 5-dihydroisoxazol-3-yI) Ph 1, 2, 3-triazol-2-yl CF3 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1,2, 4-triazol-1-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2, 4-triazol-1- methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-triazol-1-yl i-propyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1,2, 4-triazol-1-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-triazol-1-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-2-yl methyl B R 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-2-yl i-propyl 2-Me-4-SO2Me-3- (, 5-dihydroisoxazol-3-yl) Ph imidazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-2-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl)Ph imidazol-1-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph imidazol-1-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-1-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-1-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-1-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-4-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-4-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-4-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-4-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph imidazol-4-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph thiazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph thiazol-2-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph thiazol-Z-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph thiazol-2-ylcyclopropyi 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph thiazol-2-yl CF3 2-Me-4-SQzMe-3- (4, 5-ihydroisoxazol-3-yl) Ph 4-methyltiazol-2-yl H 2-Me-4-SOzMe-3-14, 5 dihydroisoxazol-3-yl) Ph 4-methylthiazol-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 4-methylthiazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4-methylthiazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4-methylthiazol-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph oxazol-2-yl H 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph oxazol-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph oxazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph oxazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph oxazol-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,5-dimethyloxazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,5-dimethyloxazol-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,5-dimethyloxazol-2-yl i-propyl 2-Me4-SO2Me-3^ (4, 5-dihydroisoxazol-3-yl)Ph 4,5-dimethyloxazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,5-dimethyloxazol-2-yl CF3 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 2-oxazolin-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-oxazolin-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-oxazolin-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-oxazolin-2-yl cyclopropyl 2-Me-4-SO2Me-3- (4, 5-dihydToisoxazol-3-yl) Ph 2-oxazolin-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,4-dimethyl-2-oxazolin-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,4-dimethyl-2-oxazolin-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,4-dimethyl-2-oxazolin-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,4-dimethyl-2-oxazolin-2-yl cyclopropyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 4, 4-dimethyl-2-oxazolin-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1, 2, 4-thiadiazol-5-yl H 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 4-thiadiazol-5-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-thiadiazol-5-yl i-propyl ABR 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-thiadiazol-5-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-thiadiazol-5-yl CF3 2-Me-4-S02Me-3- (4, 5-dihydj-oisoxazol-3-yl) Ph 3-methyl-1,2,4-thiadiazol-5-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-methyl-1, 2, 4-thiadiazol-5-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-methyl-1,2,4-thiadiazol-5-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-methyl-1,2,4-thiadiazol-5-yl cyclopropyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl)Ph 3-methyl-1,2,4-thiadiazol-5-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-trifluoromethyl-1,2,4-thiadiazol-5-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-trifluoromethyl-1,2,4-thiadiazol-5-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-trifluoromethyl-1,2,4-thiadiazol-5-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-thiadiazol-3-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1, 2, 4-thiadiazol-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1, 2, 4-thiadiazol-3-vI i-propyl 2-Me-4-S02Me-3- (4, 5-dilydroisoxazol-3-yl) Ph 1, 2, 4-thiadiazol-3-yl cycloprop1 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,2,4-thiadiazol-3-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-methyl-1, 2, 4-thiadiazol-3-l H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 5-methyl-1, 2,4-thiadiazol-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1,2,4-thiadiazol-3-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 5-methyl-1,2,4-thiaidazol-3-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1,2,4-thiadiazol-3-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1,2,4-thiadiazol-3-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-trifluoromethyl-1,2,4-thiadiazol-3-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph Stihoromethyl-1) 2, 4-thiadiazol-3-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethyl-1,2,4-thiadiazol-3-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 3, 4-thiadiazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1, 3, 4-thiadiazol-2-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 3, 4-thiadiazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,3,4-thiadiazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1,3,4-thiadiazol-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methylsulfonyl-1,3,4-thiadiazol-2-yl H 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methylsulfonyl-1, 3, 4thiadiazol-2-yl i-propyl 2 Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-methylsutfonyl-1, 3, 4-thiadiazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-methyl-1,3,4-thiadiazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1,3,4-thiadiazol-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 5-methyl-1, 3, 4-thiadiazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1,3,4-thiadiazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyl-1,3,4-thiadiazol-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph benzoxazol-2-yl H 2-Me-4-S02Me-3- (4, 5-dihydjoisoxaxol-3-yt) Ph bcnzoxazol-2-ylmethyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph benzoxazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisxoazol-3-yl) Ph benzoxazol-2-l cyclopropyl 2-Me-4-So2Me-3- (4, 5-dihydroisoxaxol-3-yl) Ph benzoxazol-2-yl CF3 A B R 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 6-methylbenzoxazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 6-methylbenzoxazol-2-yl methyl 2-Mew4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 6Tmethylbenzoxazol-2-yl i-pro y. 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 6-methylbenzoxazol-2-yl cyclopropyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph E-methylbenzoxazol-2-yl CFs 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph benzothiazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph benzothiazol-2-yl methyl 2-. Me-4-S02Me-3- (4, 5-dihydroisoxazol- 3-yl)Ph benzothiazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph benzothiazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph benzothiazol-2-yl CF3 2-Me-4-S02Me-3- (4, 5-dihy<oisoxazol-3-yl) Phpyrazol-1-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrazol-1-yl methyl 2-Me-4-SO2MC-3- (4, 5-dihydroisoxazol-3-yl) Ph pyrazol-1-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph azol-1-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrazol-1-yl CF3 2-Me-4-SO2Me-3-(4, 54hydroisoxazoW3-yl) Ph pyrazol-3-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrazol-3-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph pyrazol-3-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrazol-3-yl cyclopropyl 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph pyrazol-3-yl CF3 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3 yl) Ph 1-methylpyrazol-3-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1-methylpyrazol-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1-methylpyrazol-3-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1-methylpyrazol-3-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1-methylpyrazol-3-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph tetrazol-1-yl H 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph tetrazol-1-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph tetrazol-1-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph tetrazol-1-yl cyclopropyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph tetrazol-1-l CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyltetrazol-1-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyltetrazol-1-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyltetrazol-1-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyltetrazol-1-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyltetrazol-1-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph tetrazol-2-yl H 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph tetrazol-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph tetrazol-2-yl i-propyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph tetrazol-2-l cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph tetrazol-2-yl CF3 2-Me-4-SO2Me-3-(4, 5 dihydroisoxazol-3-yl) Ph 5-methyltetrazol-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyltetrazol-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyltetrazol-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyltetrazol-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-methyltetrazol-2-yl CF3 2-Me-4-SO2Me-3- 4, 5-dihydroisoxazol-3-yl) Ph 1-methyltetrazol-5-yl H A _ B R 2-Me-4-SO2Me-3-94,5-dihydroisoxazol-3-yl)Ph 1-methyltetrazol-5-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1-methyltetrazol-5-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 1-methyltetrazol-5-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph l-melYltetraol-S-yl CFs 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-methyltetrazol-5-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-methyltetrazol-5-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-methyltetrazol-5-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-methyltetrazol-5-yl cyclopropyl 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph, 2-methyltetrazol-5-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-2-yl H 2 Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph'din-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph din-2-1 CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-4-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-4-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-4-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-4-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-4-yl CF3 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph idin-3-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-3-yl i-propyl 2-Me4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph pyridin-3-yl cyclopropy, 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridin-3-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-nitropyridin-4-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-nitropyridin-4-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 3-nitropyridin-4-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-nitropyridin-4-yl cyclopropyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 3-nitropyridin-4-yl CFs 2-Me-4-SO2Me-3- (4, 5-dihydroisozol-3-yl) Ph 5-cyanoo idin-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-cyanopyridin-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-cyanopyridin-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-cyanopyridin-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-cyanopyridin-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethylpyridin-2-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethylpyridin-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethylpyridin-2-yl i-propyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-trifluoromethyl ridin-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 5-trifluoromethylpyridin-2-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3 yl) Ph pyrimidin-2-yl H 2-Me-4-SMe-3- (4, 5-dihydroisoxazol-3-yl) Ph yrimidin-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)ph pyrimidin-2-yl i-propyl 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph'din-2-l cyclopro 1 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph pyrimidin-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrimidin-4-yl H 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph pynmidin-4-yl methyl B R 2-Me-4-S02Me-3- (4, 3-dihydroisoxazot-3-yl) Ph pyrimidiQ-4-yli-propyi 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph yrimidin-4-yl cycloprop1 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrimidin-4-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 6-chloropyrimidin-4-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 6-chloropyrimidin-4-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 6-chloropyrimidin-4-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 6-chloropyrimidin-4-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridazin-3-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridazin-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridazin-3-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridazin-3-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyridazin-3-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 6-chloropyridazin-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 6-chloropyridazin-3-yl i-propyl 2-Me-4-SOzMe-3- (4, 5-dihydroisoxazol-3-yl) Ph 6-chloro'dazin-3-1 cyclopropyi 2-Me-4-S02Me-3- (4, 5-ditydroisoxazol-3-yl) Ph 6-chloropyrtdaztQ-3-ylCFg 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrazin-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrazin-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrazin-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph pyrazin-2-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph triazin-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph triazin-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph triazin-2-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph triazin-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph quinolin-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph quinolin-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph uinolin-2-yl cylopropyl 2-Me-4-SOzMe-3- (4, 5-dihydroisoxazol-3-yl) Ph quinolin-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl H 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 4, 4, yl5, 6-dihydc-1, 3 (4H)-oxazin-2-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4,4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4, 4,6-trimethyl-5,6-dihydro-1, 3 (4Hj-oxazin-2 yl cyclopropyl 2-Me-4-SO2Me-3-94,5-dihydroisoxazol-3-yl)Ph 4,4,6-trimethyl-5,6-dihydro-1, 3 (4H)-oxazin-2-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-oxazolidinon-3-yl H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-oxazolidinon-3-yl methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-oxazolidinon-3-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-oxazolidinon-3-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-oxazolidinon-3-yl CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yI) Ph 2-pyrrolidinon-1-l methyl 2-Me4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 2-pyrrolidinon-1-yl i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-pyrrolidinon-1-yl cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-pyrrolidinon-1-yl CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3-methylisoxazol-3-yl methyl 2-Me-4-SO2Me-3- (4, 5-dihydzoisoxazol-3-yl) Ph 3-methylisoxazol-5-1 i-prop1 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 3-methylisoxazol-5-yl cyclopropyl 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 3-methylisoxazol-5-yl CF3 A B R 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-SO2MePh H 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 2-NO2-4-SO2MePh methyl 2.-Me-4-S02Me-3- (4, 5ihydtoisoxazol-3-yl) Ph2-N02-4-S02MePhi-propyi 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-SO2MePh cyclopropyl 2-Me-4-SO2Me-3-94,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-SO2MePh CF3 2-me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-Cl-4-SO2MePh H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-Cl-4-SO2MePh methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-Cl-4-SO2MePh i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-Cl-4-SO2MePh cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-Cl-4-SO2MePh CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-CF3Ph H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-CF3Ph methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-CF3Ph i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-CF3Ph cyclopropyl 2-Me-4-S02Me-3- (4, 5-dibydroisoxazol-3-yl) Ph 2-NOz'-4-CF3Ph CjFs 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-ClPh H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-ClPh methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 2-NO2-4-ClPh i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-ClPh cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-NO2-4-ClPh CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-cl-4-NO2Ph H . 2-Me-4-SO2Me-3- (4. 5-dihydroisoxazol-3-YI) Ph 2-CI-4-NO2Ph methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-Cl-4-NO2Ph i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-Cl-4-NO2Ph cyclopropyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 2-Cl-4-N02Ph CF3 2-Me-4-S02Me-3. (4, 5-dihydroisoxazol-3-yl) Ph 2, 4-(NO2)2Ph H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2,4-(NO2)2Ph methyl 2-Me-4-S02Me-3- (4, 5-dihydToisoxazol-3-yl) Ph 2, 4- (N02) 2Phi-propyi 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2,4-(NO2)2Ph cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl) Ph 2, 4-(NO2)2Ph C 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4-F-3-NO2Ph H 2-Me4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 4-F-3-NOzPh methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 4-F-3-N02Ph i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4-F-3-NO2Ph cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 4-F-3-NO2Ph CF3 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3,5-(CF3)2Ph H 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3,5-(CF3)2Ph methyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 3, 5- (CF3) 2Ph i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3,5-(CF3)2Ph cyclopropyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 3,5-(CF3)2Ph CF3 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 2-S02Me-4-CF3Ph H 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 2-SO2Me4-CF3Ph methyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-SO2Me-4-CF3Ph i-propyl 2-Me-4-SO2Me-3-(4,5-dihydroisoxazol-3-yl)Ph 2-SO2Me-4-CF3Ph cyclopropyl 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 2-SO2Me-4-CF3Ph CF3 A | _ B R 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-oxadiazol-5-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-oxadiazol-5-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-oxadiazol-5-yl i-pro 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-oxadiazol-5-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-oxadiazol-5-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1,2,4-oxadiazol-5-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1, 2, 4-oxadiazol-5-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1,2,4-oxadiazol-5-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1,2,4-oxadiazol-5-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1,2,4-oxadiazol-5-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5- i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-14-benzoxathiin ?-yl 1, 2, 4-oxadiazol-3-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-oxadiazol-3-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-oxadiazol-3-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-oxadiazol-3-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-bezoxathiin-7-yl 1,2,4-oxadiazol-3-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1, 2, 4-oxadiazol-3-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1, 2, 4-oxadiazol-3-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-meethyl-1, 2, 4-oxadiazol-3-yl cyclopropyi 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 5-methyl-1, 2, 4-oxadiazol-3-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1,2,4-oxadiazol-3-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-tzoxathun-7-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 4, 4-dioxtde-8-Me-2, 3-dihydro-1, 4-benzoxathiin 7-yl 5ifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 5-chloro-1,2,4-oxadiazol-3-yl H 4, 4dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 5-chloro-1, 2, 4-oxadiazol-3-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-chloro-1,2,4-oxaiazol-3-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-chloro-1, 2, 4-oxadiazol-3-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-chloro-1, 2, 4-oxadiazol-3-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,3,4-oxadiazol-2-yl H 4, 4-dioxide-8-Me-2, 3-dihydro-1, ¢benzoxathiin 7-yI 1, 3, 4-oxadiazol-2-yl methyl 4, 4-dioxide-8 Me-2, 3-dydro-l, 4-benzoxathiin-7-yl 1, 3, 4-oxadiazol-2-yl i-pro 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,3,4-oxadiazol-2-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,3,4-oxadiazol-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methylsulfonyl-1, 3, 4-oxadazol-2-yl H ~ B_ _ R 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methylsulfonyl-1,3,4-oxadiazol-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl i-propy 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methylsulfonyl-1,3,4-oxadiazol-2-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1, 3, 4-oxadiazol-2-yl H 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1,3,4-oxadiazol-2-yl methyl 4, 4-&oxide-g-Me-2, 3-dihydro-1, 41--5 1, 3, 4-osadiazol4-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1,3,4-oxadiazol-2-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1,3,4-oxadiazol-2-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1,3,4-oxadiazol-2-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1,3,4-oxadiazol-2-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-4-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-4-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-4-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-4-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-4-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyl-1,2,3-triazol-4-yl H '4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathriu 7-yl 1-methyl-1, 2, 3-triazol-4-l methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyl-1,2,3-triazol-4-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyl-1,2,3-triazol-4-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyl-1,2,3-triazol-4-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyl-1,2,3-triazol-4-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-methyl-1, 2, 3-triazol-4-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxihiin-7-yl 2-methyl-1, 2, 3-triazol-4-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-methyl-1, 2, 3-triazol-4-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-methyl-1, 2, 3-triazol-4-yl CF3 4, 4-diode-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 1, 2, 3 trizol-1-1 H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-1-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-1-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-1-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-1-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-1-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-2-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-2-yl cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 1,2,3-triazol-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-triazol-1-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-triazol-1-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-triazol-1-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-triazol-1-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-triazol-1-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-2-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-2-yl methyl ABER 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-2-yl i-propyl 4, 4-dioxidde-8-Me-2, 3-dihydTo-l, 4-benzoxathiin-7-yl lITmidazol-2-yl CyClopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-2-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-1-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-1-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-1-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-1-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-1-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-4-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-4-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-4-yl i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxthiin-7-yl imidazol-4-yl Cyclopr0yl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl imidazol-4-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl thiazol-2-yl H 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl thiazol-2-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin 7-yl thiazol-2-yl 1-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl thiazol-2-ylcyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl thiazol-2-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 4-methylthiazol-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4-methylthiazol-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4-methylthiazol-2-yl i-propyl 4, Mdioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 4-methylthiazol-2-l cyclopro I 4, 4-dioxide8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 4-methylthiazol-2-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl oxazol-2-yl H 4, 4-dioxide-8-Me-2, 3 4-benzoxa. thiin-7-yl oxazol 2-1 methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl oxazol-2-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl oxazol-2-yl cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl oxazol-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4, 5-dimethyloxazol-2-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4,5-dimethyloxazol-2-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin7. yl ., 5-dimethyloxazol-2-yl i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin 7-yl 4, 5-dimethyloxazol-2-1 Cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4, 5-dimethyloxazol-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolin-2-yl H 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolin-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolin-2-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolin-2-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolin-2-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4,4-dimethyl-2-oxazolin-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4,4-dimethyl-2-oxazolin-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4,4-dimethyl-2-oxazolin-2-yl i-propyl 4, 4-dioxtde-8-Me-2, 3-hydro-1, 4-benzoxathiin-7-yl 4,4-dimethyl-2-oxazolin-2-yl cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 4, 4-dimethyl-2-oxazolin-2 yl CF3 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 1, 2, 4-thiadiazol-5-yI 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-thiadiazol-5-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-thiadiazol-5-yl i-propyl A B R 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-thiadiazol-5-yl cyclopropyl T 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-thiadiazol-5-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1,2,4-thiadiazol-5-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1, 2, 4-thiadiazol-5-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1, 2, 4-thiadiazol-5-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1,2,4-thiadiazol-5-yl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methyl-1,2,4-thiadiazol-5-yl CF3 4, 4 Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-trifluoromethyl-1, 2, 4-thiadiazol-5-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-trifluoromethyl-1,2,4-thiadiazol-5-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-thiadiazol-3-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-thiadiazol-3-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-thiadiazol-3-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,2,4-thiadiazol-3-yl cyclopropyl 4, 4-dioxide-8-M-2, 3-dihydro-1 ; 4-benzoxathiin-7-yl 1,2, 4-thiadiazol-3-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1,2,4-thiadiazol-3-yl H 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1, 2, 4-thiadiazol-3-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1, 2, 4-thiadiazol-3-yl i-propyl 4, 4-dioxide-S-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 5-methyl-1, 2, 4-thiadiazol-3-yl cyClopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1, 2, 4-thiadiazol-3-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1,2,4-thiadiazol-3-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1,2,4-thiadiazol-3-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1,2,4-thiadiazol-3-yl i-propyl 4, 4-dioxide-8-Me-2, 3-dhydro-1, 4-benzoxathiin-7-yl 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethyl-1,2,4-thiadiazol-3-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,3,4-thiadiazol-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,3,4-thiadiazol-2-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,3,4-thiadiazol-2-yl i-pro 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,3,4-thiadiazol-2-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1,3,4-thiadiazol-2-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methylsulfonyl-1, 3, 4-tbiadiazol-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl methyl 4, 4-dioxide-8-Me-2, 3-hydro-1, 4-benzoxathiin-7-yl 5-methylsulfonyl-1,3,4-thiadiazol-2-yl i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl cyclopropyl 4, 4-dioxide-8-Me-2, 3-dydro-l, 4-benzoxathiin-7-yl 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1, 3, 4-thiadiazol-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyl-1, 3, 4-thiadiazol-2-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 5-methyl-1, 3, 4-thiadiazol'. i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 5-methyl-1, 3, 4-thiadiazol-2-y1 cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxatbiin-7-yl 5-methyl-1, 3 4-thiadiazol-2-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7 yl benzoxazol-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl benzoxazol-2-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl benzoxazol-2-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl benzoxazol-2-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl benzoxazol-2-yl CF3 A. B-R 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 6-methylbenzoxazol-2-yl H 4, 4-dito) 33hydro~1, 4-benzoxatWi-7-yl 6-methylbenzoxazol-2-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 6-methylbenzoxazol-2-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 6-methylbenzoxazol-2-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 6-methylbenzoxazol-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl benzothiazol-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl benzothiazol-2-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl benzothiazol-2-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl benzothiazol-2-yl cyclopro 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl benzothiazol-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazol-1-yl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazol-1-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazol-1-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazol-1-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazol-3-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazol-3-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazol-3-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazol-3-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazol-3-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methylpyrazol-3-yl H 4, 4-dioxide-8-Me-2,3-ydro-1, 4-benzoxathiin-7-yl 1-methylpyrazol-3-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methylpyrazol-3-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methylpyrazol-3-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methylpyrazol-3-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxahiin-7-yl tetrazol-1-l H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl tetrazol-1-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxahiin-7-yl tetrazol-1-l i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl tetrazol-1-yl cyclopropyl 4, 4-diode-8-Me-2, 3-dihydro-1, 4-benzoxathin-7-yI tetrazol-1-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyltetrazol-1-yl H 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 5-methyltetrazol-l-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyltetrazol-1-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyltetrazol-1-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyltetrazol-1-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-'7-yl tetrazol-2-Y 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl tetrazol-2-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-bcnzoxathiin-7-yitetrazol-2-yl i-ro 1 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7 yl tetrazol-2-yl cyclopro l 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl tetrazol-2-yl CFg 4, 4-aioxide-8-Me-2, 3-aihihydro-1, 4-benzoxathiin 7-yl 5-methyltetrazol-2-yl H 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxafhiin-7-yl 5-methyltetrazol-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyltetrazol-2-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyltetrazol-2-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-methyltetrazol-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyltetrazol-5-yl H ABR 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyltetrazol-5-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyltetrazol-5-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyltetrazol-5-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 1-methyltetrazol-5-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-methyltetrazol-5-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-methyltetrazol-5-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 2-methyltetrazol-5-yl i-pro 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-methyltetrazol-5-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-methyltetrazol-5-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-2-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-2-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-2-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-2-yl cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl pyridin-2-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-4-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-4-yl methyl 4, 4-dioxide-8-Me 3-dihydro-1, 4-benzoxathiin-7-yl pyridin-4-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-4-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-4-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl pyridin-3-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-3-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-3-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridin-3-yl cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxthiin-7-yl ridin-3-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 3-nitropyridin-4-yl H 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 3-nitro idin-4-l methyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 3tropyridin-4-yl i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 3-nitropyridin-4-yl cyclopro 4, 4-dioXide-8-Me-2, 3-dihydro-l, 1-benzoxathiin-7-yl 3-nitropyridin-4-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-cyanopyridin-2-yl H 4, 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-cyanopyridin-2-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 5-cyanopyridin-2-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-cyanopyridin-2-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-cyanopyridin-2-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 5-t-ifluoromethylpyridin-2-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethylpyridin-2-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethylpyridin-2-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethylpyridin-2-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 5-trifluoromethylpyridin-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrimidin-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrimidin-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrimidin-2-yl i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl pyrimidin-2-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrimidin-2-yl CF3 4, 4-dioide-S-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl pyrimidin-4-yl H 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxatbiin-7-yl'midin-4-yl methyl A R 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrimidin-4-yl i-pro 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrimidin-4-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrimidin-4-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-, 4 benzoxathiin 7 yl 6-chloropyrimidin-4-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 6-chloropyrimidin-4-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 6-chloropyrimidin-4-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 6-chloropyrimidin-4-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridazin-3-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridazin-3-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridazin-3-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridazin-3-yl cyclopro 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyridazin-3-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7 yl 6-cbl10i0ridazin-3-l methyl 4, 4-dimtide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl 6-chlIOpyridazin-3-yl i-propy1 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 6-chloropyridazin-3-yl cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 6-chloropyridazin-3-l CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl pyrazin-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazin-2-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazin-2-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl pyrazin-2-yl CF3 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin-7-yl triazin-2-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl triazin-2-yl i-propyl 4, 4-dioxide-8-Me-2, 3-dydro-l, 4-benzoxathiin 7 yl triazin-2-yl cycIopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl triazin-2-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl quinolin-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl quinolin-2-yl i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxthiin-7-yl quinolin-2-l Cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin 7-yl quinolin-2-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4,4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4,4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4,4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl i-propyl 4, ,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4,4,6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4,4, 6-trimethyl-5,6-dihydro-1,3(4H)-oxazin-2-yl CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolidinon-3-yl H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolidinon-3-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolidinon-3-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolidinon-3-yl cyclopro 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-oxazolidinon-3-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-pyrrolidinon-1-yl methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-pyrrolidinon-1-yl i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-pyrrolidinon-1-yl cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin 7-yl 2-p_ olidinon-1-yl CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methylisoxazol-5-yl methyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxathiin 7-yl 3-methylisoxazol-5-yl i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methylisoxazol-5-yl cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3-methylisoxazol-5-yl CF3 A B R 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-SO2MePh H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-SO2MePh methyl A B R 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-SO2MePh H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-SO2Meph methyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-SO2MePh i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-SO2MePh cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-SO2MePh CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-Cl-4-SO2MePh H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-Cl-4-SO2MePh methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-Cl-4-SO2MePh i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-Cl-4-SO2MePh cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-Cl-4-SO2MePh CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-CF3Ph 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-CF3Ph methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-CF3-Ph i-propyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-CF3Ph cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-CF3Ph CF3 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-ClPh H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-ClPh methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-ClPh i-propyl 4, 4-oxide-8-Me-2, 3-dihydro-l,, 4-benzoxathiin-7-yl 2-NO2-4-Cll'h cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-NO2-4-ClPh CF3 4, 4-dioxide-8-Me-2, 3-dahydro-l, 4-benzoxatTiiin-7-yl 2-Cl-4-NO2Ph H 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-Cl-4-NO2Ph methyl 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 2-Cl-4 NOzPh i-propyl 4, 4-dioxide-8-Me-2, 3-dihydm-1, 4-benzoxathvn-7-yl 2-Cl-4-NO2Ph cclopropyl 4, 44oxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 2-Cl4-No2Ph CF3 4, 4-dionide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 2,4-(NO2)2Ph 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2,4-(NO2)2Ph methyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxatttiin-7-yl 2, 4- (NO2) 2Ph i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzoxtthiin-7-yl 2, 4-(NO2)2Ph cyclopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2,4-(NO2)2Ph CF3 4, 4-dioxide-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 4-F-3 NO2Ph H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4-F-3-NO2Ph methyl 4, 4-dioxide-S-Me-2, 3-dihydro-1, 4-benzoxathiin-7-yl 4-F-3-NO2Ph i-propyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 4-F-3-NO2Ph cyclopropyl 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 4-F-3-NO2Ph CF3 4, 4-dioxide-8-Me-2, 3-dihydro-l, 4-benzmxathiiu-7-yl 3, 5-(CI 2Ph H 4, 4-dioxide. 8-Me-2, 3-dihydro-1, 4-benzoxafhiin-7-yl 3, 5- (CF3) 2Ph methyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3,5-(CF3)2Ph i-propyl 4, 4-dioxide-8-Me-2, 3-dihydro-1,4-benzoxathiin-7-yl 3,5-(CF3)2Ph cyclopropyl 4,4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 3,5-(CF3)2Ph CF3 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-SO2Me-4-CF3Ph H 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-SO2Me-4-CF3Ph methyl 4, 4-dioxide-S-Me-2, 3-dihydro-l, 4-benzoxaun-7-yl 2-SO2Me-4-CF3Ph i-propyl 4, 4-diode-8-Me-2, 3-dihydro-1, 4-benzoxathiin-7 yl 2-SO2Me-4-CF3Ph clopropyl 4, 4-dioxide-8-Me-2,3-dihydro-1,4-benzoxathiin-7-yl 2-SO2Me-4-CF3Ph CF3 ABR 2-Cl-4-SO2MePh 2-trifluoromethyl-1, 3, 4-thiadiazol-5-yl cyclopropyl 2-Cl-4-SO2MePh l'dioxido-3-oxo-l, 2-benzisothiazol-2 (3)-yl cyclopropyi 4-Cl Ph 2-t-butyl-1, 3, 4-oxadiazol-5-yl CF3 2-Me-6-CF3Pyridin-3-yl 2-methyltetrazol-5-yl cyclopropyl 2-[(2-methoxyethoxy)methyl]-6-CF3Pyridin-3-yl 2-methyltetrazol-5-yl cyclopropyl 2-Cl-4-SO2MePh 2,5-dioxopyrrolidin-1-yl cyclopropyl 2-Cl-4-SO2MePh 2-oxopyridin-1(2H)-yl cyclopropyl 2-Cl-4-SO2MePh 2-oxoquinolin-1(2H)-yl cyclopropyl 2-Cl-4-SO2MePh 1,2-benzisoxazol-3-yl cyclopropyl 2-Cl-4-SO2MePh 2-oxo-1,3-benzoxazol-3(2H)-yl cyclopropyl 2-Cl-4-SO2MePh 3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl cyclopropyl 2-CI-4-SO2MePh 2-oxopyrimidin-1 (2H)-yl cyclopropyl 2-Cl-4-SO2MePh 1H-1, 2, 3-benzotriazol-1-yl cyclopropyl 2-N02-4-SO2MePh 2, 5-dioxopyrrolidin-1-yl cyclopropyl 2-NO2-4-SO2MePh 2-oxopyridin-1(2H)-yl cyclopropyl 2-NO2-4-SO2MePh 2-oxoquinolin-1 (X)-yl cyclopropyl 2-NO2-4-SO2MePh 1,2-benzisoxazol-3-yl cyclopropyl 2-NO2-4-SO2MePh 2-oxo-1,3-benzoxazol-3(2H)-yl cyclopropyl 2-N02-4-SO2MePh 3-oxo-2, 3-dihydro-4H-1, 4-benzoxazin-4-yl cyclopropyl 2-NO-4-SO2MePh 2-oxopyrimidin-1(2H)-yl cyclopropyl 2-NO2-4-SO2MePh lH-l, 2, 3-benzotriazol-1-yl cyclopropyl

The compounds having general formula (I) can be applied in the pharmaceutical field, for example in the treatment of the hereditary disease known as tyrosinemia type 1 (HT-1).

A further object of the present invention relates to processes for the preparation of compounds having general formula (I).

In particular, the compounds having general formula (I) can be prepared by the reaction of a carbonyl compound having general formula (II) with a compound having general formula (III) according to reaction scheme 1.

Scheme 1: In the general formulae indicated in this reaction scheme: - A, B and R have the meanings previously defined ; - Li represents a suitable leaving group such as, for example, a halogen atom, a CN group, an imidazol-1-yl group, an RLO-group wherein Ri, represents a C1-C4 alkyl group or a phenyl group optionally substituted,

or it represents an RL1COO-group wherein RL1 represents a hydrogen atom, a Cl-C4 alkyl or haloalkyl group, a phenyl group optionally substituted or an A group.

The reaction between the compounds having general formula (II) and the compounds having general formula (III) is preferably'carried out in the presence of an inert organic solvent and in the presence of an organic or inorganic base, at a temperature ranging from-80°C to the boiling point of the reaction mixture. The reaction can also be carried out in two distinct phases. In the latter case, in the first phase, the compounds having general formula (II) are reacted with a base. The intermediate obtained is reacted, in the subsequent phase, with an acylating compound.

Examples of solvents which can be used for the above reaction comprise aromatic hydrocarbons (benzene, toluene, xylene, chlorobenzene, etc.), ethers (diethyl ether, diisopropyl ether, dimethoxyethane, dioxane, tetrahydrofuran, etc.), aprotic dipolar solvents (dimethylformamide, dimethylacetamide, hexamethylphosphoramide, N- methylpyrrolidone, etc.).

Inorganic bases which can be used for the purpose are, for example, sodium and potassium hydrides, hydroxides and carbonates, sodium amide.

Organic bases which can be used for the purpose are, for example, sodium, potassium and magnesium alcoholates, phenyllithium, butyllithium, lithium diisopropylamide, triethylamine, pyridine, 4-N, N- dimethylaminopyridine, N, N-dimethylaniline, N-methyl piperidine, lutidine, diazabicyclooctane (DABCO), diazabicyclononene (DBN), diazabicycloundecene (DBU).

The compounds having general formula (I) can also be prepared by the reaction of a carbonyl compound having general formula (IV) with a compound having general formula (V) according to reaction scheme 2.

Scheme 2: In the general formulae indicated in this reaction scheme: - A, B and R have the meanings previously defined; - L2 represents a suitable leaving group such as, for example, a halogen atom, a CN group, an imidazol-1-yl

group, an Rio-group wherein RL represents a ClCg alkyl group or a phenyl group optionally substituted, or it represents an Rz1COO-group wherein RL1 represents a hydrogen atom, a C1-C4 alkyl or haloalkyl group, a phenyl group optionally substituted or an R group.

The reaction between the compounds having general formula (IV) and the compounds having general formula (V) is preferably carried out in the presence of an inert organic solvent and in the presence of an organic or preferably inorganic base, at a temperature ranging from-80°C to the boiling point of the reaction mixture. The reaction can also be carried out in two distinct phases. In the latter case, in the first phase, the compounds having general formula (IV) are reacted with a base. The intermediate obtained is reacted, in the subsequent phase, with an acylating compound.

Examples of solvents which can be used for the above reaction comprise aromatic hydrocarbons (benzene, toluene, xylene, chlorobenzene, etc.), ethers (diethyl ether, diisopropyl ether, dimethoxyethane, dioxane, tetrahydrofuran, etc.), aprotic dipolar solvents (dimethylformamide,

dimethylacetamide, hexamethylphosphoramide, N- methylpyrrolidone, etc. ).

Inorganic bases which can be used for the purpose are, for example, sodium and potassium hydrides, hydroxides and carbonates, sodium amide.

Organic bases which can be used for the purpose are, for example, sodium, potassium and magnesium alcoholates, phenyllithium, butyllithium, lithium diisopropylamide, triethylamine, pyridine, 4-N, N- dimethylaminopyridine, N, N-dimethylaniline, N-methyl piperidine, lutidine, diazabicyclooctane (DABCO), diazabicyclononene (DBN), diazabicycloundecene (DBU).

The compounds having general formula (I) can also be prepared by the reaction of a 1,3-dicarbonyl compound having general formula (VI) with a compound having general formula (VII) according to reaction scheme 3.

Scheme 3: In the general formulae indicated in this reaction scheme: - A, B and R have the meanings previously defined ;

- X represents a halogen atom, an RL2SO20-group, wherein RL2 represents a C1-C4 alkyl or haloalkyl group, a phenyl group optionally substituted by C1-C4 alkyl groups, or it represents an RL3SO2-group, wherein RL3 represents a Cl-C4 alkyl or haloalkyl group.

The reaction between the compounds having general formula (VI) and the compounds having general formula (VII) is preferably carried out in the presence of one or more inert organic solvents and in the presence of an organic or inorganic base, at a temperature ranging from-80°C to the boiling point of the reaction mixture.

Organic solvents which can be used for the purpose are, for example, aromatic hydrocarbons (benzene, toluene, xylene, chlorobenzene, etc. ), ethers (diethyl ether, diisopropyl ether, dimethoxyethane, dioxane, tetrahydrofuran, etc.), alcohols and glycols (methanol, ethanol, methyl cellosolve, ethylene glycol, etc. ), ketones (acetone, methyl ethyl ketone, methyl propyl ketone, methyl isobutyl ketone, etc. ), nitriles (acetonitrile, benzonitrile, etc. ), aprotic dipolar solvents (dimethylformamide, dimethylacetamide,

hexamethylphosphoramide, dimethylsulfoxide, sulfolane, N-methylpyrrolidone, etc.).

Organic bases which can be used for the purpose are, for example, sodium, potassium and magnesium alcoholates, phenyllithium, butyllithium, lithium diisopropylamide, triethylamine, pyridine, 4-N, N- dimethylaminopyridine, N, N-dimethylaniline, N-methyl piperidine, lutidine, diazabicyclooctane (DABCO), diazabicyclononene (DBN), diazabicycloundecene (DBU).

Inorganic bases which can be used for the purpose are, for example, sodium or potassium hydrides, hydroxides and carbonates, sodium amide.

The reaction can also be carried out using suitable catalysts based on transition metals, such as, for example, Cu and Pd.

Examples of these reactions are described in Chem. Pharm. Bull. (1987), vol. 35, pages 4972-4976 and J. Chem. Soc. , Perkin 1 (1976), vol. 6, pages 592-594.

The 1,3-dicarbonyl compounds having general formula (VI) can be prepared by the acylation of ketones according to what is described, for example, in Organic Reaction (1954), vol. 8, pages 59-196, or in Tetrahedron Letters (2002), vol. 43, pages 2945- 2948.

The compounds having general formula (II) can be prepared by the reaction of a compound having general formula (VIII) with an acylating compound having general formula (V) according to reaction scheme 4.

Scheme 4: In the general formulae indicated in this reaction scheme: - B and R have the meanings previously defined; L2 represents a suitable leaving group such as, for example, a halogen atom, a CN group, an imidazol-1-yl group, an RLO-group wherein RL represents a C1-C4 alkyl group or a phenyl group optionally substituted, or it represents an RL1COO-group wherein RL1 represents a hydrogen atom, a C1-C4 alkyl or haloalkyl group, a phenyl group optionally substituted or an R group.

The reaction between the compounds having general formula (VIII) and the compounds having general formula (V) is preferably carried out in the presence of an inert organic solvent and in the presence of an organic or preferably inorganic base, at a temperature ranging from-80°C to the

boiling point of the reaction mixture. The reaction can also be carried out in two distinct phases. In the latter case, in the first phase, the compounds having general formula (VIII) are reacted with a base. The intermediate obtained is reacted, in the subsequent phase, with an acylating compound.

Examples of solvents which can be used for the above reaction comprise aromatic hydrocarbons (benzene, toluene, xylene, chlorobenzene, etc.), ethers (diethyl ether, diisopropyl ether, dimethoxyethane, dioxane, tetrahydrofuran, etc.), aprotic dipolar solvents (dimethylformamide, dimethylacetamide, hexamethylphosphoramide, N- methylpyrrolidone, etc.).

Inorganic which can be used for the purpose are, for example, sodium and potassium hydrides, hydroxides and carbonates, sodium amide.

Organic bases which can be used for the purpose are, for example, sodium, potassium and magnesium alcoholates, phenyllithium, butyllithium, lithium diisopropylamide, triethylamine, pyridine, 4-N, N- dimethylaminopyridine, N, N-dimethylaniline, N-methyl piperidine, lutidine, diazabicyclooctane (DABCO), diazabicyclononene (DBN), diazabicycloundecene (DBU).

The compounds having general formula (IV) can be prepared by the reaction of a compound having general formula (VIII) with an acylating compound having general formula (III) according to reaction scheme 5.

Scheme 5: In the general formulae indicated in this reaction scheme: - B and A have the meanings previously defined; - Li represents a suitable leaving group such as, for example, a halogen atom, a CN group, an imidazol-1-yl group, an RLO-group wherein RL represents a C1-C4 alkyl group or a phenyl group optionally substituted, or it represents an RL1COO-group wherein RL1 represents a hydrogen atom, a Cl-C4 alkyl or haloalkyl group, a phenyl group optionally substituted or an A group.

The reaction between the compounds having general formula (VIII) and the compounds having general formula (III) is preferably carried out in the presence of an inert organic solvent and in the presence of an organic or inorganic base, at a temperature ranging from-80°C to the boiling point

of the reaction mixture. The reaction can also be carried out in two distinct phases. In the latter case, in the first phase, the compounds having general formula (VIII) are reacted with a base. The intermediate obtained is reacted, in the subsequent phase, with an acylating compound.

Examples of solvents which can be used for the above reaction comprise aromatic hydrocarbons (benzene, toluene, xylene, chlorobenzene, etc.), ethers (diethyl ether, diisopropyl ether, dimethoxyethane, dioxane, tetrahydrofuran, etc.), aprotic dipolar solvents (dimethylformamide, dimethylacetamide, hexamethylphosphoramide, N- methylpyrrolidone, etc.).

Inorganic bases which can be used for the purpose are, for example, sodium and potassium hydrides, hydroxides and carbonates, sodium amide.

Organic bases which can be used for the purpose are, for example, sodium, potassium and magnesium alcoholates, phenyllithium, butyllithium, lithium diisopropylamide, triethylamine, pyridine, 4-N, N- dimethylaminopyridine, N, N-dimethylaniline, N-methyl piperidine, lutidine, diazabicyclooctane (DABCO), diazabicyclbnonene (DBN), diazabicycloundecene (DBU).

The compounds having general formula (IV) can also be prepared by the reaction of a compound having general formula (IX) with an acylating compound having general formula (III) in the presence of a base. The reaction provides intermediate compounds having general formula (X) which then undergo a hydrolysis and decarboxylation process according to reaction scheme 6.

Scheme 6: In the general formulae indicated in this reaction scheme: - B and A have the meanings previously defined ; - L1 represents a suitable leaving group such as, for example, a halogen atom, a CN group, an imidazol-1-yl group, an RLO-group wherein RL represents a C1-C4 alkyl group or a phenyl group optionally substituted, or it represents an RL1COO-group wherein RL1 represents a hydrogen atom, a C1-C4 alkyl or haloalkyl group, a phenyl group optionally substituted or one of the A groups.

- Rv represents a C1-C5 alkyl or haloalkyl group, an arylalkyl or aryl group.

The compounds having general formula (II) can also be prepared by the reaction of a compound having general formula (IX) with an acylating compound having general formula (V) in the presence of a base. The reaction provides intermediate compounds having general formula (XI) which then undergo a hydrolysis and decarboxylation process according to reaction scheme 7.

Scheme 7: In the general formulae indicated in this reaction scheme: - B and R have the meanings previously defined; - L2 represents a suitable leaving group such as, for example, a halogen atom, a CN group, an imidazol-1-yl group, an RLO-group wherein RL represents a C1-C4 alkyl group or a phenyl group optionally substituted, or it represents an RL1COO-group wherein RL1 represents a hydrogen atom, a Ci-C4 alkyl or

haloalkyl group, a phenyl group optionally substituted or one of the R groups.

- Rv represents a Cl--C5 alkyl or haloalkyl group, an arylalkyl or aryl group.

The reactions indicated in reaction schemes 6 and 7 can be carried out, for example, according to the methods described in J. Am. Chem. Soc. (1950), vol. 72, pages 1352-1356 and in J. Am. Chem. Soc.

(1987), vol. 109, pages 4717-4718.

The compounds having general formula (II) wherein R has the meanings previously defined and B represents a 1, 2,4-oxadiazol-5-yl, compounds (IIa), can be prepared, for example, starting from compounds having general formula (XII) by reaction with an amidoxime having general formula (XIII) according to reaction scheme 8.

Scheme 8: The above reaction can be carried out according to the method described for example in Bull. Soc.

Chim. Belges (1949), vol. 58, pages 58-65.

The compounds having general formula (II) wherein R has the meanings previously defined and B represents tetrazol-5-yl (D = tetrazole, Rx = H), compounds (IIb), can be prepared, for example, starting from compounds having general formula (XIV) by transforming the cyano group into tetrazole, for example by heating with trimethylsilylazide, in toluene, catalyzed by dibutyltin oxide, according to what is described in J. Org. Chem. (1933), vol. 58, pages 4139-4141, or by heating with sodium azide in water with the catalysis of ZnBr2, as described in J.

Org. Chem. (2001), vol. 66, pages 7945-7950.

The above transformation is indicated in reaction scheme 9.

Scheme 9: (XIV) (IIb) The intermediates having general formulae (III), (V), (VII), (VIII), (IX), (XII), (XIII) and (XIV), when not already known as such, can be easily prepared according to methods known in organic chemistry practice.

In some cases, the compounds having general formula (I) can be obtained in the form of two or

more optic or geometric or position isomers.

Compounds having general formula (I) which are isomerically pure, and also mixtures of these, possibly obtained during the preparation of the compounds having general formula (I) or deriving from an incomplete separation of the isomers themselves, in any proportion, are therefore considered as being included within the scope of the present invention.

As already mentioned, the compounds having general formula (I) have a high herbicidal activity which makes them suitable for use in the agrarian field in the defense of useful crops from weeds.

In particular, the compounds, object of the present invention, are effective in the control, in both pre-emergence and post-emergence, of numerous monocotyledon and dicotyledon weeds. At the same time, these compounds show compatibility or the absence of toxic effects with respect to useful crops in pre-and/or post-emergence treatments.

The compounds of the present invention can act as total or selective herbicides also in relation to the quantity of active principle used.

Examples of weeds which can be effectively controlled using the compounds having general formula (I) are: Abutilon theofrasti, Alisma plantago,

Amaranthus spp., Amni maius, Capsella bursa pastoris, Chenopodium album. Convolvulus septum, Galium aparine, Geranium dissectum, Ipomea spp. , Matricaria spp., Papaver rhoaes, Phaseolus aureus, Polygonum persicalria, Portulaca oleracea, Sida spinosa, Sinapsis arvensis, Solanum nigrum, Stellaria media, Veronica spp. , Viola spp. , Xanthium spp. , Alopercurus myosuroides, Avena fatua, Cyperus spp. , Digitaria sanguinalis, Echinocloa spp. , Heleocaris avicularis, <BR> <BR> <BR> <BR> Heteranthera spp. , Panicum spp., Poa spp. , Scirpus spp., Sorghum spp. , etc.

With the doses of use suitable for agrarian applications, many of the above compounds showed no toxic effects towards one or more important agrarian crops such as corn (Zea mays), wheat' (Triticum sp.), barley (Hordeum vulgare), soybean (Glycine max), rice (Oryza sativa).

A further object of the present invention relates to a method for controlling weeds in cultivated areas by the application of the compounds having general formula (I).

The quantity of compound to be applied for obtaining the desired effect can vary in relation to various factors such as, for example, the compound

used, the crop to be preserved, the weed to be fought, the degree of infestation, the climatic conditions, the characteristics of the soil, the application method, etc.

Doses of compound ranging from 1 g to 4,000 g per hectare generally provide a sufficient control.

For use in agriculture, it is often advantageous to adopt compositions with a herbicidal activity containing, as active substance, one or more compounds having general formula (I), optionally also as a mixture of tautomers and/or isomers.

Compositions can be used in the form of dry powders, wettable powders, emulsifiable concentrates, micro-emulsions, pastes, granulates, solutions, suspensions, etc.: the selection of the type of composition depends on the specific use.

The compositions are prepared according to known methods, for example by diluting or dissolving the active substance by means of a solvent medium and/or solid diluent, possibly in the presence of surface- active agents.

Kaolin, alumina, silica, talc, bentonite, chalk, quartz, dolomite, attapulgite, montmorillonite, diatomaceous earth, cellulose, starch, etc.., can be used as inert solid diluents, or carriers.

Inert liquid diluents which can be used, are water or organic solvents such as aromatic hydrocarbons (xylols, blends of alkyl benzenes, etc..), aliphatic hydrocarbons (hexane, cyclohexane, etc..) halogenated aromatic hydrocarbons (chlorobenzene, etc..), alcohols (methanol, propanol, butanol, octanol, etc..), esters (isobutyl acetate, etc..), ketones (acetone, cyclohexanone, acetophenone, isophorone, ethylamylketone etc..), or vegetable and mineral oils or mixtures thereof, etc..

Surfactants which can be used are wetting and emulsifying agents, of the non-ionic type (polyethoxylated alkyl phenols, polyethoxylated fatty alcohols, etc..), of the anionic type (alkylbenzenesulphonates, alkylsulphonates, etc..), of the cationic type (alkyl ammonium quaternary salts, etc..).

Dispersing agents can also be added (for example lignin and its salts, cellulose derivatives, alginates, etc..), stabilizers (for example antioxidants, UV absorbers, etc..).

In order to enlarge the action range of the above compositions, it is possible to add active ingredients, such as, for example, other herbicides,

fungicides, insecticides, acaricides, fertilizers, etc..

Examples of other herbicides which can be added to the compositions containing one or more compounds having general formula (I), are the following: Acetochlor, acifluorfen, aclonifen, AKH-7088, alachlor, alloxydim, ametryn, amicarbazone, amidosulfuron, amitrole, anilofos, asulam, atrazine, azafenidin, azimsulfuron, aziprotryne, BAS 670 H, BAY MKH 6561, beflubutamid, benazolin, benfluralin, benfuresate, bensulfuron, bensulide, bentazone, benzfendizone, benzobicyclon, benzofenap, benzthiazuron, bifenox, bilanafos, bispyribac-sodium, bromacil, bromobutide, bromofenoxim, bromoxynil, butachlor, butafenacil, butamifos, butenachlor, butralin, butroxydim, butylate, cafenstrole, carbetamide, carfentrazone-ethyl, chlomethoxyfen, chloramben, chlorbromuron, chlorbufam, chlorflurenol, chloridazon, chlorimuron, chlornitrofen, chlorotoluron, chloroxuron, chlorpropham, chlorsulfuron, chlorthal, chlorthiamid, cinidon ethyl, cinmethylin, cinosulfuron, clethodim, clodinafop, clomazone, clomeprop, clopyralid, cloransulam-methyl, cumyluron (JC-940), cyanazine, cycloate, cyclosulfamuron, cycloxydim, cyhalofop-

butyl, 2,4-D, 2,4-DB, daimuron, dalapon, desmedipham, desmetryn, dicamba, dichlobenil, dichlorprop, dichlorprop-P, diclofop, diclosulam, diethatyl, difenoxuron, difenzoquat, diflufenican, diflufenzopyr, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dinitramine, dinosseb, dinoseb acetate, dinoterb, diphenamid, dipropetryn, diquat, dithiopyr, 1-diuron, eglinazine, endothal, EPTC, espropcarb, ethalfluralin, ethametsulfuron- methyl, ethidimuron, ethiozin (SMY 1500), ethofumesate, ethoxyfen-ethyl (HC-252), ethoxysulfuron, etobenzanid (HW 52), fenoxaprop, fenoxaprop-P, fentrazamide, fenuron, flamprop, flamprop-M, flazasulfuron, florasulam, fluazifop, fluazifop-P, fluazolate (JV 485), flucarbazone- sodium, fluchloralin, flufenacet, flufenpyr ethyl, flumetsulam, flumiclorac-pentyl, flumioxazin, flumipropin, fluometuron, fluoroglycofen, f luoronitrof en, flupoxam, fluproanate, flupyrsulfuron, flurenol, fluridone, flurochloridone, fluroxypyr, flurtamone, fluthiacet-methyl, fomesafen, foramsulfuron, fosamine, furyloxyfen, glufosinate, glyphosate, halosulfuron-methyl, haloxyfop, haloxyfop-P-methyl, hexazinone, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr,

imazosulfuron, indanofan, iodosulfuron, ioxynil, isopropalin, isoproturon, isouron, isoxaben, isoxachlortole, isoxaflutole, isoxapyrifop, KPP-421, lactofen, lenacil, linuron, LS830556, MCPA, MCPA- thioethyl, MCPB, mecoprop, mecoprop-P, mefenacet, mesosulfuron, mesotrione, metamitron, metazachlor, methabenzthiazuron, methazole, methoprotryne, methyldymron, metobenzuron, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron, molinate, monalide, monolinuron, naproanilide, napropamide, naptalam, NC- 330, neburon, nicosulfuron, nipyraclofen, norflurazon, orbencarb, oryzalin, oxadiargyl, oxadiazon, oxasulfuron, oxaziclomefone, oxyfluorfen, paraquat, pebulate, pendimethalin, penoxsulam, pentanochlor, pentoxazone, pethoxamid,, phenmedipham, picloram, picolinafen, piperophos, pretilachlor, primisulfuron, prodiamine, profluazol, proglinazine, prometon, prometryne, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propyzamide, prosulfocarb, prosulfuron, pyraclonil, pyraflufen-ethyl, pyrazogyl (HAS-961), pyrazolynate, pyrazosulfuron, pyrazoxyfen, pyribenzoxim, pyributicarb, pyridafol, pyridate, pyriftalid, pyriminobac-methyl, pyrithiobac-sodium, quinclorac,

quinmerac, quizalofop, quizalofop-P, rimsulfuron, sethoxydim, siduron, simazine, simetryn, sulcotrione, sulfentrazone, sulfometuron-methyl, sulfosulfuron, 2, 3, 6-TBA, TCA-sodium, tebutam, tebuthiuron, tepraloxydim, terbacil, terbumeton, terbuthyl-azine, terbutryn, thenylchlor, thiazafluron, thiazopyr, thidiazimin, thifensulfuron-methyl, thiobencarb, tiocarbazil, tioclorim, tralkoxydim, tri-allate, triasulfuron, triaziflam, tribenuron, triclopyr, trietazine, trifloxysulfuron, trifluralin, triflusulfuron-methyl, tritosulfuron, UBI-C4874, vernolate.

The concentration of active substance in the above compositions can vary within a wide range, depending on the active compound, the applications to which they are destined, the environmental conditions and the type of formulation adopted. In general, the concentration of active substance preferably ranges from 1 to 90%.

Some examples are now provided for illustrative and non-limiting purposes of the present invention.

EXAMPLE 1 Synthesis of 3, 3-dimethyl-1-(tetrazol-5-yl) butane-2-one.

NaN3 (1. 71 g) and ZnBr2 (5. 40 g) are added to a suspension of 4, 4-dimethyl-3-oxopentanenitrile (3.00 g) in 50 ml of water and 4 ml of isopropylic alcohol and the resulting mixture is stirred at 90°C for 12 hours.

After completion of the reaction, 15 ml of 10% HC1 are added, then the mixture is extracted two times with ethyl acetate ; the organic phase is then evaporated under reduced pressure. The residue is stirred with 100 ml of 10% NaOH for 20 minutes, then cooled with an ice bath and acidified with concentrated HC1 : the white precipitate is extracted two times with ethyl acetate, which is then dried with Na2SO4 and evaporated.

The resulting solid is purified by washing with dichloromethane to obtain 2.75 g of pure product (yield: 68%).

EXAMPLE 2 Synthesis of 3, 3-dimethyl-l- (2-methyl-2H-tetrazol-5- yl) butane-2-one and 3, 3-dimethyl-1-(1-methyl-lH-tetrazol- 5-yl) butane-2-one.

K2CO3 (1.40 g) and CH3I (1.32 g) are added to a solution of 3, 3-dimethyl-1-(tetrazol-5-yl) butan-2-one (1. 42 g) in 35 ml of acetone under an inert atmosphere,; the mixture is stirred at room temperature for 20 hours.

The solvent is then evaporated, the residue is taken up with water and extracted two times with ethyl acetate, which is then washed with water, dried with Na2SO4 and evaporated.

The raw product is purified by flash chromatography, isolating the two isomers 3, 3-dimethyl-1-(2-methyl-2H- tetrazol-5-yl) butan-2-one (0.60 g, yield: 39%) and 3,3- dimethyl-1-(1-methyl-lH-tetrazol-5-yl) butan-2-one (0.64 g, yield: 42%). The structure of each isomer was assigned according to the NMR spectra.

1H-NMR (CDC13) : (2-methyl isomer)-5 1.24 (s, 9H, t-butyl), 4.12 (s, 2H, CH2), 4.32 (s, 3H, N-CH3) (1-methyl isomer)-5 1.19 (s, 9H, t-butyl), 3. 90 (s, 3H, N-CH3), 4.17 (s, 2H, CH2) EXAMPLE 3 Synthesis of 1- [2-chloro-4- (methylsulphonyl) phenyl]-4, 4- dimethyl-2- (1-methyl-lH-tetrazol-5-yl) pentane-1, 3-dione (Compound N° 1).

Under an inert atmosphere, Mg (OEt) 2 (0.279 g) is added to a solution of 3, 3-dimethyl-1-(1-methyl-lH- tetrazol-5-yl) butan-2-one (0.64 g) in 16 ml of dry tetrahydrofuran ; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 16 ml of dry tetrahydrofuran, under an inert atmosphere, then a solution of 2-chloro-4- (methylsulphonyl) benzoyl chloride (1.04 g) in dry tetrahydrofuran is added ; the stirred mixture is refluxed for 3 more hours.

After completion of the reaction, the solvent is evaporated and the residue is taken up with water and ethyl acetate ; after acidification with 10% HC1 the organic phase is recovered and extracted three times with

aqueous NaHC03 saturated solution. The combined basic aqueous phases are acidified and extracted three times with ethyl acetate, which is then dried with Na2SO4 and evaporated, obtaining an off-white solid.

The raw product is purified by filtration over silica gel eluting with dichloromethane/methanol 8: 2, then by washing the obtained solid with acetone, thus obtaining 0. 60 g of product as a white solid (yield: 45%, m. p. 195-200°C).

H-NMR (CDCl3) : # 1.07 (s, 9H, t-butyl), 3.01 (s, 3H, SO2CH3), 3. 76 (s, 3H, N-CH3), 7.30-7. 94 (m, 3H, arom. H's) EXAMPLE 4 Synthesis of 1- (2, 4-dichlorophenyl)-4, 4-dimethyl-2- (2- methyl-2H-tetrazol-5-yl) pentane-1, 3-dione (Compound N° 2).

Under an inert atmosphere, Mg (OEt) 2 (0. 257 g) is added to a solution of starting 3, 3-dimethyl-1-(2-methyl-2H- tetrazol-5-yl) butan-2-one (0.59 g) in 16 ml of dry

tetrahydrofuran; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 16 ml of dry tetrahydrofuran, under an inert atmosphere, then a solution of 2,4-dichlorobenzoyl chloride (0.746 g) in dry tetrahydrofuran is added; the stirred mixture is refluxed for 3 more hours.

After completion of the reaction, the solvent is evaporated and the residue is taken up with water and extracted with ethyl acetate; the organic phase is washed with diluted HC1, with brine, then dried with Na2SO4 and evaporated.

The raw product is purified by flash chromatography to obtain 0.49 g of product (yield: 43%).

H-NMR (CDCl3) : (mixture of two keto-enolic tautomers) 5 1.05, 1.10 (2s, 9H, t-butyl), 4.19, 4.33 (2s, 3H, N-CH3), *6. 62 (s, 1H, CO-CH-CO), 7.04-7. 50 (m, 3H, arom. H's) EXAMPLE 5 Synthesis of 2- (5-tert-butyl-1, 3, 4-oxadiazol-2-yl)-l- (4- chlorophenyl)-3- (cyclopropyl) propane-1,3-dione (Compound N° 3).

Under an inert atmosphere, Mg (OEt) 2 (0. 209 g) is added to a solution of 2- (5-tert-butyl-1, 3, 4-oxadiazol-2-yl)-1- (4-chlorophenyl) ethanone (0.50 g) in 10 ml of dry tetrahydrofuran ; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 10 ml of dry tetrahydrofuran, under an inert atmosphere, then cyclopropanecarbonylchloride (0.208 g) is added ; the stirred mixture is refluxed for 3 more hours.

After completion of the reaction, the solvent is evaporated and the residue is taken up with water and extracted with ethyl acetate; the organic phase is washed with diluted HCl, with brine, then dried with Na2SO4 and evaporated.

The raw product is purified by flash chromatography to obtain 0.28 g of pure product (yield: 44%).

XH-NMR (CDC13) : 5 1.01-1. 43 (m, 4H, CH2-CH2), 1.20 (s, 9H, t-butyl), 2. 12-2 22 (m, 1H, CH), 7.26 (s, 4H, arom. H's) EXAMPLE 6 Synthesis of 1- (4-chlorophenyl)-2- (2H-tetrazol-5- yl) ethanone.

NaN3 (1.19 g) and ZnBr (3.76 g) are added to a suspension of 3- (4-chlorophenyl)-3-oxopropanenitrile (3.00 g) in 30 ml of H20 and 4 ml of isopropylic acid and the resulting mixture is stirred at 90°C for 12 hours.

After completion of the reaction, 15 ml of 10% HC1 are added, then the mixture is extracted two times with ethyl acetate ; the combined organic phases are then evaporated under reduced pressure. The residue is stirred with 100 ml of 10% NaOH for 6 hours, then the mixture is cooled with an ice bath and acidified with concentrated HC1 : the white precipitate is extracted two times with ethyl acetate, which is then dried with Na2SO4 and evaporated.

The resulting solid is purified by digestion in ethyl acetate to obtain 1.76 g of pure product (yield: 47%)

1H-NMR (acetone-d6) : 6 4.98 (s, 2H, CH2), 7. 60-8. 20 (m, 4H, arom. H's) EXAMPLE 7 Synthesis of 1- (4-chlorophenyl)-2- (2-methyl-2H-tetrazol- 5-yl) ethanone and 1- (4-chlorophenyl)-2- (l-methyl-lH- tetrazol-5-yl) ethanone.

K2CO3 (0.47 g) and CH3I (0. 32 g) are added to a solution of 1- (4-chlorophenyl)-2- (2H-tetrazol-5- yl) ethanone (0.50 g) in 15 ml of acetone, under an inert atmosphere; the mixture is stirred at room temperature for 20 hours.

The solvent is then evaporated, the residue is taken up with water and extracted two times with ethyl acetate, which is then washed with water, dried with Na2SO4 and evaporated, thus obtaining a solid raw product (0.56 g) containing the two isomers (1- (4-chlorophenyl)-2- (2- methyl-2H-tetrazol-5-yl) ethanone and 1- (4-chlorophenyl) - 2- (1-methyl-lH-tetrazol-5-yl) ethanone), which is used for the following reaction.

EXAMPLE 8 Synthesis of 1- (4-chlorophenyl)-3-cyclopropyl-2- (2- methyl-2H-tetrazol-5-yl) propane-1, 3-dione (Compound N° 4) and 1- (4-chlorophenyl)-3-cyclopropyl-2- (1-methyl-lH- tetrazol-5-yl) propane-1, 3-dione (Compound N° 5).

Under an inert atmosphere, Mg (OEt) 2 (0.263 g) is added to a solution of the starting mixture of 1- (4- chlorophenyl)-2-(2-methyl-2H-tetrazol-5-yl) ethanone and 1-(4-chlorophenyl)-2-(1-methyl-lH-tetrazol-5-yl) ethanone (0.53 g) in 10 ml of dry tetrahydrofuran ; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 10 ml of dry tetrahydrofuran, under an inert atmosphere, then cyclopropanecarbonylchloride (0.235 g) is added; the stirred mixture is refluxed for 3 more hours.

After completion of the reaction, the solvent is evaporated and the residue is taken up with water and

extracted with ethyl acetate; the organic phase is washed with diluted HC1, with brine, then dried with Na2SO4 and evaporated, The raw product is purified by flash chromatography to obtain 0.26 g of 2-methyl isomer (yield: 37%) and 0.17 g of 1-methyl isomer (yield: 24%).

1H-NMR (CDC13) : (2-methyl isomer)-6 0.90-1. 67 (m, 5H, ciclopropyl), 4.29 (s, 3H, N-CH3), 7.18 (s, 4H, arom. H's) (1-methyl isomer)-6 0.9-1. 61 (m, 5H, ciclopropyl), 3.49 (s, 3H, N-CH3), 7.12-7. 27 (m, 4H, arom. H's) EXAMPLE 9 Synthesis of 1-cyclopropyl-2- (tetrazol-5-yl) ethanone NaN3 (5.0 g) and ZnBr (14.5 g) are added to a suspension of 3-cyclopropyl-3-oxopropanenitrile (7.0 g) in 130 ml of water and 10 ml of isopropylic alcohol and the resulting mixture is stirred at 100°C for 12 hours.

After completion of the reaction, 60 ml of 10% HC1 are added, then the mixture is extracted three times with ethyl acetate; the organic phase is then evaporated under reduced pressure. The residue is stirred with 400 ml of

1% NaOH for 20 hours, cooled with an ice bath and acidified with 10% HC1 ; the mixture is extracted three times with ethyl acetate, which is then dried with Na2SO4 and evaporated.

The resulting solid is purified by washing with CH2Cl2 to obtain 3.6 g of pure product (yield :. 37%).

EXAMPLE 10 Synthesis of 1-cyclopropyl-2-(2-methyl-2H-tetrazol-5- yl) ethanone and 1-cyclopropyl-2-(1-methyl-lH-tetrazol-5- yl) ethanone K2CO3 (4.85 g) and CH3I (3.99 g) are added to a solution of 1-cyclopropyl-2- (tetrazol-5-yl) ethanone (3.56 g) in 90 ml of acetone, under an inert atmosphere; the mixture is then stirred at room temperature for 20 hours.

The solvent is then evaporated, the residue is taken up with water/ethyl acetate and the mixture is acidified to pH 1-2 with HC1 10% ; the aqueous phase is extracted two more times with ethyl acetate; the combined organic phases are then washed with brine, dried with Na2SO4 and evaporated.

The raw product is purified by flash chromatography, isolating the two isomers 2-methyl (1.95 g, yield: 50%) and 1-methyl (1.13 g, yield : 29%).

1H-NMR (CDC13) : (2-methyl isomer)-5 0.90-1. 16 (m, 4H, CH2-CH2), 2. 06 (m, 1H, COCH), 4.15 (s, 2H, COCH2), 4.33 (s, 3H, N- CH3) (1-methyl isomer)-6 0.98-1. 18 (m, 4H, CH2-CH2), 2.07 (m, 1H, COCH), 3.96 (s, 2H, COCH2), 4.25 (s, 3H, N- CH3) EXAMPLE 11 Synthesis of 1- [2-chloro-4- (methylsulphonyl) phenyl-3- cyclopropyl-2- (2-methyl-2H-tetrazol-5-yl) propane-1,3- dione (Compound ? 6, corresponding to compound N° 610 in table 2) Under an inert atmosphere, Mg (OEt) 2 (0.383 g) is added to a solution of 1-cyclopropyl-2- (2-methyl-2H- tetrazol-5-yl) ethanone (0.80 g) in 22 ml of dry

tetrahydrofuran ; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 15 ml of dry tetarhydrofuran, under an inert atmosphere, then a suspension of 2-chloro-4- (methylsulphonyl) benzoyl chloride (0.96 g) in 20 ml of dry tetrahydrofuran is added; the stirred mixture is refluxed for 5 more hours.

After completion of the reaction, the solvent is evaporated and the residue is taken up with water and ethyl acetate; after acidification with 10% HC1 the organic phase is recovered and extracted three times with aqueous NaHCO3. The combined basic aqueous phases are acidified and extracted three times with ethyl acetate, which is then dried with Na2SO4 and evaporated.

The raw product is purified by washing with warm ethyl acetate, to obtain 0.58 g of product as an orange solid (yield: 40% ; m. p. : 220°C).

1H-NMR (CDCl3) : # 1.02-1. 96 (m, 5H, cyclopropyl), 3.03 (s, 3H, SO2CH3), 4.21 (s, 3H, N-CH3), 7.42-7. 86 (m, 3H, arom. H's), 17.52 (s, 1H, OH).

EXAMPLE 12 Synthesis of 1-[2-chloro-4- (methylsulphonyl) phenyl-3- cyclopropyl-2- (1-methyl-lH-tetrazol-5-yl) propane-1,3- dione (Compound N° 7, corresponding to compound N° 605 in table 2)

Under an inert atmosphere, Mg (OEt) 2 (0.278 g) is added to a solution of starting 1-cyclopropyl-2- (1- methyl-lH-tetrazol5-yl) ethanone (0.58 g) in 15 ml of dry tetrahydrofuran; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 2 ml of dry tetrahydrofuran, under an inert atmosphere, then a suspension of 2-chloro-4 (methylsulphonyl) benzoyl chloride (0.97 g) in 16 ml of dry tetrahydrofuran is added; the stirred mixture is refluxed for 5 more hours.

The solvent is then evaporated and the residue is taken up with water and ethyl acetate; after acidification with 10% HCl the organic phase is collected and extracted two times with aqueous NaHC03. The combined basic aqueous phases are acidified and extracted three times with ethyl acetate, which is then dried with Na2SO4 and evaporated.

The raw product is purified by flash chromatography, to obtain 0.81 g of product as an orange solid (yield ; 61% ; m. p.: 104°C). tH-NMR (CDCl3) : # 1.09-1. 42 (m, 5H, cyclopropyl), 3.02 (s, 3H, SO2CH3), 3.91 (s, 3H, N-CH3), 7.47-7. 89 (m, 3H, arom. H's), 17.44 (s, 1H, OH).

EXAMPLE 13 Synthesis of 1- (4-chloro-2-nitrophenyl)-2-3-cyclopropyl- (1-methyl-1H-tetrazol-5-yl) propane-1,3-dione (Compound N° 8, corresponding to compound N° 968 in table 2).

Under an inert atmosphere, Mg (OEt) 2 (0.263 g) is added to a solution of 1-cyclopropyl-2- (1-methyl-lH- tetrazol5-yl) ethanone (0. 55 g) in 15 ml of dry tetrahydrofuran ; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 7 ml of dry tetrahydrofuran, under an inert atmosphere, then a solution of the 4-chloro-2-nitrobenzoyl chloride (0.80 g)

in 8 ml of dry tetrahydrofuran is added; the stirred mixture is refluxed for 3 more hours.

The solvent is then evaporated and the residue is taken up with water and ethyl acetate; after acidification with 10% HCl the organic phase is collected and extracted two times with aqueous NaHCO3. The combined basic aqueous phases are acidified and extracted three times with ethyl acetate, which is then dried with Na2SO4 and evaporated.

The raw product is purified by flash chromatography, to obtain 0.72 g of product as an orange solid (yield: 61% ; m. p.: 152°C). tH-NMR (CDC13) : 5 1. 05-1-52 (m, 5H, cyclopropyl), 3.92 (s, 3H, N-CH3), 7.39-7. 93 (m, 3H, arom. H's), 17.07 (s, 1H, OH).

EXAMPLE 14 Synthesis of 3-cyclopropyl-l- [4- (methylsulphonyl)-2- nitrophenyl]-2-(2-methyl-2H-tetrazol-5-yl)propane-1, 3- dione (Compound N° 9, corresponding to compound N° 247 in table 2).

Under an inert atmosphere, Mg (OEt) 2 (0.171 g) is added to a solution of 1-cyclopropyl-2- (2-methyl-2H- tetrazol5-yl) ethanone (0.35 g) in 9 ml of dry tetrahydrofuran; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 3 ml of dry tetrahydrofuran, under an inert atmosphere, then a solution of 4-methylsulphonyl-2-nitrobenzoyl chloride (0.61 g) in 6 ml of dry tetrahydrofuran is added ; the stirred mixture is refluxed for 3 more hours.

The solvent is then evaporated and the residue is taken up with water and ethyl acetate ; after acidification with 10% HC1 the organic phase is collected and extracted three times with aqueous NaHCO3. The combined basic aqueous phases are slowly acidified to pH 5 and extracted with ethyl acetate, which is then washed three times with pH 5 buffered solution until all the

benzoic acid is eliminated, dried with Na2SO4 and evaporated.

The resulting solid is purified by filtration over silica gel eluting with ethyl acetate to obtain 0.24 g of pure product as a light brown solid (yield: 61% ; m. p 186°C, decomposition). tH-NE (CDC13) : 5 1.08-1. 99 (m, 5H, cyclopropyl), 3. 09 (s, 3H, SO2CH3), 4.17 (s, 3H, N-CH3), 7.47-8. 62 (m, 3H, arom. H's), 17.19 (s, 1H, OH).

EXAMPLE 15 Synthesis of 1-cyclopropyl-2- (4-methyl-1, 3-thiazol-2- yl) ethanone.

Under an inert atmosphere and in dried glassware, 2, 4-dimethyl-1, 3-thiazole (3. 15 g) is dissolved in 90 ml of anhydrous tetrahydrofuran ; 17.4 ml of 1.6 M butyllithium solution in hexanes are then added dropwise: the solution temperature rises to about 40 °C ; after the addition, the mixture is stirred for 30 minutes, allowing the temperature to return to about 25°C.

The reaction mixture is then cooled in an ice bath and a solution of ethyl cyclopropanecarboxylate (3. 17 g) in 15 ml of anhydrous tetrahydrofuran is quickly added; the ice bath is removed and the resulting solution is stirred at 50°C for 3 hours.

After completion of the reaction, the solvent is removed at reduced pressure and the residue taken up with 5% HC1, which is washed with a little portion of diethyl ether, then slowly neutralized to pH 7-7.5 and extracted three times with diethyl ether.

The combined organic phases are dried with Na2SO4 and evaporated, yielding a dark oil, which is purified by flash chromatography to obtain O 72 g of desired product as an oil (yield: 14%).

1H-NMR (CDCl3) : # 0.89-1. 24 (m, 4H, CH2CH2), 2.06 (m, 1H, CH), 2.43 (s, 3H, CH3), 4.23 (s, 2H, CH2), 6.83 (s, 1H, thiazole H) EXAMPLE 16 Synthesis of 1-[2-chloro-4-(methylsulphonyl) phenyl]-3- cyclopropyl-2- (4-methyl-1, 3-thiazol-2-yl) propane-1, 3- dione (Compound N° 10, corresponding to compound N° 485 in table 2).

Under an inert atmosphere, Mg (OEt) 2 (0.316 g) is added to a solution of 1-cyclopropyl-2- (4-methyl-1, 3- thiazol-2-yl) ethanone (0.72 g) in 18 ml of dry tetrahydrofuran; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 3 ml of dry tetrahydrofuran, under an inert atmosphere, then a suspension of 2-chloro-4 (methylsulphonyl) benzoyl chloride (1.11 g) in 15 ml of dry tetrahydrofuran is added; the stirred mixture is refluxed for 3 more hours.

After completion of the reaction, the solvent is evaporated and the residue is taken up with ethyl acetate and 1% HC1, then the mixture is neutralized with NaHC03 and extracted three times with ethyl acetate; the combined organic phases are washed with brine, dried with Na2SO4 and evaporated.

The resulting solid is purified by washing with diethyl ether to obtain 1.06 g of pure product as an off- white solid (yield: 67% ; m. p.: 199°C).

tH-NS (CDC13) : 5 0.51-1. 35 (m,'5H, cyclopropyl), 2.43 (2s, 3H, Ar-CH3), 3.07 (s, 3H, SO2CH3), 6.59 (2s, 1H, thiazole H), 7.58-8. 02 (m, 3H, arom. H's), 14.78 (s, 1H, OH).

MS-DCI: m/z 398 (M+1).

EXAMPLE 17 Synthesis of 1-cyclopropyl-2- (3-methyl-1, 2,4-oxadiazol-5- yl) ethanone Under an inert atmosphere, acetamidoxime (1.56 g) is added to a solution of methyl 3-cyclopropyl-3- oxopropanoate (3.0 g) in 50 ml of toluene ; the stirred mixture is heated to 130°C while distilling off the solvent and methanol formed in the reaction.

When all the solvent has been removed, 50 ml of toluene and 1.56 g of acetamidoxime are added again to the residue and the distillation continued until all of this second portion of solvent has been removed.

The residue is then purified by flash chromatography to obtain 1.48 g of pure product as a violet oil (yield: 42%).

1H-NMR (CDCl3) : 5 0.95-1. 18 (m,. 4H, CH2CH2), 2.00 (m, 1H, CH), 2.40 (s, 3H, CH3), 4.14 (s, 2H, CH2).

EXAMPLE 18 Synthesis of 1-[2-chloro-4-(methylsulphonyl) phenyl] -3- cyclopropyl-2- (3-methyl-1, 2, 4-oxadiazol-5-yl) propane-l, 3- dione (Compound N° 11, corresponding to compound N° 385 in table 2).

Under an inert atmosphere, Mg (OEt) 2 (0. 239 g) is added to a solution of 1-cyclopropyl-2- (3-methyl-1, 2,4- oxadiazol-5-yl) ethanone (0.50 g) in 13 ml of dry tetrahydrofuran ; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 3 ml of dry tetrahydrofuran, under an inert atmosphere, then a suspension of 2-chloro-4- (methylsulphonyl) benzoyl chloride (0.84 g) in 10 ml of dry tetrahydrofuran is added ; the stirred mixture is refluxed for 3 more hours.

After completion of the reaction, the solvent is evaporated and the residue is taken up with ethyl acetate and 1% HCl, then neutralized with aqueous NaHC03 and extracted three times with 5% NaOH ; the combined basic aqueous phases are acidified and extracted three times with ethyl acetate, which is then washed with brine, dried with Na2SO4 and evaporated.

The resulting solid is purified by washing with diethyl ether to obtain 0.90 g of pure product as an off- white solid (yield: 78% ; m. p.: 188°C).

1H-NMR (CDC13) : # 1.19-1. 48 (m, 4H, CH2CH2), 2.29 (2s, 3H, Ar-CH3), 2.55 (m, 1H, CH), 3.06 (s, 3H, SO2CH3), 7.46- 7.93 (m, 3H, arom. H's), 17.93 (bs, 1H, OH).

EXAMPLE 19 Synthesis of 1- (4-chloro-2-nitrophenil)-3-cyclopropyl-2- (3-methyl-1, 2,4-oxadiazol-5-yl) propane-1, 3-dione (Compound N° 12, corresponding to compound ? 748 in table 2).

Under an inert atmosphere, Mg (OEt) (0. 215 g) is added to a solution of 1-ciclopropyl-2- (3-methyl-1, 2,4- oxadiazol-5-yl) ethanone (0. 45 g) in 12 ml of dry tetrahydrofuran ; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 6 ml of dry tetrahydrofuran, under an inert atmosphere, then a solution of 4-chloro-2-nitrobenzoyl chloride (0.66 g) in 6 ml of dry tetrahydrofuran is added ; the stirred mixture is refluxed for 3 more hours.

After completion of the reaction, the solvent is evaporated and the residue is taken up with ethyl acetate and 1% HC1, then neutralized with aqueous NaHC03 and extracted three times with 5% NaOH ; the combined basic aqueous phases are acidified and extracted three times with ethyl acetate, which is then washed with brine, dried with Na2SO4 and evaporated.

The resulting solid is purified by washing with a little portion of diethyl ether to obtain 0.51 g of pure product as an off-white solid (yield: 54% ; m. p. : 127°C).

H-NMR (CDC13) : 5 1. 18-1. 49 (m, 4H, CH2CH2), 2.25 (2s, 3H, Ar-CH3), 2.47 (m, 1H, CH), 7.16-8. 15 (m, 3H, arom. H's), 17.61 (bs, 1H, OH).

EXAMPLE 20 Synthesis of 1-cyclopropyl-2- (pyridin-2-yl) ethanone

Under an inert atmosphere and in dried glassware, 2- picoline (9.43 g) is dissolved in 95 ml of anhydrous tetrahydrofuran; 63.1 ml of 1.6 M buthyllithium solution in hexanes are then added: the solution temperature rises to about 40 °C ; after the addition, the mixture is stirred for 30 minutes at 40°C.

A solution of methyl cyclopropanecarboxylate (5.07 g) in 5 ml of anhydrous tetrahydrofuran is then quickly added and the mixture is stirred for 1 h at 40°C.

The mixture is then cautiously diluted with water and the organic solvent evaporated at reduced pressure; the residue is taken up with ether and a mixture of 10% HC1 and ice; the organic phase is extracted 4 times with HC1 10%.

The combined aqueous acid phases are cautiously treated with 50% NaOH until slightly acid, then basified to pH 8 with solid NaHC03 ; the mixture is then saturated with NaCl and extracted three times with ethyl acetate, which is then dried with Na2SO4 and evaporated.

The resulting dark oil is purified by flash chromatography to obtain 5.08 g of desired product as a yellow oil (yield: 31%).

1H-NMR (CDC13) : # 0.82-1. 11 (m, 4H, CH2CH2), 2.05 (m, 1H, CH), 4.03 (s, 2H, CH2), 7.19, 7.63, 8.55 (3m, 4H, arom. H's) EXAMPLE 21 Synthesis of 1- [2-chloro-4- (methylsulphonyl) phenyl] -3- cyclopropyl-2- (pyridin-2-yl) propane-1, 3-dione (Compound N° 13, corresponding to compound N° 615 in table 2).

Under an inert atmosphere, Mg (OEt) Z (0.152 g) is added to a solution of 1-ciclopropyl-2- (pyridin-2- yl) ethanone (0.30 g) in 8 ml of dry tetrahydrofuran; the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 2 ml of dry tetrahydrofuran, under an inert atmosphere, then a suspension of 2-chloro-4- (methylsulfonyl) benzoyl chloride

(0.52 g) in 6 ml of dry tetrahydrofuran is added ; the stirred mixture is refluxed for 3 more hours.

After completion of the reaction, the mixture is diluted with methanol to have an homogeneous solution, then the solvent is evaporated. The residue is taken up with water and extracted three times with ethyl acetate, which is then washed with brine, dried with Na2SO4 and evaporated.

The resulting solid is purified by flash chromatography to obtain 0.36 g of product as a yellow amorphous solid (yield: 51%).

1H-NMR (CDCl3) : 5 0.82-1. 70 (m, 5H, cyclopropyl), 3.06 (s, 3H, SO2CH3), 7.06-8. 21 (m, 7H, arom. H's), 18.05 (bs, 1H, OH).

EXAMPLE 22 Synthesis of 1-[2-chloro-4-(methylsulphonyl) phenyl]-3- (cyclopropyl) propane-1,3-dione.

Under an inert atmosphere, Mg (OEt) 2 (1.29 g) is added to a solution of t-butyl 3-cyclopropyl-3- oxopropanoate (3.0 g) in 75 ml of dry tetrahydrofuran;

the stirred mixture is refluxed for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 20 ml of dry tetrahydrofuran, under an inert atmosphere, then a suspension of 2-chloro-4- (methylsulfonyl) benzoyl chloride (4.52 g) in 55 ml of dry tetrahydrofuran is added; the stirred mixture is refluxed for 3 more hours.

After completion of the reaction, the solvent is evaporated under reduced pressure ; the residue is taken up with 30 ml of toluene and p-toluenesulphonic acid (1.13 g) is added, then the stirred mixture is refluxed for 8 hours.

The solid precipitate is filtered off and the solution is evaporated under reduced pressure ; the oily residue is purified by flash chromatography to obtain 2.64 g of solid product (yield: 54%).

H-NMR (CDCl3) : 5 0. 98-1. 80 (m, 5H, cyclopropyl), 3.07 (s, 3H, SO2CH3), 6.13 (s, 1H, enolic form =CH-), 7.74-8. 00 (m, 3H, arom. H's).

EXAMPLE 23 Synthesis of 1-[2-chloro-4-(methylsulphonyl) phenyl]-3- cyclopropyl-2- (5-trifluoromethyl-1, 3,4-thiadiazol-2- yl) propane-1, 3-dione (Compound N° 2918).

Under an inert atmosphere, NaH (60% suspension in mineral oil, 0.27 g) is suspended in 10 ml of dry tetrahydrofuran ; a solution of 1- [2-chloro-4- (methylsulphonyl) phenyl]-3- (cyclopropyl) propan-1,3-dione (1.76 g) in 15 ml of dry tetrahydrofuran is then slowly added dropwise.

The mixture is stirred for 1 hour, then a solution of 2-methylsulphonyl-5-trifluoromethyl-1, 3,4-thiadiazole (1.97 g) in 13 ml of dry tetrahydrofuran is added dropwise.

The stirred mixture is refLuxed for 3 hours, then the solvent is evaporated under reduced pressure ; the residue is taken up with diethyl ether and extracted two times with aqueous NaHC03 ; the combined aqueous phases are slowly acidified to pH 2-3 and extracted with ethyl acetate, which is then dried with Na2SO4 and evaporated.

The residue is purified by flash chromatography, then by washing with diethyl ether, to obtain 0.83 g of product as a white solid (yield: 31% ; m. p.: 185°C).

H-NMR (CDC13) : (mixture of two tautomers) 6 0.50-1. 40 (m, 5H, cyclopropyl), 3.10 (s, 3H, SO2CH3), 7. 60-8. 06 (m, 3H, arom. H's), 15.23, 15.39 (2 bs, 1H, OH).

19F-NMR (CDC13) : (mixture of two tautomers) 5-60. 52, - 60. 68 (2 s, CF3).

EXAMPLE 24 Synthesis of 1-[2-chloro-4-(methylsulphonyl) phenyl] -3- cyclopropyl-2-(2, 4-dinitrophenyl) propane-1, 3-dione (Compound N° 723).

Under an inert atmosphere, NaH (60% suspension in mineral oil, 0.12 g) is suspended in 2 ml of dry tetrahydrofuran; a solution of 1- [2-chloro-4- (methylsulphonyl) phenyl]-3- (cyclopropyl) propan-1, 3-dione (0.45 g) in 5 ml of dry tetrahydrofuran is then slowly added dropwise.

The mixture is stirred for 1 hour, then a solution of 2,4-dinitrochlorobenzene (1.52 g) in 2 ml of dry tetrahydrofuran is added dropwise.

The stirred mixture is refluxed for 5 hours, then the solvent is evaporated under reduced pressure; the residue is purified by flash chromatography, then by washing with diethyl ether, to obtain 0.40 g of product (yield: 57%; m. p.: 67°C).

1H-NMR (CDCl3) : 5 0.85-1. 40 (m, 5H, cyclopropyl), 2.97 (s, 3H, SO2CH3), 7.31-8. 67 (m, 6H, arom. H's), 16.78 (bs, 1H, OH).

EXAMPLE 25 Synthesis of 2-brom-1- [2-chloro-4- (methylsulphonyl) phenyl]-3-(cyclopropyl) propane-1, 3-dione Under an inert atmosphere, bromine (0.24 g) is slowly added dropwise to a solution of (1- [2-chloro-4- (methylsulphonyl) phenyl]-3- (cyclopropyl) propan-1,3-dione (0.43 g) in 25 ml of dichloromethane cooled to 5°C, then the mixture is stirred overnight at room temperature.

The solvent is then completely evaporated under reduced pressure and the residue (0.57 g) is used without purification for the following reaction

1H-NMR (CDCl3) : 5 1.14-1. 34 (m, 4H, cyclic CH2-CH2), 2.61 (m, 1H, cyclic CH), 3.10 (s, 3H, S02CH3), 7.52-8. 05 (m, 3H, arom. H's), 16.02 (bs, 1H, OH).

EXAMPLE 26 Synthesis of 1- [2-chloro-4- (methylsulphonyl) phenyl]-3- cyclopropyl-2- (1, 2, 4-triazol-1-yl) propane-1, 3-dione (Compound N° 460) Under an inert atmosphere, NaH (60% suspension in mineral oil, 0.133 g) is suspended in 2 ml of dry tetrahydrofuran cooled in a water bath, then 1,2, 4- triazole (0.23 g) is added.

After stirring for 30 minutes at room temperature, a solution of 2-bromo-l- [2-chloro-4- (methylsulphonyl) phenyl]-3-(cyclopropyl) propan-1,3-dione (0.63 g) in 5 ml of dry tetrahydrofuran is added, then the mixture is heated to 50°C for 8 hours.

After completion of the reaction, the mixture is diluted with water, acidified and extracted three times with ethyl acetate, which is then washed with brine, dried with Na2SO4 and evaporated.

The residue is purified by flash chromatography, then by washing with ethyl ether to obtain 0.23 g of solid product (yield: 38% ; m. p.: 162°C). tH-NMR (CDCl3) : 5 1.09-1. 40 (m, 5H, cyclopropyl), 3.01 (s, 3H, SO2CH3), 7.38-8. 05 (m, 5H, arom. H's), 16. 23 (bs, 1H, OH).

EXAMPLE 27 Synthesis of 1-[2-chloro-4-(methylsulphonyl) phenyl]-3- <BR> <BR> cyclopropyl-2- [1, 1-dioxido-3-oxo-1, 2-benzi sothiazol-2 (3H)- yl] propane-1, 3-dione (Compound N° 2919) Under an inert atmosphere, NaH (60% suspension in mineral oil, 0.114 g) is suspended in 3 ml of dry tetrahydrofuran cooled in a water bath, then saccharine (0.52 g) is added.

After stirring for 30 minutes at room temperature, a solution of 2-bromo-1-[2-chloro-4- (methylsulphonyl) phenyl]-3- (cyclopropyi) propan-l, 3-dione (0.54 g) in 8 ml of dry tetrahydrofuran is added, then the mixture is heated to 50°C for 6 hours.

After completion of the reaction, the solvent is evaporated; the residue is taken up with water, acidified and extracted three times with ethyl acetate, which is then washed with brine, dried with Na2SO4 and evaporated.

The residue is purified by flash chromatography, then by washing with ethyl ether to obtain 0.31 g of product as an amorphous solid (yield: 45%).

H-NMR (CDCl3) : 5 1.09-1. 45 (m, 4H, cyclic CH2-CH2), 1.86 (m, 1H, cyclic CH), 2.99 (s, 3H, SO2CH3), 7.51-8. 08 (m, 7H, arom. H's), 17.19 (bs, 1H, OH).

EXAMPLE 28 Synthesis of 1, 1, 1-trifluoro-3-pyridin-2-ylacetone Under an inert atmosphere, 2-picoline (4.72 g) and pyridine (20.0 g) are dissolved in 130 ml of toluene cooled in an ice bath; trifluoroacetic anhydride (31.9 g) is then slowly added dropwise and the mixture is stirred at room temperature for 48 hours.

The mixture is then cautiously poured into 500 ml of 3% Na2CO3, and extracted three times with ethyl acetate; the combined organic phases are extracted two times with 5% NaOH, then these combined basic aqueous

phases are acidified to pH 6.5 and extracted with ethyl acetate, which is washed with brine, dried with Na2SO4 and evaporated.

The raw product is purified by flash chromatography, then by washing with diethyl ether to obtain 4.24 g of product as a yellow solid (yield: 44%).

1H-NMR (CDC13) : # 5.82 (s, 1H, enolic form CH), 6.99-8. 10 (m, 4H, arom. H's), 15.88 (bs, 1H, OH).

19F-NMR (CDCl3) : 5-74. 94 (s, CF3).

EXAMPLE 29 Synthesis of 1-[2-chloro-4-(methylsulphonyl) phenyl]-2- <BR> <BR> (pyridin-2-yl) -4,4, 4-trifluorobutane-1, 3-dione (Compound N° 616).

Under an inert atmosphere, Mg (OEt) 2 (0. 336 g) is added to a solution of 1, 1, 1-trifluoro-3-pyridin-2- ylacetone (0.80 g) in 17 ml of dry tetrahydrofuran ; the stirred mixture is stirred at room temperature for 3 hours, then completely evaporated under reduced pressure.

The residue is taken up with 5 rnl of dry tetrahydrofuran, under an inert atmosphere, then a suspension of 2-chloro-4- (methylsulfonyl) benzoyl chloride (1.17 g) in 12 ml of dry tetrahydrofuran is added ; the mixture is stirred overnight at room temperature.

After completion of the reaction, the mixture is diluted with ethyl acetate, quickly washed with NH4Cl saturated'solution, with brine, then dried with Na2SO4 and evaporated.

The residue is taken up with a mixture of diethyl ether and hexane which causes the product to precipitate: 0.24 g of solid are recovered by filtration (yield: 14% ; m. p.: 189°C, with decomposition) 1H-NMR (acetone-d6): # 3.09 (s, 3H, SOCH3), 7.07-8. 37 (m, 7H, arom. H's).

F-NMR (acetone-dg) : 5-67. 43 (s, CF3) EXAMPLE 30 Following the suitable procedures, some of which are detailed in the examples above, the following compounds, listed in Table 2, have been prepared and identified by elemental analysis and/or 1H-NMR : Compound A B R Nul 14. 2-N02-4-SO2McPji tt, 2, 4-oxadiazol-5-yl H 15 2-NOr4-S02MePh l, 2, 4-oxadiazol-5-ylmethyl 16 2^NQ2-4-SO2MeP* {, Z, 4-oxadiazol-5-yl i propyl 17 2-NOz-4-so2Meph a, 2, 4-oxadiazol-S-yl oyolopropyl 18 2-NO2-4-SO2MePh 1, 2, 4-oxadiazol-Syl CF3 19 2-N02-4-SO2MeP, h 3-mey, 1-I, 2, 4-oxadiazol-5-yl H 20 2-EQ2-4-So2 » 3-wnethyl-1, 2, 4-oxadiazol-S-yl rnetllyl 21 2-NQ2-4-$02MeP. h 3-mediYl-1, 2, 4-oxadiazol-5-yl i-prOPYlF _ 22 : 2-NO2-4-S02Me=Pli 3-molhyl-1, 2, 4-oxadiazol-S-yl oyolopropyl 23 2-N02-4-S02MePh 3nethyl-l, 2, 4-oxadiazol-S-y1 CF3 24 2 N02-4-SOZiIeP 3-irifluvrarnethyl-1, 2, 4-oxadiazol-5-yl 25 2-NOr4-S02MePh 3-t ! iRuorometb. yii-l, 2, 4-oxadiazol-5-yl methyl 26 2-NO24-SO2A¢ePh 3-tailuoronzedil-1 2 4-oxadiazol-5-Yl i-proPVI 27 2-NO24-SO2MePh 3-t ororneiyl-1 2 4-oxadiazol-S-yl cyclopropyl 23 2-N :) r4402MePh 3-*oromethy1-I, 2, 4-oxadiazol-5-yl CF3 29 2-NO24-SO2MePh 1, 2, 4-oxadiæol-3-yl 30 2-NO2-4-S02MeF', h 1, 2, 4-oxadiazol-3- 1 rneth 1 31 2-N02-4-S02MePh l, 2, 4-oxadiazol-3-yli-propyi 32 2-NO2-4-SO2MePh 1, 2, 4-odiazol-3- 1 cyclopro yl 33 2-NO2-4-$02MePh 1, 2, 4-oxadiazol-3-yl CF3 34 2-NO2-4 SO2MePh 5-ne1hyl-I, 2, A-oxadiazol-3-yl H 35 2 NOZ-4-SOZMePh S-methyl-1, 2, 4-oxadiazol-3-yl 36 2-NO2-4-SCJ2MePh 5-methyl-1, 2, 4-oxadiazol-3-l i-propyl 37 2-NO2-4-SO2MePh 5-methyl-1, 2, 4-oxadiazdl-3-yl cyclopropyr 38 2-NO2-4-SO2MePh 5-methyl-1, 2, 4-axadiazol-3-yl CF3 39 2-Nor4-so2Meph 5 w2, 4-oxadiazol-3-yl 40 2-NO2-4=SOzT2MePh 5-triffuoromethyl-1, 2, 4-oxadiazol-3-ylmethyl 41 2-NO2-4-SO2MePh S-b7H1úoromethyl-l 2 4-oxadìazol-3-yl i-propvI 42 2-NO2-4 SO2MePh S-brdluoromethyl-l>2n4exadiazol-3-yl cyclopropyl 43'2-NO2-4-SO « ePh S-Fifluororned} yl-1, 2, 4-oxadiazol-3-yl CF3 44 2-NO2-4-SO2MePh S-chloro-1, 2, 4-oxadiazol-3-yl H 45 2-NO2-4-SO2MePh 5<hlcro-! 1, 2, 4*oxadiazo1-3-yl meiyl 46 2-NO24-SO2NIePh 5-chloro-l, 2, 4-oxadiazol-3-yl i-propyl 47 2-NO24-SO2MeP, h S-chloro-1, 2, 4-oxadiazol-3-yl cyclopropyl 48 2-NO2-4-202MePh S-chloro-l, 2, 4-oxadiazol-3-yl CF3 49 2-NO24-SO2MeP, h 1, 3, 4-oxadiazol-2-yl H 50 2-N02-4-SOaIVMePh 1, 3, 4-oxadiazol-2-yl methyl 51 2-NO2-4-SO2MePh if3, oxadiazol-2-yl _ i-propyl 52 2-NO2-4-SO2MePh 1, 3, 4-oxadiazol-2-yl cyelopropyl 53 2-NO2-4-SO2MePh 1, 3, 4-oxadiazol-2-yl CF3 . 54 2-NO2-4-SO2MeP. h S-inethgsi3D£onyl-i, 3, 4-oxadiazol-2-yl H Compound N X B R m p. (4C) 55 2-NQz-4-S02MePh 5-itBethylsuIfbnyM, 3, 4-oxadiazol-2-. yljmethyl 56 2-02-4-SOIePh :. SmethyIsMUbnyl''l, 3, 4-pxadiazoI-2-yli-propyi 57 2 IIQ, XiS S-methyb iffnyl-l34-oxadiåzol-2-yl syolopropyl 58 2-NQr4-S02MePh. -methylsMlfdnyl-l, 3, 4-oxadiazol-2-ylCPa 39 2-N, 024-$ (92MePh 5Sme* 34-oxadiazb-yl H 60 X-NOx--SOxMePh metb. yM, 3, 4-oxaaiazol.-2ylmethyl 6 G 2-NO2-4-SO2MeP. h ; 5-meiyl-1, 3, 4-oxaazol-2^yl i-propyl 62 2-NP2-4-SQ2MePh S-mefHyl- ! t, 3, 4-oxadiazol-2-ylcyolopropyi 63 2-N02-4'-S02MePh 5-methyl-l ; 3, 4-oxadiazol-2-ylCFa . 64 2-N02-4-g02'MePh. S-iBiSuoniethyM, 3, 4-oxadiazol-2-ylH 65 2-NO2-42lvv, tePh 5 : iiifliitironath 1-J., 3, 4-oxadiazdl-2-yl methyl 66 2-NO24-, 89 S-iflhoromely. l-l 3 4-oxadi'azol-2-yl i-ProPv . 67 2'N02-4-S02MePh 5aaor0me<'hyH, 3, 4-oxadiazal-2-ylcyclopropyi 68 2-NO2-4-SO2IeP. h 5-isi 1 dhyl-1, 3, 4-oxadiazol-2-yl CF3 69 2-NOr4-S02MePh I., 2, 3-tnazol-4-ylJH 70 2-MOz-4-SP2'MePh 2, 3-taazol-4-ylmethyl 71 2-NQr4-SOzMePh l, 2', 3-triazol-4-yli-propyi 72 2 NO2-4 :-Sw 1, 2, 3-fitiazol-4-yZ cyclopropyl 73 2-N02-4-SO : MePh l, 2, 3-tdazol-41CF3 74 2-NO2-4-SO2M : eP. h l-rnethyl-1, 2, 3-iriazol-4 yl Ii 75 2-NO2-4-SO2MePh X-methyl-1, 2, 3--. triiazol-4-yl methyl 76 2-No2-4'SO2MPh il emethyl-l, 2, 3-iazol-4-yl i-. propyl 77 2-NC) 2-4-SO2MePh 1-rnethyl-1, 2, 3-triazol-4-yl cyclopropyl 78 2-NO2-4-S02MePh l nethyl-. M, 2, 3-triazol-4-yl CF3 79 2-NO-4 ; S02MePh 2 methyl-1, 2, 3-tliazol-4-yl H 80 2-NO24-SO2MePh 2-methvl-12 3-tiiazol4-Yl rnetEvl < v 81 2-NO2-4-SO2MeP. h 2imethyl-1 2 3-triazol-4-yl. i-Dropvl x < 82-2-NO2-4-SO2MePh 2-elethyl-l 2 3-Xiazol-4-yl cvoloproDyl 83 2-NO24-SO2MePh 2-metbyl-l, 2, 3-tnLazol-4-yl CFs 84 2-NO2-4-SO2MePh 1 2, 3-triazol-1-yl H 85 2-NO2-4-SO2MePh 1, 2, 3 triazol-1-1 meth 1 86 2-NO24-SQ2MeP. h 1, 2, 3-triazol-l-yl i-propyl 87 2-NO2-4-SO2MePh 1, 2, 3-'triazdl-l-yleyclopropyi 88 2-NO2-4-SQ2NleP. h 1 2 3-triazol-1-yl CF3 89 2-NO2-4-SO2MePh 1, 2 3-triazol-2-yl lI '9Q 2-N02-4-S02MePh'l, 2, 3-triazoi-2- 1 meth 1 91 2-NO2-4-SOzMePh 1, 2, 3 triazof-2 y1 i-pmpyl 92 2-NO2-4-SO2MePh 1 2, 3-triazol-2-yl cyclopropyl '93 2-NO2-4-SO2MePh 1, 2, 3-triazol-2-yl O3 94 2-NO24-SC>2MePh k, 2, 4-triazol-1-yl H 95 2-NO2-4-SO2MePh il, 2 4-tiazol-l-yl _ niethvl 96 96 2-NO2-4-SOiMePh l, 2, 4-. triazol-i-yl'inpropyl 97 2-NO2-4-SO2hRePh 1, 2, 4-triazol.-li-yl. cyclopropyl 98 2-NO2-4-SO2MePh 1, 2, 4-tiazol-1-yl CF3 99 2-NO2-4 SQ2MePh imidazol-2-sl H 100 2-NO2-4-SO2MePh iniid'azol-2-yl meXhyl Compound NABR m. p. QO 101 2-NO2-4nS w. dazol-2-yl l-propyl M2 2-N02-4-SOMePh ttnidazol-2-ylcyclopropyi 103 2-N02-4-S02MePh imjdazol-2-ylCFs 103 w7 izol-2-yl CE3 104 2-NO2-4-SC} 2MePh'a'daze ; l-l-yl E. 1QS 2-æ2-4-SO2MePla,'gliidazol-lwyl miethyl 106 2-NO2-4-$02MqPh vXzol-l-yl _ i-propyl 107 2-N02-4-S02MePhMdazol-l-yloyolopropyi 108 2-NO24-£iO2ti wkdz-yl CF3 109 2-NO2-4-SO2MePh P zol-4-yl H,, 110 2 (32-4-SOi2MePh. iiziXzol4-yl meiyl ill 2-NOz-4-S02MePh'muiiazdL-4yli-propyi 11 ; 2 i-NCIii2-4-so2Meph,.. cyclopropyl 'i113 2-NO2-4-Sw. 4-yl CE3 114 2-N172-4-S02Me1'h tliia. zol-2-yl H 115 2-NO24-SO, i2MePh i'AZQS2-... melyl ! t. it6 2-N02-4-S02MSRh azdt-yli-propyi 117 2-NO2-4-SQ2MePh ç 1-cyclopropyl 118 2-N02-4-SQzIVMeb thiazol-2-yl CF3 1 Q 9 Z Np2-4=a021UIePh. 4-meh Xhiazol-2-1 H 120 2-NO2-4-SO2MePh 4-mçlilhyllhiazol-2-yl methyl 121 2-NO2-4-SO2MePIl 4-methylEbi'azol'-2-yl i-propyl 122 2-NO2-4,-SO2MePh 4-methXiazol-2-yl cyclopropyl 123 2-NO2-4-SO2MePh 4-rnetidylthi'azol-2-yl C1F3 124 2-N02-4-SrJ2MePh oxazol-2-1 H 125 2-N02-4-S02MPhoxazol-2-ylmetbyl 126 2-NO2-4-SO2MePh oxazol-2-yl i-propyl 127 2-NO2-4-SO2MePh oxazol-2-1 cyclopropyl 128 2-NO2-4-S02MePh oxazol-2-yl CF3 129 2-NO2-4-SO2MePh 4, 5-dimethyloxazol-2-y FI 130 2-NO2-4-SO2MePh 4, 5-dirnethyloxazol-2-yl methyl 131 2-N02-4-S02MePh4, 5-dmie<liyloxazol-2-yli-propyi 132 2-NO24-SO2MePh 4, 5-dfinediyloxazol-2-yl oyclopropyl 133 2-NO2-4-SO2MePh 4, 53iTneblayloxazol-2-yl CF3 134 2-NO2-4-S02MePh 2-oxazolin-2-l H 135 2-NO2-4-SO2MePh 2-oxazolin-2-yl methyl 136 2-NO2-4-S02MePh 2-oxazolin-2-yl i-propyl 137 2-NOr4-SO2MePh 2-oxazoliV-2-yl eyelopropyl 138 2-NO2-4-SO2MePh 2-oxazolin-2-yl CF3 13 2-NO2-4-SO2MePh 4, 4ieiyl-2voxazoi-2-vl 140 2ON-4.-SOzIuMePh 4, 4-dimethyl-2-oxazolin-2-yl methyl 141 2-NO2-4-SO21ZePll 4, 4-dimethyl-2-oxazolixI-2-yl i-propyl 142 2-NO2-4-SO2MePh 4, 4-ciimet l-2-oxazolin-2-yl c clopropyl 143 2-NO2-4-SO2MePh 4, 4-ciimethyl-2-oxazolin-2-yl CE3 144 2-NO2-4-SO2MePh 1, 2, 4 thiadiazol-5-l H 145 2-N02-4-S02MePh l, 2, 4-fhiadiazol-5-ylmethyl 146 2-NO2-4-SO2MePh 1, 2, 4-thiadiazol-5-yl i-propyl CompoundN A B R inep m 147'2 1, 2j4 tbi'adiazol-5-yl çyeloprop 148 2-NO2-4-'StD2MePh 1, 2, 4+iadiatoli5-yl CF3 149 2-N02-4-Sp2MePh 3methyM, 2, 4-lhiadiazol-5-yl : E1 150 2602-4-SO2M, ePh 3-mellly1-1., 2, 4-*i'adiazol-5-yl meiyl 151 2m2-4-S, Q2MeP. h 3-taethyl-1, 2, 4-iadiazol-5-yl, i-propyl 152 2-N02-4-SO : MePh 3-iH9tbyt-t, 2, 4-ibiadiazol-5-. ylcyolopropyi 153 2-NO-4-SG'2MeP& 3-me&yl'l, 2, 4-ihiaazol-5-'yl CFa 154 2-N02-4-S02MePh 3-tnauoMnithyl-l, 2, 4-iadiazol-5-yl lI 155 2-NQ24-92 3-eWl, 2 4-*iadiazol-5-yl methyl 156 2'NQ2-4''SO&MeEb 3-toe-l, 2, 4-'tbiadiazol-5-yli-pmpyi 157 2-N02-4-SOzMeBh 3-tMuopo] : QQthyt-l, 2. 4-tbiadiazol-5-yl cyclopropyi 158'2-NO24-Sw 3-E gXmAySl, 2, 4-Madazol-5-yl O3 159 2-NO2-, 4-SC ?. 2M : ei ? h 1, 2, 4wiazo&-3-yl H 160 260. 2-4-SO2MePh 1, 2, 4-tbiadiazol-3-yl rnethyl I61 2gÒ24-SO2MeP. h 1, 2, 4-th ; d3-yl i-propyl M2 -NOs-'SOMePh t, 2, 4Maazol-3-yloyclopropyi 163 2-NO24-SO2MePh 1, 2, 4-thiadiazol-3-yl CF3 164 2-NO2-4-SO2MePh 5-meXhyl-1, 2, 4mffiiadiazol-3-yl EW 165. 2-N02-4-SO2MelBh S-Lel3i&1-I, 2, 4<thiadiazol-3-yl methyl 166 2-NO24-SOiMePh 5-methyl,-1, 2, 4-thiadiazol-3-yl i-propyl 167 2-N02-4-S02MBPh 5-mcfhyH, 2, 4-thiadiazol-3-yloyclopropyi M8 2-N02-4-S02MeEb 3-me&yM, 2, 4-tbiiadiazol-3-ylCFa 169 2-N02-4-SO2MePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-YI E 170 2-NO2-4 SO2MePh 5-triiluorornediyl-1, 2, 4 ; iiadiazol-3-yl nlethyl 171 2-N. C32-4-SQ2MePh 5-illlorornel tryl-1, 2, 4niadiazol-3-yl i-propyl 172 2-NO24-SÒ2MePh 5-trif luorometl iyl-1, 2, 4-thiadiazol-3- 1 c clo 0 1 17. 3 2-NO2-4-SO2MePh 5-lifluorornethyl-1, 2, 4-*iadiazol-3-yl CF3 174 2-NO2-4-SO2MePh 1, 3, 4-tbiadiazol-2-yl 175 2-NO24-SO2MelXh 1, 3, 4-thiadiazol-2-I methyl 176 2-NC>2-4-SO2MeP. h 1, 3, 4-t hiadiazol-2-yl i-propyl 177 2-NO2-4-SO2MePh 1, 3, 4 thiadiazo'1-2-1 c clo ro 1 178 2-NO2-4-SO2MePh 1, 3, 4-thiadiazol-2-yl CF3 179 2-NOr4-SOaI2MePh 5-methylsulfonyl-1, 3, 4 tliiadiazol-2-yl H 180 2-NO2-4-SOzIVMePh 5-methylsulonyl-1, 3, 4-thiadiazol-2-yl methyl 18. 1 2-N02-4-SOzIVIePh 5-methyl'sulfonyl-1, 3, 4-thiadiazol-2-yl i-propyl 3 :82 2-NO2-4-SO2MeP, h Smethylsulfonyl-1, 3, 4 thiadiazol-2-1 c clo ro 1 183 2-NO2-4-SO2MePh 5-methylsulfonyl-l, 3, 4-thiadiazol-2-yl CF3 184 2-NO2-4-SO2MeP-h 5-melJiyl-1, 3, 4-thiadiazol-2-yl H ? 5 2-N02-4-S02MePh. 5-meaiyl-l, 3, 4adiazol-2-ylmethyl 186 2-NO2-4-S02MePh 5-methyl-1, 3, 4-thiadiazol-2-yl i-propyl 187 2-NO2-4-SOzMePh 5-methyl-. 1, 3, 4 ; thiadiazol-2-yl cyclopropi 188 2-NO2-4-SC) 2MePh 5-: rnethy4-1, 3ç4-4hiadiazol-2-yl CF3 189 9 2-NO2 4-SOzMePh benzoxazol-2-yl II 190 2-NO2-4-SO2MePh benzoxazol-2-l methyl 191 2-NO24-SO2MePh Ibenzoxazeil-2-yl i-propyl 192 2-NO2-4-SO2MePh benzoxazol-2-yl cyclopropyl 193 2-NO2-4-SO2MePh ibenzoxazo1-2-yl CF3 Compound N A R 194 2-N02-4-SO ; ! MePh 6-methylbeazoxazol-2-ylH 195 2-NO2-4-SO2MePh'6snePìyllienzoxazol-2byl | 196 2-N02-4-SOePh 6-methylt'ea ! zoxazol-2-yliropyi 196 2-NO2-4-St) 2MePh w IrptOpyl _ 197 2-NQ2-4S02MePh6- ! Nefhylbenzoxazol-2-yIoyclopropyi 198 2-NO2-4,-'802MePh r6 enzoxazol2-yl CF3 199 2-NO2-4-SQzMen benzothiazolylH 200 2-N04-S02'M : ePh beuzothtazl-2-ylmemyi 201 2-No-4-soX ; b : enzotl dazol*2-yl i-p} opyl. _ _ 202 2-N'C'2-4-SQ2MePh benzothiazoM-yIcyclopro-pyi 203 2 TO2-=so2Mh bezofiao1-2-1 cF3 204 2NO2-4-SI32'MePh pytaz. ol-l.-yl 13 2 () 5 2-NO2-4.-SO2MèP. b pyrazo ryl. rnethyl 206 2N02-4-S02MePh pycazol--yli-propyi 207 2-NO2-4-So pæol-l-yl oyoloprtDpyl 208 2-N02-4''S02MePh pyEazol-l-ylCFs 209 2-ND2-4-S6t2MPh ppzol-3-yl H 21 () 2-NOr4-SO2MePh pyrazol-3-yl'methyl 211 2-N024-SO2MePh pyrazol-3-yl i-propyl 212 212 2-NO2-4 SO2MePh pyrazoWl-3-yl oyolopropyl 213 2-NO2-4-SO2MePh CF3 214 _2-NO2-4-SO2MePh L+methy, lpy zol-3-yl H 215 y CW l-methylpyrazçtl-3-yl methyl 216 2-NO2-4-SO2MePh 1,-m, ethylpyraz 3-yl i-propyl 217 2-NO2-4-SO2MePh 1-meiyllvyrazol-3-yl oyolopropyl -218 2-NtG) 2-4-SO2MePh 1-methylpyrazol-3-yl CF3 21 Sk 2-NO24-St02MePJ3e tetrazol-l-yl SI 220 2-N. 02-4-SO2MePh tetrazol-l-yl metyl 221 2-NO2-4-SOzIVMePh tetrazol-l-l i-propyl 222 2-NO2-4-SO2MePh tetrazol-1 yl cyclopropyl 223 2-NO2-4-SO2MePh tetrazol-l-yl CF3 224 2-NO2-4-S02MePh 5-methyltetrazol-1-yl H 225 2-NO2-4.-SO2MePh 5-methyltetrazol-I-yl methyl 226 2-ND24-SO2MeP. h 5-nictlnyltetrazol-l-yl i-propyl 227 2-NQ2-4-SO2MePh 5-methyltetrazol-1-yl cyclopropyl 228 2-NO2-4-S02MePh 5-methyltetrazol-1-l CF3 229 2-NO24-SO2MePh tetrazol-2-yl H 230 2-NO2-4-SO2MePh tetrazol-2-yl methyl 231 2-NO2-4-SO2MePh h tetrazol-2-yl i-p} opyl 232 2-N02-4-SOzIvMePh tetrazol-2-yl cyclopropyl 233 2-NO2-4-SQ2MePh tetrazol-2-ylCF' 234 2-N02-4-S02MePh 5-methyltetrazol-2-yl T3 235 2-NO24-SO21ZePh 5-1 : aethgtetrazol-2-yl tmelhyl 236 2-NO24-SO2MePh 5-methyltetrazol-2-yl i-propyl 237 2-NO2-4 SG>2MePh 5-methyltetrazol-2-yl oyolopropyl 238 2-NO2-4-SO2MePh 5-methyltetrazol-2-ylCPs" 239 2-NO24-SO2MeiPh 1-methyltetrazol-5-yl H Compound NABR m. p. CC) 240 2-NO2-4-S02MePh 1-methyltetrazol-S-yl methyl 241 2602-4-SO2MeP. h'1-meiy. lteEzi 5 yl Fpropyl 242 2-NO24-SQ2 1-mefiyliekol-S-yl oycloproPyl 243 2NO, 2-4-SO2MePh l-Re, thyStetrazol-5-yl CF3 244 2-N024-'SO. MePh 2-mefhyltetrazol-S-ylH 245 2-N02-4-SQzMeP& X-nictbylteol-S-ylmethyl 246 2-NO2-4-SO2MePh 2rnethy : ltetrazol-5- J i-propyl 24. 7 2 ; NO24-SC9IePh 291tetrazo-yl oyclopropyl 186 248 2-N02-4-SC'2MePh 2-nietbyltetrazol-5-ylCFg 249 2 NJ-4=SQ'zMeP. h 2SO XNOx-SOzMsPli pyndin-2-y ! methyl 251 2-N024-S02MeBh pymdm-X-yti-propyi 252 2-NOr4-SOzMePh pyidm-ytcyclopropyi 253 2- ! Sr02-4-SOePh pyndm-2-ylCFs 2S4 2-. N02-4-S02MePh pyndm-4-ylH 253 2sNO24-S, 02M, e, Ph P>>-yl H. 25$ 2-ND24-$, h PW4-yl melyl 256 2-NO24-SQ2 » h pyndill-4-yl i-propyl 257 2-N (:) p4-SO2MéPh pylidffl-4-yl eyclopropyl 258 2-N02-4-S02MePh pyndm-4-ylCF3 259 2-NO2-4, SO2MePh pyridk-3-yl 260 2-NO2-4-SO2Me : lEh py-3-yl meffiyl 261 2-N. 02-4-SO2MePh l3padìn-3-yl i-propyl 262 2-NOz-4-SO2MePh'diu-3-l cyclopropyl 263 2-NO2-4~S'02hIePh pyridill-3-yl CF3 264 2-N02-4-S02MePh 3-mt]-opyjim-4-ylH 265 2-NO24 SO2MePh FJw methyl 266 2-NO2-4-SO2MePh itro, pyr, idin-4-yl i-propyl 267 2 NZ-4=SZMePh 3 nitro"din-4.-I c clo ro 1 268 2-NO2-4-S (} zMePh 3-riitroDyndi-n4-yl cE3 269 2-NO2-4'SQ2MePh 5-cyanopyx-2-yl H 270 2-NO24 SO2MePh 5-oyanopyridin-2-yl Dlethyl 271 2-NO2-4-SO2MePh 5-oyanopyri'din-2-yl ì-propyl 272 2-NC>2-4-$02MePh 5-cyanoDYndin-2-yl cYoloDroDYl 273 2-NO2-4-SO2MePh 5-cyanopyridin-2-yl CF3 274 2-N02-4-SQ2MePh 5-triffuoromethyl'din-2-1 IH 275 2-NOz-4.-SO2MePh 5-trifluoromethyl ytitlin-2-yl : methyl 276 2-NO2-4-SO2MePh 5-. trifluoromethylpyridsn.-2-yl i-propyl 277 2-NO2-4-SO2MePh 5-tcifluoromethylp°din-2-1'cyclopropy1 278 2 NCO-9=St72MePh 5 tiifluoromethylp ric'Gin-2 yl GF3 279 2-NO24-SO2MePh pyrimi&-2-yl H 280 2-NO24-SO2MePh _ pyrimidin-2-yl methyl 281 2-NO2-A-SO2MePh py. r ; ir iidin-2^yl i-propyl 282 2 N02-4-SOZMePIz din-2-1 c clo ro 1 283 2-NO2-4-SO2MePh pvdìn-2-yl CF3 284 2-N02-4-S02MePh pynmdm-4-ylH 285 2-NO2-4-SO2MePh pyrimidin-4-yl methyl -/ort Compound NABR m. p. (°C) 2862-NOr4-SOxMePh pynmidm.-4-yli-propyi -. 28 7. 2eNQ2-. 4-SO2Me *,, 4-yl,,, cyclopropyl 287 2-jSrOz-4-S02MPh pynmidin-4-ylcyelopropyi 2$9 2-N02-4-S02MePli pydmidin-4-ylCFs 2, 90 2 vM02-4-S02 6-C66-4-Yl i-pIOpyl _ us 291 2 NCl2-4-S02MePk 6-ohlosQ "din-4-1 c clo xo 1 dz T02-4SCJ2MePh 6 oilorp ; yritnidin--yI CF3 293 2-NQ2-4-SOePh pynagn-3-ylH 294 2 : Nd2-4-50211ePh da-.-T meth 1 : 295 ZNQx-SOzMePh pyndazla-3-yli-propyi 296 _ 2-NO2 » 4-SO, 2Mel pyTidazm-3-yl cyclopropyl 297 2 : N02-4SI721VZePli'daziii-3=yl B8 _ 2-NO2+. 4-S'6-o1qpylidakia-3-yl melhyl 2992-NOr4-S02MePh6-oMoropyndazin-3-yll-pjropyi 3002-N024-SQzMeP. h6-cldoropyndazm-3-yloyolopropyi 301 2-2-4-SO2MePh ; 6-ioropyx, idazal 3-yl (: F3 302 2-NO2-4-SO2MePh pyrazin-2-yl methyl 303 2 N02-4-SOzMeh pyrazin 2 1 z-co y . 3 4 2-N (32-4-SQ2MePh pBazrn-2-yl cyclopropyl 305 2-NQ2-4-SO2MePh pyrav : 1n-2-yl CF3 306 2-NO2-4-SO2MePh Eazin-2-yl methyl 307 2-ND2-4-SO ; : MepJi azin-2-y ! t-propyi 308 2-NO2-4-SO2MePh triazrn-2-yl cyclopropyl 389 2-N02-4-S02MeEh. (nazim-2-ylCFa 3 i 2-NO2-4-S021. QèPh, quinolin ;-2-yl melEyl 311 2-NO24-SO2MePh quiilolin-2-yl i-propyl Sl2 2-NO24-Sl :) 2MePh jqumok 2-yl cyclopropyl 313 2-N02-4-SOzMePh qumolm-2-ylCFs 314 2 NOZ-4-S02MePh 4, 4, 6fiim 1-5, dm-I, 3 (4'2-H 315 2-N02-4-S02MePli 4A6-tnmel-5, 6-<Shydm- !) (4B-oxan] i-2-yl methyl 316 2-NO24-$02MePh 4, 4, 6-tnmekl-5, 6-dihydro-1, 3 (41"mm-2-yl i-propyl 317 2-NO24-SO2MePh _ _ 4, 4, 6ietliyl5, iXyb1, 3 (4n-2-yl cyclopropyl 318 2-N02-4-SOMeEbL 4, 4, 6-tnme-5, 6-<Sdm-l, 3 (4-oxazin-2-yl CFs 319 2-NO2-4-SO2MePh 2-oxazolidinon-3-1 H 320 2-NO2-4-SO2MePh 2-oxazoliduon-3-yl methyl 321 2-NO2-4.-SUZ02MePh 2-oxazolatldinon-3-yl i-ropyl 322 2-NO2-4-SO2MePh 2-oxazolidinon-3-yl cyclopropyl 323 2-NO2-4-SO2MePh 2-oxazoli&on-3-yl CF3 _ 324 2-NO2-4-SQ2MePh 2epyilTolådinon-l-yl me&Zyl 325 2-NO24-$02MePh. 2-pyIrolidibon-l-yl i-propyl 326 2-NO2-4-SO2MePh 2-pyrrolidirton-Xa-yl-cyclopropyl . 327 _ 2-NO2-. 4-SO2Me 2-pyirdidinox-yl CF3 _ 328 2-NO2-4-SO2MePh 3-methylisoxazol-5 yl methyl 329 2-NO2-4-SO2MePh 3-methylisoxazol-5-l i-propi 330 _ 2-NO24-SO2MèPh 3-: elyliZsoxazol-5-yl cyclopropyl 331 2-NO2-4-SO2MePh 3-melhylisox3zol-5-yl CF3 CompotmdNABR m. p. ("C) . 332 2-NO2-4-SO2MePh 2-NO2-4-SO2MePh H 333 2-N02-4-S02MePh 2-N02-4-S02MePhmethyl 334 2-Na2--SQ2MePh 2-NO24-SO2MePh i-propyl . 3. 5 2wNO2-4-SO2MePh 2-NO, 2-4 SO2MePh cyclopropyi 336 2-N02-4-SOzMePh 2-N02-4-S02MePh-C 337 2-N02-4-S02MePh 2-Cl-4-S02MePhH 338 2-N02-4-S02MePh 2-Cl-4-S02MePhmeyl '339 2-NÓ2-ß'SQ2MePh 2-Cl-4-S02MePhi-propyi 340 2-N02-4-S02MePh 2-Cl-4-S02MePhcyclopropyi 341 2-N02-4-S02MePh 2. Cit-4-S02M : ePhCFa 342 X-NOS&zM'h 2-N02-4-CFPhH 343 2-NO2-4-S02MePh 2-Nò2-4XF3Ph methyl 344 2-OJO2-4-'SO2Me, P, h 2-ND2-4-C3RgPh. i-propyl T3 4 5 2-NO2-4-SO2MePh 2-NO2-4-CF3Ph cyclopropyl 3 46 2-NO2-4-SO2MePh 2-N 024-CF3Ph CF3 347 347 2-NO2-4tSO2Me ; Ph 2-m2-4v h H 348 2-NO24-S02MePh 2-NQ24-ClPh methyl 349 2-NO2-4-S02MePh 2-N02-4-ClPh i-propyl 350 2-NO2-4-SOzIUMePh 2-N02-4-CIPh cyclopropyl 351 2-N02-4-SQ2MePh 2-N02-4-C ! PhCFa . 52. 2-NO2-4-SO2MePh 2-Cl-4-NO2Ph 353 2--NO2-4-SO2MeP, h 2-Gl-4-NOiPh zmethyl 354 2-NO2-4-SO2MePh 2-CI4-NO2Ph i-propyl . 3 55 2-NO2-4-SO2MePh 2-CI-4-NO2Ph cyolopropyl 3 5 6 2-NO2-4-SO2MeP. h 2-C1-4-NO2P. h CF3 3 57 2-NO2-4-SOzMePh 2, 4-(NO2) 2Ph E . 358 2-NO2-4-502MePh 2, 4- (NO,) 2Ph methyl 359 2-NO2-4-, SO2MePh 2, 4- (NO02Ph i-propyl 360 2-NO24-SO2MePh 2, 4- (N02) 2Phcyeloppyi . 361 2-N02-4-SOMePh 2, 4- (N02) 2PhCFa 362 2-NO2-4'SQ2MePh 4 F-3-NO2Ph H 363 2-N02-4-SO2MePh 4-F-3-NO2Ph methyl 3640 2-NO24 SO2MePh 4-F-3-No2Ph i-propyl 365 2-N02-4-S02MePh 4-F-3-N02Phoyclopropyi 366 2-NO24-SO2MePh 4-F-3-NO2Ph CF3 . 367 2-NQr4-S02MePh 3, S- (CF3) 2PhH 368 2-NO24-SO2MePh 3, 5- (CF3) 2Ph 369 2-N02-4-SO2MePh 3, 5-(CF3) 2Ph i-propyl . 370 2-NO2-44302Meph 3, 5-(CF3) 2Ph cyclopropyl 3 71 2-NO24-SQ2MePh 3, 5- (CF3) 2Ph CF3 372 2-NO2-4-SO2MePh 2-SO2Me-4-CF3Ph H 373 2-N02-4-S02MBPh 2-S02Me-4-CFPhmethyl 3 74 2-NO24-SO2MePh 2-SO2Me4-CF3Ph i-propyl . 375 2-NO2-4-SO2MePh 2-SO2Me-4-CF3Ph cyclopropyl 376 2-NQ2-4 SO2MePh 2-SO2Me-4-CF3Ph CF3 J Compound N A B R ULP. 377 2-iCI-4-SON, ePh 1, 2, 4-oxadiazol-5-yl H. 378 2-C1-4 SO2MePh 1, 2, 4-oxadiazol-5-yl methyl 379'2wCI-4-SO2M, i « Pll | lt2, 4-owadivt 5-yl i-propyl 380 2-Cl-4-S02MePh l, 2, 4-oxadiazol-5-yl cyclopropyl 381 2-Cl-4-S02MePh l, 2, 4-oxadia ? ol-5-ylCFg 32 2-iCl-4-SÒ2wPh 3-methyl-l, 2, 4-oxadiazol-5-yl H 383 2-Cl-4-S03MePh 3-me<hyt-l, 2, 4-oxadiazol-5-ylmethyl oil 384 2-Cl-4-S02MePh 3-methyl-l, 2, 4-'oxadiazol-5-yli-propyi 174 385 2-Cl-4-SO2MePh 3-methyl-l, 2, 4-oxadiazol-S-yl cyclopropyl 188 386 2-CM-SOePh 3-ni9thyl-l, 2, 4-oxadiazol-5'ylCFs 387 2-Cl-4-. S02'MePh 3-tnRHoromethyl-l, 2, 4-oxadiazol-5-yl EI 388 2-Cl-4-$ePh 3-tnfluorom3thyl » 1, 2, 4-oxadiazol-5-yl methyl 389 2-Cl-4-SO2MePh 0 3-tri, E'l'uorometh, yl-1, 9., 4-oxadiazol-5-yl i-propyl 390 2-Cl-4-S02MePh 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 391 2l-4- S02MePh 3-lrifluoromethyl-1, 2, 4-oxadiazol-5-yl CF3 392 2-Cl-4-S02MePh 1, 2, 4-oxadiazol-3-yl H 393 2-CI-4-SO2MePh 1, 2, 4-oxadiazol-3-yl methyl 394 2-CI-4-SO2MePh 1, 2, 4-oxadiazol-3-yl i-propyl 395 2-Cl-4-S02MePh 1, 2, 4-oxdiazol-3- 1 cyclopro yl 396 | 2-C1-4-SO2MePh 1, 2, 4-oxadiazbl-3-yl CF3 397 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-oxadiazol-3-yl H 398 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-oxadiazol-3-yl methyl 399 2-Cl-4-S02MePh 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 400 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 401 2-Cl-4-SO2123 ; ePh 5-methyl-1, 2, 4-oxadiazol-3-yl CF3 402 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl H 403 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl methyl 404 2-Cl-4-SO2MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 405 2-Cl-4-S02MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 406 2-CI-4-SO2MePh 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 407 2-Cl-4-SOSMePh 5-chloro-1, 2, 4-oxadiazol-3-yl H 408 2-Cl-4-S02MePh 5-chloro-l, 2, 4-oxadiazol-3-ylmethyl 409 2-Cl-4-SO2MePh 5-chloro-1, 2, 4-oxadiazol-3-yl i-propyl 4 ; 10 2-Cl-4-SOXePh 5-chloro-1, 2g4-oxadiazol-3-yl cyclopropyl 411 2-Cl-4-SO2MePh 5-chloro-1, 2, 4-oxadiazol-3-yl CF3 412 2-Cl-4-SO2MePh 1, 34-oxadiazol-2-yl H 413 2-Cl-4-SO2MePh 1, 3, 4-oxadiazol-2-yl methyl 414 2-Cl-4-SO2MePh 13, 4-oxadia2 ; ol-2-yl i-propyl . 415 2-Cl-4-SO2MePh 1, 3, 4-oxadiazol-2-yl cyclopropyl 416 2-Cl-4-SO2MePh 1, 3, 4-oxadiazol-2-yl CF3 417 2-Cl-4-SO2MePh 5-methylsulEonyl-i, 3, 4-oxadiazol-2-yl H mp, Compound N. ( B R 2-Cl-4O02MePh S,-methylsulfonyl-1, 3, 4-oxadiazol-2-yl methyl 419 2-CI-4-SOsMePh 5-met. hylsulionyl-1, 3, 4-oxadiazol-2-yl i-propyl or 420 2-Cl-4-SO2M, ePh 5<, ethyls onyl-1, 3, 4-oxa, dlazol-2-yl cyclopropya 421 2-Cl-4-$02MePh 5-methylsulfonyl,-1, 3, 4-oxadiazol-2-yl CF3 422 2-CI-4-SOfePh 3-methyl-3, 4-oxadiazol-2-ylJH 423 2-Cl-4-SO2Wh 5yl-1, 3, 4-oxadiazol-2-ylmethyl 424 2-CI-4-SÒ 5-triethyl-1, 374-oxadiaz, Jol-2-yl i-propyl 425 2-CI-4-S4 ; 5-rn'ethyl-1 3v4 ; osa, diazol.-2-yl cyclopropyl 426 2-Cl-4-S02MePh 5-metliyl-1, 3, 4-oxadiazol-2-yl CFs 427 2-Cl-4S02MePh 5-tnorodethyl-l, 3, 4-oxadiazolyl H 428 2-Cl-4-S (72MePh 5-trifluoxoznethyl-1, 3, 4-oxadiazol-2-yl 429 2-CI-4-SQaI2MePh 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl i-propyl 430 2-Cl-4-S02MePh 5't !-ifluoromethyl-l, 3, 4-oxadiazol-2-yl cyclopropyl 431 2-Cl-4-S02MePh 5-t)-iQuorometbyl-l, 3, 4-oxadiazol-2-yl CF3 432-2-Cl-4-SO2Wh 1, 2, 3-iazol-4-yl H 43 3 2-Cl-4-SO2MePh 1, 2, 3-triazol-4-yl methyl 434 2-Cl-4-S02MePh 1, 2, 3-tiazol-4-yl l-propyl 435 2-Cl-4-S021VIePh 1, 2, 3-triazol-4-yl cyclopropyl 436 2-Cl-4-SOXePh 1, 2, 3-triazol-4-yl CF3 437 2-Cl-4-SOzIVMePh l-methyl-1, 2, 3-triazol-4-yl H 438l 2-Cl-4-SO2MePh 1-methyl-1, 2, 3-triazol-4-yl methyl 439 2-Cl-4-S02MePh 1-rnethyl-1, 2, 3-triazol-4-yl i-propyl 440 2-Cl-4-S02MePh 1-methyl-1, 2, 3-triazol-4-yl cyclopropyl 441 2-Cl-4-SO2MePh 1-methyl-1, 2, 3-triazol-4-yl CF3 442 2-Cl-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl H 443 2-Cl-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl methyl s 444 2-Cl-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl i-propyl 445 2-Cl-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl cyclopropyl 446 2-Cl-4-SO2MePh 2-methyl-1, 2, 3-triazol-4-yl CF3 447 2-C1-4-SQ2M ePh 1, 2, 3-triazol-1-yl H 448 2-Cl-4-S02MePh 1, 2, 3-triazol-1-yl methyl 449 2-Cl-4-S02MePh 1, 2, 3-triazol-I--yl i-propyl 45 () 2-Cl-4-SO2MePh l, 2, 3-triazol-l-yl cyclopropyl 2-Cl-4-SO2MePh 1, 2, 3-triazol-1-yl CF3 452 2-Cl-4-SO2MePh l, 2, 3-triazol-2-yl H 453 2-CI-4-SO2MePE 1, v>3-triazol-2-yl methyl 454 2-Cl-4-SOzMePh 1, 2, 3-triazol-2-yl i-propyl 455 2-Cl-4-SO2MePh 1, 2, 3-triazol-2-yl cyclopropyl 436 2-Cl-4-SO2MePh 1, 2, 3-tiazol-2-yl CF3 457 2-Cl-4-S02MePh 1, 2, 4-triazol-1-yl H 458 2-Cl-4-SO2MePh 1, 2, 4-triazol-1-yl methyl 459 2-Cl-4-S02MePh 1, 2, 4-tiazol-1-sl. i-propyl 460 2-CI-4-S02MePh 1, 2, 4-triazol-1-yl cyclopropyl 162 461 2-Cl-4-SO2MePh 1, 2, 4-triazol-1-yl CF3 462 2-CI-4-SO2MePh imidazol-2-yl H 463 2-Cl-4-SQ2MePh imidazol-2-yl methyl CompoundN B | _ _ 464 2-Cl-4-SOePh imidaz, ol-2 yl i-propyi 465 2-CI-4-S02MePh imidazol-2-l cyclopropyl 466 2-C1-4-SO2gePh iBildazoi-2-yl CF3 467 2-Cl-4-SO2MePh imidazo1-1-yl II 468 2"4-SO2MbPh imidazol-1-ylmethyl 469 2Cl-4-SQ2MePh imidazol-1-yli-propyi 470 2-Cl-4 $0 » h imidazol-l-yl cyclopropyl 471 2-Cl-4-S02MePh imidazol-1-yljCFs 472 2-Cl-4-S02MePh imidazol-4-ylJH 47. 3 2-Cl-4-S02MePh imidazol-4-ylmethyl 474 2-Cl-4-S029h imIdAzo1-4-yl i-propyl 475 2-Cl-4-S02MePh imtdazol-4-ylcyclopropyi 476 2-Cl-4-S02MePh imidazol-4-yljO 477 2-Cl-4-S02M ; ePh thiazol-2-ylH 478 2-Cl-4-SOAlePh thiazol-2-yl methyl 479 2-Cl-4-SO2MePh thiazol-2-yl i-propyl 480 2-CI-4-SO2MePh thiazol-2-yl cyclopropyl 481 2-Cl-4-S02MePh thiazol-2-yl CF3 482 2-Cl-4-SO2MePh 4-m, ethylthia2ol-2-yl H 483 2-Cl-4-S02MePh 4-methylthiazol-2-ylmethyl 484 : 021YIePh 4-methyltliiazol-2-y i-ro yl 485 2-Cl-4-S02MePh 4-methylthiazol-2-y ! cyclopropyi 199 486 2-Cl-4-S02MePh 4-methylthiazol-2-yl CF3 487 2-Cl-4-SO2MePh oxazol-2-yl H 488 2-Cl-4-S02MePh oxazol-2-yl methyl 489 2-Cl-4-SOaMePh oxazol-2-yl i-propyl 490 2-Cl-4-S02MePh oxazol-2-ylcyclopropyi 491 2-Cl-4-SQ2MePh oxazol-2 yl CF3 492 2-Cl-4-S OPIePh 4, 5-dimethyloxazol-2-ylH 493 2-Cl-4-SO2MePh 4, 5-dimeXhy. loxazol-2-yl methyl 494 2-Cl-4-SO2MePh 4, 5-ditn. ethyloxazol-2-yl i-ro 1 495 2-Cl-4-SQ2*Ph 4, 5-dimethyloxazol-2-yl cyclopropyl 496 2-Cl-4-SO2MePh 4, 5-dimethyloxazol-2-yl CF3 497 2-Cl-4-S02MePh 2-oxazolm-2-ylH 498 2-Cl-4-SO2MePh 2-oxazolin-2-y1 methyl 499 2-Cl-4-SGJ2MePh 2-oxazolin-2-yl i-propyl 500 2-Cl-4-S02MePh 2-oxazolin-2-ylcyclopropyi 501 2-Cl-4-SO2MePh 2-oxazolin-2-yl CF3 502 2-Cl-4-S02MePh 4o4-dirnethyl-2-oxazolin-2-yl H 503 2-Cl-4-S02MePh 4, 4-dimethyl-2-oxazolin-2-ylmethyl 504 2-Cl-4-SO2MePh 4i4-dimethyl-2-oxazolin-2-yl i-propyl 505 2-Cl-4-SO2MePh 4, 4-dimethyl-2-oxazolin-2-yl cyclopropyl 506 2-U-4-802MePh 4, 4-dimethyl-2-oxazolin-2-yl CE3 507 2-Cl-4-SO2MePh 1, 2, 4-thiadiazol-5-yl H 508 2-Cl-4-SOAMePh 1, 2, 4-thiadiazol-5-yl methyl 509 2-Cl-4-S02MePh 2, 4-miadiazol-5-yli-propyi CompoundN A B R'' 5M"2-Cl-4-SOMePh l, 2, 4-thiadiazol-5-yl cyclopropyi 511 2-CI-4-S02MePh I, 2, 4-thtadiazol-5-ylCFs 5112 2-CI-4-S02MePh 3-methyl-1 2, 4ihiadiazol-5-ylH 513 2-CI-4-S02MePh 3-methyl-l, 2, 4-thiadiazol-5-yl methyl 514 2-Cl-d4-Sß2MePh. 3. methyl-l, 2, 4-thiadiazol-5-yli-propyi 515 2-Cl-4-SQ2IVIePk 3-methyl-1, 2, 4-thiadiazo-5-y1 cyclo rro yl 516 2-CI-4-fSfQ2MePh 3-methyl-1 ? 2, 4-tMadtazol-ylCFg 517 2-CI-4-S02MePh 3-ttiitMoromethyl-l, 2, 4-tluadiazoI-5-yl H 518 -Cl-4-SOalV. e' 3ti'toomethyl-1, 2, 4-tliiadiazol5-yl methyl 2-Cl-4TS02MePh 3-txifluoxorilethyl-1, 2, 4-thiadiazolSyl i-propyl 520 2-CI-4-S02MePh 3-tnanoromethyl-l, 2, 4-thiadiazol-S-yl cyclopropyl 521 2-Cl-4-S'Q2MePh 3-Xuorometliyl-172, 4-iadiazol-5-yl CF3 522 2-Cl-4-SQ2M, ePh 1, 2, 4-tliiadiazol-3-yl H 523 2-CI-4-S12MePh 1, 2, 4-thiadiazol-3-yl methyl 524 2-CI-4-S02MePh l, 2, 4-thiadiazol-3-yli-propyi 525 2-Cl-4-SO2MePh 1, 2, 4-1 hiadiazo-1-3-yl cyclopropyl 526 2-Cl-4-SO2MePh 1, 2, 4-thiadiazol-3-yl CF3 527 2-Cl-4-SO2MePh 5-methyl-l, 2, 4-thiadiazol-3-yl H 528 2-CI-4-SO2MePh 5-methyl-1, 2, 4Tthiadiazol-3-yl methy 529 2-Cl-4-SOX-Ph-thi 529 2-Cl-4=SO. VIePh 5-methyl-1, 2, 4-thiadiazol-3-yl i-propyl 530 2-Cl-4-SO2MePh 5-methyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 531 2-CI-4-SOXePh 5-methyl-1, 2, 4-thiadiazol-3-yl CF3 532 2-CI-4-SO2MePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl H 533 2-CI-4-SO2MePh 5-trifluoromethyl-1, 2, 4 thiadiazol-3-yl methyl 534 2-CI-4-SO2MePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl i-propyl 535 2-Cl-4-S02MePh 5-trifluoromethyl-1, 2, w _ cyclopropyl 536 2-Cl-4-S0zIVMePh 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl CF3 537 2-Cl-4-SO2MePh 113, 4-*iadiazol-2-yl H 538 2-Cl-4-SO2MePh 1, 3, 4-thiadiazol-2-yl methyl 539 2-Cl-4-SO2MePh 1, 3, 4-thiadiazol-2-yl i-propyl 540 2-Cl-4-SO2MePh 1, 374-thiadiazol-2-yl cyclopropyl 541 2-CI-4-SO2MePh 1, 3, 4-*iadiazol-2-yl C} S3 542 2-Cl-4-SO2MePh 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl H 543 2-CI-4-SO MePh 5-methy ulfonyl-1 3, 4-thiadiazol-2-yl methyl 544 2-Cl-4-SO2MePh 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl i-propyl 54s 2-Cl-4-SO2MePh 5-methylsulfonyl-1, 3o4-thiadiazol-2-yl I cyclopropyl 546 2-Cl-4-SO2MePh 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl CE3 547-2-Cl-4-SO2MePh 5-methyl-l, 3o4-thiadiazol-2-yl H 543 2-Cl-4-SO2M : ePh 5-methyl-1, 3, 4-thiadiazol-2-yl methyl 549 2-Cl-4-SO2MePh 5-methyl-1, 3, 4-thiadiazol-2-yl i-propyl 550 2-Cl-4-SO2MePh 5-methyl-1, 3, 4-thiadiazol-2-yl cyclopropyl 551 2-Cl-4-SO2MePh 5-methyl-1, 3, 4-thiadiazol-2-yl CF3 552 2-CI-4-SO2MePh benzoxazol-2-yl H s53 2-C1-4 SO2MePh benzoxazol-2-yl methyl 554 2-Cl-4-SO2MePh benzoxazol-2-yl i-propyl 555 2-C1-4-S 02MePh benzoxazol-2-yl cyclopropyl 556 2-Cl-4-SO2MePh benzoxazol-2-yl CF3 msp. CompoundN A B B 557 2CI-4-SOMePh 6-methylb-pnzoxizol-2-yl H 5S7 2. Cl-4-SO2MePh 6 _ H 5s8 2-Cl-4-SO2MePh W M methyl 559 2-GX-4S021V. e' 6-anethyl, benoxaol-2- 1 i-opyX 560 2-Cl-4-StJ2MePh 6-methyltienzoxazol-2-yl cyclopropyl 561 2-Cl-4-S02M, ePh kethybeooxsol-2-yl CE3 562 2-C402MePh_ beiazol-2-yl H 563 2-CI-4-SO2MePh beBzpthiazol-2-ylmethyl 564 2-. e 4-SO2Wh f betòtXol-2-yl i-propyl 565 2-Cl-4-S02MePh benzothiazol-2-yl cyclopropyl 566 2-Cl-4-S02MePh benzotbiazol-2-ylCFg 567 2-Cl-4-S02MePh pyrazdl-l-yl H 568 2-Cl-4-SO2MePh pyrazol-l yl methyl 2-oC1~4-S w pyråzS l-yl q i-propyl 570 2-CI-4-SO2A {ePh pymzol-1-yl cyclopropyl s 2-CI-4-SOMePh pyrazol--yljCFs 572 2-Cl-4-S02MePh pyrazol-3-yl H 573 2-C1-4-: pyrazol-3-ylmethyl 574 2-CI-4-S023Å : çPh pyra, zol-3-yl Fpropyl 575 2-Cl-4-SO2MePh pyrazol-3-yl cyclopropyl 576 2-Cl-4-S02MePh pyrazol-3-yl CF3 577 2-CI-4-SO2MeEh I-methylpyrazol-3-yl H 57 ; 8 2-Cl-4-SO2MePh 1 hylpyrazol-3-yl methyl 579 2-Cl-4-S02MePh 1-methylpyrazol-3-yl i-propyl 580 2-Cl-4-SO2MePh l-methylpyrazol-3-yl cyclopropyl 581 2-Cl-4-SO2MePh 1-methylpyrazol-3-yl CF3 582 2-Cl-4-SO2MePh tetrazol-1-yl H 583 2-Cl-4-SO2MePh tetrazol-l-yl methyl 584 2-CI-4-S02MePh tetrazol-l-yl i-propyl 585 2-Cl-4-SO2MePh tetrazol-1-yl cyclopropyl 586 2-Cl-4-SO2MePh tetrazol-1-yl CF3 597 2-CI-4-SO2MePh 5-methyltetrazol-I-yl H 588 2-Cl-4-S02MePh 5-methyltetrazol-l-ylmethyl 589 2-Cl-4-S02MePh 5-methyltetrazol-1-yl i-propyl 590 2-Cl-4-S2MePh 5-methyltetrazol-1-yl cyclopropyl 591 2-Cl-4-SO2MePh 5-methyltetraal-1-yl CF3 592 2-Cl-4-SO2MePh tetrazol-2-yl H 593 2-Cl-4-S02MePh tetrazol-2-yl methyl 594 2-Cl-4-S (32MePh teixazol-2-yl i-rop I 595 2-Cl-4-SO2 ; 1NIePh tetrazol-2-yl cyclopropyl 596 2-Cl-4-SO2MePh tetrazol-2-yl CF3 597 2-Cl-4-SO2MePh 5-methyltetrazol-2-yl H 598 2-Cl-4-SOaIVMePh 5-methyltetrazol-2-yl methyl 599 2-Cl-4-SO2MePh 5-methyltetrazol-2-yl i-propyl 600 2-Cl-4-SO : RePh 5-methyltetrazol-2-yl cyclopropyl 601 2-Cl-4-SO2MePh 5-methyltetrazol-2-yl CF3 2-Cl-4-S02MePh 1-methyltetrazol-5-yl i ups Compound N A g R mp. (duc) 603 2 CI-4-SO2MePh l-meFtetrazol-5-yl methyl... 604 2-Cl-4-S02MePh l-methyltetrazol-5-yli-propyi t605 o. C1-4-80 lwtetgol-S-yl cyclopropyl 104i 606 2-Cl-4-SOtePh l-methyltetrazol-5-ylCFs 607 2-Cl-4-SO2M ePh_. 2<ethylte. trazol-5-yl t-butilç oil 698 2-Cl-4-S02MePh 2-methyltetrazol-5-ylmethyl 609 Z.. GI-4-5021IePh -xnetliy : tetrazol-S-yl i-pxop 210 6. 16 2-Ct-4-S02Me ? h 2-methyltetrazol-5-ylcyclopropyi 220 611 2-Gl-4-$02MePh 2-methyltetrazol-5-yl O3 a 2-Cl-4-S02IVlePh pyridin-2-yl H 613 2-ClaMePh pyridin-2-yl methyl 614 2-CI-4-S (32MePh p, y-^ridin-2-yl i-propyl 2-Cl-4-S02MePh pyridin-2-yl cyclopropyl 616 2-Cl-4-SO2MePh pyridin-2-yl CF3 189 2-Cl-4.-. SOePh pyridin-4-yl H 618 2-Cl-4-SO2MePh pyridin-4-yl methyl 619. 2-C1+S OXePh pyridin-4-yl i-propyl 620 2-Cl-4-S02MePh pyridm-4-ylcyclopropyi 621 2-Cl-4-S02MePh pyridin-4-yl CF3 -622 2-Cl-4-SO2Who g H 623 2-Cl-4-SO2MePh pyridin-3-yl methyl 624 2-Cl-4-S02MePh pyridm-3-yli-propyi 62 s 2-C1-4-S 02MePh pyridin-3-yl cyclopropyl 626 2-Cl-4-SO2MePh pyridin-3-yl CF3 627 2-Cl-4-S02MePh 3-nitropyridin-4-yl H 628 2-Cl4SOiMePh 3-nitropyridin-4-yl methyl 629 2-Cl-4-SO2MePh 3-nitropyridin-4-yl i-propyl 630 2-Cl-4-SO2MePh 3-nitropyridin-4-yl cyclopropyl 631 2-Cl-4-S03MeEh 3-nitropyridm-4-ylCFg 632 2-Cl-4-SO2MePh 5-cyanopyridin-2-yl H 633 2-Cl-4-SOeMePh 5-cyanopyridin-2-yl methyl i634 2-Cl-4-S02MePh 5-cyanopyridin-2-yl i-propyl 635 2-Cl-4-SO2MePh 5-cyanopyridin-2-yl cyclopropyl 636 2-Cl-4-SO2MePh 5-cyanopyridin-2-yl CF3 637 2-Cl-4-SO2MSh 5tifluoromethylpyridin-2-yl H 638 2-Cl-4-SO « ePh 5-trifluoromethylpyridin-2-yl methyl G39 2-Cl-4-SO2MePh 5-trifLuoromethy1pyridin-2-yl i-propyl 640 2-CI-4-SO2MePh 5-trifluoromethylpyridin-2-yl cyclopropyl 641 2-Cl-4-S02MePh 5-tnauojromethylpyridm-2-ylCFs 2-C1-4-SOZMePh pyrimidin-2-yl H 643 2-Cl-4-SÓ2MePh pyritnidin-2-yl 00 0 methyl 644 2-Cl-4-SO2MePh yrimidin-2-yl i-propyl 645 2-Cl-4-SO2MePh pynmidin-2-yl < X cyclopropyl 646 2-Cl-4-SO2MePh pyrimidin-2-yl CF3 647 2-Cl-4-SO2MePh pyrimidin-4-yl H -648 2-Cl-4-SO2MePh pylimidin-4-yl methyl CompoundN A B R 649 2-Cl-4'SQeT ? h pyrimidm-4-yli-propyi 650 2-Cl-4-S02MePh pymmdin-4-ylcyclopropyi 651 2-Cl-4S02MePh pynmidm-4-ylCFg 652 2-Cl-4-SQ2SPh vdin-4-yl methyl 6s3 2-C1-4-SO » Ph S i-propyl 654 2-Cl-4-SONePh in-4-yl cyc10propyl 655 2-Cl-4-SòXeth Ymidin-4-yl CEi3 G56 2 Cl-4-SO. 2 » vda*3-yl E 657 2-Cl-4-S02MePh pyjddazm-3-ylmethyl 658 2-Cl-4-S02IYIePh pyridazin-3-yl i-propyl 659 2-Cl-4-SOeh pyndazin-3-ylcyclopropyi . 660 2-C1-4-SO2MPh pwdvin-3 zyl CF3 1661 2-CM-SQ2aPh6-cMGrQpyrid9zin-3-ylmethyl 662 2-Cl-4-SOzIVMePh 6-ch pyridain-3-yl i-propyl _ 2-Cl-4-S02MePh 6-ohloropy]'idazni-3-ylcyclopropyi 664 2-Cl-4-SO2wt h 6-chloropyridazin-3-yl CP3 66s 2-Cl-A-S021VIeFh pyrazi'n-2 Yl meth 1 666 2-Cl-4-SO2MePh pyrazW bpropyl 667 2 Cl-4-SO2MaPh pyrazin-2-yl_ _ cyclopropy 668 2-Cl-4-S02MePh pyiazm-2-ylCFs 669 2-Cl-4-SO2MePh triazin-2-yl methyl 670 2-Cl-4-SO2MePh triazin-2-yl i-propyl 671 2-Cl-4-S02MePh triazin-2-yl cyclopropyl 672 2-Cl-4-S02MePh triazin-2-yl CF3 673 2-Cl-4-S02MePh quinolin-2-yl methyl 674 2-Cl-4-SO2MePh uinolin-2-yI i-ropyl 2-CI-4-SO2MePh uinolin-2-l cyclopropyl 676 _1_q. _S'p2ePh uinolin-2-yl CF3 677 2-Cl-4-S02MePh 4, 4, 6. <nmeaiyl-3, 6-didto-l (4H)-oxazni-2-yl H 678 2-Cl-4-SO2MePh 4, 4, l73fl+-2-methyl 679 9,-Cl-4-SO2MePh 424, 6t yldb diihyb1b (4W-2-yl i-propyl 680 2-Cl-4-SO2MePh 4, 46-rimethyl 5 ; 6=dydro-l, 3' (4I-oxazan 2 yl cyclopropyl 681 2-Cl-4-SO2MePh 4, 4, 6-ttimethyl-, 5., 6-dihydro-1, 3 (4M-oxa2in-2-yl CF3 692 2-CI-4-SO2MePh 2-oxazolidinon-3-yl H 683 2-Cl-4-SO2MePh 2-oxazolidinon-3-yl methyl . 684 2-Cl-4-SO2MeP_ 2-osazolidinon-3-yl i-propyl. 685 2-Cl-4LS'0XePh v cyclopropyl 686 2-Cl-4-SO2MePh 2-oxazolidinori_-yl. CP3 G87 2-CI-4-SO : ePh 2-. pyrrolidinon-1-yl methyl 688 2-Cl-4-S02MePh 2-pylTolidinon-l-yl i-propyl 689 2-Cl-4-SO2MePh 2-pyrrolidinon-1-yl cyclopropyl 690 2-Cl-4-SO2MePh 2-pyrroldinon-1-yl CE3 691 2-Cl-4-SO2MePh 3-methylisoxazol-5-y methyl 692 2-Cl-4-SO2MePh 3-methylisoxazol-5-yl i-propyl 693 2-Cl-4-S02MePh 3-methylisoxazol-5-yl cyclopropyl 04 2-Cl-4-SO2MePh 3-methylisoxazol-5-yl CF3 Compound N B CL) 6295'2-Cl-4-SO2MePh 2-NO2-4-SO2MePh. 696 2-CI-4-S02MePh 2-NO2-4-SOaMePh methyl 697 SCl-4-SOA 2 NQZ-4-SOah2MePh i-propyl 698 2-Ck4-SOH'ON02-4-SO3 cyclopropyl . 699 2-Cl-4-S02MePh N02-4-S02MePhCFg 700 2-Cl-4-S02MePh 2-Cl-4-S02MePhJH 701 2-Cl-4-SOXPh 2 4-, SONePh methyl 792 2-Cl-4-S02ePh 2-Cl-4-S02MePhi-propyi 703 2-Cl-4-S02MePh 0 2tC1-4-SO2WPh cyclopropyl 704 2-Cl-4-S02MePh 2-Cl-4-S02MePhCF 705 2-Cl-4-SOiMePh 2-NQ2-4-@3Ph H 706 wh 26Q2-4-Wh methyl 707 2-Cl-4-SO2MePh -NQ2-4-CERh ì-propyi 708 2-Cl-4-S02MePh 2-N02-4-CF3Ph cyclopropyl 709 2-Cl-4-S02MePh 2-N02-4-CF. 3PhCFs 710 2-Cl-4-SO2MePh 2-NO2-4-ClPh H 711 2-Cl-4-SO2MePh 2-N02-4-ClPh methyl 712 2-Cl-4-SO2MePh 2-N02-4-CIPhi-propyi 713 2-Cl-4-SO2MePh 2-NO2-4-ClPh cyclopropyl 714 2-Cl-4-SO2MePh 2-N02-4--C'Eh CF3 715 2-Cl-4-SO2MePh 2-Cl-4-NO2Ph H 716 2-Cl-4-SO2MePh -CM-NOzPhmethyl 717 2-Cl-4-$Q2MePh 2-Cl-4-NO2Ph i-propyl Z-Cl-4-SO2MePh 2-Cl-4-N02Ph cyclopropyl 719 2-Cl-4-SOiIVIePh 2-Cl-4-NO2Ph CF3 720 2-Cl-4-S021VIePh 2, 4- (NO2) 2Ph H 721 2-Cl-4-SOzM : ePh 2, 4- (N02) 2Phmethyl 722 2-Cl-4-SO2MePh 2, 4- (N02) 2Phi-propyi w 723 2-Cl-4-SO) £ePh 2, 4->002Ph cyclopropyl 67 724 2-Cl-4-SO2MePh 2, 4-6Q2) 2Ph CF3 725 2-Cl-4-SO2MePh 4-F-3-NOzPh H 726 2-Cl-4-SO21 ! SePh 4-F-3-NO2Ph methyl 727 2-Cl-4-SOzIVIePh 4-F-3-NO2Ph i-propyl 728 2-Cl-4-S02MePh 4-F-3-NQ2Phcyclopropyi 729 2-Cl-4-SO2MePh 4-F-3-N02Ph CF3 730 2-Cl-4-S02MePh 3, 5- (CF3) 2Ph H 731 2-Cl-4-S02MePh 3 ; 5- (CF3) zPhmethyl 732 2-Cl-4-S02MePh 3, 5- (CF3) 2Phi-propyi 733 2-Cl-4-SO2MePh 3, 5-(CF3) 2Ph cyclopropyl 734 2-CI-4-SV : NePh 3, 5- (CF3) 2Ph CF3 735 2-Cl-4-S02MePh 2-S02Me-4-CF3PhH 736 2-Cl-4-SO2MePh 2-SO2Me-4-CF3Ph methyl 737 2-Cl-4-SO2MePh 2-S02Me-4-CF3Ph i-propyl 738 2-Cl-4-S1.'2MePh 2-SO2Me-4-CF3Ph cyclopropyl 739 2-C 1-4-S 02MePh 2-S 02Me-4-CF3Ph CF3 CompoundN A B R m p. ¢C) 740 4-Cl-2-NO2Ph 1 ? 2j4-oxadiazol-5^yl H 741 4-Cl-2-fl) iPh 0, 4 oxadiazol-5-yl methyl.. 742 4-C1-2XR, h 1, 2, 4-oxadiazol-5-yli-propyi 743 4-Cl-2-N02Ph 2, 4-oxadiazol-5-ylcyclopropyi ? 44 4-Cl-2-. M12Phi 1, 2, 4-oxadiaz : ol-5-yl C : F3 745 4-C1-2-NiO2Ph 3-me*ß-1, 2ç4-osadiazol-5-yl H,,,, 746 4-Cl--N'02Ph 3-methyM, 2, 4-oxadiazol-5-yl mçthyl 747 4-Cl-z-NO,-Xii _ _ + ;-1, 2j4-oxadiazol-5-yl iupropyl 748 4-Ci-2-N. 3ethyl-2, 4-oxadiazol-5-ylcyclopropyi 127 749 _Cl-2-NO2Ph 3-methyt-I >2, 4-oxadiazol-5-yl CF3 750 4-Cl-2-NQ2Ph 3-1na ; uoromethyl-l, 2, 4-oxadiazol-5-yl H 751 -Cl2-T42Ph 3=triflucromethy-1, 2, 4-oxadiazol-S-yl methyl 752 4-Cl-2-N02Ph 3-tnNnoromemyl-l, 2, 4-oxadiazol-5-yl i-propyl 753 4-C1-2,-N02Ph 3-XifluoroWl, 2, 4-oxadiazol-5-yl cydopropyl 7s4 4-Cl-2-N02Pk 3-triifluiorometliyl-1 ? 2, 4-o2cadiazol-S-yl CF3,. 755 4-CI 2-NO2Ph 1, 2, 4-oxadiazol-3-yl Ii 756 4-Cl-2-NO2Ph 1, 2, 4-oxadiazol-3-yl methyl 4-Cl-2NOZPh 1, ; 4-oxadiazol-3-yl i-propyl 758 4-Cl-2-NO2Ph 1, 2, 4-oxadiazol-3-yl cyclopropyi 759 4-Cl-2-N02Ph l, 2, 4-oxadiazol-3-ylCFs 760 4wCl-2-NQ2Ph S-methyl-l, 2, 4-oxadiazol-3-yl H 761 4-Cl-2-NO2Ph 5-methyl-1, 2, 4-oxadiazol-3-yl methyl 762 4-CI-2-NO2Ph 5-methyl-l, Ç+4-oxadiazol-3-yl i-propyl 763 4-Cl-2-NO2Ph S-methyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 764 4-Cl-2-NO2Ph 5-methyl-122i4 xadiazol-3-yl __ CF3 765 4-Cl-2-N02Ph 5-triikoromethyl-1, 2, 4-oxadiazol-3-yl H 766 4-Cl-2-NO2Ph S-trifluoromethyl-1, 2, 4-oxadiazol-3-yl methyl 767 4-Cl-2-NO2Ph 5-trifluoromethyl-1, ?, 4-oxadiazol-3-yl i-propyl 768 4-CI-2-N02Ph 5-trifl. oromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 769 4-Cl-2-N02Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 770 4-Cl-2-N02Ph 5-chloro-1, 2, 4-oxadiazol-3-yl H 771 4-Cl-2-N, 02Ph 5-chloroZ, 4-oxadiazol-3-yl methyl 772 4-Cl-2-NO2Ph 5-cKoro-1, 2, 4-oxadiazol-3-yl i-propyl 773 4-Cl-2-NO2Ph 5-chloro-1, 2, 4-oxadiazol-3-yl cyclopropyl 774 4-Cl-2-NO2Ph 5chlor-l, r2, 4-oxadiazol-3-yl CE3 775 4-Cl-2-N02Ph 1, 3, 4-oxadiazol-2-yl H 4-Cl-2-NO2Ph 1, 3, 4-oxadiazol-2-yl methyl 777 4-Cl-2-NO2Ph 1, 3, 4-oxadiazol-2-yl i-propyl 778 4-C1-2 N02Ph 1, 3, 4-oxadiazol-2-yl cyclopropyl 779 N02Ph 1, 3, 4-oxadiazol-2-yl CF3 780 4-Cl-2-NO2Ph 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl Compound N A R 7, 81 4-C, 1-2m0Wh X < methyl 782 4-CI-2-NpO@h S-methylsibuyl-l, 3, 4-oxadiazol-2-yl i-propyl 783 4sCl-2-NORh'5-meWs~. nyl-l, 3, 4-oxadiazol-2-yl cyciopropyl 784 4-Clt2w2Ph 5+1sinAl, 3, 4-oxadiazol-2-yl CF3 785 4-Cl-2-N02Ph 5-memyl-l, 3, 4-oxadiazol-2-ylH 786 4-Cl-2-NQzPh 5-methyl-l, 3, 4-oxadiazol-2-ylmethyl 4-CT-2,-'T42P1 -rnethY-a ;'-oxadiazoX-2-yl i-propyl 7S8 4-Cl-2-N02Ph5-methyl ? l, 3, 4-oxadiazo2-ylcyclopropyi 789 4-Cl-2-N02Ph 5-methyl-l, 3, 4-oxadiazol-2-yljCFg 790 4-Cl-2-N02Ph S-tSuoromethyl'-l, 3, 4'-oxadiazol-2-yl H 791 4-Cl-2-N02Ph 5-tttNuoEomethyl-l, 3, 4-oxadiazdl-2-yl methyl 792 4-Cl-2-N02Ph 5-fluorornethyl-1, 3, 4-oxadiazol-2-yl i-propyl 793 4-Cl-2-N02Ph5-tdSuoromethyl-l, 3, 4-owaFazol-2-yl cyclopropyl 794 4-CI-2-NO2Ph $-ttiflúoromelylrl, 3, 4-oxadiazol-2-yl CF3 795 4-Cl-2-N02Ph l, 2, 3-tRazol-4-ylH 796 4-Cl-2-N02Ph T, 2, 3-triazol-4-yl methyl 797 4-Cl-2-NO2Ph 1, 2, 3-triazol-4-yl i-propyl 798 4-Cl-2-NO2Ph 1, 2,3-triazol-4-yl cyclopropyl 799 4-Cl-2-NO2Ph 1, 2, 3-triazol-4-yl CF3 800 4-Cl-9-NO2Ph l-methyl-122, 3-triazol-4-yl H 801 4-Cl-2-NO2Ph 1-methyl-1, 2, 3-triazol-4-yl methyl : 802 4-Cl-2-N02Ph 1-methyl-1, 2, 3-triazol-4-yl i-propyl 803 4-CI-2-NO2Ph l-methyl-l, 2, 3-triazol-4-yl cyclopropyl so4 4-Cl--N02Ph T-methyl-1, 2, 3-triazol-4-yl CF3 sos 4-Cl-2-N02Ph 2-methyl-1, 2, 3-triazol-4-yl H 806 4-CI-2-NO2Ph 2-methyl-1, 2, 3-triazol-4-yl methyl ; 807 4-Cl-2-NO2Ph 2-methyl-1, 2, 3-iazol-4-yl i-propyl 808 4-Cl-2-NO2Ph 2-methyl-1, 2, 3-triazol-4-yl cyclopropyl 809 4-Cl-2-NO2Ph 2-methyl-1, 2, 3-triazol-4-yl CF3 810 4-Cl-2-NO2Ph 1, 2, 3-triazol.-1-yl H 811 4-Cl-2-NOPh 1, 2, 3-triazol-l-yl methyl 812 4-Cl-2-NO2Ph 1, 2, 3 tria : zol-1- 1 i-pro yl 813 4-Cl-2-NO2Ph 1, 2, 3-triazol-1-yi cyclopropy, 814 4-Cl-2-NOsPh 172, 3-triazol-1-yl CF3 815 4-Cl-2-NO2Ph 1, 2, 3-triazol-2-yl 816 4-CI-2-NO2Ph 1, 2, 3-triazol-2-yl methyl 817 4-Cl-2-NO2Ph 1, 2, 3-triazol-2-yl i-propyl _ 8818 _ 4-Cl-2-NO2Ph 1, 2, 3-triazol-2-yl cyclopropyl 819 4-Cl-2-N02Ph l, 2, 3-triazol-2-yl CF3 820 4-Cl-2-N02Ph 1, 2, 4-triazol-1-yl H ; 82& 4-Cl-2-NO2Ph 1 t, 4-triazol-1-yl methyl 822 4-Cl-2-NO2Ph 1, 2, 4-triazol-1-yl i-propyl 823 4-Cl-2-NO2Ph 1, 2, 4-triazol-1-yl cyclopropyl 824 4-Cl-2-NO2Ph 1, 2, 4-triazol-1-yl CF3 825 4-Cl-2-NO2Ph imidazol-2-yl H ; 826 4-Cl-2-NO2Ph imidazol-2-yl methyl D mtp Compound N A $ R m, p. : gz7 4-Cl-2-N02Ph imidazol-2-yl i-propyl 828 4-Cl'-2-N02Phimidazol-2-ylcyclopropyi : 829 4-Cl-2-N02Ph imidazol-2-ylCFg 830 4-CI-2-NO2Ph inidazol-1-yl. : 8 4-Cl-2-N02Ph imidazol-1-ylmethyl 832 4-Cl-2-N02Phimidazdl-1-yli-propyi , 4-'Cl-2-N02Phimidazol-1-ylcyclopropyi 834 4-'Cl-2-N02Ph imidazol-l-ylCFg 835 4-Cl-2-NQ2Ph imidazol-4-ylH : 836 4-Cl-2ffiPh imidvol-4-yl meiyl.. 837 4-C1-2-N irWd. ol-4-yl i-propyl 838 4-Cl'-2-02Phimidazol-4-ylcyclopropyi 839 4-Cl-2-NO2Ph imidazol-4-yl CF3 840 4-Cl-2-N ( ? a. 'l thiazol-2 yl H . 841 4-Cl"2-N02Ph thiazol-2-ylmethyl 842 4-Cl-2-N02Ph thiazol-2-yl i-propyl . 843 4-Cl-2-N02Phthiazol-2-ylcyclopropyi 844 4-Cl-2-NO2Ph thiazol-2-yl CF3 845 4-Cl-2-N02Ph 4-methylthiazol-2-ylJH 846 4-Cl-2-N42Ph 4-methylthiazol-2-yl methyl 847 4-Cl-2-NO2Ph 4-methylthiazol-2-yl i-propyl 848 4-C1-. 2-NO2Ph 4-methylieol-2-yl cyclopropyl 849 4-Cl-2-N4zPh 4-methylthiazol-2-yl CF3 850 4-Cl-2-NO2Ph oxazol-2-yl H 851 4-Cl-2-NO2Ph oxazol-2-yl methyl 852 4-CI-2-NO2Ph oxazol-2-yl i-propyl . 833 4-Cl-2-N02Ph oxazol-2-ylcyclopropyi 854 4-Cl-2-NO2Ph oxazol-2-yl CF3 ; 855 4-CI-2-NO2Ph 4, 5-dimethyloxazol-2-yl H 856 4-Cl-2-NO2Ph 4, 5-dimethyloxazol-2-yl methyl 857 4-Cl-2-N02Ph 4, 5-dirnethyloxazol-2-yl i-propyl 858 4-Cl-2-N02Ph 4, 5-dimethyloxazol-2-yl cyclopropyl 859 4-Cl-2-N02Ph 4, 5-dimethyloxazol-2-ylCF3 : 860 4-Cl-2-N02Ph 2-oxazolin-2-yl H 861 4-Cl-2-NO2Ph 2-oxazolin-2-yl methyl : 862 4-Cl-2-NO2Ph 2-oxazolin-2-yl i-propyl 863 4-Cl-2-NO2Ph 2-oxazolin-2-yl cyclopropyl , 84 4-Cl-2-NO2Ph 2-oxazolin-2-l CF3 86S 4-Cl-2-N02Ph 4, 4-dimethyl-2-oxazolm-2-yl 866 4-Cl-2-NO2Ph 4, 4-dimethyl-2-oxazolin-2-yl methyl , 867 4-Cl-2-NO2Ph 4j4-dimethyl-2-oxæolin-2-yl i-propyl 868 4-Cl-2-NO2Ph 4, 4-dimethyl-2-oxazolin-2-yl cyclopropyi 869 4-Cl-2-N02Ph 4, 4-dimethyl-2-oxazolm-2-ylCF 870 4-Cl-2m0Wh 1, 2, 4-iaivol-5-yl E 871 4-Cl-2-N02Ph 1, 2, 4-thiadiaol-5 yl methyl $72 4-CI-2-NO2Ph 1, 2, 4-thiadiazol-5-yl i-propyl CompoundN 873 4-Cl-2-N02Ph l, 2, 4-thiadiazol-5-yl cyclopropyi 874 4-Cl-2-N02Ph l, 2, 4-wiadiazol-5-. ylCFs 87. 4'. Cl-2-N02Ph 3'-methyl-1. 2, 4-miadiazol-ylH 87, 5 4CI-2-NO, 2Ph 3- 876 4-Cl-2-N02Ph 3'. methyl-l, 2, 4-thi. adi : gol-5-yl rnethyl S77 4-C12-N02Ph 3-methyM, 2, 4-thtadiazol-5-yli-propyi -'878 4-Cl-2MQ2Ph 3-mes1, 2, 4-thd-5-yl cyclopropyl 879 4-Cl-2-N02Ph 3-methyH, 2, 4-thiadiazol-5-ylCFg 880 -1- : 2IOPh 3'triluorcrneth, l, l., , 4-thiadazo5 : y1 H 88'1 4-CI-2-M02Ph 3 Wor4ét} Syl 1, 2, 4 !-*iXazol-5-yl methyl 882 4-Cl. 2-NO2Ph 3-tn'fluorome-t-hiadiazol-5 i-prmyl 883 4-CI-260mPh 3 eifllaNyl-1, 2, 4-iadi azol-5-yl cyclopropyl 84 4-C2-NG !'jPh 3-tna : uoromcthyl-l, 2, 4-thiad'iazol-5-yl CF3 di '885 4-Cl-2-N02Ph l, 2, 4-thiadiazol-3-ylja 886 4-CI-2-NO2Ph 1, 2, 4-* 13 yl methyl % 87 4-Cld^NO2Ph i, 2, 42d3iadiazo-3-yl i-propyl 888 4-Cl-2-lyQ2Ph 1, 2, 4-thiadiazol-3-yl cyclopropyi 889 4-Cl-2-NQ2Ph l, 2, 4 thiadiazol-3byl CF3 890 4-CI-2-NO2Ph 5-methyl-l, 2, 4-thiadiazol-3-yl 891 4-CI-2-NO2Ph S-melyl-I, 2, 4-thiadiazol-3-yl methyl 892 4-Cl-2-N02Ph 5-methyl-l, 2, 4-thiadiazol-3-yli-propyi 893 4-Cl-2-NO2Ph 5-methyl-l, 2, 4-thiadiazol-3-yl cyclopropyl S94 4-Cl-2-N03Ph 5methyl-l, 2, 4-thiadiazol-3-ylCFs 895 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl H 896 4-Cl-2-N02Ph5-tdfluorometbyl-I, 2, 4-tbiadiazol-3-yl methyl 897 4-Cl-2-NO2Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl i-propyl 898 4-Cl-2-NO2Ph 5-trifluoromethyl-T, 2, 4-thiadiazol-3-yl cyclopropyl 899 4-Cl-2-N02Ph 5-tdfluoromemyl-l, 2, 4-thiadiazol-3-yl CF3 900 4-Cl-2-N02Ph 1, 3, 4-thiadiazol-2-yl H 901 4-Cl-2-NO2Ph 1, 3, 4-thiadiazol-2-yl methyl 902 4-CI-2-N02Ph 1, 3, 4-tliiadiazo4-2-yl i-propyl 903 4-Cl-2-N02Ph 1, 3, 4-thiadiazol-2-yl cyclopropyl 904 4-Cl-2-NO2Ph 1, 3, 4-thiadiazol-2-yl CF3 905 4-Cl-2-N02Ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl H 906 4-C1-2-NOjPh _ 5-methylsubonyl-1, 3+ol-2-yl methyl 907 4-Cl-2-NO2Ph S-methylsulfonyl-l, 3, 4-tlliadiazol-2-yl i-propyl 908 4-Cl-2-NO2Ph 5-meth. ylsubonyl-1, 3., 4-thiadiazol-2-sl cyclopropyl 909 4-Cl-2-NOzPh _'5-methylsifonyl-l, 3, 4-iaitol-2-yl CF3 910 4-Cl-2-NO2Ph S-methyl-I, 3, 4-thiadiazol-2-yl H 4=Cl-2 NCOPh 5-methyl-1, 3, -thiael : iazol-2-1 methyl 912 4-CI-2-NO2Ph 5-methyl-1, 3, 4-thiadiazol-2-yl i-propyl 913 4-Cl-2-NO2Ph 5-meiyl-l, 3, 4-thiadiazol-2-yl cyclopropyl 914 4-CI-2-NO2Ph 5-methyl-1, 3, 4-thiadiazol-2-yl CF3 s 4-Cl-2-NOa, Ph benzoxazol-2-yl H 916 4-Cl-2-NO2Ph benzoxazol-2-yl methyl 917 4-Cl-2-NO2Ph benzoxazol-2-yl i-propyl 4-Cl-2-NO2Ph benzoxazol-2-yl cyclopro I 919 4-Cl-2-N02Ph benzoxazol-2-yl CF3 CompoundN A R 920 4-Cl-2-NO2Ph 6-meiylbenzoxazol-7.-yl H _ 921 4-Cl-2-NO2Ph 6-methylbenzo, xazol-2-yl methyl 922 4'-Cl-2'-NOPh 6-methylbetizoxazol-2-yli'-propyi 923 4-Cl-2-NO2Ph 6.-methylbenzoxazol-2-yl cyclopropyl 924 4-C1-2, NO2Ph 6-meEemxazol-2-yl CF3. 925 4-Cl-2-N02Ph _ benwlhiazol-2-yl H 926 4-Cl-2-NO2Ph benzothiazol-2--l methyl 927 4-Cl-2-N02Ph benzpthi$zol-2-yli-propyi 928 4-Cl-2-N02Ph benzothiazol-2-yX cyclopropyl 929 4-Cl-2-N02Ph beHZQmiazol-2-'ylCFs 930 4CI : 2 N4aP pyrazol--y1 H 93 4-Cl-2N02Ph pyrazol-1-ylmethyl 932 4-C1-2~NO2Ph pyrazol-l Wyl i-propyl 933 4-Cl-2-NO2Ph pyrazol-l-yl cyclopropyl 934 4-Cl-2-N02Ph pyrazoM-ylCFs 93 5 4-Cl-2-NO2Ph pyrazol-3-yl H 4C1-2 NUiPh pyrazol-3 yl methyl 937 4-Cl-2-N02Ph pyrazol-3-yli-propyi 938 4-Cl-2-NO2Ph pyrazol-3-yl cyclopropyl 939 4Cl-2-N02Ph pyrazol-3-ylCFs 940 4-Cl-2-N02Ph 1-methylpyrazol-3-yl H 941 4-Cl-2-NO2Ph, 1-met y pyrazol-3-yl methyl 942 4-Cl-2-NO2Ph 1-methylpyrazol-3-yl i-propyl 943 4-Cl-2-N02Ph 1-methylpyrazol-3-yl cyclopropyl 944 4-Cl-2-NO2Ph 1-methylpyrazol-3-yl CF3 945 4-Cl-2-NO2Ph tetrazol-l-yl H 946 4-Cl-2-NO2Ph tetrazol-1-yl methyl 947 4-Cl-2-N02Ph tetrazol-1-yl i-propyl 948 4-Cl-2-NO2Ph tetrazol-1-yl cyclopro yl 949 4-Cl-2-NO2Ph tetrazol-1-yl CF3 950 4-Cl-2-N02Ph 5iiylt_aZ_1-yl H 951 4-Cl-2-NO2Ph 5-methyltetrazol-1-yl methyl 952 4-Cl-2-NO2Ph 5-methyltetrazol-1-yl i-propyl 953 4-Cl-2-NO2Ph S-methyltetrazol-1-yl cyclopropyl 954 4-CI-2-NO2Ph 5-methyltetrazol-1-yl CF3 s 5 4-Cl-2-NO2Ph tetrazol-2-Y1 II 956 4-Cl-2-NO2Ph tetrazol-2-yl methyl 957 4-Cl-2-NO2Ph tetrazol-2-l i-propyi sss 4-Cl-2-NO2Ph tetrazol-2-yl cyclopropyl 959 4-Cl-2-NO2Ph tetrazol-2-yl CF3 960 4-C1-2-NQ2Ph S-methyltetrazol-2-yl E 961 4-Cl-2-N02Ph 5-methyltetrazol-2-yl methyl 962 4-Cl-2-NO2Ph Syltetrazol-2-yl i-propyl 963 4-Cl-2-NO2Ph 5-methyltetrazol-2-yl cyclopropyl 964 4-CI-2-N02Ph 5-methyltetrazol-2-yl CF3 965 4-Cl-2-NO2Ph 1-methyltetrazol-5-yl i Compound A R nLp. 966 4-CI2-N02Ph l'. methyltetrazol5-yl methyl 967 4-CI-2-N02Ph I-methyltetrazol-S-yl i-propyl 96 4-Cl-2-N02Ph l"methyltetrazol-5-ylcyclopropyi 152 969 4-Cl-2-NO2Ph l-met Shyltetrazol-5-yl C1y3 970 2-CI-4-NO2Ph_ 2-methyltetra ; zol-5-yl cyclopropyl 137 971 4-Cl-2-NO2Ph 2-m. al hyfitétrazol-S-yl methyl 972 4-Cl-2-N02Ph 2-methyltetrazol-5-yli-propyi 973 4-Cl-2-NO2Ph 2-me,. thyiltetrazol-, S-yl cyclopropyl 126 974 4-Cl-2-NO2Ph 2-methyltetrazol-S-yl CF3 97, 2, 4- (N02) 2Ph2-methyltetrazol-5-ylcyclopropyi 144 976 4-Cl-2-N02Ph pyridin-2-yl methyl 977 4-CI-2-NO2Ph pyridin-2-yl i-propyl 978 4-C1-2-NO2Ph 91 cyclopropyl 979 4-Cl-2-NO2Ph pyridin-2-yl CF3 980 4-Cl-2-N02Ph pyridm-4-ylJH 981 4-Cl-2-NO2Ph pyridin-4-yl methyl 982 4-Cl-2-NO2Ph pyridin-4-yl i-propyl 983 4-Cl-2-NO2Ph pyridin-4-yl cyclopropyl 984 4-Cl-2-NO2Ph pyridin-4-yl CF3 9s5 4-Cl-2-N02Ph pyridm-3-yl H 986 4-Cl-2-NO2Ph n-3-yl methyl 987 4-_Cl-2-N02Ph pyridin-3-yl i-propyl 988 4-Cl-2-N02Ph pyridin-3-yl cyclopropyl 989 4-Cl-2-NO2Ph pyridin-3-yl CF3 990 4-CI-2-NOiPh 3--nitropyridin-4-yl H 991 4-Cl-2-NO2Ph 3-nitropyridin-4-yl methyl 992 4-Cl-2-N02Ph 3-nitropyridin-4-yl i-ropyl 993 4-Cl-2-N02Ph 3-nitropyridin-4-yl cyclopropyl 994 4-Cl-2-NO2Ph 3- : nitropyridin-4-yl CF3 995 4-Cl-2-NO2Ph 5-cyanopyridin-2-yl H 996 4-Cl-2-NO2Ph 5-cyanopyidin-2-yl methyl s 997 4-'Cl-2-NO2Ph 5-cymopyridm-9.-sl i-propyt 998 4-Cl-2-N02Ph 5-cyanopyridin-2-y1 cyclopropyl 999 4-Cl-2-N02Ph 5-cyanopyridin-2-yl CF3 1000 4-Cl-2-N02Ph 5-trifluoromethylpyridin-2-yl H 11001 4-Cl-2-NO2Ph 5 t-ifluoromethylpyridin-2-yl methyl 1002 4-Cl-2-NO2Ph 5-trifluoromethylpyridin-2-yl i-propyl 1003 4-Cl-2-NO2Ph S-trifluoromethylpyridin-2-yl cyclopropyl M04 4-Cl-2-N02Ph 5-tnjauoromethylpyridm-2-ylCPs 1005 4-Cl-2-NO2Ph pyrimidin-2-ylJH lo006 4-Cl-2-N02Ph pyrimidin-2-yl methyl 1007 4-Cl-2-NO2Ph pyrimidin-2-yl i-propyl M08 4-Cl-2-N02Ph pyrimidin-2-ylcyclopropyi 1009 4-Cl-2-NO2Ph pylimidin-2^yl cE3 1010 4-CI-2-NO2Ph ppimidin-4-yl H 1ou 4-Cl-2-NO2Ph.pyrimidin-4-yl methyl Compound N A W2012 4-Cl-2-NO2Ph pyrmib-4-yl i-propyl t 1013 4-CI-2-NO2Ph pyrimidia-4-yl cyclopEo-py-I xo ; l4 4-Cl- NOz'h, yximri-4-yl 101, 4-Cl-2-NQ2Ph pyrimtdin-4-ylCFs 1016 4-CI-2 NO2Ph 6-cloropyrimidin-4-yl i-propyl 1017 4-Cl-2-NQ2Ph 6-hloropynrnidin-4-yl cyclopropyl 1018 4-CI-2-NO2Ph 6-c, wyrlmidin-4-yl, C1y3 M19 2, 4- (Clh l-memyltotfazol-5-ylt-butil 124 1020 4-Cl-2-NO2Ph pyndazin-3-yl methyl tezi 4-Cl-2-N. Q2Ph pytidazm-3-yli-propyi 1022 4-Cl-2-NO2Ph pyrtdazin-3-yl cyclopropyl M23 4-Cl-? pyndazin-SylCF3 1024 4-Cl-2-N02Ph 6-ehloropyridazm-3-ylmethyl 1025 4-Cl-2-NOzPh 6-chloropyridazin-3-yl i-propyl M26 4-'Cl-2-N02'h 6-chloropyridazm-3-ylcyclopropyi 1027 4-Cl-2-N02Ph 6-chloropyridazin-3-yl CFs l'02S 4-Cl-2-N02Ph pyrazm-2-ylmethyl 1029 4-CI-2-NO2Ph pyrazin-2-yl i-propyl 1030 4-Cl-2-NO2Ph pyrazin-2-yl cyclopropyl 031 4-, Cl-2-NORh pwin-2-yl CF3 1032 4-Cl-2-NO2Ph triazin-2-yl methyl M33 4-Cl--N02Ph triazin-2-yl i-propyl 1034 4-CI-2-NOaPh tnazin-2-ylcyclopropyi M35 4-Cl-2-N02Ph triazin-2-ylCFs 1036 4 Cl-2-NOiPh quinol1n-2-yl methyl 1037 4-Cl-2-NOxPh quinolm-2-yli-propyi 1038 4-U-2-NO2Ph a olin-2-yl cvcloproD 1039 4-Cl-2uN, 02Ph qwolin-2-yl CF3 . 1040 4-CI-2-NOPh 4, 4, 6- (dm6&yt-5, 6-dthydro-lH)-oxazin-2-yl H 1041 4-Cl-2-NO2Ph 4>4, 6-t yl-5, 6lydm1, 3 (4H) *oxamn-2-yl methyl 1042 4-Cl-2-NO2Ph 4, 4, 6-trimethyl-5, 6lyb1J (44e-2-yl i-propyl 9043 4-C1-2-N02Ph 4, 4, 6*imeiyl-5, 6*61, 3 (4FoxazE-2-yl cyclopropyl 1044 4-Gl-2-N (JaPh 4, 4, 6-trimethyl-5, 6-aydro-1, 3 (4H)-mazin-2-34 CF3 1045 4-CI-2-NO2Ph 2-oxazolidinon-3-yl H 1046 4-Cl-2-NO2Ph 2-oxazolidinon-3-yl methyl ao47 4-Cl-2-NO2Ph 2-oxazolidinon-. pli-propyl 1048 4-Cl-2-NO2Ph 2-oxazolidinon-3-yl cyclopropyl 1049 4-Cl-2-NO2Ph 2-oxazolidinon-3-Y1 CF3 '1050 4-Cl-2-N02Ph 2-pyrrolidmon-l-ylmethyl 1051 4-Cl-2-N02Ph 2-pyrrolidinon-1-yl i-propyl M52 4-Cl-2-N02Ph 2-pyrrolidmon-l-ylcyclopropyi 1053 4-Cl-2-N02Ph 2-pyrrolidinon-1-l CF3 054 4-Cl-2-NOPh 3-meibylisoxazol-5-ylmethyl 1055 4-Cl-2-NO2Ph 3-methylisoxazol-5-yl i-propyl 1056 4-Cl-2-NO2Ph 3-methylisoxazol-5-yl cyclopropyl 1057 4-Cl-2-NOPh 3-methylisoxazol-5-ylCF3 Compound N Bp. losg .., C., 2 p 2^N, 2^^S2MePh _. 1059 4-CI-2-NO2Ph 0 2-NO2-4-SO*dePh methyl 1060 4-Cl-2-N02Ph 2-N02-4-S02MePhi-propyi 10611 4-Cl-2-NO2Ph 2-N02-4-SQzI2MePh c clopropyl i :062 4-Cl-2-N02Ph 2-NO2T4-S02'IVIePh CF3 1063 4-a-2-NO2Ph 2 4°2W, Ph, X, 1063 4-Cl-2-N02Ph 2-Cl-4-S02fePhH 1064 4-Cl-2-N02Ph 2-Cl-4-SQ2MePhmethyl 1065 _ 4-CW02Ph 2-Cl-4-SO2MePh cyclopropyl . 1'067 4-C1-2-N02Pt | 2-Ci-4-: SO2MPh CE3 4-cr-. NO2Ph -r.-sQ2zvph 1068 4-CI-2-N, Q2Ph 2-NO2-4-CE3Ph H 1069 4-Cl-2-N02Ph 2-N02-4-CF3Ph methyl 1070 4-ClAQxPh.-NQ2-4-CP3Ph. i-propyl 1071 4-CI-2-NO2Ph 2-NO2-4-CF j3Ph cvclopronyl M72 4-Cl-2-N02Ph 2-N02-4-CF3PhCFs 1073 4-Cl-2-NQ2Ph 2-NO2-4-CIPh H 1074 4-Cl-2-NOPh 2-N02-4-CIPhmethyl 1075 4-Cl-2-N02, Ph 2-NO2-4-CPh i-propyl 1076 4-Cl-2-NO2Ph 2-N02-4-CIPh cyclopropyl 1'077 4-Cl-2-ND2Ph 2-NO2-4-CSh, CE3 1078 4-Cl-2-NO2Ph 2-Cl-4-NO2Ph H 1. 079 4-Cl-2-N02Ph 2-Cl-4-N02Phmethyl 1080 4-Cl-2-NO2Ph 2-Cl-4-NO2Ph i-propyl 1081 4-Cl-2-NO2Ph 2-Cl-4-NO2Ph cyclopropyl 1082 4-Cl-2 N02Ph 2=Cl-4-NQ2Ph CF3 1083 4-Cl-2-NO2Ph 224-(N02bPh 1 084 4-Cl-2-NO2Ph 2 44- C02) 2Ph methyl 1085 4-Cl-2-NO2Ph 2, 4-(N02) i2Ph i-propyl 1086 4-CI-2-NO2Ph 2, 4-602,) 2Ph cyclopropyl 1087 4-Cl-2-NO2Ph 2, 4-QV02) 2Ph CE3 1088 4-Cl-2-NO2Ph 4-F-3-NO2Ph H loss 4-CI-2-NO2Ph 4-B-3-NO2Ph methyl 1090 4-CI-2-NO2Ph 4-F-3-NO2Ph i-propyl 1091 4-Cl-2-NO2Ph 4-N-N02Ph cyclopropyl 1092 4-Cl-2-N02Ph 4-F-3-N02Ph CE3 1û93 4-Cl-2-NO2Ph 3, 5-(CF3) 2Ph 1094 4-Cl-2-NO2Ph 3, 5 (CF3) 2Ph methyl 1095 4-C1-2-N02Ph 3, 5- (CF3) 2Ph i-propyl 2 3, 5'Ph 1096 4-Cl-2-N02Ph 3, 5- (CF3) 2Phcyclopropyi 1097 4-CI-2-NO2Ph 3, 5- (CF3) CF3 1098 4-Cl-2-N02Ph 2-SOzMe-4-CF3Ph H 1099 4-Cl-2-N02Ph 2-SO2Me-4-CF3Ph methyl ilion 4-Cl-2-NO2Ph ?-SOSMe-4-CF3Ph i-propyl 1101 4-CI-2-NO2Ph 2xSO2Me-4-CF3Ph cyclopropyl 1102 4-Cl-2-NOa'h 2-SO2Me-4-CP3Ph CP3,. CompoundN m - CC) 4M3 2-SOJMLe-4-CFPhl, 2, 4-oxadiazol-5-yl H 1104 2-SO2Me-4-CE3Ph 1, 2, 4-oxadiazol-5-yl methyl q 5 2-S02MEe-4-CI ! 3P. h l, 2, 4-oxadiazol-5-yli-propyi 1106 2-S4a : VIe-4-CF3'P 1, 2, 4-oxadiazol-5-yl cyclopropyl q qloa 2-SO2Me-4-a3Ph 1, 274-oxadiazol-5-vl C1S3 1108 2-SG2Me-4-CF3Ph 3-mefhyl-l, 2, 4-oxadiazo-Sl I 1109 2-$0Ne-4-CEP3Ph 3-methyl-1, 2, 4-oxadiazol-ylmethyl -, Ph 3 oxadi niethyl HH'0 2-. S02MB-4-CF3Ph 3-methyH, 2, 4-oxadiaz : ol-5-yli-propyi nil 2-S02Me-4-CF3Ph 3-metRyM, 2, 4-oxadiazol-5-yIcydopropyi '12 2S02Me-4-C3Ph 3-Jnethyl-l, 2, 4-oxagol-5-yl CE3 1113 2-S92MLe-4-CF3Ph 3-tnRnoromefhyl-l, 2, 4-oxadiazol-5'yl H H14 2-S02Me-4'GF3 ? h 3-triflnoj'omethyl-l, 2, 4-oxadiazol-5-yl methyl 2-SO2Me-4=CF3Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl i-propyl 1116 2-S'OzMe-4-CF3Ph 3duoromedIyl-1 2, 4-oxadiazol-5-yl cyclopropyl 1117 2-SOs-4'CF3Ph 3-tnluotomeyl-l, 2, 4-oxadiazol-5-yl CP3 1118 2-SOaMe-4-CF3Ph 1, 2, 4-oxadiazol-3-yl t9 2-SOM [e-4-CI''3Ph l, 2, 4-oxadiazol-3-ylmethyl 1120 2-SO2Me-4-CF3Ph 1, 2, 4-oxadiazol-3-yl i-propyl 1121 2-SOzMe-4-CF3Ph 1, 2, 4-oxadiazol-3-yl cyclopropyl 1122 7--S% Me-4-CF3Pch 1, 2, 4-oxadlazol-3-yl CPS 1123 2-SS Me-4-CE3Ph 5-methyl-1 2 4-oxadiazol-3-yl H v s ! H24 2-S02Me-4-CF3Ph 5-methyl-l, 2, 4-oxadiazol-3-ylmethyl 1125 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl H26 2-SO2Me-4-CF3Ph S-methyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 1127 2-SO2Me-4-CF3Ph S-methyl-1, 2, 4-oxadiazol-3-yl CF3 1128 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl H M29 2-S02Me-4-CF3Ph 5-tnftuoromsthyl-l, 2, 4-oxadiazol-3-yl methyl 1130 2-S'OMe-4-CF3Ph 5-trifluorornetli. yl-1, 2, 4-oxadiazol-3-yl i-propyl 1131 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 1132 2-S02Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 i 133 2-SO2Me-4-CF3Ph S-chloro-1, 2+4-oxadiazol-3-+rl H 1134 2-SO2Me-4-C : F3Eth 5-chloro-1, 254-oxadiazol-3-yl methyl 1135 2-SO2Me-4-CF3Ph 5-chloro-1, 2, 4-oxadiazol-3-yl i-propyl lit36 2-S02Me-4-CF3Ph 5-chloro-1, 2, 4-oxadiazol-3-yl cyclopropyl a 1137 2-SO2Me-4-CF3Ph 5-chloro-1 2, 4-oxadiazol-3-yl CP3 d d3, 8 2-S02Me-4-CF3Ph 1, 3, 4oxadiazol-2- 1 H 1139 2=SO2Me-4-CF3Ph 1, 3, 4-oxadiazol-2-yl methyl 1140 2-S02Me-4-CF3Ph 1, 3 74-oxadiazol-2-yl i-propyl t1 W41 2-SO2Me-4-CP3Ph 1, 3, 4-oxadiazol-2-yl cyclopropyl 1142 2-SO2Me-4-CF3Ph 1, 3, 4-oxadiazol-2-yl CF3 q {43 2-SO2 Me-4-CE3Ph 5-methylsulMonyl-1, 3, 4-oxadiazol-2-yl H Compound N A B ' 144 2-SO2Me-4-CF3Ph 5-met. ylsulfonyl-1, 3, 4-oxadiazol-2-yl methyl 1145 2-SOe-4CF3Ph ?-methylsuljB3nyl-l, 3, 4-oxadiazol-2-yX i-ro I H46 -. SQzMe--CFgPh 5'. methylsuHotiyl-'l, 3, 4''oxadiazol-2-yl cyclopropyi 11. 7 2-S02M-4-CF3Ph S-m, ethyl'sulonylT, 3, 4-oxadiazol-2-yl CF3 ! 2S03Me-4CF3Ph 5-methyl''3, 4-oxadiaol-2-ylH 1149 2-$0ß. Ie-4-CM 5tiyl-1, 3., 4-oxadlazol-2-yl methyl 1150 2-SDVIe-ACF31°h 5-methy-a,, 3, 4-oxadsazo1-2-yI i-propyl H5l 2-SOe-4CFPh 3-. methyl-'l, 3, 4-oxadiazol-2-ylcyclopropyi 1152 2-$02Me-4-CF3Ph 5-methyl-1, 3, 4-oxadiazol-2-yl CF3 i [l. 53 2-S02Me-4-Cf3Ph 5-tn. Quoromethyl-l, 3, 4-oxadiazol-2-yl H 1154 2-SO2Me-4-CF3Ph_ S-trifluoromethyl-l, 3, 4-oxadiazol-2-yl methyl M55 2-S03Me-4-CF3Ph 5'-tnRn9romethyl-l, 3, 4-oxadiazol-2-yl i-propyl M56 2-SO2Me4-CF3Ph 5-tnfluoroinothyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 1157 2-SO2Me-4-CEr3Ph S*if ! uoromethyl-1, 3, 4-oxadiazol-2-yl CE3.. 1458 9--SOAIe-4-C : F3Ph 1, 2, 3-+azol-4-yl II 1159 2-SONe-4-CF3Ph 1, 2, 3-triazol-4-yl methyl l so 2-SO2Me-4-CP3Ph 1, 2, 3-triazol-4-yl i-propyl 1161 2-'SO2Me-4-CF3Ph 1, 2, 3-triazol-4-yl cyclopropyl 1162 2-SO2Me-4-CF3Ph 1, 2, 3-triazol4-yl CF3 . 1M3 2-S02Me-4-CF3Ph l-methyl-l, 2, 3-triazol-4-ylH 1164 2-SO2Me-4-CF3Ph 1-methyl-1, 2, 3-triazol-4-yl methyl H > ll65 2-SOXe-<3Ph l-rnethyl-l, 2, 3-triaol-4-yl i-propyl 1166 2-SO2Me-4-CF3Ph 1-methyl-1, 2, 3-triazol-4-yl cyclopropyl 1167 2-SO2Me-4-CF3Ph l-methyl-1, 2, 3-triazol-4-yl CF3 1168 2-SO2Me-4--CF3Ph 2-methyl-1, 2, 3-triazol-4-yl H 1169 2-SO2Me-4-CF3Ph 2-methyl-I, 2, 3-triazol-4-yl methyl aa70 2-SOWe-A-CF, 3Ph 2-methyl-1, 2 3-triazol-4-yl i-propyl 1171 2-SO2Me-4-CE3Ph 2-methyl-1, 2, 3-triazol-4-yl cyclopropyl M72 2-S02Me-4-CF3Ph 2-methyl-l, 2, 3-triazol-4-yl CF3 1173 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-1-yl 11 1174 2-SO2Me-4-CF3Ph 1, 2, 3-triazol-1-yl methyl 1175 2-SONe-4-CIiWPh 1, 2, 3-triazol-1-yl i-propyl 1176 2-SO2Me-4-CF3Ph 1, 2, 3-tivol-l-yl cyclopropyl 11177 2-SQ2Me-4-CF3Ph 1, 2, 3 triazoll yl C'3 1178 2-S02Me-4-CF3Ph 1, 2, 3-triazol-2-yl H a i179 2-SO2Me-4-CE3Ph 1, 2, 3-triazol-2-yl methyl 1180 2'S02Me-4-CE3Ph 1, 2, 3-ttiazol-2-yl i-propyl 1181 2-S02Me-4-CFgPh l, 2, 3-triazol-2-yl cyclopropyl a a82 Z-SO2Me-4-CF3Ph 1, 2, 3-tiazol-2-yl CE3 1183 2-SOzMe-4-CF3Ph 1, 2, 4-triazol-1-yl ) ll84 2-S02Me-4-CFsPh 1, 2, 4-tiazol-1-yl methyl 1185 2-SO2Me-4-CF3Ph 1, 2, 4-biazol-l-yl i-propyl Q Q86 2-SO2Me-4-CF, 3Ph 1, 2, 4-triazol-1 yI c clo ro 1 11'87 2-SO2Me-4-CE3 eh 1, 2, 4-triazol-1-yl CP3 1188 2-SO2Me-4-CF3Ph imidazol-2-ylH ! Q 2-S02Me-4-CF3Fh imidazol-2-ylmethyl Compound N A B R m. p- CC) 1190 2-SONe4-CF3Ph itol-2-yl i propyl 1191 2-SO21We-4-CEP, h imtd'azolw2-rl cyclopropyl a 192 2-SO2Me-4-CF3Ph imidazol-2-yl CF3 2-0-7) &-H 1193 2-S02Me-4-CE3CPh iwdgol-l-yl H., a 194 2-SO7Me-4-CF3Ph inaidazol-l-yl methyl 1195 2-S02Me-4-CFgPh imidazoM-yli-propyi 1196 2-$ ONe-4-a3Ph imsidazol-1-yl cyclopropyl M97 2-S02Me-4-CF3Ph imidazol-1-ylCFs 1198 2-S02Me-4-CF3Ph imidazol-4-ylJH ! 1199 2S03Me-4-CF3Ph imidazol-4-ylmethyl 1200 2-S 02hIe-4-CFsPh imidazol-4-yl i-propyl 1201 2-SQAIe « 4-CP3Ph imidazol-4-yl çyçlopropyi 1202 2-SO2Me-4-CF3Ph imidazol-4-yl CF3 1203 2-SO2Me-4-CF3Ph thiazol-2-yl H 1204 2-SO2Me-4-CF3Ph thiazol-2-yl methyl 1205 2-S02Me-4-CF3Ph thiazol-2-yl i-propyl 1206 2-SO2Me-4-CF3Ph iazol-2-yl cyclopropyl 1207 2-S 02Me-4-CF3Ph thiazol-2-yl C : F3 1208 2-SO2Me-4-CF3Ph 4-methylthiazol-2-yl H t2G9 2-S02Me-4-C '.'h 4-methylthiazol-2-yl methyl 1210 2-SO2Me-4-CF3Ph 4-methylthiazol-2-yl i-propyl qçl I 2-SOAIe-4-a3Ph 4-methylthiazol-2-yl cyclopropyl 1212 2-SOMe-4-CF3Ph 4-methylffiiazol-2-yl CF3 1213 2-S02Me-4-CF3Ph oxazol-2-ylH 1214 2-SO2Me-4-CF3Ph oxazol-2-yl methyl 1215 2-SO2Me-4-CF3Ph oxazol-2-yl i-propyi ! 2-SOjMe-4-CE3Ph oxazol-2-yl cvclopropyi 1217 2-SO2Me-4-CF3Ph oxazol-2-yl CF3 12118 2-SO2Me4-CF3Ph 4, 5-dimethyloxazol-2-yl H 1219 2-SO2Me-4-CF3Ph 4, 5-Xethyloxsol-2-yl methyl 1220 2-SO2Me-4-CF3Ph 4, 5-ethyloxazol-2-yl i-DroDY i221 2-SOgMe-4-CI ? 3Ph 4 5-dimethyloxazol-2-yl cyclopropyl 1222 2-S02Me-4-CF3Ph 4, 5-dimethyloxazol-2-yl CF3 ) t223 2-S02Me-4-CF3Ph 2-oxa2 : olin-2-ylH 1224 2-SO2Me-4-CF3Ph 2-oxazolin-2-1 methyl 1225 2-SO2Me-4-CE3Ph 2-oxazolin-2-yl i-propyl 1226 2-SQ2Me-4-C : F3Ph 2-oxazolin-2-yl cyclopropyl 1227 2-SO2Me-4-CF3Ph 2-oxazolin-2-yl CF3 1228 2-SO2Me-4-C3Ph 4, 4-dimethyl-2-oxazolin-2-yl H 1229 2-S02Me-4-CF3Ph 4, 4-dimethyl-2-oxazolin-2-yl methyl 1230 2-SO2Me-4-CF3Ph 4, 4-dimethyl-2-oxazolin-2-yl i-ropyl 1231 2-SO2Me-4-CF3Ph 4, 4-dimeth 1-2-oxazolin-2-1 cyclo ro 1 1232 2-SONe4-CP3Ph 4, 4-dimethyl-2-oxazolin-2-yl CF3 1233 2-SO2Me-4-CP3Ph 1, 2, 4-thiadiazol-5-yl H 1234 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-5-yl methyl l235 2-SOgMe-4-CE3Ph 1, 2, 4-*iadiazol-5-yl i-propyl Compound D1 . 1236 2-SOsMe-4-CF3Ph l, 2, 4-thi. diazol-S-yl cyclopropyl 1237 2-SO2Me-4-CE3Ph 1 2, 4-thiadxazol-5... 1 CF3 1238 2-S02Me-4-CF3Ph 3-methyM, 4hiadiazol-5-ylJH 1239 2-SQ2Me-4-G@3Ph 3-methyl-1, 2, 4 thiadiazol-5-yl. methyl M40 2-SO : iMe-4-(: F3Ph. 3-1, 2, 4+iadiazol-5-yl i-propyl 1241 2-S02Me-4-CF3Fh 3-methyl-l, 2, 4-thiadiazol-5-yl cyclopropyl 1242 2-SÒSMe-4-CE3P, 3-methyl-l, 2, 4-thiadiazol-$-yl CP3 M43 2'S02Me-4-CF3Ph 3-tri : 0MQromethyl-l, 2, 4-thiadiazol-5-yl H 1244 2-S02Me-4-CF3Ph 3-tEiuoromethyI-I 2, 4-thiadjazol-5-yl methyl 1245 2-S02Me-4-CFPh. 3'tQNtioromsthy'l-l, 2, 4-tliiadiazol-5-yl i-propyi 1246 2-SOzMe-4-C : F3Ph ~ 1 wjv 1 cyclopropyl _ 1247 2-S. OiMe-4-CEPh 3-tri£l'uXomet. hyl-l, 2, 4-thiadiazoI-5-yl CF3 1248 2-SO2Me-4-CF3Ph l, 2, 4adiazol-3-ylH 1249 2-SOA¢e-4-CPsPh 1, Z, 4-iadiazol-3-yl methyl 1250 2-SO2Me-4-CB3Ph 1, 2, 4-1hiadi. azol-3-yl i-proP 1251 2-SO2Me-4-CF3Ph 1, 2, 4-thiadiazol-3-yl cyclopropyl 1252 2-SO2Me-4-CF3Ph 1., 2, 4-thiadiazol-3-yl CF3 1253 2-S03Me-4-CF9Ph 5-mefhyl-l, 2, 4-thiadiazol-3-yl H 1254 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-thiadiazol-3-yl methyl 1255 2-SOaMe-4-CF3Ph 5-methylw, 4-thiadiazol-3-yl i-propyl 1256 2-S02Me-4-CF3Ph 5-methyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 1257 2-SO2Me-4-CF3Ph 5-methyl-1, 2, 4-thiadiazol-3-yl CF3 1258 2-SO2Me-4-CF3Ph 5-trifluoromethyl-I, 2, 4-thiadiazol-3-yl H 1259 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl methyl 1260 2-SO2Me-4-CF3Ph 5 triluoromethyl-1, 2, 4-thiadiazol-3-yl i-propyl 1261 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 1262 2-SO2Me-4-CF3Ph 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl CF3 1263 2-SOzMe-4-CF3Ph 1, 3, 4 tliiadiazol-2 yl H 1264 2-SOge-4-CF3Ph 1, 3, 4-tbiadiazol-2-yl methyl 1265 2-SO2Me-4-CF3Ph 1, 3, 4 ti. dazol-2 : yl i-ro 1 1266 2-S02Me-4-CF3Ph l, 3, 4-thiadiazol-2-ylcyclopropyi 1267 2-S02Me-4-CF3Ph 1, 3, 4-thiadiazol-2-yl Cfi'3 1268 ~ 2-SO2Mc-4-CFsPh | 5-methylsulfonyl-1 3, 4-thiadiazol-2-yl _ 1269 2-SO2Me-4-CF3Ph 5-meth, ylsul£onyl-1, 3, 4-thiadiazol-2-yl methyl 1270 2-S02Me-4-CF3Ph 5-methylsulfonYl-1, 3 4-thiadiazol-2-yl i-DroDvl 1271 7-SO2Me-4-CF3Ph S-methylsdonsl-1, 3i4-thiadiazol-2-sl cycloPropyl 1272 2-soaMe-4-cF3ph 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl CE3 1273 2-SO2Me-4-CF3Ph 5-methyl-1, 3, 4-thiadiazol-2-yl H 1274 2-SO2Me-4-CF3Ph 5-methyl-1, 3, 4-thiadiazol-2-yl methyl 1275 2-SO2Me-4-CFBPh 5-methyl-1, 3, 4-thiadiazol-2-yl i-propyl 127, 6 2-SO2Me4-CF3Ph Smethyl-l, 3, 4-thiadiazol-2-yl cyclopropyl 1277 2-SO2Me-4-CF3Ph 5-methvl-1, 3 4-thiadiazol-2-sl C : F3 ç X v 1278 2-SO2Me-4-CF3Ph benzoxazol-2-yl H 1279 2-S02Me-4-CF3Ph benzoxazol-2-ylmethyl 1280 2-SO2Me-4-CF3Ph benzoxazol-2-yl i-propyl 1281 2-S02Me-4-CF3Ph benzoxazol-2-yl cyclopropyl 1282 2-SO2Me-4-CF3Ph benzoxazol-2-yl CF3 CmmpoundN A B R"' 1283 2SO ; Me-4-. CFgPh 6methylbenzoxazol-2-yl H 1284 2-SO2Me-i-C9h 6-me*olbe. =oxazoI-2-yl methyl 1285 2-. SQM'e-4-CF3Ph 6-methylbenzoxazol-2-yli-propyi 1286 2-SONe-4-CFWk G-methylbenzoxazol-2-y cyclopropyl M87 2-S<32Me-4-CI'3Ph 6-methylbeazox8zol-2-ylCFg 1288 2-S02Me-4-CI ? Ph henzothiazol-2-ylJEt 1289 Z-SOzMe-CFaPh benzothiazol-2-ylmethyl 1290 2-S02Me-4-CFsPh bettzohiazQl-'2-yli'propyi 1291 2-'S02Me"4-C3Fh benzothiazol-2-ylcyclopropyi 1292 2-. S'C'e-4-CF3 ? h benzothiazol-2-ylCPs 1293 2-SONe-4-CFsPh pyrazol-l-yl H 1294 2-SOaMe-4-CF3Ph pyrwol-l--yl methyl 1295 2-SO2Me-4"CF3Ph Pyrazol-l-yl i-propy 1296 2-S02Me-4-CFPh pyrazol-l-ylcyclopropyi 1297 2-SOxMe-4-CF3Ph pyrazol-lylCPg 1298 2-S02Me-4-CF3Ph pyrazol-3-yl H 1299 2-SO2Me-4-CF3Ph pyrazol-3-yl methyl 13 00 2-SQ2Me-4-CF3Ph pyrazol-3-yl i-propyl 130, 1 2-SO2Me-4-CF3Ph yrazol-3-yl cyclopropyl 1302 2-SO2Me-4-CF3Ph pyrazol-3-ylCFs 1303 2-S02Me-4-CF3Ph 1-methylpyrazol-3-yl H 1304 2-S02Me-4-CF3Ph l-methylpyrazol-3-ylmethyl 1305 2-S02Me-4-CF3Ph I-methylpyrazol-3-yl i-propyl 1306 2-SO2Me-4-CF3Ph l-methylpyrazol-3-yl cyclopro yl 1307 2-S02Me-4-CF3Ph l-methylpyrazol-3-yl CP3 1308 2-SOiMe-4-CF3Ph tetrazol-l-yl H 1309 2-S02Me-4-CF3Ph tetrazol-1-yl methyl 1310 2-SO2Me-4-CF3Ph tetrazol-1-yl i-propyl 1311 2-SO2Me-4-CF3Ph tetrazol-1-yl cyclopropyl 1312 2-SO2Me-4-CF3Ph tetrazol-1-yl CF3 1313 2-SO2Me-4-CE3Ph S-methyltetrazol-l-yl H 1314 2-S02Me-4-CF3Ph 5-methyltetrazol-l-ylmethyl 1315 2-S02Me-4-CF3Ph 5-methyltetazol-1-yl i-propyl i 3, 106 2-SOgMe-4-CF3Ph S-methyltetrazol-1-yl cyclopropyl 1317 2-SO2Me-4-CF3Ph S-methvltetrazol-l-Y1 CF3 . 1318 2-S02Me-4-CF3Ph tetrazol-2-ylJH 1319 2-SO2Me-4-CF3Ph tetrazol-2-yl methyl 1320 2-S02Me-4-CF3Ph tetrazol-2-yl i-propyl 1324 2-SO2Me-4-CF3Ph tetrazol-2-yl cyclopropyl 1322 2-SO2Me-4-CF3Ph tetrazol-2-yl CF3 1323 2-SO2Me-4-CF. 3Ph 5-methyltetrazol-2-yl H 1324 2-SO2Me-4-CF3Ph 5-methyltetrazol-2-yl methyl 1325 2-SO2Me-4-CF3Ph 5-methyltetrazol-2-yl i-propyl 1326 2-S0z11rMe-4-CF3Ph 5-methyltetrazol-2-yl cyclopropyl 1327 2-SO2Me-4-CF3Ph 5-methyltetrazol-2-yl CF3 1328 2-SQzMe-4-F3Ph 1-methyltetrazol-5-1 H Compound N A 1329 2-SO2Me-4-CE3Ph 1-n, elylteteol-S-yl methyl 1330 2-S02Me-4-CsPh T-rrxeth ltetrzol5-1 i-ropyl 1331 2-SQ « : e-4-CE3Ph 1, meth'ylteWazol-S « yl cyclopropyl 1332 2-SO2Me-4-CEiSPh l-methyltetrazol-S yl CP3 M33 2-. S02M9-4-CF'3Ph 2'-methyltetrazol-5-ylJH 1. 334 2-SOzNMe-4-CF3Ph 2-methyltetrazol-5-yl rnethyl 1335 2-S02Me-4-CE3P. 2. rneblylttazo5 yl i-ro yl 1336 2SQ2M : e-4-. CF'h 2methyltetraz ; ol-5-ylcyclopropyi 157 337 2-S02Me-4CF3Ph 2-methyltetrazol-5-ylCFs 133 2-SOaMe-4-CF3Ph pyridin-2-ylJH 1339 2-SO, 2Me-4-CF3 ? li pyridin-2-yl methyl 1340 2-SO2Me-4-CF3Ph Pwdin2-yl i-propyl 1341 2-SO2Me-4-a3Ph pyiin-2-yl cyclopropyl 1342 2-SO2Me-4-CF3Ph pyndir>-2-yl CF3 1343 2-SO2IVTe-4-CF3Ph pyridin-4-yl I3 1344 2-S02Me-4-CFPh pyridin-4-yl methyl '1345 2-. S03Me-4-CF3Ph pyddin-4-yli-propyi 1346 2-SO2Me-4-CF3Ph pyridin-4-yl cyclopropyl 1. 347 2-SO2Me-4-CF3Ph pyridin-4-yl CF3 1348 2-SO2Me-4-CF3Ph pyridin-3-yl H 1349 2-SO2Me-4-CF3Ph pyridin-3-yl methyl 1350 2-S4VIe-4-CF3Ph pyridin-3-yl i-propyl 1351 2-SO2Me-4-CF3Ph pyridin-3-yl cyclopropyl 4352 2-S02Me-4-CF3Ph pyridim-3-yljCFg 1353 2-SO2Me-4-CF3Ph 3-nitropyridin-4-yI H 1354 2-S02Me-4-CF3Ph 3-nitropyridin-4-l methyl 1355 2-SONe-4-CF3Ph, 3-nitropyri dill-4-yl i-propyl 1356 2-SOVIe-4-CF3Ph 3-nitropyridin-4-yl cyclopropyl 13. 57 2-S 02Me-4-CF3Ph. 3-nitropwdin-4-yl CF3 1358 2-SO2Me-4-CF3Ph 5-cyanopyridin-2-yl H 1359 2-SO2Me-4-f3Ph 5-cyanopyridin-2-yl methyl 1360 2-SO2Me-4-XP3Ph 5-cyanopyridin-2-yl i-propyl 1361 2-SO2Me-4-CF3Ph 5-cyanopyridin-2-yl cyclopropyl 1362 2-SO ? Me-4-CF3Ph 5-cyanopyridin-2-yl CF3 1363 2-SO2Me-4-CF3Ph 5t lpyridin-2-yl H 1364 2-SOgMe-4-CF3Ph 5"uoromethylpyridin-2-yl methyl 1365 2-S02Me-4-CF3Ph 5-tifluoromethylpyridin-2-yl i-propyl 1366 2-S02Me-4-CF3Ph 5-trifluoromethylpyridin-2-yl cyclopropyl M67 -SOMe-CFgPh 5-tnauoromeihylpyridin-2-ylCFs 1368 2-SO2Me-4-Cli3Ph pyrimidin-2-yl H ffi- 1369 2-SO2Me-4-CFRh pyTimidin-2-yl methyl 1370 2-SO2Me-4-CF3Ph pyrimidin-2-yl i-propyl 1371 2TSOMe-4-CF3Ph pyrrimidin-2-yl cyclo ropyl 1372 2-SO2Me-4-CFRh pyrimidin-2-yl CFs 1373 2-SOAMe-4-ClS3Ph pyrimidin-4-yl H 1374 2-SOWMe-4-CERh pyrimidin-4-yl methyl Compolmid N... mp. fi 1375 2-'S03Me-4-CF ? Ph pyrimidm-4-yli-propyi 1376 2-SO « e-4-CF. 3Ph pynmidin-4-yl cyclopropyl ''1i3i7 , Oe-. rCFsPI, xmadin4, yl 1378 Z-SOe--CFsPh 6-chloEopyrimidm-4-ylmethyl 1379 2-S'. 02Me-4-C. h 6-*opm'X4-yl i-propyl 1380 2-S02Me-4'-CF3Ph -chloj'opyrimidm-4-ylcyclopropyi 1381 2-S02Me-4-CF'3Bh 6-c : Moropyrimidm-4-ylCFs , M, din-4-yl CF3 1382 2-S02Me-4-CE3Pb pyrjdazin-ylJS 1383 2-S. 02Me-4-CE3Ph p. yiaza-q-yl yl j. 384 2-SOMe-4-CP3Ph pyridaxin-3-yli-propyi 1385 2-S. oSMe-4-CFSPh p, azin-3^yl cyclopropyl 1386 2Q2Me-4-CF3Ph pyndaztn-3ylCF3 1387 2., S. O2Me-4-CF31 :'1 6-chloropyridazin-3-yl methyl 1388 2-SO2Me-4-C9h 6-idan-3-yl i-propyl . 1389 2-$02Me-4-CFRh 6-chloTopyridazin-3-yl cyclopropyl 1390 2-S02Me-4-CF3Ph 6-chloro yridazin, 3-yl CF3 139a 2-S02Me-4-CF3Ph pyrazin-2-yl methyl 1392 2-S02Me-4-CF3Ph pyrazin-2-yl i-propyl 139. 3 2-SO2Me^4-CE3Ph pyrazin-2-yl cyclopropyl 1394 2-. SO2Me-4-CF3Ph pyrazin-2-yl CF3 1395 2-SO2Me-4-CF3Ph triazin-2-l methyl 1396 2-SO2Me-4-CF3Ph ivin-2-yl i-propyl 1397 2-SO2Me-4-CF3Ph triazin-2-yl cyclopropyl 1398 2-SOAMe-4-CF3Ph triazin-2-yl CF3 1399'2-SO2Me-4-CF3Ph quirtolin-2-yl methyl 1400 2-SO2Me-4-CF3Ph quinolin-2-yl i-propyl 1401 2-g. 02Me-4-CF3Ph quillolin-)-yl cyclopropyl 1402 2-S. 02hIe-4-CF3Ph quinolin-2-yl CF3 i A03 2-S O2Me-A-CF3Ph 4 4, 6'1-N, 646 1b (4*<u-2-g H 1404 2-$02Me-4-CPsPh 424n6^ melkyl-5>6 dihydm1, 3 (4<-2-yl methyl 1405 2-SO2Me-4-(X3Ph 4s4XeffWl-5X6dbybl3 (4H ;) <zm-2-yl i-propyl 1406 2-SO2Me-4-a3Ph 4, 476iyl-5, Wybl (4>i-yl cyclopropyl I 1407 2-SO2Me-4-CF3Ph 4, 4, 6-~yL5, Zyi1J (4>-2-yl CF3 1408 2-S02M : e-4-C : FBPh 2-oxazolidinon-3-, yl 11 1409 2-SO2Me-4-CF3Ph 2-oxazolidinon-3-YI mefliyl Mie 2-S. O, 2Me-4-CE3Ph 2-oxaolidinon-3-yl i-propyl 1411 2-SO iMe-4t143Ph 2-oxazolidinon-3-yl cyclôpropyl 1412 2-SQzMe-4-CF3Ph 2-oxazolidinon-3-yl CF3 1413 2-SO : Meu4-CE3Ph 2-py¢olidinon-1-yl methyl 1414 2-SO2Me-4-CF3Ph 2-pyrrolidinon-1-yl i-propyl 1415 2-SO2Me-4-CF3Ph 2-yrrolidinon-l-yl cyclopropyl 1416 2-SO2Me-4-CF3Ph 2-pyffolidinon-1-yl CF3 1417 2-SO2Me-4-CP3Ph 3-methylisoxazol-5-yl methyl 1418 2-SO2Me-4-CF3Ph 3-methylisoxazol-5-yl i-propyl 1419 2-SOzMe-4-CFPh 3-methylisoxazol-5-yl cyclopropyl 1420 2-SO2Me-4-CF3Ph. 3-rnethylisoxazol-5-yl CF3 Compound N R msp. CC) l42t"'2-S02Me-4-CF3Pb"2-N02-4-S02MePh H 1422 2-SONe-4-CF3P ! h 2@oa-4-sOil ! deph methyl M23 2-S02Me-4-CF3Ph 2-N02-4-S02MePhi-propyi 1424 2-SOzIYMe-4-Ck'3Ph 2-N02-4-S02MePh cyclopropyl 1425 2-SQ3Me4-CF3Ph 2-N02-4-S02MePhjCFs 1426 2-S02Me-4-CF3Ph 2-Cl-4-S02MePhJH 1A27 2-SO2A§e-4-CF3Ph 2-Cl-4-S'wh methyl 1428 2-SOMe-4-CF3Ph 2Cl-4-SQ2M9Phi-propyi 1429 2-SQ2Me ! 4-CFyPh 2-Cl-4-SO2MePh cyclopropyl 1430 2-SOMe-4CF3Pb 2-Cl-4-S02MePhCFs 1431 2-SO2ge-4-CF3Ph 2 NO2-4-Ct3Ph H M32 2-S02Me-4-CF3Ph 2-N02-4CF3Phmethyl 1433 2-$02Me~4-CE3Ph 2-ND2-4-~h i-propyl 1434 2-SO2Me-4-CF3Ph 2-NO2-4-C, F3Ph cyclopropyl 1435 2-SO2Me-4-CF3Ph 2-NO2-4-CE3Ph CF3 1436 2-S02Me-4-CF3Ph 2-NO2-4-CIPh H 2S'OMe-4CF31'h 2 N2-4-CIPh methyl 1438 2-'SO2Me-4-CF3Ph t-NO2-4-CSh i-propyl 14, 3 9 2-SO2Me-4-CF3Ph 2-Pf02-4-ClPh cyclopropyl 1440 2-S02Me-4-CF3Ph 2-N02-4-ClPhCPg 1441 2-SO2Me-4-CF3Ph 2-CI-4-NO2Ph H 1442 2-SO2Me-4-CF3Ph 2-Cl-4-NO : >2Ph methyl 1443 2-SO2Me-4-CF3Ph 2-Cl-4-NO2Ph i-propyl 1444 7-SOXe-4-C, F3Ph 2-C1-4-NORh cyclopropyl 1445 2-SO2Me-4-CF3Ph 2-Cl-4-N02Ph CF3 1446 2-SO2Me-4-CF3Ph 2, 4- NOZ h I3 1447 2-S02Me-4-CF3Ph 2, 4-(NO2),, Ph methyl 1448 2-SO2Me-4-CF3Ph 2, 4-M02) 2Ph i-propyl 1449 2-SO2Me-4-CF3Ph 2, 4-602) 2Ph cyclopropyl 1450 2-S02Me-4-CF3Ph 2, 4-(NO2) 2Ph CE3 l45 l 2-SO2Me-4-CP3Ph 4-F-3-NO2Ph H 1452 2-SO2Me-4-CF3Ph 4-F-3-NO2Ph methyl 1453 2-SO2Me-4-CF3Ph 4-F-3-NO2Ph'i-propyl 1454. 2-SO2Me-4 CE3Ph 4-F-3-N02Ph cyclopropyl 1455 2-S02Me-4-CF3Ph 4-F-3-N02Ph CF3 1456 2-S 02Me-4-CP3Ph. 3, 5-(CF'3) 2Ph H 1457 2-S02Me-4-CF3Ph 3, 5- CF3 : 2Ph methyl 1458 2-SOiMe-4-CP3Ph 3, 5- (CF3) zPh itropyl 1459 2-SONe-4-CP3Ph 3, 5- (CF3) 2Phcyclopropyi 1460 2-S02Me-4-CF3Ph 3, 5- (CF3 2Ph CF3 1461 2-SO2Me-4-C : F3Ph 2-SONe-4-CE3Ph H 1462 2-SO2Me-4-CP3Ph 2-SO2Me-4-CF3Ph methyl 1463 2-SOXe-4-CP3Ph 2-SiO2Me-4-CE3Ph i-propyl 1464 2-SO2Me-4-CF3Ph 2-SO2iIe-4-CF3Ph cyclopropyl : 1 lA65 2-SOAMe-4-CF3Ph 2-SO2Me-4-CE3Ph CF3 Compound N Comp 3-Cl-5-CFsPyridin-2-yl l, 2, 4-oxadiazol-5-ylJH 1467 3-Cl-5-CFdi-2-y 1, 2,, 4-oxadiazol-5 yl rethyl 1468 3-Cl-S-CFPynd]) n-2-l l, 2, 4-oxadiazol-5-yli-propyi '1'W69'. 3 Cl,-S-*v-yi 1, 2, 4-divol-5 yl', cyclòpropyl 1470 3-Cl-5-CF'yndm-2-yl l, 2, 4-oxadiazol-5-ylCFg 1. 3-C5-CFmdm-2-yl 3'methyl-l, 2, 4-oxadiazol-5-ylJH 1472 3-Cl-S->dinOyl 3lyl-1, 2, 4-oxadiazol-5-yl methyl 1473 ; 73 3-Cl-S> Syl 3+'-1, 7, 4-oxadiwld-yl i-propyl_.. 1474 yndin. 2- I 3-methyl-1, 2i4-oxadiazol-5-YI 1. 75 3-C-S-CP'idin-2=yl 3.. meth-1-1, 2, 4-oxadiazol-5-yl 6. 3-Cl-5-QE ? tidin-2-yl 3-1, nNi. tommethyl-l, 2, 4-oxadiazol-5-yl H 1477 3-Cl-s-ei99&-2-yl 3-tnfluioromethyl-1, 2, 4-oxadiazol-5-yl methyl 1477 8. 3-CI-5->-yl 3+fluorowth, yl-1, 2i4-oxadazol-5-yl i-propyl 1479 3-CI-5-CEXyl 3 +Ruoromethyl-l, 2, 4-oxadivol-5-yl cyclopropyl 1480 3-CI-5-CF3Pyridin-2 yI 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl CF3 148t 3-Cl-5-CF3Pynctin-2-yl l, 2, 4-oxadiazol-3-ylH 1482 3-C1-£C F3Pyridin-2-yl 1, 2, 4-oxadiazol-3-yl methyl 1483 3-CI-5-CF<1 1, 2, 4-oxadiazol-3-yl i-propyl 1484 3-Cl-5-CF3Pyndin-2-yl l, 2, 4-oxadiazol-3-ylcydopropyi 1485 3-Cl-5-CF3Pyridin-2-yl l, 2, 4-oxadiazol-3-ylCFs 1486 3-Cl-5-C » yridint-yl 5-methyl-1, 2, 4-oxadiazol-3-yl H 1487 3-Cl-5-CF3Pyridin-2-yl 5-methyl-I, 2, 4-oxadiazol-3-yl methyl 1488 3-Cl-5-CF, Ryridin-2-yl 5-. methyl-1.,'2, 4-oxadiazol-3-yl i-propyl 1489 3-Cl-5-% Pyridin4-yl 5-methyl-1, 2, 4-oxadiazol-3-yl cyclopropyl qA90 3-Cl-5-»-yl-5-methyl-1, 2, 4-oxadìazol-3-yl CF3 1491 3-Cl-5-CF37'yridin-2-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl H 1492 3-CI-S-iPyri&-2-yl S-trifluoromeiyl-1, 2, 4-oxadiazol-3-yl methyl 1493 3-Cl-5-CF3Pyridin 2-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 1494 3-CI-5-CFSPyridin-2-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 1495 3-CI-5-CF~yl 5-duoromethyl-1, 2, 4-oxadiazol-3-yl CF3 1496 3-CL-5-CF3Pyridin-2 yl 5-chloro-1, 2, 4-oxadiazol-3-yl H 1497 3-C1-5-CF ; Pyridin-2-y1 5-cKoro-1, 2, 4-oxadiazol-3-yl methyl 1498 3-CI-5- 5-chloro-1, 2, 4-oxadiazol-3-yl i-ropyl 1499 3-Cl-5-CFE 2-yl 5-chlorF1 2, 4-oxadiazol-3-yl cyclopropyl 1500 3-Cl-5-CF3PyridHi-2-yl S-cbloro-l, 2, 4-oxadiazol-3-yl CF3 1501 3-Cl-5-CF3Pyridin-2-yl 1, 3, 4-oxadiazol-2-yl H 1502. 3-Cl-S-CFSPyridin-2-yl 1, 3, 4-oxadiazol-2-yl methyl 1503 3-Cl-S-CFSPyridin-2-yl 1 73, 4-oxadiazol-2-yl i-propyl 1504. 3-Cl-5-CF3Pyridin-2-yl 1, 3, 4-oxadiazol-2-yl cyclopropyl 1505 3-Cl-5-CF3bi-2-yl 1 3, 4-oxadiazol-2-yl cP3 1506 3-Cl-5-CF'din 2-1 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl H Compound N A B R m. p. cc) 1507 3, CI-5. 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl methyl 1508 3-Cl-5- (3Pyddm2-yI methylsul&ayl i-propyi 1509 3-CkS-C+1 5eelylsionyl-1, 3, < ÇyClOpIOp 1510 3-Cl 5-CFaPy ! ridiu-2 yl 5-nn, ehysulfon-1-I, 3, 4-oxadzazol-2-yl CF3 1511 _ 3-Cl-5eb 2-yi 5ç*yl-Ig3, 4-osa, digol-2-yl H- 1512 3-Cl-5-CFa'E9 {idh} yt 5-meiy, l-l>3v4-oxaXol-2-yl yl 1513 3-Cl-5v yl 5<ey, 1-1, 3, 4-a2cadiazol-2-yl i-propyl 1514 3-C1-5-CE3N+ : w. r gyclopropyl ! 5) [5 3-Cl- ?-CF3Pyndm-2-yI j-methyl'-l, 3, 4-oxad ! azo2-y ! CFg 15F 3-Cl-5-CFPyndin-yt 5-triotome H 1517 3-CI-5~CF3~i-2-yl 5-Xfluoromet-1, 3, 4-oxadiazol-2-yl methyl '1318 3-Ct-5-CFndm-<2-yt -tn : SuoromethyI-l, 3, 4-oxadiazol-2-yl i-propyi yn. 2yl 1519 3-Cl-SCF'iia=2 yl 5-trifluoromethyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 1520 3-Cl-5-CF3Pyridin Z yl 5-tifluorometh 11, 3, 4-oxadiazol-2-yl CF3 1521 3-Cl-5-CEi73Psidin-Syl 1, 2, 3 Striazol-4-yl H : 1522 3-Cl-5-CF'din-2-yl 1, 273-tiazol-4-yl mediyl 1523 3-Cl-3-CF3Pyddin-2-yl l, 2, 3-tnazol-4-yli-propyi 1524 3CI-5-1, 2, 3-triazol-4-yl cvclop Yi 1 525 3-Cl-S-C : FTidinOyl 1, 2, 3-tnazol-4-vl CE3 1526 3-Cl-S-CFI'yridin 2 y1 . methyl-1, 2, 3-triazol-4-yl H 1527 3-Cl-5-CF3Pyriidin -1 1-methyl-1, 2, 3-triazol-4-yl methyl 1528 3-CI-5-CE'din-2-l 1-methyl-1, 2, 3-triazol-4-yl i-propyl 1529 3-Cl-5-CF3Pyridin-2-yl 1-methyl-1, 2, 3-tiazol-4-yJ cyclopropyl 1530 3-Cl-5-CF'din-2 yl lrnethy-1, 2, 3-triazol-4- 1 CFs 1531 3-Cl-5-iridiS-yl 2-methyl-1, 2, 3-triazol-4-yl H 1532 3-Cl-5-CFsPyridin-2-yl -methyl-l, 2, 3-triazol-4-y1 methyl 1533. 3-C1-5-EF-2-yl 2sethyl-1, 2, 3-triazol-4-yl i-propyl 1534 3-Cl-5-CF3PyridmL-2-yl 2-methyl-l, 2, 3-triazol-4-yl cYclopropyl i535 3-Cl-5-CFsPyridin-2-yl 2-rnethyl-1, 2, 3-triazol-4-yl CF3 1536 3-Cl-5-1, 2, 3-iazol-1-yl H 1537 3-Cl-5-CFbidm-2 yl 1, 2, 3-triazol-l-ylmethyl S38 3-Cl-5-CF3PyndmL-2-yl 1, 2, 3-triazol-1-yl i-propyl 1539 3-Cl-5-CF3Pyridin-2-yl 1, 2, 3-triazol-1-yl cyclo ro 1 1540 3e1-5->-2-yl 1, 2, 3-triazol-1-yl CF3 1541 3-Cl-S-w2-vl 1, 2 3-ieol-2-vl H 1542 3-CI-5-CFRyiidin-2-. yl 1, 2, 3-ivol-2-yl meisl 1543 3-Cl-5-3Pyridbyl 1, 2, 3-triazol-2-yl i-propyl 1544 3-CI-5-CFbidi2-yl 1., 2, 3-triazol-2-yl cyclopropyl 1545 3-Cl-5-CF3Pridin-2-yl 1, 2, 3-triazol-2-yl CF3 1546 3-Cl-5-ibdin-2-yl 1, 2, 4-triazol-1-yl H 1547 3-Cl-S-» i-2-21 1, 2, 4-triazol-l-yl methyl 1548 3-Cl-5-CF3Pyridin-2-yl 1, 2, 4-triazol-1-yl i-pro l 549 3-CI-5-CP3PyNdH !-2-yI J, 2, 4-tazol-1-yl cyclopropyl 1550 3-Cl-5-CF3Pyridin-2-yl 1, 4-triazol-1-yl CF3 1551 3-Cl-S-Bi62-yl imidazol-2-yl _ H 1552 _ 3-Cl-S-CFRyn-£yl indvol-2-yl mAyl CompomtdN A B R mp-m 1553 3-Cl-5-CF3Pyridm-2-yl imidazoM-yl i-propyi 1554 3-Cl-5-CFPyridin-2-yl imidazol-2-ylcyclopropyi IS55 3-Cl-5-Obi& imidazol-2'-ylCFs M56 3-Cl-5-CF3Py [idin-2-yl imidazoM-ylH 1557 3-Cl-5-CT ? Pyndin-2-yl imidazol-l-ylmethyl , 1558. 3-CI-s-ws yl, imidvol-l-yl Fpropyl 1559 3-Cl-5-CFsPyndin2-yl imidazol-1-ylcyclopropyi 60 3. Cl-5-Cli3pyrtdui-2-yl jtiudazol-'I-ylCFg 1561 3-CI-S 1, midaol-4-yl H 1562 S-C-CFsPyndm-yt JEEtidazoI-4-ylmethyl IF3PYn 1563 3-Cl-S-LF. 3Pyridin 2 yl imitazol-4 yl i-pro 1 1564 3-Cl-5-CF'din, 2 y imdazol-4-yl Gyclo ro yl 1565,, 3-C-5-CFti&-2 Yl imidaol-4-yl., O3 1566 S-Cl-S-CFPyndm-S-yl thiazol-2-ylJS 1567 3-Cl-S-CF>i& 2-yl WwoI-2-yl methyl 1568 3-Cl-5-CF3ndin-2-yl thiazol--yli-propyi 1569 3-Cl 5-C3Pyrzdit-2-yl thiazol-2-yl cyclopropyI 1570 3-Cl-5-CF3Pyridin-2-yl thiazol-2-yl CF3 1571 3-Cl-5-CF1'yridin 2-yl 4-methylthiazol-2-yl H 1572 3-Cl-S-C>din-2-yl 4-methylthiazol-2-yi methyl 1573 3-Cl-5-CF3Pyridin-2-yl 4-methylthiazol-2-yl i-propyl 1574 3-Cl-5-CF3Pycidin-2 yl 4-meth Ithiazol2-yl cyclopro yl 1575 3-Cl-5-CF3Pyridin-2-yl 4-methylthiazol-2-yl CF3 1576 3-CI-5-CF3Pyridin-2-yl oxazol-2-yl H 1577 3-Cl-5-CF3Pyddm-2-yl xazol-2-ylmethyl 1578 3-CI-5-CF3Pyridin-2-yl oxazol-2-yl i-propyl 1579 3-CI-5-CF3Pyridi-2-yl oxazol-2-yl cycloPr 1580 3-Cl-5-3Nidit-yl oxsol-2 jl CE3 1581 3-Cl-5-CF3Pyridin 2-yl 4, 5-dimethyloxazol-2-yl H 1582 3-CI-5-CEPyridinO, yl 4, 5t nethyloxazol-2-yl methyl 158 ? 3-CI-5-CF3Pyndm-2-yl 4, 5-dimethyloxazol-2-yl i-propyl 1584 3-Cl-5-CP'3Pyridin-2-yl 4, 5-dimethyloxazol-2-yl cyclopropyl 1585 3-Cl-5-C Pyridin-24yl 4, 5-dimethyloxazol-2-yl CF3 1586 3-Cl-5-CF'din-2 yl 2-oxazolin-2-yl H 1587 3-CI-S-imdiS-yl 2-oxazolin-2-yl _ _ ttlethyl 1588 3-Cl-5-CF3Pyridin-2-yl 2-oxazolin-2-yl i-propyl 58Y. 3-Cl-5->din-2-yI 2-oxazolin-2-yl cyclopropyl 1590 3-Cl-5-CF3Pyridin-2-yl 2-oxazolin-2-yl CFa 1591 3-CI-S^ (>idin-2-yl 4j4-dimethyl-2-oxazolin-2-yl EI 1592 3-Cl-5-CFPyndm-2-yl 4, 4-dimethyl-2-oxazolin-2-ylmethyl 1593 3-Cl-5-CF'din-2-yl 4, 4-dimeth 1-2-oxazolin-2-yl i-ro yl 1594 3-Cl-5-CF3'clin-2-yl 4, 4-d. imeth 1-2-oxazolin-2-1 clo ro I 1595 3-Cl-5^CFt-2^yl 474-dimethyl-2-oxazoliD-2-yl CF3 M9 3-CI-5-CP3Pyndia-. 2-y) l, 2, 4-&iadiazol-5-ylJH 1597 3-Cl-5-CF'din-2-yl 1, 2, 4-thiadiazol-5-yl methyl 1598 3-Cl-S^GF3PyridE yl 1"2, 4-*iadiazol-5-yl i-propyl Compuiiiid N A B CC) 1599 3-Cl-5-CFPyndm'-3-yl l, 2, 4-thiadiazol-3'-ylcyclopropyl 1600 3-Gl-S-CF3Pyridin-2 yl 1, Z, 4-*adiazel-5-yl i3 st. 60 3-Ci-5-CF3Pytidin-2-yl 3-metRyl, 2, 4-thiadio5-ylJEI 1602 3-Cl-§-CF5PyndmL-2-yl 3-mcthyt-l, 2, 4-thiadiazol-5-ylmethyl t. 603 3-Cl-S'CFNdm-2-yl 3-methyl-l, 2, 4-thtadiazol-3-yli-propyi 1604 3-C1-5 w S-methyt-l, 2, 4-thladtazol4-yl. cy, clopropyl 1605 3-Cl-3-. CF3Pytidm-2-. yl 3-niethyl-l, 2, 4-thiadiazol-5-ylCFg 3-Cl-'SCdin. 2 y'1 -'tri. fluoromethyl-1, 2, t'iaclxaol-5-1 H 1606 3-Cl-Sb 3+zX, oærnlyl-l, 2, 41-5-yl _H 1607 3-Cl-5-CP3Pymdm-2-yl 3-trtopometliyl-l, 2, 4-thiadiazol-5-yl H 1 GO 8. 3-C1-5-> 3 duorHyl-1, 2, 4-tiaia, zol-5-yl i-propyl 1609 3-Cl-5-wbyl 3-ifuoromflhyl-1, 2, 4-thiadiazol-S-yl cyclopropy1 Ig6ii0 3-C1-5-e*-2-yi. 3 :-t, riSiuororneîhyl-1, 2 thiadvol-5-yl. 1611 3-C. l-S-CF+<il 1, Zj4Xw1-3-yl H _ 1612 3-Cl-5-CF'yndin-2-yt l, 2, 4-aMadiazQl-3-ylmethyl 1613 3-C1-5-bi2-yl 1, 2¢t4-. XWivol-3-yl t-propyl 1614 3-CI-5-CF3Pyndfn-2-y ! l, 2, 4-&iadiazol-3-ytcyclopropyi a5zs 3=C15-CFiditi-2 yl , 2, 4-thiadiazl-3y1 CF3 1616 3-Cl-5-CF3Pyridin-2-yl 5-methyl-1, 2, 4-thiadiazol-3-yl H 1617 3-CI-5-C » yridin-2-yl 5-methyl-1, 2, 4-thiadiazol-3-yl melyl 1618 3-Q-3-CF3Pyddm-2-yl -mcthyl-l, 2, 4-thiadiazol-3-yli-propyi 1619 3-Cl-5-CF3Pyndm-2-yl 5-methyl-l, 2, 4-thiadiazol-3-yl cyclopropyl 1620 3-Cl-3-CF3Pyndm-2-yl 5-nethyl-l, 2, 4-thiadiazol-3-yl CFg 1621 wl 5-iiquoresmeffiyl-1, 2, 4-thiadiazol-3-yl H 1622 3-Cl 5-GF3Pyricin 2 yl 5-trifluoromethyl-1, 2, 4-*iadiazol-3-yl meiyl 1623 3-Cl-5-CF3Pyadin-2-yl 5-tdBomethyl-l, 2, 4-thiadiazol-3-yl i-propyl 1624 3-CI-5-@ridi33-2-yl 5-trifluoromethyl-1 ? 2, 4-thiadiazol-3-yl cyclopropyl 625 3-Cl-5-CE3PyYl S-. trifíuorotnethyl-1, 2, 4-thiadiazol-3-yl CE3 1626 3-Cl-S-CF3Pyridin-2-yl 1, 3, 4-thiadiazol-2-yl H 1627 3-CI-5-CF3ui-2-yl 1, 3., 4*Xieol-2-yl methyl 1628 3-CI-5-a3ai-2-yl 1, 3, 4-thiacliazol-2-yl i-propyl 1629 3-Cl-5-C.-yl 13 4-thadiazol-2-yl cvclooroDyl 1630 3-Ql-5-CF3Pyriiditr2 yl 1, 3, 4-iadiazal-2 yl CF3 1631 3-CI-5-CE3Pyridin-2-yl 5-nethisffinyl-1, 3 4-iadiazol-2-yl H 132 3-Cl-S-CF3Pyridin-2-yl 5-rnethyls lfonyl-1, 3, 4-thiadiazol-2-yl methyl 1633 3-Cl-S-CPyridin-2-yl S-methylsuliònyl-l, 3, 4-thiadiazol-2-yl i-propyl 1634 3-Cl-5-CF3Pyndm-2-yl 5-methyisuI6) nyl-l, 3, 4-thiadiazol-2-yl cyclopropyi 1635 3-Cl-5-CFbi-2-yl 5-meiylSulffont 34-thiaiazol-2-yl _ _ _ _ 1636 3-Cl-5-CFPyridm-2-yl-5-methyl-l, 3, 4-thiadiazol-2-yl H . 1637 3-Cl-5-CF3Pytidin-2-yI 5-memyl-l, 3, 4-tbtadiazol-2-ylmethyl 1638 3-Cl-5-CFigridin-2-yl S-methyl-l 3, 4-thiadiazol-2-yl-propyl ? 39 3-Cl-5-Ct'3Jidm-2-yl 5-methyl-l, 3, 4-tbiadiazol-2-ylcyclopropyi 1640 3-Cl-S-CF3Pyridin-2-yl 5-methyl-1, 3, 4-thiadiazol-2-yl CF3 M49 641 3-CI-5-CFsPyndin-2-yl benzoxazol-2-yl B 1642 3-C1-5"2-yl bezoxeol-2-yl methyl. 1643 3-Cl-S-CF3pytidin-2-yl benzoxazol-2-yl i-propyl 1644 3-CI-5 wS-yl beeoxæol-2-yl cyclopropyl. 1645 3-Cl-5-CF3Pyridin-2-yl benzoxazol-2-yl CF3 Com ound A B-R- 1646 3-CI-5-CF [idm-2-yI 6-methylbeiizoxazol-2-ylJS 1647 3-Cl-S-CF3Pyr) Ldm-21 6-me&ylbenzoxazol-2-ylmethyl 1648 3-Cl-5-CF3dtn-2-yI 6-methylbeazoxazoli-propyi 1649 3-Cl-S-CP3Pdih-2-yl 6-methylbet ! ! tzoxazol-2-ylcyclopropyi 1650 3-Cl-5-» yridinj2-yl 6-mathylbenzoxgzol-2>yl CP3 165low 1, 651 T 1652 3-Cl-5-CF3Pyn [dm-2-yl beBzothiazol-2-ylmethyl 1653 3-Ck5-w-2-Yl beao. tiOolMyl i-propyl 1654 3-Cl-S-CPa3ia--yl beHzothiazpl-2-ylcyclopropyi 1655 3-CI-5-CF3Ptdm-2-yI benzotbiazol-2-ylCPs 1656 3-C 5C31'yriclin-2, yxazolTl yl 1657 3-Cl-S-CF3ndm-2-yt pyrazol-1-ylmethyl 1659 S-Cl-CFgPyBtdtn-X-yI pyrazot-1-yli-propyt t659 3-Cl-5-CFyBdm-2-yl pyrzol-ylcyclopropyi 1660 3-Cl 5-CF3Pyridin-2-yl pyrazol-1-yI CF3 1661 3-Cl-5-CF3Pdin-2-yi pyrazol-S-ylH 1662 3-CK5->-2-yl p, +-3-yl meffiy1 1663 3-Cl-5-CFPytidin-2-yl pyrazol-S-yli-propyi 1664 3-C1-5-C>dill-2-yl pyrazol 3-yl cyclopropyl 1s665 3-Cl-5-C>i-2-y1 pyrgol-3-yl CF3 1666 3-Cl-S-Cl ? S idin-2-yl l-methYlDyrazol-3-yl H 1667 3-Cl-5-CP 2-yl 1-methylpyrvol-3-yl meiyl 1668 3-CI-5-azol-3-yl i-propyl 1669 3-CI-5-CF3Pyxicin-2-yl 1-methylpyrazol-3-yl clopropyl 1670 3-Cl-5-CF3Pyndin-2-yl l-methylpyrazol-3-ylCFs 1671 3-Cl-5-CF3Pyridin-2 y1 tetrazol-1-yl I , 1672 3-Cl-5-CP3PyX 2-yl tetrazol-I-yl methyl 1673 3aCl-5->i-2-yl {etaol-1-yl i-propyl 1674 3-Cl-5-CF31'yidin-2 : yl tetrazol-1-yl cyclo ro yl 1675 3-Cl-5-CF3Pptidin 2-yl tetrazol-1-yl CF3 d 1676 3-CI-5-CEbbyl S-methyltetr=ol-1-yl H 1677 3-Cl-5-CF3Pyrildin-2-yl 5-methyltetrazol-1-yl methyl 1678 3-Cl-5-CF3Nidill-2-yl S-m, etliyltetrazol-l-yl i-propyl 3-Cl 5-CFF'yridi.-2 yl S meth. ltetrazol-1-yl c clo ro 1 -'1680 3-C1-5-CFb-2-yl Ssethyltetreol-1-yl CE3.. 16g1 3-Cl-5-CF'yridiu 2-yl tetrazol-2 yl H I6S2 3-CI-5-CF3Pyrtdtn-2-yI. tetrazol-2-y ! methyl 1683 3-Cl-5-CF2gTidin-2-yl tetrazol-2-yl i-propyl 4684 3-Cl-S-CPrgidin-2-yl tetrazol-2-yl _ cyclõpropl 1685 68S 3-Cl-5-CFa'Py [idia-2yl tetazol-2-yi CF3 1686 3-Cl-5-CF3Pyridin-2-yl 5-methyltetrazol-2-yl H 1687 3-Cl-5-CPTidin-2-yl S-methyltetrazol-, ?-yl _ methyl 1688 3-Cl-5-CPbidin-2-yl 5-methyltetriazol-2-yl i-propyl 1689 3-C F>i-2-y} keth, ylrteteol-2-yl cyclopropyl 1690 3-Cl-5-CF'din-2 y1 5-meth ltetrazol-2-yl F3 1691 3-Cl-5-CF3Pyridin.-2-yl I-methyltetrazol-5-yl H Compound NABRm-p. (°C) ! 3-CI-5-CP3Py ! idm-2-yl l-methyltetrazol-5-ylmethyl ? 93 S'-Cl-S-CFPyjidm-yl l-efhyltetrazol-5-yli-propyi 1694 3-CI-5-CFdin. 1-mol-S-yl cycloEpyi Mas 3-'Cl-S-CFsPydin.-2-yl l-methyltetrazol-3-ylJCFs 1696 3-. Cl-5-CFPyndm-2-yl 2methyttetrazQl-5-ylJH 1697 3-CI-5- 2methyttetrazol-5-yi H 1698'< 2-metìiylte-yl i-propyl 1699 S-Cl-S-CFgPyridin--yI 2methyltetrazol-5-ylcyclopropyi 1700 3-CIz-*i, l. tEl ; razol-5-yl cE3 I701 3 Cl s wibyl oX--. yn-., 1702 3-C !-5-C3R3Pyndm.-2-yl pyridm-'-ylmethyl 1703 3-l-5-CF3Pyddin-2-yl pytidin-yli-propyi 1704 3 C1 5 CEiXditl 2 yl pyridin 2 yl cyclopropyl 1705 3t1-5-Cw pyndm-2-ylCFs 1706 3çaS ql pWdin-4-yl H 1707 3-Cls5-GFddla-2-yl. dqn-4-yl methyl 1708 3-Cl-5- » idirl-2-yl pyridili-4-yl i-propyl 1709 3-Cl-5-C'EPy [idin-21 pyridm-4-ylcyclopropyi 1710 3-CI-5-C>din-2-yl pyridin-4-yl CE3 i7H 3-Cl-5-CF3 ! dui-2-yl'pyridin-3-ylH 1712 3-Ci-5-GP3Pyx-2-yl pyrid. in-3-yl methyl 1713 3-Cl-S-GPmdin-2-yl pyridin-3-yl,, i-propyl 1714 3-Cl-5-CFPyndin-2-yI pyridim-3-ylcyclopropyi 171 s 3-C1-5-CF3Pyridin-2-yl pyridin-3-yl CF3 1716 3-Cl-5-CFsPyrid] n-2-yl 3-nitrppyridm-4-ylJH 1717 3-Cl-5-CF3Pyridin-2-yl 3-nitropyridain-4-yl methyl 1718 3-Cl-S-CF3Pyndin-2-yl 3-mtropyndm-4-yli-propyi 171, 9 3-CI-5-CF3Pyiidin2-yl 3-nitropyridin-4-yl cyclopropyl 1720 3-Cl-5-CF3Pyridin-2 yl 3-nitro yridin 4-yl CF3 72l 3-CI-5-CPEtcttn-2-yI 5-cyaNopyridMi-2-yIJH 1722 3-Cl-5-CFbdin-2-yl 5-cyanopyrIdin-2-yl methyl 1723 3-CI-d yl 5-0cymspyidin-2-yl i-propyl... 1724 3-Cl-5-yl 5-cymopyridm-2-yl cyclopropyl 1725 3-Cl-5-CF3Pyridin-2-yl 5-cyanopyridin-2-yl CF3 1725-cy=py CF3 1726 3-Cl-5-CF3Pyridin-2-y 5--Liluoromethylpyridin-2-yl H 1727 3-CI-5-CF'din-2-yl 5-trifluoromethylpyridin-2-yi methyl i72S 3-Ci-5-CF3Pysdin-2-yI -tnSuoromethylpyridm-2-yIi-piopyi 1729 3-Cl-5-CFPyridin-2-yl 5-trifluoromethylpyridin-2-yl cyclopropyl q 73 0 3-cí-s-Cwdi2-yl 5-duoromethylpyri din-2-yl CE3 1731 3=Cl-5-CF3Pyric'in2 yl primidin-2-yl H 1732 3-Cl-5-CF3Pyddin-2-yl pyrimidm-2-ylmethyl 1733 3-Cl-S-CEi 2-yl py nidin-2-y1 i-propyl 1734 3-Cl-5-CF3din-2 yl pyrimidin-2-yl cyclopropyi 1735 3-Cl-5-CFPyEidm-2-y ! pyrimidm-2-ylCJFg 1736 3-Cl-5-CFPyridm-2-yl pyrimidm-4-ylJH v1737 3-Cl-5-CFPyritin-2-1 yrimidin-4-yl methyl Compound N A B . . 1738 3-Cl-5-CF3Pyadia-yl pyrimidm-4-yli-PMpy ! 1739 S-Cl-S-CFsPyrtdin-. yl pyrimidm-4-ylcyclopropyi 1740 X 76>w1 pXdi, n-4-yl.. CF3. midin-4-yl melbyl 1742 3 Cl-5-CF31+yl 6-óSoropSiiiiidin-4-yl i-propyl 17i43 12 5 C44 =. 1 56-dWröpWmídin-4-yl cyclopropyl 1744 3-Cl-5-CF3Pyndm-2-yl 6-chloropynmidin-4-ylCFg 1 74s 3-Cl-Sw-yl pm, dam-3-yl H.., q746 3-C'I-5 yt +3-yl methyl 1747 3"S->2-yl PR-3-yl i-propyl 174 3-Cl-5-CFdd ! n-2-yl pyridazm--ylcydopropyi 1749 m pyndazin4-yl CE3 ! t75G 3-Cl-5-CFPdm-yl 6-cMotQpyndazin-3ylmethyl 1751 3-C1-$-CF~w-yl ó-cKoropyndmn-3-yl l-propyl x752 3-Cl-5-CFn-2-yl 6-cliloxopyxidazin--y cyclopropyl 1753 3-Cl-5-CFytidin-2-yl'6-chtQropyddazin-3-yl CFg 1754 3-CI 5-CF3Pyriidin 2-I yrazin 2-yl meth, 1 1755 3-. C1-5-CT ; ~ » l pwin 2-yl i-pTopyl 1756 3-Cl-S-CFSPyridm-Nyl pyrazin-2-yl cyclopropyl 1757 3-Cl-5-CF3Pyndm-2-yl pycazm-2-ylCFa 1758 3-Cl-5-CF3Pyridm.-2-yl tnazim-2-ytmethyl 1759 3-Cl-5-CP3Py [idin-2-yl Wiazin-2-yl i-propyl 1760 3-Cl-S-CFPyEidin-2-yl nazm-2-ylcyclopropyi 1761 3-Ci-5-CF3Pyndm-2-yI tnazin-2-ylCFs 1762 3-Cl-. 5-ClBidin-Syl, qui3lolm-2-yl methyl 1763 3-Cl-S-GEi-2-yl quinolin-2-yl i-propyl 1764 3-C1-5->1 qwnolm-2-yl cyclopropyl 1765 5 3-C1-5-CE-yl Eqmolm-2-yl CF3 1766 3-Cl-5-CF3Pyndii2-yl 46-tn61-5, 6ib 767 3aC1-5-wi-2syl 4, 4, ~iyl-5j64bla. (4Rsi-yl methyl 1768 3-CI-5-CFbi-2-yl Sv » mbI i-propyl 1769 3-Cl-5-CP3Pyridin-. 2-yl 4, 4, 6-trhnel-S, 6-dthydm-l, 3 (4H)-oxaan-2-yl cyclopropyi 1770 3-Cl-5-CF3Pyndin-2-yl 4, 4, ~iyl-5, 6Oyb1, 3 (44-2-yl CF3 1771 3-CI-5-CFPynidin 2 yl 2-oxazolidinon-3-yl H 1772 3-Cl-S-Cwdínd-yl 2-oxazolidinon-3-yl methyl 1773 3-CI-5-CF PyE 2-oxazolidinon-3-yl i-propyl 1774 2-oxa : zolidinon-3-yl cyclopropyl 1775 3-Cl-5-CF3Pyndin-2-yl 2-oxazolidinon-3-ylCF3 1776 3-Cl-5-CE3WK-yl 2-pwolidinon-1-yl methyl 1'777 3-Cl-5widin-2-yl 2-pylrolidinon-1-yl i-propyl 1778 3-Cl-5-CEbyl 2-pflrolidnon-1-yl cyclopropyl 1779. 3-Ci-5-CF3Pyndm-2-yI j2-pyrrolidinon-l-ylCFg 1780 3-Cl-S-CF Pyridin-2^yl 3-methylisoxiazol-5-yl methyl 17s1 3-CI-5-CF3Pyridin-2-yI 3-methylisoxazol-5-yI i-ropyl 1782 3-Cl-5-CF. clin-2 yl 3-meth lisoxazol-S.-yl cyclo ropyl 1783 3-Cl-5-CF3Pyridin-2-yl 3-methylisoxazol-5-yl CF3 Compound N A B R m. p. -- (°C) 1784 3-C).-5-CF3Pyridi-2 y 2-NOZ-A-S (JzleP H 1795 3-Cl-5-CF3Pydai-2-yl 2-N02-4-S02MePhmethyl 'A786 1 3-C. l-S+iAl-w f l-propyl 1787 3-Cl-5-CF3Pyiidin-2-yl 2-N02-4-S02MePhcyclopropyi 1788 _ 3-Cl-Sw yl 2-m2-4-SO2MePh. CF3 1788 3-Cl-5-CF3Pyridin-2-yl 2-Cl-4-S02MePh H 1790 3-Cl-5-CFsPyndin-2-yl. 2-Cl-4-SOzMePh methyl 1791 3-CH-2-yl 2-a-4 SO2Wh i-propyl 1792 3-Cl-5-CF3Pyridi) i-2-yl 2-Cl-4-S02MePhcyclopropyi ! 793 3-Cl-5-CF3PyNdm-2-yl 2-Cl-4-S02MePhCFg 1794 1<t twl 2-N02-4-CF3Ph 3 1795 3-Cl-S-CF3Pyrid n-2-yl 2-N2-4-CF3Ph methyl 1796 3-Cl-5-CFyndin-2-yl 2-N02-4-CF3Phi-propyi 1797 3-Gl-5-CFZd&-2-yl 2-NO2-4-CFRh cyclopropyl.. 1798 3-Cl-. S-CF, ~2din-2 yl 2-NO2-AnCF3Ph. CE3 1799 3-Cl-5-CF~dr-2-yl 2-NO2-4-CPh H 1 : 800 3-Cl-5-CF3Pyridin-2-yl 2-N02-4-ClPhmethyl 1801 3-Cl-5-CFPyddm-2-yl 2-N02-4-ClPhi-propyi 1802 3-Cl-S-C~b2-yl 2-NO2-4-ClPh cyclopropyl 1803 3-Cl-5-CF3Pyadm.-2-yl 2-N02-4-ClPhCFs 1804 3-Cl-5-CF3Pyridin-2-yl 2-Cl-4-NO2Ph H 1805 3-C1-5-Cwid yl 2-C-4-NO2Ph methyl din 1806 3-CI-5-CF~i-2-yl 2-C1-4-NOzPh, i-propyl 1807 3-Cl-5-CF3Pyrids yl 2-Cl-4-NO2Ph cyclopropyl rsos 3-Cl-5-CF3Pyxidin-2 yl 2-Cl-4-N4zh CF 1809 3-Cl-5-CF3Pyridin-2-yl 2, 4- (NOz2Ph H Mio 3-Cl-5-CF3Pytidm-2-yl 2, 4- (N02Phmethyl 1811 3-Cl-5-CF3Pyridki-2-yl 2, 4-(N02EPh i-propyl 1812 3-Cl-S-C>i-2-yl 24-. % Oa3Rh cyclopropyl 1813 3-Cl-5-CF3Pyridm-2-yl 2, 4-(NO2) 2Ph CF3 1. 814 3-Cl-5-CF bidin-2-yl 4-F-3-NO2Ph E 1'815 3-Cld-CFi-Dyl SF-3-NO2Ph. meiyl 1816 3-Cl-S-CP3Pyridm-2 yl 4-F-3-NO2Eh i-propyl , 1. 817 3-Cl-5-4-F-3-NO2Ph cyclopropyl 1818 3-Cl-S-CP31 ? ytidin-2-yl 4-F-3-NQ2Ph CP3 1$ l 9 3-Cl-S-ibidin-2-yl 3, S-(CE3) 2Ph 1820 3-Cl-5-CF3Pyndm-2-yl 3, 5- (CF3) xPhmethyl 1821 3-Cl-5-CF3Pyridm-2-yl 3, 5-(CP3) 2Ph i-propyl 1. 822 3Sl-S-CF3P5r 2-yl 3, 5- (CF3) 2Phcyclopropyi 1823 3-Cl-5-CF3P'yridin 2-yl 3, 5- (CF3) 2Ph CF3 jt824 3-Cl-5-CF3PyNdin-2-yI 2-S02Me-4-CF3PhJH 1825 3-Cl-5-CF'din-2-yl 2-S02Me-4-CF3Ph methyl 1. 826. 3-CI-5-CE ;-2-yl 2-SOgMa-4-CF3Ph i-propyl 1827 3-Cl-5-CF3Pyridm-2-yl 2-S02Me-4-CF3Phcyclopropyi 1828 3-Cl-5-CF3Pyridin-2-yl 2-S02Me-4--CF3Ph CF3 CompoundN A B R tN. p. CO 1829 2, 4- (Me) 2Thiazpl-5'-yl l, 2, 4'-oxadiazol-5-ylH 18s4 2, 4- e aThiazol-5, 1, 2, oxadiazol-5-y1 meth 1 1831 X, 4-, Ne) 2Nvol-. 5-yl 1, 2v4-oxaigol-5-yl iSpropyl 1832 2, 4-(MehThiæipl S-yl IX2X4-oxadiaZol-5-yl cyclopropyl 1833 2, 833 2'Iazol-5-yl 1, 2, 4-oxadiazol-S-ylCFg 1834 2, 4- (e) 2TEMazol-5-yl 3-methyl-l, 2, 4-oxa&ol-5-yl H 1835 2, 4-LMe) 2Ihi 61-5-yl 3-methyl-1, 2, 4-oxpazol-5-yl mehyl'.. 1836 2, 4- (Me) 2'EhiazoM-yl 3-methyl-l, 2, 4 oxadiàzol-$-yl i-propyl 1837 2, 4- (Me) 2'Hiiaz : ot-'5-yt 3-methyl-l, 2, 4-oxadiazol-5-y cyclopropyl 3~ì838, 2, 4-44w1-5, yl 3+1-1, +2j4-oxaiazol-5-yl CP3.,, 1839 2, 4-XeOaXol-5-yl 3-Xelyl-1, 2, 4-oxadiazol-5-yl H 1840 2, 4- (Me) xniiazol-5-yl 3-tdflrometbyl'-l, 2, 4-oxadiazol-5-yl methyl 1841 2, 4-ah-5-yiL 3-Xfluoromethyl-1, 7-, 4-oxadazol-5-yl i-propyl 1842 2, 4- (Me) 2Thiazol-5-yl 3-triluaromethyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 1844 2, 4- (Me) 2Thiazol-5-yl I, 2, 4-oxadiazol-3-ylH 1s44 2, 4- e zQl-5-yl 1, 2, 4-oxadiazal-3-yl H 1844 2, 4-(Me) 2Thiazol-5-yl 1, 2, 4-oxadiazol-3-yl H 1845 2, 4- (Me) 2'Duazol-5-yI l, 2, 4-oxadiazol-3'ylmethyl 1846 2, 4- (Me) 2Thtazol-5-yl l, 2, 4-oxadiazol-3-yl i-propyl l. 847 2, 4- (Me 2Thiazol-5-yl 1, 2, 4-oxadiazol-3-yl cyclopropyl 1848 2, 4-(Me32Thiazol-5-yl 1, 2, 4-oxadiazol-3-yl CF3 1849 2, 4- e) 2Thiazol-5-yl 5-methyl-1, 2, 4-oxadiazol-3-yl H ! I850 2, 4- (Me) 2Th] azol-5-yI 5-methyl-l, 2, 4-oxadiazol-3-yl methyl 1851 2, 4- (Me) 2Thiazol-5-yl 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 1852 2, 4"e32Tlìiazol-3-yl 5-mei, 4-owadiazol-3-yl cyclouronyl ,..-. z. _. 1853 2, 4-(Me) 21hiazol-5-yl 5-methyl-1, 2, 4-oxadiazol-3-yl CE3 1854 2, 4-e) 21>1iazol-5-yl 5-trifluoromethyI-1, 2, 4-oxadiazol-3-yl H 1854 2, 4- (Me) 2Thiazol-5-yI 5-tnQuoromethyl-l, 2, 4-oxadiazol-3-yl methyl 1856 2, 4- (Me) 2Thiazol-5-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl . 1857 5-triguoromet'hyl-1, 2i4-oxadiazol-3-yl cyclopropyl 1858 2, 4-(Me3211jiazoi-5-yl 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 aisss 2, 4- (e) 2Tbiazol-5-yl 5-chloro-I, 2, 4-oxadiazol-3-yl H 1 860 2, 4-< (Me) 2'IMazol-S-yl 5-chloro-l, 2, 4-oxadiazol-3-ylmethyl i861_ 2, 4-(Me ? 2hazol-5-yl 5-chloro-1, 2, 4-oxadiazol-3-yl i-propyl ,, T-862. 2, 4- (Me) 2lMazol-5-yl 5-chloM-l, 2, 4-oxa. diazol-3-ylcyclopropyi 1863 2, 4- (Me) 2Thiazol-5-yl S-chloro-l, 2, 4-oxadiazol-3-yl CF3 1. 864 2, 4- (Me) 2ThiazoI-yI l, 3, 4-oxadia2 ; ol-2-ylH 1865 2, 4- (Me) 2Thiazol-5-yl 1, 3, 4-oxadiazol-2-yl methyl 1866 2, 4- (Me) 2lhiazol-5-yl l, 3, 4-oxadiazol-2- 1 i-ro 1 1867 2, 4-' (Me) 2Thiazol-5-yl l, 3, 4-oxadiazol-2-ylcyclopropyi 1868 2, 4- (Me) 2Tbiazol-S-yl 1, 3, 4-oxadiazol-2-yl CF3 1869 lnazol-5-yl I 5 : ple, ylsul., fonyl-1, 3, 4-oxadiazol-2-yl Compound N A B R m. p. CC) 1870 2, 4-Ie32'thiazol-5-yl 5-methylsulPonyl-1, 3, 4-oxadiazol-2-yl methyl 1871 2, 4- (Me) 2Thiazol-5-yl 5-methylsul&nyl-l, 3, 4-oxadiazol-2-yl i-propyi j 872 274-(Me3Gh iaz O] r, 5ryl 5-mëth, yls. @ionyl-l, 3, 4-osadiazo-2-y] cyclopropyl 1873 5-methylsulfonyl-1, 3, 4-oxadiazol-2-yl CE3 it874 2, 4- (Me) 2lhiazol-5-yI 5-methyl-l, 3, 4-oxadiazol-2-ylH yl- 1875 2, 4-0*32hazol-S-yl 5-me-hy, 1-1, 3, 4-oxadiazol-2-yl meiyl 1876 2, 4- (Me) 2Tbiazol-5--yl 5--metliyl-l, 3, 4-oxadiazol-2-yli-propyi 4877 2, 4- (M [e) 2'I'biazol-5-. yl 5-methyl-l., 3, 4''oxadiazol-2'-ylcyclopropyi 1878 2, 4- (Me) 2Thiazol- ?-yl 5--methyl-I, 3, 4-oxadiazol-2 yl C : F3 ? 79 2, 4- (Me) 2Thia2 ; ol-5-yI 5-M0aoMmethyl-l, 3, 4-oxadiazol-2-yl H 1880 2, 4- (Me) 2'D'nazol-5-yl 5-tn0ttoromethyl-l, 3, 4-oxadiazol-2-yl methyl . sa 7, 4-(Me) 2niiæol-S-yl S-tri*uoromethyl-1, 3, 4-oxadiazol4-yl i-propyl 1882 2, 4-'e) 2Thiazol-5-yl 5trifluoromethyl-1, 3, 4-oxadiazol-2-yl cyclopropyl 1883 2, 4 e 2Thiazol-5-1 5-trifluoromethyl-1 ; 3, 4-oxadiazol-2-yl CF3 . 1. 884 2, 4-' (MLe) 2TMazol-5-yl l, 2, 3-t !-iazol-4-ylH 1885 2, 4-(Me) 21híazol-S-yl I, 2, 3-triazol-4-yl methyl ! [886 2, 4- (Me) 2Thiazol-5-yl l, 2, 3-trjazol-4-yli-propyi 1887 2, 4-@¢e) 21hiazol-5-yl 1, 2, 3-triazol-4-yl cyclopropyl 1888 2, 4- (Me) 2Thiazol'5-yl l, 2, 3-triazol-4-yl cE3 ! l889 2, 4- (Me) 2Thiazol-5-yl l-meihyl-l, 2, 3-triazol-4-ylH 1890 2, 4-Ne) i2ZazoI-5-yl 1-methyl-l, 2, 3-triazol-4-yl methyl 1891 2, 4- (M : e) 2Thiazol-5-yl J.-mefhyl-l, 2, 3-triazol-4-yli-propyi 1892 2. 4- (Me) 2Thiazol-5-yl 1-methyl-1, 2, 3-triazol-4-yl cyclopropyl 1893 2, 4-Ne32Tiazol-5-yl I-methyl-1ß2, 3-triazol-4-yl cE3 1894 2, 4- e iThiazol=5-yl 2-met. yl-1, 2, 3-triazol-4-yl H 1895 2, 4-Ne) 2Zieol-5-yl 2-methyl-1, 2, 3-triazol-4-yl methyl itS96 2, 4-e) >1-5-0 2seffiyl-'1,, 2, 3-tivol-4-yl i-propyl 1897 2, 4- (Me) 2Tbiazol-S-yl 2-methyl-l, 2, 3-triazol-4-yl cyclopropyl 2, 4- (Me) 2Thiazol-5-yl 2 methyl-1, 2, 3-triazol-4-yl CF3 1899 2, 4- (Me) 2Thiazol-5-yl 2, 3-inazol-I-yIH 1900 2, 4- (Me) 2Thiazol-5-yl 1, 2, 3-triazol-1-yl methyl MOl 2, 4- (Me) 2Thiazol-5-yl 1, 2, 3-iazol-1-yl i-propyl 1902 2, 4-QWe) 2Thiazol-S-yl 1, 2, 3-triazol-1-yl cyclopropyl t9Q3 2, 4- (Me) 2Tmazol-5-yl 1. 2, 3-tnaxol-l-ylCFs 1904 2, 4- (Me) 2Thiazol-5-yl 1, 2, 3-triazol-2-yl H 1905 2, 4- (Me) z'Thiazol-5S yl 1, 2, 3-triazol-2-yl methyl so6 2, 4- (Me) 2Thiazol-5-yl 1, 2, 3-ttiazol-2-yl i-propyl 1907 2, 4- (Me) 2Thiazol-5-yl 1, 2, 3-tTiazol-2-yl cyclopropyl 1908 2, 4- : e) 2hiazo1-5-y1 1, 2, 3-tdazol-2-ylCFs 1909 2, 4- (Me) 2Thiazol-5-yl 1, 2, 4-triazol-1-yl H 491. 2, 4-(Me) 2Miazol-5-y1 1, 2, 4-iazol-l-yl methyi 0 1911 2, 4- e zThiazol-5 yl 1, 2, 4-triazol-1-yl i-ropyl 1912 2, 4- (Me) 2'I'hiazoI--yI 1, 2, 4-triazol-I-yl cyclopropyl 1913 2, 4-e) 2Ziazol-S-yl 1, 2, 4-triazol-1-yl CF3 1914 2, 4- (Me) 2Thiazol-5-yl imidazol-2-yl H 1915 2, 4- 2Thiazol-5-yl imidazol-2-yl methyl Compound N A B Et mp. CC) 1916 2, 4- 2, 4-(Me) 2 lMiazol-5-yl iniidazol-2-yl i-propyl 1917 2, 4- (Me) 2Thiazol"5-yl imidazol-2-ylcydopropyi d91s 2, 4- (Me) 2'I'biazol-5'yl imjdazol-2-ylCFg 1919 2, 4- (Me) N imidazol-1-ylH 920 2, 4- (te) 2Thiazol-3-yl irnidazol-'l-ylmethyl 921 wbiazol-5-yl îniida ; zol-l-yl 1922 2, 4- (Me) 2'Imazol-5-yl imidazol-l-ylcydopropyi 23 2, 4-e') 2'IMazol-5-yl imidazol-l-ylCFg 1924 2, 4-2) 2Egcil-5^yA imidazol-4-yl H jt925 2, 4- (Me) 2TMazoi-yl imidapl-4-ylmethyl 1926 2, 4- (Me) 2Thiazol-5-yl tmidazol-4-yli-propyi ! t927 2, 4- (M9) 2'n'uazol-5-yl inudazol-4-ylcydopropyi 1928 2, 4- (Me) 2'I'hiazol-'5-yl imidazol-4-ylCFg 1929 2, 4- (Me) 2Tbiazol-5yI thiazol-2-yljH 1938 2, 4- (Me) 2Thiazol-5-yl lihiazol-2-ylmethyl 1931 2, 4- (Me) 2'Huazol-S thiazpl-2-yli-propyi 1, 932. 2. 4- (Me,) 2Thiazol-5-yl tbiazoln2-yl cyclopropy, 1933 2, 4- (Mee iThiazol-5-yl thiazol-2-yl CF3 1934 2, 4- (Me) 2Thiazol-5-yl 4-methylthiazol-2-ylJEf it935 2, 4- (Me) 2HMazol-5yl 4-methylthiazol-2-ylmethyl 1936 2, 4-e) 2Tiazol-5-yl 4-meRiazol-2-yl i-propyl 1937 24- (Me) 2Thiazol-5-yl 4-methylthiazol-2-ylcydopropyi ) 2Thi I g3 8 2, 4-(Me) 2Tfliazol-5-yl 4-methyliazol-2-yl CP3 M39 2, 4- (Me) 2lbiazol-5-yl oxazol-2-ylJH 1940 2, 4-' e 2Thiazol=5-1 oxazol--yI methyl 1941 2, 4-(lM : e) 2Thiazol-S-yl oxazol-2-yl i-propyl 1941 2, 4-&e azo 92 2, 4- (Me) 2Thiazol-S-yl, oxazol-2-yl cycloplopyl 1943 2, 4- (Me) 2Thiazol-5-yl oxazol-2-l CF3 1944 2, 4- (Me) 2'Imazol-5-yl 4, S-dimethyloxazol-2-yl H 1945 2, 4- (Me) 3TMazol-5-yl 4, 5-dimethyloxazol-2-yl methyl 1946 2, 4- (Me) 2Thiazol-5-yl 4, 5-dimethyloxazol-2-yl i-propyl 1947 2, 4- (Me) 2hiazol-S-yl 4, 5-dimethyloxazol-2-yl cyclopropyl 1948 2, 4-(Me) 21hiazol-S-yl 4, S-ciimethyloxazol-2-yl CF3 l ne. 49 2, 4-(Me) 2Thiazol-5-yl 2-owazolinf2-yl, H 1950 2, 4- 8 aThiazol-5-yl 2-oxazolin-2-l methyl ! L95 ! l 2, 4- e 2Thrazol- : -yl 2-oxazoIin 2-y i-pro yl 1952 2, 4- (Me) 2Thiazol-5-yl 2-oxazolin-2-yl cyclopropyl 1953 2, 4-(Me42Thiazol-5-yl 2-oxazolin-2-el cE3 1954 2, 4-p\§e) 2Thia2ol-5-yl 4, 4-dimethyl-2-oxazolin-2-ylJS 1955 2, 4- {Me2'Thiazol-5-yl 4, 4-dimethyl-2-oxazolin-2-yl methyl a 956 2, 4-(Me) 2Thiazol-S-yl 4, 4-dimathy1-2-oxazolin-2-yl i-propyl 1957 2, 4- (Me) 2Thiazol-5-yl 4, 4-dimethyl-2-oxazolin-2-yl cyclopropyl 1958 2, 4-(Me) 2Ihiazol-5-yl 4, 4-dimethyl-2-oxazolin-2-yl CF3 1. 959 2, 4- (Me) 2Thiazol-5-yl l, 2, 4-thiadiazol-5-ylja 1960 2, 4-(Me) 2Thiæol-S-yl 1, 2, 4-thiadiazol-5-yl methyl ) 2Thiazol-5-y. I 1961 2, 4-Ne) » ieol-S-yl 1 1, 2, 4-tEadivol-5-yl i-propyl Compound A B R m. p. N 1962 2, 4- (Me) 2Thiazol-5-yl 1, 2, 4-thiadiazol-5 yl cyclopropyl 1963 2, 4 e 2'I.'kazoX.-5-yI x, 2, 4-adiazol-5-yl CE3... 964 2, 4- (Me) 2Thi3zol-5-yl 3-methyl, 2, 4-thiadiazol-5ylJS 1965 2, 4- (Me) hyl-l, 2, 4,-. *iadiazoi-5-yl methyl 1966 2, 4-.. e zTlziazo-5-1 rnethy-T, Z, rthadiazol-5, 1 ipro 1 1966 2, 4- (Me) 2Thiazol--yl 3'-methyl-]., 2, 4--tlziacliazz-5- 1 cycXo ro yl 1968 2, 4-(Me) 2>zol-S-yl 3-rn, elyl-: l, 2, 4-t, hladiazol-5-yl CF3 1969 2, 4-Ne) 2hazol-5-yl 3+Joromethyl, 4-thiavdiazol-5-yl H 1970 2, 4- (Me) 2Thiazol-5--yl 3-inoromethyl-l, 2, 4-thiadiazol-5-yl methyl 1971 2, 4-Ne) 2ti ; azol-5-yl. 34ifluorom, yl-1, 2, 4-thiadiazol--yl i-propyl 1972 2, 4- (Me) 2Thiazol-5-yt 3-'tnfluoromethyl-l, 2, 4-iadiazol-5-yl cyclopropyl 1973 2, 4- (Me) 2Thiazol-5-yl 3'-tnRuorometliyl-l, 2, 4-thiadiazol-S-yl CF3 1974 2, 4- (Me) 2Thiazol-5-yl l, 2, 4-thia<jiazol-3-ylJH 1975 2, 4- (Me) 2Thiazol-5-yl l, 2, 4-<Madiazol-3-ylmethyl 197i6 2, 4-p\Ie) 2Thiazol-5-yl 172, 4-adi, azol-3-yl i propyl- 1977 2, 4- (Me) 2Wazol-5-yl I, 2, 4-thiadiazol-3-yl cyclopropyl 1978 2, 4 Xe) 2Thiazol-5-yl 1., 2, 4-thiadiazol-3-yl CF3 1979 2, 4- (Me) 2Thiazol-S-yl 5-methyl-1, 2,4-thiadiazol-3-yl H 1980 2, 4- (Me) 2Thiazol-5-yl 5-methyl-1, 2, 4-thiadiazol-3-yl methyl 198t 2, 4- (Me) 2Thiazol-5-yl 5-methyl-l, 2, 4-thiadiazol-3-yli-propyi 1982 2, 4-(Mej zThiazol-5-yl 5-methyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 1983 2, 4-(Mei2Thiazol-5-yl 5snethyl-1, 2, 4-thiadiazol-3-yl CF3 1984 2, 4- (Me) 2Thiazol-5-yl 5-trifluoromethyl-, 2, 4-thiadiazol-3-yl H 1985 2, 4- (Me) 2Thiazol-S-yl 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl methyl 1986 2, 4 (Me) 2Thiazol-5-yl 5-rifluoromethyl-1, 2, 4-thiadiazol-3-yl i-propyl 1987 2, 4- e 2Thiazol-5-yl 5-trifluoromethyl-l, 2, 4-thiadiazol-3-yl cyclopropyl ! t988 2, 4- (] M : e) 2Tbiazol-5-yl 5-triHttoromethyl-l, 2, 4-thiadiazol-3-yl CF3 1989 2, 4- (Me zThiazol-5 yl 1, 3, 4-thiadiazol-2-yl H 1990 2, 4- (Me) 2Thiazol-5-yl 1., 3, 4-thiadiazol-2-yl methyl 1991 2 ? 4-(Me) 2Niazol-5-yl 1, 3, 4-thiadiazol-2-yl i-propyl 1992 2, 4-Ne) 2Thiazol-5-yl 1, 3, 4-thiadiazol-2-yl cyclopropyl 1993 2, 4-N : e32Thiazol-5-yl 1, 3, 4-thiadiazol-2-yl CF3 1994 2, 4-(Me) 21hiazol-5-yl 5-metlìylsulMonyl-1, 3, 4-thiadiazol-2-yl H J995 2, 4- (Me) 2Thiazol-3-yl 5-methylsulibnyl-l, 3, 4-thiadiazol-2-yl methyl 1996 2, 4-(Me) 21hiazol-5-yl 5-methylsi£onyl-1, 3, 4-thiadiazol-2-yl i-propyl 1997 2, 4-e) 2Thiazol-5-yl 5-methylsulfonyl-1 ? 3, 4~iadiazol-2-yl cyclopropyl 1998 2, 4- ! de) 2Thiazol-5-yl 5-methylsionyl-l, 3, 4-*iadiazol-2-yl CE3 1999 2, 4- (Me) 2Thiazol-5-yl 5-methyl-1, 3, 4-thiadiazol-2-yl H 2000 2, 4- (Me) 2Thiazol-5-yl 5-mefhyl-l, 3, 4-thiadiazol-2-ylmethyl 2001 2, 4- (Me) 2Thiazol-5-yl 5-methyl-1, 3, 4-thiadiazol-2-yl i-propyl 2002 2, 4 (Me) 2Thiazol-5-yl 5-methyl-1, 3, 4-thiadiazol-2-yl cyclopropyl 2003 2, 4- 2Thiazol-5-yl 5-methyl-1>3, 4-thiadiazol-2-yl CE3 2004 2, 4- (Me) 2Thiazol-5-yl benzoxazol-2-yl H 2005 2, 4- (Me) 2Thiazol-5-yl benzoxazol-2-yl methyl 2006 2, 4- (Me) 2Thiazol-5-yl benzoxazol-2-yl i-propyl 2007 2, 4- (Me) 2Thiazol-5-yl benzoxazol-2-ylcyclopropyi 2oos 2, 4- e zThiazol-5-yl benzoxazol-2-yl CF3 Compound N A B R m.. (°G' 2009 2, 4- e a''hiazol-5-yl 6 metlylbenzoxazol-2-yX H 2010 2, 4- (Me) 2'Imazol-5-yl 6-. methylbenzoxazol-2-ylmethyl 2011 2, 4- (Me z'hiazol-5- 6-metylbemzoxazol ;.-2- 1 i-r4 yl 20jet2 2, 4- (Me) 2Thiazol-5-yl 6methylbenzoxazol-2"ylcyclopropyi 2013 2, 4- (Me) 2liiazol-5-yl 6-methylbenzoxazol-2-yl GFs 2D14 2, 4- (. e aTlazol-S : yX benzothiazol--yl H 2015 2, 4- (Me) 2Tbiazol-5-yl bepzothiazol-2-ylmethyl 2015 2, 4 e a'.'h-iazol-5. yl berazotkiazol-2yX i, ro yl 2017 2, 4- (Me) 2Thiazol-5-yl benzothiazol-2-yl cyclopropyl 2018 2, 4- e 2Thiazol-5-yl benzotlziazol-2-yl 2019 2, 4- (Me,) 2Thiazol-5 : Ll 2020 2, 4- e aThiazol-5-1 p azp1-yl methyl 2021 2,4-e. 2Z,hiazol-5-yl pyrazol-1 yI 2022 2, 4- e. iThiazol-5-y pyrazol1-yl cyclopropyl 2023 2, 4- (Me) 2Thiazol-S-yl pyrazol-l-ylCFs 2024 2 ; 4-. e) 2Thiazol-5-yl pyrazol-3-ylIH 2025 2, 4- e zThiazol-5-ypyrazol-3-1 methyl 2026 2, 4- (Me) 2Thiazol-5-yl azol-3y1 i-pro yl 2027 2, 4- (Me) 2Thiazol-5-yl pyrazol-3-yl cyclopropyl 2028 2, 4- (Me) 2Thiazol-5-yl pyrazol-3-yl CF3 2029 2, 4- (Me) 2Tbiazol-5-yl 1-methylpyrazol-3-yl H 2030 2, 4- aThiazol-5-yl 1-methylpyrazol-3-yl methyl 2031 , 4- lVle) 2Thiazol-5-yl 1-methylpyrazol-33 yI i-propy1 2032 2, 4- (Me) 2Tliazol-5-yl 1-methylpyrazol-3-yl cycloprop1 2033 2, 4- e aThiazol-5-yl 1-methylpyrazol-3-1 CF 2034 2, 4- (Me) Thiazol-5-yl tetrazol-1-yl H 2035 2, 4- (Me) 2Thiazol-5-yI tetrazol-1-yl methyl 2036 2 ; 4- e) 2Thiazol-5-yi tetrazol-1-yl i-propyl 2037 2, 4- (Me) 2Thiazol-5-yl tetrazol-1-yl cyclopropyl 2038 2, 4- (Me) 2Thiazol-5-yl tetrazol-1-ylCFs 2039 2, 4- (Me) 2Thiazol-5-yl 5-methyltetrazol-1-yl H 2040 2 ;- (Me)aTliiazol-5-yl 5-methyltetrazol-1-yl methyl 2041 2, 4- e z'Thia. zol-5-yl 5-methyltetrazol-1-I i-propyl 2042 2, 4- e zThiazol-5-yl 5-methyltetrazol-l-yl cyclopropyl 2043 2 ; 4- e) 2T'hivl-5-yl 5-metliyltetrazol-1 _yl CF3 2044 2, 4- (Me) 2Thiazol-5-yl tetrazol-2-yl H 2045 2, 4- (Me) 2Thiazol-5-yI tetrazol-2-yl methyl 2046 2, 4- (Me) 2Thiazol-5-yl tetrazol-2-1 i-propyl 2047 2, 4- (Me) 2lhiazol-5-yl tetrazol-2-ylcyclopropyi 2048 2, 4- (Me) 2Tbiazol-5-yl tetrazol-2-yI CF3 2049 2, 4- e ZThiazol-5-yl 5-methyltetrazol-2-yl H 2050 2, 4- (Me) 2Thiazol-5-yl 5-methyltetrazol-2-ylmethyl 205. 1 2, 4- (Me) 2Thiazol-5-yl 5-methyltetrazol-2-1 i-propyl 2052 2, 4- (Me) 2Thiazol-5-y1 5-methyltetrazol-2-y cyclopropy1 2053 2, 4- e 2Thiazol-5-yl 5-methyltetrazol-2-yl CF3 2054 2, 4- (Me) 2Thiazol-5-yl 1-methyltetrazol-5-yl H CompoundN A B R imp. CC) 2055 2, 4- (Me) 2Thiz. ol-5'-yl l-methyltetrazol-5-ylmethyl 2056 2, 4- (Mc) 2lhiazol-5-yl l-methyltetrazol-5-yli-propyi 2057 2, 4- (Me) 2Thiazol-5-yl l-methyltetraol-5-ylcyclopropyi 2058 2, 4- (Me) 2ThiazoS-yl 1-methyltetrazol-S-ylCFg 2059 2, 4-(Me) SChíazol-5-yl 2-methylteltazol-5-yl. NG0 « 2v4-(Me) zThirvdl-5-yl 2"thyltetrazol-5-yl methyl 2061 2, 4-(42Thiazol-5-yl 2-l} teåzol-5-yl i-pTopyl cyclp zo 1 2062 2, j4-(S) 21% iazol-5-yl 2-methyltetrazol-5-yl cycloplopyl 2063 tj4-Xol-5-yl W » c 3 2064 2Thiazol,-5-yl ppidiii-2 2064 2, 4- (Me _-Yl H 2065 2, 4-Me) 2l'hiazol-5'-yl pyridiR-yltnetbyl 2066 2, 4-tAhAaxol-s-yl P/*-2-yl i-propyl 2067 2, 4- e. zThiazol-S-yl pyri, 2yI cyclopropyl 2068 2, 4- (Me) 2Thiazol-5-yl py)-idin-2-ylCFs 2069 2, 4- (Me) T-bazol-5-yl pyridin-4-yl H 20'70 2, 4 (Me) 2Thiazol-5-yl pyridui'-4'-ylmethyl 2071 2, 4- e ZThiazol-5-1'din-4-I i-ro yl 2072 2 ; 4- e aT'$iazol-5-yl pyridin-4-yl cyclopropyl 2073 2, 4-(Me) 2Thiazol-S-yl pgiidin-4-yl CF3 2074 2, 4- (Me) 2Thiazo5-yl pyridin-3-ylH 2075 2, 4-e) 2Thiazol-S-yl pyrid. in-3-yl methyl 2076 2S4-(Me) 2Thiazol-5-yl pyridin-3-yl Fpropyl 2077 2, 4- 29iazol-5-yl pyridiIi-3-yl cyclopropyl 2078 2, 4- (Me) 2Thiazol-5-yl pyridin-3-yl CF3 S 2079 2, 4-(M 42Thiazol-5-Yl 3-nitropyridin-4-yl H 2080 2, 4- (Me) 2Thiazol-5-yl 3-nitropyridin-4-yl methyl 2081 2, 4- (Me) 2Thiazol-5-yI 3-nitropyridm-4-yli-propyi 2082 2, 4-» azol-5-yl 3-nitropyridin-4-yl cyclopropyl 2083 2, 4- (Me) 2hiazol-5-yl 3-nitro. yridin-4-l CF3 2084 2, 4-(Me) 2tlazol-5-yl 5-cyanopyridin-2-yl H 2085 2, 4- (Me) 2'Ihiazol5-yl S-cyanopyridin-2-yI methyl 2086 2ç4-(Me) 2htazol-5-yl 5-cyanopyridin-2-yl i-propyl 2087 2, 4= e 2Thiaol-S yl 5-cyano idin-2 yl c clopro yl 2088 2 ? 4 (Me) 2llìiazol $-yl 5-cyanopyridin-2-yl CF3 2089 2, 4- zThiazol-5-yl S-trifluoromethylpyridin-2-yl H 2090 2, 4-Q\ {eiazol-S-yl 5-tri ; upy-yl | me1hyl 209t 2, 4- (Me) 2Thiazol-5-yl 5 trifluoromethylpyridin-2-yl i-propyl 2092 2, 4- (Ms) 2Thiazol-S-yl 5-trifluoromethylpyridm-2-ylcyclopropyi 2093 2, 4-Ie) 2Tláiazol-S-yI 5-uoromethylpyridin-2-yl CF3 2094 2, 4- e 2Thiazal-5 yl imidirz-2-1 H 2095 2, 4- (Me) 2Thiazol-S-yl pyrimidin-2-l methyl 2096 2, 4- (Me) 2lhiazol-5-yl pyrimidin-2-yli-propyi 2097 2, 4- Me)ZThiazol-5-yl'din-2-yl cyclopropyl v x t a 2098 2, 4- (Me) 2Tbiazol-5-yl pyrimidin-2-ylCF 2099 2, 4-fume) 2Thiazol-5-yl pyrimidin-4-yl H 2100 2, 4-(Me) 2Thiazol-5-yl IpyTimidin-4-yl methyl Compound NAItRm. p. <°0 2M ! t 2, 4-M [e) 2TnMazol-5-yl pyrimidin-4-yli-propyi 2102 2, 4-e) 21Miazo1-S-yl, pyxmain-4-yl cyclopropyl 2 103 2, 4-Ne) 2BiazoI-5-YI PBimidin-4-. yl CF3 2ffç04 2 4= 2Thraz o, l-5-yl 6-öpyrinit-yl methyl 2105 i4-e) 2 : Fhiazol Cha~WwdiD +-yl i-propyl 1M6 2, 4-(W2Thiatol-5-yl 6Xos midixpl oyclopropyl 2 2, 4- (Me) 2lMazol-5'. yI 6-chtoropytimidin-4-ylCFg 2108 2, 4--t2'=o1-5 yl dE-3-yl H 2109 2, 4-ie) 2T'hiaxbl-5--yl pyridazm-3-ylmethyl 2L10 t+ » pyiidazi-3 yl Fprop ; yl 2, 111 2 eiiTbia>1-5-yl ~pyr*3-yl cyclopropyl 2112 2, 4-(*e) iazol-S-yl pgiin-3-. yl Cf3 2, 2, 4-CMe) 2T3itazol-3-yl -cMoropyddaziu-S-yimethyl 2114 2, 4-2e) 2T} 6 opyndazinlyl i-propyl 2115 2, 4- (ZVIe aTkiiazpl-5-yl 6-chloropyridazin-3-yl cyclopropyl 2t'l6 2, 4- (M9) 2TMazol-51 6-chloropyridazin-3-. ylCFg 2117 2, 4- 2Niazold-yl pyraziz-2-yl meihyl 215. 8 2, 4-(e) 2zazol-5-y1 pyrazin-2-yl l-propyl 2119 2, 4-(Me) 2lMiazol-5-yl pyra23n-2-yl cyclopropyl 2120 2, 4- (Me) 2Thiazol-S-yl pyrazm-2-ylCFs 2121 2, 4-'te) 2'nuazol-5-yl triazm-2-ylmethyl 2122 2, 4- (Me) 2Thiazol-5-yl triazin-2-yl i-ropyl 2123 2, 4- (Me) 2Thiazol-5-yl triazm-2-ylcyclopropyi 2124 2, 4- (Me) 2Thiazol-5-yl triazin-2-yl CF3 2125 2, 4-(Me) e e) ia : zol-5-yl uinolin-2-yl methyl 2126 2, 4- (Me) 2Thiazol-5-yl quinolin-2-yl i-propyl 2127 2, 4-. e02Thiazol-S-yl uinolin-2-yl cyclopropyl 2128 2 ; 4- e) 2Thiazol-5-yl quinolin-2-1 CF3 2129 2, 4-(Me) hiazol-S-yl quinolin-2-yl C : F 3 2129_ 1 2, 4we) 2Thiazol-S-yl H _ 2130 2, 4- (Me) 2TJiiazl-5-yl 4 HIydro 1, 3 (4El) exazin-2-yl methyl 2131 2, 4- e 2Tliiazol-5-yl 4, 4, 6-methyl-5, 6-c&hxdro-1, 3 (4I. oxaan 2 yI i-propyl 2, 132 2, 4-pWe) 2Niazol-5-yl 4, 4i6-1rimefiyl-5, 6 dihydml, 3 (4EW 2-yl cyclopropyl 2133 2, 4- (Me) 2Thiazol-5-yl 4, 46-himefihyl-S, 6-dhyaro-1, 3' (4. H)-oxazin-2-yl CF3 2134 2, 4- (Me) 2Thiazol-5-yl 2-oxazolidinon-3-yl H 2135 2, 4 Me 27'lz, iazo-. 5-yl 2-oxazolidinon-. 3 yl rneth 1 2136 2, 4- (Me zThiazol-5-yl 2-oxazolidinon-3-y1 i-propyl 2137 2, 2, 4-e) 2tiazol-5-yl 2-oxazolidinon-3-yl cyclopropyl 2138 2, 4- (Me) 2Thiazol-5-yl 2-oxazolidinon-3-yl CF3 2139 2, 4-(Me) 29inzol-5-yl 2-pyrolidinon-1-yl methyl 2140 2, 4-(Me) iazol-'5-yl 2-pyrrolidinon-1-yl i-propyl 2141 2, 4- e 2Thiazol-5-yl 2-pyrrolidinon-1-yl cyclopropyl 21142 2, 4- e 2Thiazol-S-yl 2p lidinon-1-yl CF3 2143 2, 4- (Me) 2Thiazol-5-yl 3-methylisoxazol-5-yl methyl 2144 2, 4-.Me) 2Thiazol-5-yl 3-methylisoxazol-5-yl i-ropyl 2145 2, 4- e) 2Thiazol-5-yl 3-methylisoxazol-5-yl cyclopropyl 2146 2, 4- (Me) 2Thiazol-5-yl 3-methylisoxazol-5-yl CF3 Compound NABR m. p. (°C) 2147 2, 4-<] Me) 2Thiazol-5-yl 2-NQ2-4-SOMePhH 2148 2, 4- (Me) 2TMazo-yl -. NOz-SOzMePhmethyl 2149 wiazol-5-yl 2-NO2-4-SO2MePh i-propyl 2'MQ 4-eTMazo. l-5-yl 2-N02-4-S02sPhcyclopropyi 2151 2, 4-CMe) 2'nuaol-5-yl 2-N02-4-SOM : ePhCFg 2t52 2, 4-MeMiaxol-5-yl 2-Gl-4-S02ePhH 2153 2, 4- (Me) 2ihiaz'o"I-5,-yl 2-CI64. I$02MePh 2154 2. 4- (MB) 2Thiazolyl 2-CMSePhi-propyi 2155 2, 4- (M2TMazol-5'-yl 2-Cl-4-$0ePhcyclopropyt 2156 2 4->32Thiazol-5-Yl 2-Cl-4-SOiMePh cE3 297 2, 4- (M9) 2'It3z-5--yl Oz-CFsPhH 2158 2158 2, 4-azòl-5-yl 2-~-CP3Ph mediyl 2159 2, 4-(Içatol-S-yl 2-NO2-4-@F3Ph i-propyl. 2160 2, 4--(W2>azòl-5-yl 2-Ní) 2-4-Cti\Ph cyclopropyl 2161 4- (Me) 2TIaiazol-5-yl 2-N02-4-CF3PhCFs 2162 2, 4-M : eTMazol-5-yl 2-N02-4'CIPhH 2163 2, 4- (Me) 2T'hiazoI-5-yl 2-N02-4-CJPhmethyl 2164 2, 4- (Me) 2liaxol-5-yl 2-N02-4-ClPhi-propyi 2165 2, 4-(Me) 21Miazol-5-l 2-N02-4-CEh ~ cyclopropyl _ =_ 266 2, 4- (Me) 2Thiazot-5-yl 2-N02-4-C] PhCFg 2167 2, 4-le) 2T1nazol-5-) il 2-Cl-4-NOzPh E 21 6s 2, 4- (Me) azol'-5-yl 2-C14-NO2Ph methyl 241e69 2 ; 4-Ne) 2hazol-S-yl 2-Cl-4-NO2Ph i-Dropvl 2170 2, 4- e xTniazoI-5-yl 2-Cl -NO2Ph cyclo ro yl 2171 2, 4- (Me) 2Hliazol-5-yl -CM-NOPhCPs 2172 2, 4- 2t, ia zol-5-yl 2, 4- (NO2) 2Ph H 2, 17, 3 2, 4- (Me) 2Thiazol-5-yI 2, 4- (NQ2) 2Phmethyl 2174 2, 4- (Me) 2TMazol-5-yl 2, 4-- Oa aPh i-ro yl 2175 2, 4- : 2'ISiazol-S-yl 2, 4- (NiQ2) 2Phcyclopropyi 2176 2, 4- e 2Thiazol-5 yl 2, 4- Oa iPh CF3- 2177 2, 4- (Me) z'rhiazoI-5-yI 4-F-3-N02PhH 2178 2, 4- (Me) 2l'hjazol-5-yl 4-F-3-N02Phmethyl 2179 2, 4-Chiazol"5-yl 4-F-3-NOwPh i-propyl 218so 2, 4- (Me) Thiazol-5-yl 4 F-3-N2Ph cyclopropy1 218 2, 4- (Me) 2'rhiazol-5-yl 4-F-3-N02PhCFs 2182 2, 4- e zThia. zol-5-yl 3, 5-(CF3) 2Ph E 21. 2, 4- 4-(Me32Aazol-5-yl 3, S- (CF3) 2Ph methyl 2184 2, 4- e 2Thia : zol-S- 1 3, 5-(CF3) 2Ph i-propyl 2185 2, 4-(Me32Aiæol-5-yl 3, 5 CF's ZPh cyclo ro yl 2186 2, 4- (Me) 2TTnazol-3-yl 3, 5- (CF3) 2PhCFs 2187 2, 4- (Me) 2Thiazol-5-yI 2-S02Me-4-CF3PhH 2lss 2, 4- e 2Thiazol-5-yl 2-SO2Me-4-CF3Ph methyl 2189 2, 4- e) 2Thiazol-5-yl 2-S02Me-4-CF3Ph i-propyl 2190 2, 4- (Me) 2Thiazol-5-yl 2-S02Me-4-CFPhcyclopropyi 2191 2, 4-e) 2Thiæol-S-yl 2-SO21We-4-CE3Ph CF3 Comp iund N mB 2192 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3yl) Ph 1, 2, 4-oxadiazol-5-yl H 2193 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 4-oxadiazol-5-yl methyl 2194 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3yl) Ph 1, 2, 4-oxadiazol-5-yl i-propyl 2195 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yI Ph 1, 2, 4-oxadiazol-5-yl cyclopropyl 2196 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-l) Ph 1, 2, 4-oxadiazol-5-yl CF3 2197 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 3-methyl-1, 2, 4-oxadiazol-5-yl H 2198 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 3-methyl-1, 2, 4-oxadiazol-5-yl methyl 2199 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3,yJ Ph 3-methyl 1, 2, 4-oxadiazol-5-yl i-propyl 2200 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 3-methyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 2201 2-Me-4-SO2Me-3- (4, 5-djhydroisoxazol-3-yl) Ph 3-methyl-1, 2, 4-oxadiazol-5-yl CF3 2202 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 3-trifluoromethyl-l, 2, 4-oxadiazol-5-yl H 2209 2-MeX502Me-3-(4, 5-dihydroisoxazol-3-sl) Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl methyl 2204 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl i-propyl 2205 2-Me-4-SO2Me~3-(4, 5-dìhydroisoxazol-3-yl) Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl cyclopropyl 2206 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3yl) Ph 3-trifluoromethyl-1, 2, 4-oxadiazol-5-yl CF3 2207 2-Me-4-S02Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 4-oxadiazol-3-yl H 2208 2-Me-4-SOMe-3- (4, 5-dthydmisoxazot-3-yl) Ph 1, 2, 4-oxadiazol-3-yl methyl 2209 2-Me-4-SOzMe-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 4-oxadiazol-3-yl i-propyl 2210 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 4-oxadiazol-3-yl cyclopropyl 2211 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 4-oxadiazol-3-yl CF3 2212 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-methyl-1, 2, 4-oxadiazol-3-yl H 2213 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yljPh 5-methyl-1, 2, 4-oxadiazol-3-yl methyl 2214 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 5-methyl-1, 2, 4-oxadiazol-3-yl i-propyl 2215 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-I Ph 5-methyl-1, 2, 4-oxadiazol-3-yl syclopropyl 2216 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-1 Ph 5-methyl-1, 2, 4-oxadiazol-3-yl CF3 2217 2-Me-4-SOzMe-3- (4, 5-dihydroisoxazol-3-I Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yi H 2218 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl methyl 2219 2-Me-4-S02Me-3- (4, 3-dihydroisoxazol-3-yt) Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl i-propyl 2220 Z-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl cyclopropyl 2221 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-l) Ph 5-trifluoromethyl-1, 2, 4-oxadiazol-3-yl CF3 2222 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yljPh S-chloro-1, 2, 4-oxadiazol-3-yl H 2223 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 5-chloro-1, 2, 4-oxadiazol-3-yl methyl 2224 2-Me-4-SOMe-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-chloro-1, 2, 4-oxadiazol-3-yl i-propyl o '2225 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-chloro-1, 2, 4-oxadiazol-3-yl cyclopropyl 2226 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5-chloro-1, 2, 4-oxadiazol-3-yl CF3 2227 2-Me-4-SO2Me-3-04 5-dihvdroisoxazol-3-vl) Ph 1 3 4-oxadiazol-2-yl H ZZ28 2-Me-4-S02Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 3, 4-oxadiazol-2-yl methyl 2229 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 3, 4-oxadiazol-2-yl i-propyl 2239 2v=tvie (4,'SiHyamsM ! az0&yP&' ti, 3, -oxadiaZ9t-ylcyctopM. pyI |-2231. 2-Me-4-Swe-3-daiydowd) Ph, _ ; i, 4-oxadiazXyi- (3F3 _- -2251,, '-2. Me-4-SOM'6. I344,, 5dilhd' i-"I 574ii6t-bts-ulforly-I z, 5 'X-_,-'j'_ _ Compound N A R 2233 2-Me-4-SO2Me-3-S, 5-diliydroisoxazol-3-yl) Ph 5-melylsulrollyt 3 4-oxadiazol 2-yl metyl 2234 2-1 ! wIe-4 SO2Mev3--8 (4, 5lydroisoxåz. U1-3-yl) Ph 5-me&ylsulroItylq, 3, 4-oxadìazoi-2-y1 i-propyl 2235 ZMe4-S () zMe-3'- (4, 5'draisoxazol-3-yl) Ph 5-methylsulfonyl 1, 3, 4-oxadiazol-2-yl cyclopropyl 2236 2-Me-4-02Me-3' : (4-dihydrois6zol-3-yl) I'h 3-methyllnyl-l, 3 CF3 2237 2-Me-4-'SOMP,- (4, 5. 0isoxazdli-yl) Ph 2238 2-Me4-sO2Me-3-ç4754ildroïsoxazel-3-yl) ph 5-me&y. 14>3, 4+xilml-2 yl meyl 2239 2-Mc-4-SMe-3- (4, 5-d : ydroisoxazol-3-yl) Bh ?-methyl-l, 3, 4-oxadiazol-2-yli-propyi 2240 2-Me-4-S () 2Me4-(4 s-dilSoisoxazol-3 ; g) Ph 5-metliyl-! 1, 3, 4 ioBadiazolt-yi syclopropyl 2241 2-Me Sßi2Mee3-(4i, 5-oxaz@^ylSPh 5-me&yl-1, 3, 4*d. CE3 i242-2&e-4-S ; ; We-3-(4, 5 roisos r3-yl3ph 5-yl-13X-axsidiazol-2-yl E 2243 2-Me4-'$Qime-, 3- (4,, 5-dihydr6isoxazol-3-Yl) Ph methyl 2244. 2-Me4 ;-SO2Me-3-b4, 5 dibRox4YI1Pb 5-i [iRaXc8kyl-l3iWadiazol-2-yl i-propyl 2245 2-Me-4-S02M8-3-. (4-dihy (] roisoxel-3yt) t'h S-tdauoMethyl-'l-oiaxol-Z-yl cydopropyi 2246 2-MeS-S 2Me-3-(4., 5-diOoisiazol-3-yl3P-h S-ìr alomE1, 3, 4. 4xadiazol-2-yl CF3 2247 2-Me9-SO2Mé-3-rt4, 5 dih, ydi8oilsoxawl 3-yl) Ph 1, 2, 3-tnazol-4-ylH 2248 2-Me-4-SOMe'3- (4, 5-dAWdroisoxaz6l3-yI) Ph 1, 2, raethyl 2249 2-Me4-SO2Me-3-(4., 5-(3ihydroisoxazol-3-yL, hPh 1 7, 3-Wiazol-yl i-propyl 2250 2-MB-S02Me-3- (4, 5-<IihydToisQxazot-3-yl) P& l, 2, 3-tnazol-4-ytcydopfopyi 2251 2-Me-4-SOMe-3- (4, 5-dihydroisoxazol-. 3-yl) Ph 1, 2, 3-biazol4yl CF3 2252 _ 2-Me4-SO2Me-3-(4, 5-dikyd : oïsoxazol-3-yl) Ph l-melhyl-1, 273-2iazol-4.-yl H 2253 2-Mé-4-SO2h-3-(4 5 dilWdisoxazol-3-sl) Ph l-melhylkL2, 3-1riazol4-yl meXyl 2254 2-M64-SOe-3. (4, 5-ddrdtsoxaz0l-3-yl) Ph l-methyl-l, 2, 3-riaz0l-4-yli-propyi 2255 2-Me4-SO2Me-3-(4, 5ZiWydroisoxazol-3-yl3Ph l-meiyl-1k, 2, 3-triaiol ; 4-yl cyclopropyl 2256 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph 1-meiyl-l, 2, 3--lriåzol4-yl Cs3 2257 2-Mç4-SO2Mç-3-(4 5thy&. olsoxStol-3-y13th 2-mediyl-1, 2, 3-b iazol~4-yl. 2258 2-Me4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) 6'h 2 ;-meffiyL-1 2, 3-b ; iazol4-yl methyl 2259 2-Me-4-SQ2Me-3-(4, 5-dihvdroisoxazol4-yl) Ph 2-meiyl-1, 2, 3-hiazol-4-yl i-propyl 2260 2-Me-4-SO ! Me-3- (4, 5-dihydt ! oisoxazc'l-3-yl) Sh 2-meQiyl, 3-tnaxol-4-yloyolopropyi 2261 2-Me-4-SOMe-3- (4, -dihydFoisoxazoM-y !) Ph 2-methyi-I, A3-<mzoI-4-yICFs 2262 2-Me-4-SO2Me-3- (4, 5-dihydr, caisoxazol-3-yl) Ph 1, 2, 3-tiazol-1-yl H 2263 2-Me-4=SOZMe-S- (4, - droisoxazol-3-1) Ph 1, 2, 3-'triaaol 1-yl methyl 2264 2 Me-4-SOZIvIe-3- (4, 5-di dosoo-3 y1) Ph 1, 2, 3-tciazo 1-yl i pmpyT 2265 _i 4 SOMS>r4 0) 1 ? 2 ? 3-Fazol-l yl syclopropyl 2266 2-Me-4-SO2Me-3-(4, 5 dihydilsoxazoS3-yl3Ph 1, 2, 3-@iazol-1-yl CF3 2267 2-Me-4-SQZMe-3-4, S-clih droisoxazol-3-lPh 1, 2, 3-iriazol-2-yl H 2268 2 Me--S02Me 3-4, 5-dih. dcoisoazol-3- : 1) Ph 1, 2, 3-tiazol-4 !-yl mediyl 2269 2-Me4-SC>2Me-3-(4, 5 dihydroisoxazol-3-yl3Ph 1, 2, 3-kiazol-2-yl i-propyl 2270 2-Me4-SO2Me-3-(4, 5 dihyFoi-soxazol-3< Ph 1, 2, 3-'iåzol-2-yl eyclopropyl 2271 2-Me-S02Me-3- (4, 5-ydi'oisoxaz-3-yl) Ph l, 2, 3-tQazol-2-ylCFa 2272 2-Me4-SO2Me-3-(4, 5 diWydioisoxazòl-3-yl3Ph l, 2, 4-eiazol-1-yl H 2273 2-ME-4-Sp2Me-3- (4, S-dihyQrQisoxazol-3-yl) m 1, 2, 4-tnazol-l-ylmethyl 2274 2-Me-4-SO2Me-3K (4, 5 dihydroisoxazol-3-y13Ph GL>2, 4hazoX yl l propyl 2275 2-Me-4-SO2Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 1, 2, 4-triazol-1-yl cyclopropyl 2276 2-Me-4-SO2Me-. 3- (A, 5-cliliydroisoxazol-3-yl) Ph 1, 2, 4triazol-l-yl CF3 2277 2-Me-4-SOiMe-3-(4, 5-dihydroisoxazol-3-X. 13Ph imidazel-2-yl 11 2278 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) Ph imidazol-2-yl 'Compound N A R 2279 2-Me-4-SO ! Me-3- (4, 5-d ! hydrotsoxazoI-3yI) Ph inutol-2-yjti-propyi 2280 2-M-SOMe-3< (4, 3'<Niydroisoxazol-3--yBh Mnldazol-2-ylcyclopmpyj 2281 2-Me4-SOsMç-3-64, 5Oydiiso2Æl) Ph urd U Z-Y1 CE3 2282 2Me-4-SC>zMe-3_ (4, 5dihw3-yl) P ! i t-yl El 1293 2, MP4. so2me-3-<4, 54ihydrdisoxazol-3-yl) Ph methyl 2284 2-Me-4-SQMe-3- (4, 5-y<&ofsoxazol--3-yl) Ph tnudazd-. E-'yIi-propyi 2285 2-Me-4nSG- (4, 5-dihydroiso) Mz- itpidazol-t-ylcyclopropyi 2286 AJMea e43-(4, S-dihydid somot^3~yl} Ph imx n1-1-yl CP3 22$7 2-Me-4-5 3 laZO&IYl CF3 2288 2-M-4-SO2Me-) (4, S ydraiSoWol-3Ph Xò-yl melyl 2289 2-M*4 S (*-(4, 5-diiilsoxa yl Ph iCazolAyl t-prWyl 2290 t-Me4-SO2Me-3-(A< imtdàzolAyl cyclopropyl 2291 2-MeSG'2Me, 5-d ! hoiSQxaol-. 3-. yl) Bh imi. dazal'4-ylCFs 2292 2-Me-402Me-3- (4, 5-dadroMO ! Nz : ol-3) Pb Suaz-ylja 2293 2-Me Me-3-(4, SE _ ihia$2wyl L meshyl 2294 2-Me24-SO22e-3-(4, 5Wdihydi>sisowot-3 y1) R -yl i-propyl 2295 _ 2-Me4-SO2Me-3-(4, 5-dihydroiso1-3-yl) P. ih thiazoi-2-y1 cyçlopropyl 2296 _ < = m t » yl CF3 2297 2 : Me-4. S2IvIe-3.- A, S-dihydroisoxazdl 3 3) Ph -metiiylthiazol2 yl H 2298 2-Me-4-SO2Me-3-(i, 5-dihydr isoxazol-3-yl) Ph_ 4 ; mediyltliiazol-2-yl methyl 2299 2-Me-4-S02Me-3- (4, S-dibydroisoxazoM-yl) E& 4-methylthiazol-2-yti-propyi 23Q0 wsoxazok3-p, h 4 melhyllli : tazol-2-yl cyclopropyl 2301 2-Me-4-S02Me-3- (4, 5-dihydro ! soxazol-3-y !) Ph 4-methyKluazoM-yljCFg 2302 2-Me-4-SOMe-3- (4, 5-dihydroisoxazol-3-yI) P. h oxazoM-ylH 23D3 2-Me-4-SO2Me-3-(475-hydroisoxazol-3-ylA oxrzol-2-yl methyl _ 2304 2-Me-4-SO2Me-3-(4, 5-dihydroisoxazol-3-yl) ph oxazol ; 2-yl i-propyl L 28305 2-Me-4-SO 2 Me-3-(4, 5-dihydroisoxazol-3-yXl) Ph oxazol-2-yl cyclopropyl 2306 2-Me4-SO2Me-3-(4 Stihydrotsoxa2 ; ol-3-yl) Ph oxazol-2-yl CF3 2307 2-Me-4-SO2Me-3-(4, 5-diliyikaolsowazol-3-yl) P. h. 4, S-dimetli. yloxazol-2-yl H 2308 = » ; soxazok3Ph 4bS dime, thyloxazol-2-yl methyl 2309 2-Me-4-so2Me-3-(4, 5-dihydtöïsoxazoi-3-y k 4, 5-dimelEyloxazolO-yl i-propyl 2310 2-NEeA-SO2Me-3-(¢75-dibydicisoxs701-3-yl) Ph 4, 5-dimethyloxazol-2-yl cyclopropyl 23111 l 2-Me-4-SO : Me-35-dihydfoisoxaz@l-3-yl) Bh 4, 5-dimethyloxazol2-yl _ CF3 2312 2M : e-4-SO2Me-3-(4, 5Xisoxazo1-3-&l) Ph 2-oxazofin-2-yd __ 2313 2-Me4-SC) 2Me-3-(4, 5-dieisoxazol-3-yI) Ph 2-oxazoliS2-yl methyl 2316 3t4 e-4-S02Me- (4, 5-hyoisoxazQl-3-yRh 2-pxazolm-'2-yli-propy ! 2315 2-Me4-sO2Ms3^ (A5-aihydroisoxazol-3<yl) ph 2-oxazolin-2-yl cyclopropyl 2316 2-Me4-SO2Me-3-t4, 5-djhv. dieisoxazol-3-8) Ph 2-oxazolin-2-yl CF3 23>7 9-Me4-so2Me-3 ; (4X54 yFoisoxazol-3-yI) Pzh 4, 4 ditiieXh. yl-2oxazolin-2-y1 H 2318 2-Me4-SO2Me-3-(4, 5-dihydroisoXazol-3-yl) Ph 4, 4Ldimethyl-2-oxazoli-2 yl methyl 23 19 2-Me4-SO2Me-3-(4, 5-dihydboisoxgzol-3z) Ph 4, 4-_ bpropyl 2320 2-Me-S02Me-3< (4, 5-3thydrMsozol-3--yl) Ph jt, 4-dioieN). y !-2-oxazo. Ea-2-ylcyclopropyi 2321 2-Me4-SQ2Me-3-(4, 5Evdioisoxazòl-3-sl) Ph 4, 4-dinethyl-2-oxazolin-2-yl CF3 2322 2-Me-4-SO2Me-3-(4, 5-diliydioisoxazol4-ykl3Ph 1b2, 4 5-yl EI. 2323 2-Me-4-SO2Me-3, (4, 5-dihycb'disoxazol-3-yl) PJi l, 2, 4-iadiazol-5-yl melyl 2324 2-Me4-SO2Me-3-(4, 5 dihydroiso2 ; azol-3-yl) Ph 1, 2, 4-iadiazol-5-yl i-propyl Compound N R 2325 2-Me'4-S02Me-3- (4, 3-dihydr0isoxazot-3-yl) Eh 1, 2, 4wiazol-5 yl cyçlopropyl 2326 3#e-4 ç 1, 2, 4r-5-yl CF3 _ 2327 2-W4-SO2Me-3-(4, 5 dihy. droisexzol-3-y. l) Ph 3-methyl-1, 2, 4-iadiazol-5vyl _ _ 2328 0 2-Me4-802Me-3. V64, 5+icVyL 3-m l0íyl-l djazol-5-yl meeiyl 2329 *4OiMe4e 3-mèlEyS, 4>Xadi3zeil-5-« l _ 9mpyl_ 2330-dihydioisoydzol-3-yl) Ph 3-methyl-l, Z, 4- ; adiazol-5'-yl cy 2331 _ Ux 1X 3AliyS ol-S-yl CF3 2331-dffiy. &, 6isoxazol-3-yl) Ph 3-'rkiethyl1, 2i4-thiadiazol-5-yl CF3 2332'2-'Mo+SO2Me-3- (4., 5-diliydroisexzol-3-) FI,) Ph 3-tlifiuotoraethyl, 1 ; 2, 4-dadiazol5yl H 2333 A4SSOi2Me-3-5 ; itól 3-t. 131 3 « tn4uorQrnethy 2 iaæol-S-yl i-propyl 2334 % MS02Me-34yMs9ol-3-yl) 3triamethyM, 2, 4Hiia<tazol-5-yl i-pTOpyI 2335 2-Me4-SOe-3' (4, 5-diyaioisb. azil-3-l) Ph 3-tni !. uoEomefh. yI. 4, 2, 4-tMaazol-5-yl cyctopropyt 2336 --SO2M'-3- (4,'5-&hydroisoxazol-3-yt) Ph 3-trmuorotnethyl-1, 2, 4-thiadiazol-5 : Ll CF3 23. 37 2-MQ-4-,"SOiMe-3- (4, 5Ak, dr-6is, H 2338 2-Me-440iMe-3 soiXl3Ph l 2 4-*iadiazdL-3-yl meffiyl 2339. 2Me4-S (D. i2Me-3-(4, <. ioF3-ylvi 1, 2, 4 tbiadi 3yi i-propyl 2340 2e4-S02Me4, 5-dihydtoisazeiI-3-yl) h !)., 2, 4aazol-3-ylcyclqpiropyj 2341 2-Me4-S02Mb3-t45>diliydniiso7zazoB-yl, dPh t 2, 4-thiadiazol-3-yl CF3 2342 1 2-M"-$OMe-3- (4, 5-dihvisbazol,-3-yl) Ph 5-moth1-1, 2,, 4-Nadiazol-3-yi H 2343 -M-SOe-5-yc ! Fbis@xazoM-yl) Ph 5-me (hyM, 2, 4-MtazoI-3-ylmethyl 2344 2 X&ç-yl3Ph 5-meiyl-1, 2, + : iadi-azol-3-yl Fpropyl 2345 2-Me4-SO2W3-(4 o 5-ineiyl-1, 2 » ì4azol 3~yl tyclopropyl 2346 _ _2-Me &-802Me-3-it4, 5 iihydroieewl-3@ !) ph 5me « yt, 2, 4-tol-3-yl CF3 _ 2347 2-Me-4-SOzMe-3- (4, 5-"ydroisoxpzol-'3-yl) Ph 5 ; Uffluoromethyl-1, 2, 4-thiadiazol-3-yi H 2348 2-Me 4-S. 0Ne-3-(4, 54~3-y. l) Ph 5-triituorometittyl-l, 2"4&di 3-yl me1hyl 2349 2e4-S02Me- (4, SyisQ ! a-3-yl) Ph 5- : upMtnethyl-. l, 2, 4-thiaaMzol-3-yl 1-pmpyl 2350 2-Me 4-SO2Me-3-(4., 5 yl ! 5 ! w » @1 cyclopropyl 23 51 2-Me-4402b1e-3-, 5 ~soxazol3-yl) Ph 54ritSuoromelyl-1, 2, 4-thiadiazol-3-yl CF3 2352 2-MeX4-SQ2Me-3-(4, S dbdroi$oxazol-3-Ph 1, 3, 4* iàzöl-2 5t1 E 2353 2-Me4-SO2Me-3-(4, S+ioisösazol-NyljPh I, 3, 4-fuadiazol-2-yl mejdiyl 2354 2-Mb4-SOi-3-(45 dillydroisoxazol-3vyl) Ph 1 34-iadiazol-2-yl i-propyl 0=')'3-', 1)'ph 2355 2-Me-SOe-3- (4, 5-dili3 (drotsoxazdM-yl) Ph l, 3, 4-tMadiazdL-2-. ylcydopropyi 2356 2-Me-4-SOMe-3- (4, 3-dihydtoisoxazol.-3-yl) Ph 1, 3, 4-tbiadiåzol-2-yl CF, 2357 _ _2 _-yl) P=h 5-melylsLulSoeyl-1, 3, 4 {diatol 2-yl _ 2358 2-Me4-SO2Me-3-(4tS4hydrolsodawS-3-yl) Plt 5-melliylsiìlSonyl-1 3, 4-lìiadiazol-2-yl melEyl 23 59 2-Me4-S. 02Me-3-(4t, 5 dibydrolsosàzo>3-_, iPh 5 me0iylsulSodyl-1, 3, 4-thiådiàzol-2-yl i-propyl 2360 _ _2-Me-SO>Me-3-(4, 59 isoxazòl-3^ylt z lllylsyi di cyclofpropyl 2361 2-SO0Vle 3-5+1isowol-3~ylvlph 5-mel3iYbu3 w CF3 2362 2 M4-S02Me-3- (4>S-dih droisoxizoT-3-I) Ph 5-methyl-1', 3, 4'-thiadzazol 2 yl H 23G3 2-Me-A-S (M « 3 ; (A, 5 ydroisgazo1-3-yl) P : h 5-methylwl, 3 4-1hiadiazól-2^yl methyl 2364 2-Me+$02hi3-(4, 5OyOõisaxS-yl) Ph 5-melliyl-l, 3, 4-tMadiazol-2-yli-propyi 2365 2-Me-4-SO2Me-3-(4, 5-diXydXisoxazol-3-yl) Ph 5-meffiyS1, 3, 4-thìadiazol ; 2-yl cydopropyl 2366 _ 2-M-202b3-(4, 5-dihyiisoxazol-3 « yl) PIl 5-mediyl-l, 3, 49iadiazol-2-yl CF3 2367 2-Me4-SOiMe 3-(4, 5-dibydroi « izol-3-yl) Ph betizoxazol-2-yl. 2368 2-Me4-SC) iMe 3~ (4 5 diliM*oisosazol-3-yl) Ph lwenzoxazol-2-yl metyl 2369 2-Me4-SO2Me-3< (4j5Xisoxazol-3-yl3 ebeiizoxazol2-yl i-propyl 2370 ; 2-Mb4-SO2>3-64, 5drvdroisoxazol-3-vl3Ps benzoxazol-2-yl cyelopropyl 2371 2 SO2Me-3-(4, 5 dihydroiso2razol-3-yl3Ph benzoxazol-2-yl CF3 Compuund N-' A B-_. _ 2372 _ 0 2-} ke-4-SO2Me-3-, 5-dihydroisoxazol-3, yl f-1nethylbet ol-2-yl H h 6-inethylbenzoxqzol-2-YI M : thYl 2373 2-Me-4-SQ2Me-3- (4, 5-<Bhyroisox8zol-3-yl) Bh 6-tnethylbsnzoxazol-2-ylmethyl 2374 2-Me4-SO ! Me-3- (4-, 5-<Shydrotso ! azol-3-yl) Ph 6-methylbenzoxazol-2-yl i-propyi 237 « 6 9 SO2ge-3-(4<5-dihydroisox PE 6-. melyll3enzoxagoi.-2-yl CF3 2377 | 2-ge-4-SO2Me.-3-, 5>/< _ benz9wiyl H _2378_ 2-Me-4S. SOzge-3-ffi4, 5*di-3-ylwPh benzoiazol-2-yl melhyl 2379 2-Me402Me-35ildtoisoxazdl-3-yl) Bh benzothiazolyli-propyi 23 2-] -SOe-3- (4, S-dildEOMOxazot--3-yl) Pb benzothiazdt-2-ylcyclopropyi 231 2e-4-SC) 2Me-3- (4, 5-dysoxaz JbenzazoI-Z-ytCFs 2382 2Mea4eSWe-3-(4 5 dlEydroiJox Ph pyrazol-l~DlL H : 2383 2 Me-4SOzMe-3- (4, 5-dih. droisocazol-_. 1) h pytazol--yk methyl 3 23sS 2-Me4XSez2* 3-(4, 5 ; diiìydr, oisoxaz ; 1-3-pFol-l-Cl cyclopropyl 2386 2-Me4-S02Me-3-(4j, 5~o sowol-3-Ye pyWol lwyl CF3 2387 2-MeX, SO2NIè-3 « ydrois-3ryl3Ph pyizel-3-yl H 2388 2-Me4-S02Me-3-(4 @ Psrazol 3-yl methyl 23 89 2-Mc4-sozMe-3-645*Xiso3-yl) Ph pyrazol-3-yl i-propyl 23 2'Me-S02Me-3- (4, 5-y<otsozoM-l) Ph pytazol-3-ylcyclopropyi 2391 Z-Me+WzMe 3-(4, 5 diloisoxazoF3-yl) Ph pyiazot-3-ylCF3 2392 2~Me-4-SO2Me-3-S, 5-dihydiolsoxazol-3-yl) Ph 1snel hylpyrazol-3-yl II 2393 3 2Me4SOMe-3-4, 5-dihydro7isoxazol, 3-yI) Ph I azoi-s-, yi luietIKY1 2394 2-Me-4-SOzMe-3- (4, 5-dtdroisoxaol-3'-yl) Ph l-methytpyrazot-3-yli-propyi 2395 _ IDr I Sn, uD 3 gSwoxazol-3-yllPh I-met ylpyrazal-3-yl eyclopropyl 2396 2'Me-4-SO. M : e-3- (4, S-dihydteisexazdl-3-yPh l-meaiylpyrazol-3-ylCF 2397 12-Me4,,-SO2Me-3- » X tetrazol l-yl R 2398 2-je4-S02Me-3- (4, 5-dihydcoisoxazE'l-3-yl) Ph thazol-I-yl meiyl 2399 2-Me-4 SO21 ! 4e-3-(4, 5 dihydroisoxazol-3-yl} Ph {etrazol-l-yl i-propyl 2400 Z-Me-4-SO2Me-3-(4, 54yciroisoxazol-3-yl) Ph tetrazol-l-yl cyclopropyl 2401 2-1% 4e-4-'SOMe-3. (4, 5-dihydr6isoxatol-3-yl) Ph tetrazol-'1 yl CF3 2402 2-Me-4-SOlMe-3- (4, 5-dihydroisoxazol-3-yljPh 5-methyltetrazol-1-yl H 2403 2-Me-4-SO2Me-3-(4 5kihvdroisoxazo1-3-sl3Ph 5-methylte1razol-1-yl melhyl 2404 2-Me-4-S02Me-3- (4, 5-dJhyd !'oisoxazdl-3-Ph 5-mefhyltetrazoM-yli-propyi 2405 2-Me-4-S02Me-3- (4, 5-dibyc) roisoxazdl-3-yl) Ph 5-metliltetrazol-1-yl cyclopropyl 2406 2-Me-4-SO2Me-3- (4., 5 ol-3-yl) Ph 5-inethyltetrazol-1-yl CF3 2407 2 Me-4-SOZIvIe--4, 5-dihyi : iroisoxazril-3') Ph teazol-2 : y1 H 2408 2-Me-4-SOzM'e-3- (4, 5-dih ;'droisoxazdl-3-yl) Pk tetrazot-2-ylmethyl 2409 2-Me-4-SOzMe-3- (4, S-dihydioisoxazol-3 yl) Ph tetrazol'-2-yl i-propyl 2410 2-Me-4-SOMe-3- (4, 5dlroisoxazol-3-, 1) Ph tetrazol2-yl cyclopropyl 2411 2-Me-4-SOMe-3- (4, 5-dihychrojsoxazol-3-yI) Ph tetrazol-2-ylCF3 2412 2-Me-4-SOMe-3- (4, 5-dihydroJsoxazol-3-yl) Ph 5-meihyKet [azol-2-ylH 2413 2-Me-A-SO2Me-3-*, 5* iyoisoxazol-3-yl) Ph 5-meXhylteEazol-2-yl methyl __ 24 14 2-Me4-SO2Me-3-(4 5-dibydroisoxazol-3-yl) l'h 5-methyltetræol-2-yl l-propyl 2415 2-Me-4-SOMe-3-(45 diliydFoisoxazol-3-yllth 5-indíyltetiazol-2-yl cyclopropyl 24t'6 2-Me-4-SOtMe-3- (4, 5-dihydroisoxazd !-3-yl) P. h S-methyltBtiazoM-ylCFa 2417 2 lVle-A.-SOZMe-3- (4 :, 5-dihydroisoxazol-3 yI) Ph 1-methyltetrazol-5-yl H Compound N, A B R m. P. PG) 2418 2-Me-4-. S02Me-3-4 ydroisoxazol-3-yl) P h I-melylteta a zol-5-yl melyl 2419 2Me-4Q2Me-3- (4dihy (aisGxazot-3-yl) Bh. l-methyltetiazol-5-ylt-propyi 2420 2-Me4-SO, Me-çe (+, 5-ihydwoisoxazol-3-yl3Ph 1-meatyleeem} l-5-yl cyelopropyl 2421 2-Me-4-SQiMB4, Mihydroixazol-3-. yl) Ph Jl-mei&yltetraGl.--yICFg 2422 Sle-4-Sl32M : e4-2-meAylteereizol-5-yl 1]. 2423 2-Me4FSO2Me-3-(A5XiloxazokS.-ylUPh ç< meAyl 2<4 2-Me 02Me-3-i 5-2ihydroisoxazol4--yl) Ph-why eeuaXzof5 yl i-propyl 2425 » e t 2-tehyleéer-5-yl syclopropyl 2426 9 s 2-methyltetrazol-S-yl CF3 2427 2SO : Me-4ydroisoxoI-3. y ! l) Ph pyddm-2-ylH 2428 Xe-4 SQ2Me 3= (44$-dihyFoisiazdl-3-yl3Ph pw2. yl meAyl 2429 2-Me4 ! S02Me-3,- (4, 5Aftdroi, §oxazol73-yl) Ph PYT-2-yi i-propyl 2430 2-MQ-4-SQ2Me-3-' (4, 5-dihydQisoz-3 pypdm.-2-ylcyclopropyi 2431 2 MeQ ; SO 4, 5-dibydtoi+ 3tgP. Jh PYwy1 CF3 2432 2 Snz ÇisoxX3-yl~) Ph p, yad Ayl 1S : 2433 2 IvIe4-'.) ZIVIe 3-C4, 5rtdiyiiraisoxazol-3- : 1) Ph, pyridiit4-yl methyl 2434 2-3Ze-4-sme-3-95diiyiMrisexazdl-3-yl) ph Pyfiyl i-propyl 2435 2-Me4-SO2Me-3-64j5-dihXisoxazol-3-yli) Ph pyridiS4-yJ cyclopropyl 436 2-Me-4-S02Ma-3-- (4, 5--dihydi'oisoxazol-3-P pyndin-4-ylCFs 2437 < 5 1<3@1) Ph pyridin ; 3-yl 1 I 2438 2-Me-4-S02e-345-dihyd. EoisoxBz3-ylPh pyndm-3-ylmethyl 2439 0-Me-4-S » Ie-3t (£7S4iyHsioxi ol-^2 l) Ph PYi-yl i-propyl 2440 2-Me4-SO2Me-3-(4 dioïsoxazol-3-Ph pysidin-3-yl cyclopropyl 244it 2-Mi3-4-SQMe- (4, -. dihydroiSQxazol-3-yl) Ph pyndin-3. ylCFa 2442 2Z4e-4SOMe-3 (4, 5dihy&disoxaz6l3-. yI) Ph 3-iiitropyndin4-yl H 2443 2-M « *4-só2Me-3-54liSydboiisexazol-3-glhih 3-rl °pWdin4 yl methyl 2444 2-Me-4- : SO2Mp-3-IA ; 5dffiydroig6xazol-3-yl) Ph 3-nitropyndin4-yl i-propyl 2445 2Me-4-SOzMe-3-- (4, 5-dmydcaisoxBzol-3-y ! lBh 3-BitropyBtd ! n-4-ylcyclopropyi 2446 2-Me-4-SO2Me-3-(4, 5-dibydioisomzol-R-yl) Ph 3-nitzopyridin-4-. yl CF3 2447 2-Mç-4-. SO2Me-3-{4 5dilíydroisoxazól-3-yl3Ph 5-cyanopyIidin-2-yl H 2448 2-Me-4-SO2Nfe-3J (4@4iSyditsoxazo1-S Ph 5-cyanoppdin-2-yl methyl 2449 2-M"-SO2Me-3- azol-yl) Ph 5-cyanopyridin 2-yl i-propyl 2450 2-lWe-4iswe-344f 5-dihydtoisioxzol~3-ylaSh 5-cyanp3mdib-2-yl cyelopropy1 2451 2-Me4-$% Me-3- (4, 5-dihydroisoxazol-3-yl) Ph 5--cyanopyridin-2-Yi CF3 2452 2-Me-4-SO2Me-3 4, 5-ciifiydroisoxazol-3-yl) Ph 5-trifluorotnethylpyridin-2-yl H 2453 2eS02Me- (4, 5-dihyoMoxazal-3-yl) Ph 54dauoromBtbyJpyaam-2-yl methyl 2454 2-Me-4-S02Me-3- (4, 5-dmydroisoxazdl-3-yl) Ph 5-tritluoromethylpyiidin-2-yl i-propyl 2455 2-Me-4-SQvMe-3-(A, 5-dihybóisoxazol-3-yl) Ph 5~<al cyclopropyl . 2456 2-Me-4-SOIIe-3(4, 5-dihyclioisoxazol-3-yl) Phh 5-triflunromethylpyadin 2-yl CF3 2457 2-Me-4-SOzMe-3 ^ (4, 5-dillydroisoxazol-3-vl) Ph pysimidin-2-yl E 2458 2-Me4-SO24-3, (4, 5* yboisoxazol-3-yl) Ph pythllidiW meiyl 2439 J2-Me-4-SOMe-3-' (4, 5-diKyapoisoz0l-3-yl) Ph pynmidm-2-yli-piopyi 2460 IvTe-4.-S2Me 3-4, 5-elih clioisozol-3 1) Ph pyrimidib 2 yl cyclopropyl 2461 2-Me-4-SO2Me-3-(475-dilìydroisoxazol-3-yi) PIl pymnill-2-yl CF3 2462 2-Me4-SG) 2Me-3-' (4, §-dibyarMsoxaz0l-3-y ! [) Ph pynmim-4-ylH 2463 2-Me4-SO2Me-3-(4, 5-dihyioïsoxazol-3-yl) Ph pylilmdin4-yl methyl CompmmdN ABRm. p. (*C !) 2464 2-M-S02Me-3- (4, (-d$doisoxazol-3-yl)Ph pyrimidin-4-yl i-propyl 2465 2-Me-4-SOMe-3-, 5- (N] ydroisoKtzpI-3yl) Bb. p) T) midui-4-yIcyelopropyi 2466 2-Me4-SO2Me. 3-(4, *dmïsoxazol-3-sl) Plì pyrimidix yl Cf3 2467 2-M-S03- (4, S-dihy<jrQis6M2 : Ql-3-yl) Pb..'-ctoropy)'imi'lm-4-yl methyl = 03 z Sffi ; § X3t óhiMpynmiõin-4tyl 5 i-propyl . 2-Me4SO ; >3-04, 5 zEydloísoxa olM Plì ; 6eiloropyWi* yl çyclopropyl 2470 2 Mi4-SOMe-3¢ oisoxazol-. 3ry13P : 6-: abloropdin4-yl CF3 24. 7i 244-Swè-3-(ß>54yiaisoxazoli3-yl i P-3-yl G 2472 2-Me-SQe- (4, 5-dihydmts0ol-methyl 2473 2--SQi3r (4, 5-y ! soxazpl-3-yl : j-propyi 2474 2--SOaMe-3- (4 ; 5Htsomzo py) idazm-3-ylcyelopropyi 2475 2-Me-4-SO2Me-3-64-5div. d£oïsòxazo. 3'Xyl) Pli Fv = CP3 2476 2-Me4-S02Me- (4, 5-<ydTo ! soxazol-3'yl'h -cblQtQpy. aaziit-3'. ylmethyl 2477 2-e4-SOz ! 3- (4, 5'ydt (M031-3-yl 6-cblat'opyndazm-3-yli-propyi 2478 2-Me4. 4043-64, 5 dilkdiòiso-3-Ph 6dlOropyiidgin,-3-yl eyelopi : opyl 0 2_79 2 MeZrSC54ydroisoxazol-3^yl) Ph 6 ; chlHdazir-3-yl CP3 2480 1 2-MQ4-SO2M, -3- (4, 5-dihydroisowol-3-yl) Ph pyrazin-2-yi meihyl 2481 2~ _ P*Z@. i-propyl 2482 2-MeSOe-3 (4, 5-dihy<Gisoxa pyrazm-Z-ylcyelopropyi 2483 2-Me4-SO2Me3-64, 5-dihyd soxasol-3-ylph pyrazi21-2-yl CF3 2484 _ _2-1b¢m* 4 Syl metliyl 2485 2-Me4-SO-3, 5-amyGisoxazt) M-Ph tqzm-2-ylpropyi 2486 2-Me-S02Me-3- (4, 5yoisoxazbjt-3-yl) Ph tnazm-2-ylcyelopropyi 2487 2-Me^5-SC) Me-3-(4, $6ydío^woNazel-3-ylwh bdazin4-yl CF3 2488 2-Me-SOe-34, 5-dihydrotso- ! S (zol-3-yl) Pli qumo ! m-2-ylmethyl 2489 2-Me4-SOtMè-3-(4, 5 dihvdroisoxazol ; 3-vl) Ph quinolïll-2-yl i-propyl 2490 2-Me-4=Sf2Me-3- (4, 5-dihydroisoxazol, 3-yl) Ph quinolu-2-yl cyclopropyl 2491 2-ME-4-S02MB-3--dihydroisoxazol-3-yl) Pii qumolm-2-ylCFg 2492 2 Me-4-SOzMe-3- (4, 5-dihydroisoxazol 3-l) Ph 4, 46ndWyl-5, 6v1, 3 (4H+2-yl H 2493 2-Me-4-SO, 2Me-3- (4, 5_ 4, 4, 64mvkyl-5, 6-dhydro-1, 3 (4H)-m-2-yl methyl 2494, 2-MB4-SO : -3- (4, 5-dihySToisoxazol-3-yl) Ph 4, 4, 64Bm65, 6-di) dto-l, 3 (4E) sazm.-2-yl i-pTOpy ! L 2495 2-Me4-SO2Mv3 {4 5esoxazol-3-yl) Ph 4, 4, SmdlyM, 6d1. 3 (4EWcF2-yi cycioptopyl 2496 2-w-SO2Me-3-(4, 5-dihydr isoxazdl-3-yl) PIl 4*, 6*dx>1, 3 (4Pboxazirs2-yl CF3 2497 2-Me4-SOA4>3-(A, 54ihydroisoxazol-3-yl) Ph 2-oxazohdinon-3-yl H 2498 2-Me4-so2Me-3-l » 5Eydioisoxazol-3-yl) ph 2-oxazolidinon-3-yl melyl 2499 2-Me-4'» iMe-3-(4, 5Xdrwsoxazo1-3 Ph 2-oxazolidinon-3-yl i-propyl 2500 2-Me-4-SOZIvIe-3- (4, 5-clihydrdisoxazol-3-yl) Ph 2-oxazolidinon-3-yl cyclopropyl 2501 2 Me-4-SQZMe-3 4, 5-dih clcoisoxazol 3-1) Ph 2-oxazoli'dyon 3 yl CF3 2502 2-MB4SOM3- (4, 5-yoisoxazol-a-y}) Bh 2-pyn'0iidinpn-l-yljnethyl 2503 2-Me 1-SO2Me-3-(4, 5woxazol'3-yl) P4n 2-pyrrolidi « ion-1 ;-yl i-propyl 2504 2-Me4-SOlMS3-(4, 5lydrotsoxazol 3-yl) 2-pywolïdinon-1-yl cyclopropyl 2S05 2-b4-SCE2Me~3ç. (4, 5 dihydroisoxS Ph 2-q dE on-l-yl CF3 2506 2-Me-4-SOzMe-3- (4, 5-dihydtoisoXazol-3-yjt) Ph 3-methyKsoxazol-S-ylmethyl 2507 2-Me4-92Me-3-, 5*droisoxazol-3uyl3Ps 3snet hylisoxazol-5-yl i-propyl 2508 2-M"S0, Me-3- (4, 5-dihydroisoxazol-3-yl,) Ph 3-methylisoxazol-5-yi cyclopropyl 2509 2-Me4-SO2Me-3, 5 diliydroisoxazol-3-yi) Ph S-methylisoxazol-5-yl CF3 Compound N B R nup. p 2S 10 _ 2-Mo+S02Mr3-(4, 54íhydroisosaæol-3-yl) Ph 2602-4-SOlhtePh E. 25 ! H 2-Me-4-S02Me-3- (4, 5-<aihych-oo ! azol-3d) Ph 2-N02-4'SO ! MePh methyl 2512 24Me4-SO2Me-3-(4, 5 dihydr isoiazol-3-yl) Ph 2-NO24. SO2MePIl ; i-propyl 2513 2-Me4-SQAIe-3, (4 ; Sv ydXolsoBzolA3-yl) Phr 2-NO24-SO2MePh Gyelopr . qß. 2-, SOi 6-34 ihydroisoxazo>3eyt) ph 2-N024-SO2MePh CF3 251 2-Me-4-SO2Me-3- (4,, 5-day&, oisoxazol-3, yl) Ph 2CI"4,-, $O2MePh fl 2516 2-MB-4S02Me-3-<4'-ddroisoxaz6l !-3-yBh 2-CI-4'Sp : M : Bh methyl 2517 2 w *< 2-gCi4-S029 ; ePh i-propyl 2518 2~MA93 Mv 3 » dihydroisöxazöl4-yl3Ph 2-C14SO,, MePh cyelopropyl 2519 2-Me44o2Me-3-: l45wXyHis0xa2ol-3-sl3ph W14-SO2MePh CF3 2520 Me4SOMe-3-, S-dtpiso'm 3Qr4<h H 2521 2-Me-SO ! 3- (4, 5ibydtGis9ol-3-yl) Ph 2-NOr4-CF3Ph methyl ..... 2522 2-M s 3-@ » ; » wh x-propF _ _ 2523 2e4-SOe-3- (4 ; 5-tso X-NO-CFh cyclopropyi 2524 2-w-so2Me-3-! 5toïsc 2-NCW. E1Wh CF3 2525 2-Me=SOMe 3- 4 ; 5-dih, elroisocazol,-3-, 1) Ph 2 NO-4-CII'h H 2526 2-Me-4-S02M9-3- (4, ; soXazol-3-y13Pfi ; 2-N@-CIPh melhyl 2527 2-Me-S02e-3- (4, 5ydtBis6xazol-. 3-yl) Pb 2-NOr4-Clp] h i-propyi 2528 2-M-SOe-3- (4, 3yd)'soxazol--3-yl) Ph 2-N02-4-C} Eh cyclopropyi 2529 2-Me4-S02M3- (5-dihydroiso : H ! zol-3-yl) Ph 2-N02-4-C'IPh CPg 2530 2-MeX OXe-S (49$i isòxazol'3-yl) Ph 2-t NiiO2Ph 253 2-Me4-S02Me'3- (4, $-yaroisoMzoI-3-yl) Ph 2-Ct-4-N02Ph H 2532 2-Me-4-SQ2Me-3- (4. 5-dib-y&oisoxazol-3-yl) Ph 2-CI4-NO2Ph i-propyl 2533 2-Mc-4-S02Ms-3- ('4, 5-ydroisoxazol-3-yl) Ph 2-CM-NOtPhcyclopropyi 2534 2-MèAS@Ie-3-; (4, 5 « 1ihy3roisoxazol-3-yl3Ph SCl4-Nû2Ph CF3 2535 2-Me-4-S02Me-3- (4, y-didmisoxazol-3-yl) Ph 2, 4- (NOPhH 25. 36 2 IVIe-S02Me3-, (4 $-ciihydioisoxazol-3 yl) Ph 2, 4- (N02) zPh methyl 2537 2'MeS02Me-3-' (4, 5-hydroisoxazol-3-yl) Ph Z-CNOPhi-propyi 2538 _MeXSO2w5 dihyWoisosazol-3 yl) Ph_ 2, 4- (NO2) 2Ph cyclopropyl 2539 2-Me4-SQ2N4-3- (4, 5-dibydr6isoxazol-3-yl) Ph 2, 4- (NO2) 2Ph CF3 2548 2-Me-4-S02Me-3- (4, 54ihydtoisoxazoL-3-yl) Ph 4 P-3 ; NO. 2Ph H 2541 2-Me4-SO2Ze, (4, 5*dtoisoxazol'-3-yl) Ph 4 F 3-NCQZPh methyl 2542 2-MeWS<3 ; 2Me-3 olsoxazol-3-yl3Pe 4. F-3-NOmPh i-propyl. 2543 2-IvIe-4-=SOZIvMe-3- (4, 5-diliydroisoxazol-3-yl) Ph 4 :-F-3-NO2Ph cyclopropyl 2544 2-MeXSO2MS3-(4, 5-dilivdilsoxazol-3-yl) Ph 4-F-3-NO2Ph CP3 2545 2H2Mé-3-(4, 5+isg1-3-yl3Ph 3, 54CF332Ph. H 2546 2-Me-4-S02Me-3- (S- (Bldroisoxazol-3-yl) Ph 3, 5- (CF3) aPh methyl 2547 2-Me-4-802Me-3- (4, 5-6hydroisDWOI-3-yt) Ph 3, 5- (CF3) ; IPh L-propyl 548 2-Me-4-S03- (4, 5-oisoxazol-3-yl) Ph 3, 5- (GE332Ph cyelopropyl 2549 2-MOSO2Me-> (4, 5wsoxazol-3-vl) Ph 3, 5- {CF3,) 2Ph CE3 2550 2-Me4-SOMe-3- (4, 5 drohox=ol-3-yi) Ph 2-S02Ma-4-CF3Ph H 25 !) 2-Me-4-S02Me-3- (4, 5Biyroisoxazol-3Eh Z-SOzMe-CFsPh methyl 2552 2-Me-4-S02K3- (4. 5ydrGisoxazol-3-yl) Hi 2-SOM&4-CFjPh t-propyi 2553 2-ME4-SO22Xe-3-(4 ? 5dihydroisoxazol-3-y13Ph 2-SO2Me4-CF3Ph eyBlopropyl 2554 2-MeSQj-3-<dtsoxazol-3-yl) Ph 2-S02Me-4-CF3Ph CF3 CompoundN R cc) 2555 4, 4oM-MMat4-'benzotMm :. T-yt l, 2, 4-oxadiazol-5-ylH 2556 4, 4p<--4-b6t<Nn-7 l, 2, 4'oxadiazpl-5-ylmettl 2557 1, 2, 4-oxa4iozol-5-yl cyc 0 rop 2558 4, 2, 4-oxa diazol5-Yl 3 2559 3 : metlit,-I,'2, 4-oxadiazol-5-Yl- B 2, 560 4-i-dYam- ! n.'7y1 3-tneth 1 1, 2, 4-axadiazol-5 yl H 356it 4, 4<ati 4~i ; E7-j 3-meEyl'-1, 2, 4-oxadiazol-5-yl. 2562. , 4M24-tsnmmasM-l 3-. metbyt-l, 2, 4oxadiazol-5-yli-propyi 25G2 _< +> = i-propyl 2563, 44dioxidC Miz ; 3 <ß-oxFdiazol-5-yl çyçlopropyl 2564 7. :, yi-ttifluor, 6, methll-oxadiaze4- 2565-4~-> i*1, ~78I 3^ Ih71=1, 2, 4-oxadiazol-5-yl H 2566 4, <- ! 3ih) % 4-<'entM 3-tt ! tSum-otne&yl-l, 2, 4-oxad] az9l-S-yl nieiyj 2567 , cmds-MBihy), 4-4'ent 36. uo] : 6meyl-2., 4-oxadiaz0l-5-yl i-propyi 2568 >-$ k' Y1 3 tiifl, uoxomethyl 1, 2, A-oxadiazol-5 yl cyalo o yl 2569 1, 2, 4-oxadiazol-3-Yi.., methyl 2570 a, 4-<uoa. s=. , ydma ; q. =y1 1, 2, 4-oxadiazo-3 : y1 2571 4, 4-aoxiae. 8-tv-2 ; 3i, 4-sxtt1 t, 2, 4 2572 ~ 4~4"diosidS » 23"dihydu » zq2ra*F7-g l 2, 4-oxadiazol-. 3- 1 i-ro 1 2573 4 ; 4-aioXide=8-Mo-3-dih,-ycn. 4=benzottiiir9 : yl 1, 2, 4-oxadiazol 3-yl cyalo opyl 2574 4, 44isp2>34+li467 9 1_2, 4-oxadiazol-3-yl CF3 2575 4, 4<m-Mc-2ihydl, 4enzoxatHm. 7-y ! l, 2, 4-OXadiazql-3-ylCFa 2576 4, 4 diXde : 8 ~_w1 5-methy1-i, 2j4~oxadiæol-3-yl melyl 2577 4, 4 dicsidiÇ 5-me1hyl-1, 2, 4~oxadiazol-3-yl i-propl 2578 Smethyl-1, 24-oxadiazcil-3-yl CF3 2579 4, 44 8-M>2, 3vdihy3>l>460 vl gS-rnelEyl-1, 2j4-oxadiazdl-3-yl CF3 2580 4, 4-dio ! dde-8-Mb-23-<Nodto-i, 4-bEttscmthiii)-7-yt S-tcifhioromethyl-l, 2, 4-oxadiazol-31 H 2581 47 íiyo4Bti 7vyl 5-t if luorome1hyl-1<2, 4-oxadiazK methyl 2582 8=M3y' Yl S-trifluoromeh 1-1, 2, 4-oxadiazol-3 1 i-ro 1 2583 4, 4Qms-M2ad], 4-benatHim-7-yt 5-tnSuoromeQ) yl-l, 2, 4-oxadiazol-3-yl cyclopropyi 2584 5-chloro-1, 2, 4-oxadiazol-3-yl H 2585 4, 4doxìdS8-Mb-2, 3 _ S-cSoro-1, 2, 4-oxadiazol-3-yl H 2587-Y-oMor-o-1, 2, 4-oxadiazol-3-yl methyl 2588 S-chlDro-1, 2, 4o-xadiazol-3-yl 1-YI-IOPrOPYI 2588 4, 4Ezido 8-Ms2>3*dn ; i, sb 7-yl 5-411lOrO-l 2, 4^oxadiazol-3-yl cyolopropyl l 2589 i, 4 diondbs-Ms23Wi4 lienzaxatiiii} 7yi 5shloro-1 2 4 xadiazol-3-sl CF3 _ 2590 4, 4-diioxida. s-Ma-z, 3-tt, y'Q-, 4=ty 1, 3, q-oxadiazol-2-yl H 2591 4, 4 di6s-Ms2, 3 dibyd>L4*7yl 1 3 4-oxadiazol-2-yl mediyl 2592 4x4<fioxt 46ai7*yl 1, 3, 4-oxadiasoI-2-y} i-propyl 2593 4, 4dionde 8@^2, 340vdml, <-a-yl 1, 3, 4-oxadiazoi-2-yl 4yo1Opropyl 2594 4,-4 dia2zdo X-MS2, 3 di, 46ç-yl 1, 3 4-oxadiazol-2-yl CF3 2595 R 2596 4, 4-dioyiO--NI-7, 3-4-ffiiirt-7-yi 5-mothylsWfoayl-1, 9, 4-oncliazol-2- raetliyl 2597 Srnethyliulfonyl-1, 3, 4-oxa-,-2-yi 2598 4, 4 diosidMis2>34iydel, Sbenmthnii 7-yl 5-me4ìylsul£onySl, 3, 4-oxadiazol-2-yl ey41Opropyl 259 4, 4ioao-s--3aya ; 4-r-7 y S-meth, lsirtfo 1, l, 3 ; 4Qxadiazol-2-y1 CF3 2500 iW-&. v>34Wdel 1hy 5-melX 94-oxadiazol-2-yl H 2601 4, 4o8-2dl, 4-bacthm-7-yt'5-methyl-l, 3, 4-oxadiazol-2-yl methyl () MetE 6 5-tnfluoromethyl-1, 3, 4--oxadiazol-2yl CF3 2G03, > 5@ < wI°pyl 26 4, 4-u -sri- ? -ayam-1 ; ¢ut-7=x S-zneth 1, J. 3>4-oxatli'azoT, 2.-., 1 CF3 2605 4, 4o-yacpMm-7'-yl 3.-. tna. ubfome< : byl-3, 4-oxa<Hazol-2-yl H 26 4, 4ioxiael: s 1v . 2 dt. ydro : 4-t : yl 5-tclklitoromethyl T, 4. odiol-2-yl etbyl 2606 : 8w} 7t1 5g° g@ [LS methyl 2607 A, 4 diòxid >8-j6t, 34d _ 5-o@edxyl-l, S, 4ghdÇ i-propyl 25OF, 4, *dis4>3kyde. *i+yl 5wyl-l, 3, 4Waxadlaz yl cycloproP 2609 ; t--diius3-a3hY4t : 7yt : uoraine -"1, 3, 4-Aiazol-2-yl CF3 2610 4 ond » iví> ; 934 1, 2, 3. ^biazol4. ^yl H 26 4, 4~dsioxiS8->2>3+dihydl**x30~7yl 1, 2, 3aiaèò+ç4-yI-melihyi , taothyl, 1, 2, 3-tiiazol 4-yl 2613 4, 4. dioxide-8-b2, 3 di4ydt1, 44*1liiii7-yl 1, 2 :, 3.-#i-aiól4-yl cyelopropyl 26J4 4, 4-dioxide4 » ~¢ 9 1, 2, 3-itlazol-4-yl CF3 2615 4, *ivydjvl, i 7y 0 Xyl-ln2p3-1Xiazollyl H 2616 4, 4-dioxiaa-s-n-a ; -aya. ; 4-oxatyl 1 methyl', 2', 3'-triazol4-yl methyl 26 ! 17 4, 44ionde ; S-« 3-dily~ ; @ t 1, 2, 3-b : iazol-4 rl i-propyl 2618 4, 4dibxiila8Mo-3-dydm-1, 4-bxatltiiir'1yl 1-meth 11, 2', 3-iriazol-4 yl cycloprop 1 2619 a, 4. aoaaa-3-yd. ; 9-uEnzar-p met -. 1, 2, 3-fazol-4-y1 CF3 2S0 U ~ 91 2-fiiëthyl<, 3-1dazo1-4-yl M 262 1 4, 4-din : nde-8-Ib2, 3Xywl, 7yl 7 2w1-1, 2, 3-b7iazol4-yl melhyl 2622 4, 44usidb o-1, i-7yl 1 2-333 2, 3-tiazol-4-yl i-progyl 2623 4, 4~diondo : 8-. b2, 3w yl tt L _ cyolopropyl_ 2624 44~dìofide-8 3~ffi » 7yl 2<i 1 hyl-1, 2, 3-triazol4-yl CF3 2625 4. a-oao- t2, a-auyar-, taay r, 2, 3 : tciazol-1- 1 H 2630 To 8-M-V-d i hyd-1, 4-b--"-7-y I-1, 2, 3-triazol-2--yl H 2629 4, 4cm8-Me-2, 3-tl, 4-bstta&a) tanl 1, 2, 3-tnazol-l-ylCFa 2630 4<de-S-MB-2-dBdm-l, 4-b6nzoxattmm-7-yt I, 2, 3-t ! iazol-2-ylH' 2629 44-3 ; oxig : Nto-2a. Yc7co-, 4 : beuzcair'ryl 12, 3 triazol-1-1 CF3 2630 4, 4 diagide 8 ; Me-234flíydnF 47-yl i, 2, 3'-bïazo. 1-2-yl ~ ~ 2631 4, 4 dis3gide 8-. Mg3Wdihgb1, 4Xnz (ixadiiinll^yl 1, 2, 3-. @1azol-2-yl melliy 2632 4, 4"dioxid*8-WI, 3 dihydol, $iS yl 1, 2, 3-triazol 2-1 i-ro 1 2633 4, 4-&oNid (Me-2, 3-d&yd-1, 4-b-D-OiUn-7-yl 1, 2, 3-triazol-2-yl cycl2PLOMI 2634 ~ 4awiEr7-Bg74iWydr lhib7-34-1, 2, 34iazol-2-yl CF3 2635 4oxldes-W2, S~gais7 « yl-i24-egazol-l-el H 2636 1, 2, 4-tiiazol-1-Yi- . 2637 4a-tuonastv. s. am-a ; a-nzca : y, , 2, 4-tnazl-l-yti-propyi 2638 4, 4-dioxiila. 8-Ma-2, 3-dydro-1, 46enza7ryi 1, 2, 4 triazol-1 yl cyclopro yl 2639 4, 4-di'oxida-8dve2, 3-dt7ydco-1, 4bzvsat6iar'lyt i, 2, 4-triazol-1- 1 CF3 2640 4, 4-&oxidt-B-Mf-Z3-dihyd-1. 4-b--ififfitL-7-yl imidazol--2-yl 2641 4, 4-di'oxi3e-8-Me-2, 3-dliydm-l, 4bemaxatluin-7 yt zol- yl methyl Compound NABRm. p. (°C) 2643 4A 8 « 34> adazol-2-yl oyolopropyl 2643 4-oxlaa : 8-Mc-2, s. ihYdiv-1, 4 ; benzouun 7 : Yt itnidazo-2-ylo ro 1 '2645-4, 4+id>8s, a3t w+e iniidRol-lvyl y, H, 645 4-uoae, s : zv. -23ltau°, t ;-y dazo-lT 26464, 4oxid% 3-<dto-l, 4-bettzo0uin-7-ytimiazol-l'-yl methyl 2G47 44dianW, 3 « blyd*wfliibl-7-yl imiizol Yl i-propyl 648 Q-daa-s-zz : 3-aya.. , ata-yt iniidazol-1_-1 c cI4 ro l 26494, 4r9-imu. 7-Y''n'n. 61-1VI 26SO4, 4c<s-2-dih) l, 44) s ! s<inudaz () l-4-ytH 26514, 4T<Bo-M2, 3'hydl, 4-bs<tz<tM7 imidazol-4-ylmethyl" 2G51 M imid olS4-yl meshyl 2653 4, 4oa-2-<Udi4-btmQMut'7-yl inudazol-4-'ylcyolopropyi 654 4, 4-dioue8 : n% fa3 : Ydrv' ; 4benzoxaHtiuY7 : Y1 1t121C8Z0-- 265 4Xoxid<3 9 imL ol4-yl i-propyl 2653 4g0w34 =iw3ih} 7-el i oyolopr 2G54 4444s 4-yl-CF3 2655) 4u*. 771_ iiaziol92-yl EW 2656 imidazol-4-yl methyl 2656 4, 4bsd-] -di4-betEothi liiaz6t-2-ylmethyl 2658 4, 3Aihydrol44nnzmdiiia-7-yl-ih-laikol,-2-Yi rO 2659 4, 4L&oside-g-NI. 3-ftydw. 4-pltliiazol-2-YI i-PrOPYI 2663 ol-2-yl-,-YqloPrOPYI 2664 4, 4S-Ss2>34iydeL44ihii*-7-yl 4-meihvlXiazol-*-sl -2666-orazol-2 : !-. yl methyl _ 2662 OxazOl-2--YI i-propyl- 2663 4, 44iwdfS-b2>3+J*6 7 yl 4-wlhYIXzol-2-y1 boyçlopropyl 2664 4, 4dioiae-8-Me 2, 3-J'hydm-1 ; 4-benzoathiui-7 yl q jeyltliiazol-2-1 CF3 2665 X M oxazol-2-yl H 2666"4, 4oad-M2Bdtt, 4-bet) zotMm-7 oxazQl-'2=yl methyl'* 2667 4, 44Oxide-S-W2, 3+1h>4tbiix-7-yl oxázol-2-yl i-propyl < 2668 4, 4 dia>ud*8-b2, 3gdihydie xadiiin^7wyl foxazol-2-yl oyolopropyl 26G9 A, 44 ds8-Me-2, 3~} 1, W= x0-7-g oxazol-2-vl CF3 2670 4, 5-, dimethyloxazol-2-Yi cyclopropyl 2671 4, 4 dioxt by4ihydol 7-yl 4, 5 » lhyloxazol-2-yl melhyl 2672 4, 4 (ds-] \2, 3-aih)'dtl, 4-benz (thH 4, 5-dimef) iyloxazol-2-yl i-propyi 2673 ¢-s-Ma--''''d'""°" ? '1 4 5-durieth. l'oxazol-2- 1 c clo ro 1 2674 4, 4 dionde-8-b2, 34ihydXad 7-yl 405 dimediyloxazol-2-yl CF3 2677-2-oxazohft-2-YI i-propyl 2676 44 diòxide-8 : W2, 3 *iin 7ta 2-oxæolia-2--vl met : hyl 2677 4, 4-dioxide ; 8-. MES2, 3dw 1, Ibine7-g 2-axazoli-2-Yl i-propyl 2678 4, 4 dioxtde-S W2 ; 3v1 » IID ; » YI 2-oxazblin-2-yl cyclõpropyl 2679 4, 4n7 dd 7 MiZ, 7+1+YI 2-oxazolin-2-vl CF3 2680''4 (md\2, 3dl ; 4enz 4, 4-dimethyl-2-oxazolin-2-yl H 2681 4, 4 dia nd>8-b23yd>1sbaE=awyl 4, 4-dimethyl-2-oxazoliii-2-yl metbyl 2682 4, 4 » dioxid>8-W2, 3~o7-yl 4 4~diXethyl-2-oxazoi-2-yl i-propyl 2683 4, 4-<) iosf) e-8-Mc-% 3-aihydm-l, 4-benzoxa<Hm-7-yl 4, 4-diimethyt-2-oxazo ! iin-2'-yl cyclopropyi 2694 4,"odd"-Me-Z34&Yd-L4-b7-YI 4, 4-ditieffìyl-2-oxazolin-2-yl C1Ss3 2685 4, 44 (> 8-MS2, 34ihydre1Abe=67-yl 1 2Aoiadiazol-5-y1 3686 4, 4^aioxideS8-b2, 3ydeWbexa « 7-yl 1, 2, 4-iadiazol-5-vl mel : tiyl 2687 4, 4-aioxiae-s-Me-2, 3-dihydo-1, 4-boxathW- yi 1, 2, 4=thiadiazol-5 yl i, 0 1 Compound NABR m. p. (°C) 2688 4, 4-dioxids-zvie-2, 3, al ; g-benzoxathmH7-yl 1, 2, 4., thiadiazol-^3' cycopro yl 2689 1, 2, 4-thi-adizz-ol--5 7t CF3 2690 4, 4 diaxide a-, 3 disydro i4siie7-7l 3-1ne§ryls124-thiådiazol-5 2691 4de-8-W, 3OySdro-i » udy. 7. y] 3-methylsl, 2, 4 ádXtàzol-s-yl meiYl 2692 4oaae. M% 3yafo-t, 4-be ; m ! M 3methyl-'l, 2, 4-tbiaazol-5.-yli-propyi 2693 , 4-dioxi-z, 3dam-4-twn-7-y1 3 : riiethyl,.. , 2', 4-thacliazol S-y cyclo ro yl 26944, 4cms-t2, 3-i, 4-tenzo) ; atMm- ?-yt. 3-mefhyl- ! l, 2, 4-t ! itadiazol-5-ylCFg 2695 4, 4diò$d>8-w41tdwi, 4Xilriba 7-d 3*trYJ lu « i deFyi-tß2, 4 adiazol-5-yl 2696 4-bas-2, 3dTo-t, 4-tnzpntMt71 3-tnQuoEottietbyl-l, 2, 4--thiadiazol-5-yl mefhyl 2697 4, 4od-] y<-benz<M (hm-7-yt 3tdauoronietb. yH, 4-t) Nadiazol'-5-yl i.-propyi 2698 4, 4<m8-% 3-dto. !, 4-bmzo (hm 3-trMuoEomethyl-l, 2, 4-hicliazol-5- X cyolo zo l 2699 4>q-eioxiae-s-v-3, ydm- ; -boxath7y1 3-trifluororixeth'1-1, 2, 4-thiacli'azQl'-S- 1 CF'3 2700 4, +8 « 1 + _ » 1, 2, 4-ttuaiazol-3-ylH 2701'4 () xi8-y4-T) cnz (Bm l, 2, 4-ttua<Bazol-3-ylmethyl 2704 1, 1., 4-thiadipitEpl-3-yl CF3 X 2703 0XV Xiw i 1, 2, 4-l : biaåXol-3-yl cyclopropyl : 2704-4, 4 dioW dwble*7-yl 1, 2, 4-thiacliazol-3- 1 CF3 dR. 5-inethyl-1, 2,, 4"thladiazol-3-yl yl 2706 i, 44ioxiw34 7-yl 5-rietliv 24-ß3iaiazol-3-Ttl rnediYl 2707 4, 4 « 1io nd>S-w34ydro 1, 46 7-yl 5-methyl 1 2, 4-thiadiazol-3-yl i-propyl 2708 4, 4 dioQndè S mydiol, 4ber=n-7-yl 5-ni5iyl-1, 2, 4-*i'åzol-3-yl oyclopropyl 2709 4, 4Xi sde4~ 3Xydi1> z*7-yl S-rael3rYlPl 2, 4-diiadiazol-3-Yl eF3 2710 4, WYn 7-ydo1, 4> {afiF7-yl 5XorornethY 2-4-iadiagol-3-yl 271, 1 4"omdo-S Me-2, 3-dkdt-1, 4-b-o"ffiiin-7-yi. 5-tlifltorompthyl--. 1, 2, 4-thiadiazol-3-yl meihyl 44. imuas-zvre- 3aih dro-4 : y 5=tri'flitoromethl 1>2, A-thradiazol-3 yl i-proPYi ,, 2713 4, +&oddD-8-M-V4ffwd-L447-YI 5-trifluoromethyl-1, 2, 4-thiadiazol-3-yl cyclopropyl 2714 4, ' d--¢iin 7-yz -trifluoromethyl-1, 2, 4-lhiadiazol-3-yl CF3 2715 4A-cmd&8-M-Z3-dftdto-L4-bm-diii-7-yl 1, 3, 4-iåd 2-g H 2716 4,"Ddd-8-M-V-dihYd-L4-b-z-AH-7-YI 1, 3, 4-t-hiadiazol,-2--yl methyl 2717 4, 4di°n 34WtEinn-7-yl 1X3, 4"adiazol-2-yl i-propyl 271'9 4, 4-&omd-8-Nfo-Z3-&Yd-L4-b-tif-n-7-YI 1, 3, 4-1 hiadiazol-2-yl cyclopropyl 2719 4, 4dioxidSMß2, 34ydil, SbenzzaF7-yl 1 3 4-thiadi : azol-2-yl CF3 2720 (3 4, 4 dioxt s-Mia, 34ihydro-l, {« 7-yl. 5-methylsulfonyl-1, 3, 4-i híadiazol-2-y1 H 2721 4, 4-&-d-8-M-V-djhyd-L44>----fim-7-YI 5-methylsulfonyl-1, 3, 4-thiadiazol-2-yl methyl 2722 4M--dY-i'Y 5-inethylsul'fonyl-1, 3, 4-thiadiazol-2-yl 2723'4, 4oxia-M2i (kQ-'l, benzt) x. (a) Hn-7-yl"5-iB. ethylsutfonyl-l, 3, 4-thiadiazol-2-yl cyclopropyi 2724 4,"oxi"-M-V-dkd-L4-b--ffiii-7-YI 5-metbylsulfonyl-1, 3, 4-thiadiazol-2-yl CF3 2725 4, 4 dioådb^S-Me 2, 3+1, 4benzoxaaF7-yl 5-melliyl-1, 3, 4-tibiadiazol-2-yl 272 (5 44aionaeas-34ihydroi xa*is-yl 5metliyl-173, 4-lhiadiazok2-yl mettiyl 2727 4,"odd-g-M-% 344d-lkbet-thii-7-yl 5-methyl-1, 3, 4-thi'adiazol2 yl i-prop 1 2728 4, --Y---Y 5-methyl-1, , 4thiadfazoZ'-2 yl c clo rop 1 2729 4, 44ioå8-Me 2, 3 dwl 5-meiyl-1, 37A-63ìadazol-2-yl CF3 2730 4, 4dioåd>S-Mv273~ » L4 bcnzasatiin-7-yl benzoxazol2-yl H 2731 4ß4 » dioxiaF8-ai2234ydslj-yl benzoxazol-2 yl melliyl 2732 4, 4 dioxide-8-MS2, 3 aikydgXzzaX 7-9 bellzaxazol-2-yl i-propyl 2733 _4_kl~-» «. <1 bewxazol-2-yl cyclopropf 2734 4, 4 dioådo R-Ms234ihydro-lß4 beiwailiün-7-yi berlzoxæol-2-yl CF3 CompotmdNABR m. p. CQ 2735 4, a-droxids-r- ? -aYdo-za-ruiur1 6-meth lbenzoxazol-2- H __ _ 2736 4''ag. t,'"Yam-1, ! b'u ! : 7y 6 xnetl ; lbenzoxazol-2-yl rnethyl 2737 4, 4-da. s-M, 3dY ! n- ! uti 7 yl 6-meth lbenGZOxazol-2,. 1 i-ro-1 273S 4~1, 4 1 5X1 « > » y1-cyclopropy 2739 benzothiazol-2-yl CF3 2747 _pyraz6ll : Ll i-propyl 2742 4, 44od-a-M, » 2, 3ly+Fiìa 7y} benzol hiàzol-2-yl rne*Y 2751 4, +dio,, id.-"2341, yd-1, 44v- methyl 2752 273 4, a-c&oxicia. -Ie-, , 3-dpcto-l ; 4-bzaauu, : 7 y benzothiazol 2 _ y cla xo yl 2744 4jsdSe8e ; e : beX ffiiazol-2-yl CF3 ol-3yl 2746 4, 4-d ! oxiavra-3-a7yaro- ; u-7>y ol -'rneth t 2749 4+8*25 ? 3iiiWl ; 4+w ípyrazO yl i-propyl _48 4, 4t W4ihydi<r1~b7. yl pyrazol-1-yl cyclopropyl 2749 a, a-aoas--2 : aya- ; ! a : y yrazol- yl CF3 275 () 4, wisdZ : pflagol-3-yl E3.. 2751 + pyrazol-3-yl meiyl 2752 a. q-a « aa. - ?, yO-, a-mu ? y1 aal=3-X i-ra 1 2753 » E 1 pyrazol-3-yl cyc10propyl 2754 < pyrazoF3-Yl CF3 2755 X5<it ldnelylpyrazol-3-yl H 27556 > e 1-riy ; lpyrazol-3-yl-meJhyl 2758, I : p ylp azol-3-yl cyclopropyl 2758 4, 4 dioiñde 8-Mg3-dilyFl~ ; alhi1-yl I-melhylpyrazol-3~yl cyclopropyl 2759 methylpymzol-3-yl 2760, tetrazol-1-yl ..,,.. 2758 ----7y1 1 W ethlp : azoT-3-1 cyclo zo yl 2761 4, 44ioNde8-b2, 34hydril, 4 bOxaSyl, tetrazol-l-yl methyl 2762 4 ; 4=aiide-s ri-z-aya- ; 4 , tt-2 : y1 tetrazol-1-1 H 2763 4, 4diuside eMathat-7-yl tetNzol-1-yJcyclopropyi a52 4a-aoiaa. s : : z, s. a. am.. u. -tti. : y tetsazol-1-1 i ro 1 2763 ¢BMe-Y telrazol-l. yl cyclo ropyl 2764 4, 4di id>8-Mi>2, 34 in7yl tetrazol-l-yl CF3 2765 4, 4 ; diosiaèS-Me2, 3 « H 5 înethylteXazol-l-yl H 2766 , 4oNde-Me-2, 3ydl, 4-benMMtt) jmt-7-yl 5-mehyltetrazol-l-yl methyl 2767 4, 5-methyltetrazol-1-yl i-propyl _ 2768 4, 4naa8-M&-aihyan4-t) eiEfsaO) im-7-yt5-methyltetrazol-l-ylcyclopropyi 2769 4, 4 dioside*8-Ng3o7bl43~q_-7-d 5-methyltetrazol-1-yl CF3 2770 4oNa&8-M3yat, 4-tenzm ! a<tmn-71tetrazoi"2-yl'H 2771 4, 4 diói 8-Mb2, 3 di. hydìv 1, 4-bçbzos-7-yl tetræol-2-yl methyl 2772 Ma--- y1 tehazol-2-1 i, zo 1 277. 3 44-diaetvio-2, 3-dyHro-7, 4nzmrtliiln7yi, tehazol2-yl cyclo rop 2774 4, 4asd&-s-M2-dih) rd] l, 4-benB) thiit7-yttetrazol-2-ylCFg 2775 5-methyltetrazol-2-yl H 2776 4, 4di0n$8-M » 2, 3 ; dlhyq*, 44oqqinq 1 5-methyltelrazo_-yl, methyl 2777 4, 4dg 2, 3dyds>1JbMßße7*ylS-methylt : iæol-2-yl i-propyl 2778 4 4-&om&8 W% 3-ddod-, 1, 4-b.--ftm 7y) 5 methyltetrazal 2 yl CYCIopropyl 2779 , 4 (8-MB-% 3-ditafl, 4-tenB) xatHiin-7-yl. 3-methyltetrazol-2-ylCF 2780 42 osido 8-Mb-2-3-diliy~1, 4&1zot 7-yl 1-methyltetrazol-5-yl H CompoumdN A B R m. p. CQ 4, 4ds-t-di4-) 3enzoMtHm-. 7-yt l-niethyltetrazol-5-ylmethyl 2787 4>4-dioxide-8-w3 dilvlAt4i1167 yl I-methiltetrazol-5-yl i-propyl 2783 4, 4-dloxids ? 4-b6tE ( ! Mthnn-7--y ! 1-metbyltetrazol-ylcyclopropyi 2784 4, 44i tdeXt-l : zo3dS » w7 yl 1-melhvllelsaSol-5-yl CF3 2785 4, 4de-8-ih ; m-l, 4-benH) mb7- 2-methyl. tetrazbl-5-ylH 27815 4, 4-2~ » gis~7 71 2+et} iyltetrazol-5-yl metyl 27ç87 4, 4 diwd&8w3>1hi7y1 2-rne6jiteiiaiól-5 yl i-propyl 2788 t 2<tetrazol-5-yl cyclopropyl 2789 4, 4s-2, 3-i, 4-beazea-7-yl 2-iaethyltetfazQl-S'ylCFs 2790 4, 4-&o4d-g-M-2, 3 44 2794 4, 4-&o) dde-8-% 3 CF3 : , 4<a&2, 3-% l, 4-<t7'yt" pyttjnj-propyi 2793 44AdeJ8-b23-dilbdSl4Wiz7yl ç cyolopropyl 2799 4' 2795 4, 4-2, 3ide !) tb-7r pyndm-4-'yl H 2796 4, 4as-2yam44) ema<liimethyl 2796 ih 1 methyl 2797 oxids-Bdt-bena''7'yf pydin-4-yli-propyi 27 ; 98 4tAdiow 8-*2X3Xt 7 » yl P*-4 yl CyGlopIopyl. 2805 4, 474 3ydio-Met : m<-7-yt pyddm-4-'yl cyclopropyi' 280 () 44 » dioxidè+Mi23ydrow bwdir771 pYridilt-3-Yl 280al 4, 4-dii 8-Me-. 2, 3ZDydi> » 4 PY4-3-vl methyl 2801 4a-g3-ihydm', rii'din-3-1 meth 1 2802 4,"o) 4 nde'8*s2, 3+], 4 71 pyndin-3-yl i-propyl 2803 4744exide-8S, 3+J, b6 ; i, 67-, 4 pyndin-3-yl cyolopropyl 2809 u 2805 0. 4,"mddp4-Mp-% 34lyd-1, 4-b-ftm47-yl 5-H 4,"oxid-$-go-23 L4-b-zmffiik-7-yi 5-anno-Yi methvl 2807 4, 4oa- ! 2, 3dm-T, 4-T) enMKatHm-7-yt. 3-m. tropyndm-4-'yli-propyi 2808 4, 4 dioxide-8-hi23fdihydSl*lwi 7-yl 3-mhoPyt-4-yl cyClõpropyl _ 2809 4, 4-díondeJ8-1*2, 3el, 4-beni&ffiiiii-7-yl 3-eitropyridiki-4-yl CF3 28"14 4, 4-&-d-8-M-2, 3-dffiydro-44-b--th-7-YI 5--Oyanopyridin-2-Yi CF3 2811 4, 4dioxiS8w ? 3+ 7yl 5-cyanopi 2-yl methyl _ 28 4,"o) dde-g-Me,-2, 3-dlydr- 5-Wfluoromethylpyridin-2-yl methyl 2813 4, 4-&oddi,-8-m, Z3-dihYdo-IA-bcpzmq ! ifti-7-YI 5 i7PO-Ul- 2814 1, 4 : diasida-Mo-2, 3-l7iydfin-1, 4-benzoAattuni--y1 5-e, ano clW2-1 CF3 28l5 4, »-, 3Ji*jSb=amidiiin-7-yl 5> 1 2816 u aioxib8 b2w3Vydoi 5-hiRuoiomeEylpytidin-2-yl mel iiyl 2816 17 4, 4a&A Mi2, 3-dihyrd->bubiS7-yl 5-iuo hylpi-2-yl i-propyl 2817 4 5-triffuooinethylpyridin2-yl i-ro 1 2822 4, 4Ai. id.-8-M.-Z3-dibydr,-IA-b.. tbii.-7-yl pyriMidin-2-yl i-propyl 2820 4, 4 d ; &« 391, 6, ; is7-yl pymlidiiX-2-vl 2821 42 2, 3zt íiinoyl pylimidin~2-vl methyl 2820 4a-aioa-s-ro-3-auxyam-, a-uxaa : y1'din 2-1 H 2821 , 4dM2, 3-aol, 4-ben ( ! mn.-7f' pyrimidin-2-ylmethyl 2822 ; a-aas-, 3-ayan-1, a--y'din-2-yl i_ . 0 1 2824 4, $ 48-b2, 3diWydro-1, 4-w1iiii-7-yl Ipvi in 2 y1 CF3 | _ 2824 4, 4 diend*8-kS2, 3~i*1, 4XaìbìiiF7. yl Pyrimidia vl u as2s ¢a-aWa-8 r. --1> yZ yri, iain-4.- 1 H 2826 ¢-amae-s-. za-aya-¢ttay ;'din-4-1 zneth 1 Compound NABR m. p. (°C) 2827 -diyd-1, 4--=tbu-7-Yi Pyridin-4-YI clopropyl 'r4_ c co ro 1 2828 $-Mb-Z3 6-cWciroijwiiaidin- 2831'diiR-4-i-proPYI 2830 4, : 4divxid¢*W. 23tb<7. S 0 6-oWoropyrimidin-4-yl meiyl. 383 1 _ dlhy3>1, ~1SYI 6-eh-yl i propy1 2832 4d--dnl, 4-benzaMthmb7-yt 6pMotopynmi<lin-4-ylcyelopropyi pyfidazia-3 3834 4, 2l+k8wXlb13~+7ayl 1 :) Yndazia^3-yl 1I Va 4uJ.yl. 2836 V<t zpJi yl i propyl 2837 4784ioxíd3-7 1 I,-l, methyl 2838 4, 42 xi*3Xybwewb ; ii7-X1_ pR im-3-yl a ? 3 2835 4, 44.. dd, 8-23-dihyd-44-b--*-, 7-yl 28, 38 4, 4-icodd"-go-2, 3-dkdroL+bmamtbjut-7-YI ME ! daM-3-yl CV3 2840 44-aiaa-zv-2 ; =a, ya. ; 4-tn. -yt 6_GhlQr.,. _3_ 1 i-ro 1 2841 6-,, hloroO'ridazin-3-yl CF3 2842 4, 4Hd*S w_ < 6Hb3bropylidazm-3-yl CF3 2843 O'La2-1 2844 4a Meadsaro-, a : a, zow-7y RYz ? yl i-opyl 2845 4 » 3S3W, 34*+, 1 -2-yl_ oyolopropyl 2846 4 ; 4-aio$i3e : s-zvio-2, 3. dyd. l, 4izoxaHui'1-Yl yrazin 2-yl Ck's 2847 4,-doxiae-s-M2, 3 : dyaro-1 9-bexaiue-. 7 Yl tiazin-2-l meth l 2848 4, WdSs-w34Wyd~Lw < i-propyl 2849 4, 4 diasde s-Wt3ybl, 7-31 triazin-2-yl cyclopropyl 2850 4. axias : . z, -dyam- ; 4-un-7 yi triazin-2-yl cycloCyl -2951 methyl 2852 ~ qifinoli-2-yl i-propyl 2853 4, 4 die, 3<, 4ir-yl quinolin-2-Yl oyclopropyl 2852 4, 4-disdMI>,-2, 3-dEdx44. 4*7 7l qiinolin-2-yl CF3 2853 4-$-M-"d'°'7y1 lin-2-1 c clo ro 1 - 2854 q=ohn-2l CF3 -2855 4, 4, &tmA*-5, &, chhydro-1, 3 (4H)-p-2-yl H 2855 4, 4ttioxide=sMo-2, 3Ysn-4msatry1 qa, 5 ; 6-dtydro-1, 3 (4I-on2- meth 1 2856 MmMMwMmMM 4mm&&dlHMEm mc&yl" -t4-b=oxagiiia-7-4. 6*ip i56-ftdro-I,-m--yl CF3 2858 4A-Rcxide-S-Nfi 3dihydro 4, 4, adhyl 3 (4E) 2 2859 4, Mtox : 8-zvts2, 3i1ihydro=4-hzmiatLiin=731 4 9 ; 5-fim'1=5, 6-tiydco-1, 3C4Ixan2 YI GFa 2860 4, 4-Aceid-g-M-2, 3-dihyd--444-dii*-7-34 2-oxazohditoii-9-yl H 2861 4, 4divid>S-Me 2, 3~1, 467ql 2-oxazolidinon-3-vl mediyl 2862 4, 4dio S-Me-23diyihel67S1 2-oxazolitor-3-yl i-ptopyl 2863 4'+--M-'a'°v°°° yl 2-oxazoliduon-3-1 o clo ro 1 2864 4, Sdiosid*8-Mi2, 3~FI, 46fiF7-yl 2-oxazolidinon-3-yl CF3 2865 oda . , : ayo. 4-uinyl 2_.. olidinonl-1 metb. 1 2866 , 4-dEcmd2-<dm-,'H) enzoxattm-7-y 2-pyn'olidmon-l-yl i-propyi 2867 4, 4-ditmde-2-hydm-, 4-bsnz) xahHa-7-y 2-pyn'olt<Imon-l-yl cyelopropyi 2868''4o) ad-M2, 3-< ! &<)-l. be) E () xat !) iin-7t'2-pyEroMiaotl-l-ylCFg' 2856 4, 4 dioxide 8-Mi2, 3 dihydrò 1kFbenza7 : yl 2-pyrrolidinon-1-yl i-propy1 2867 4>M--'°'u"'7yi Z_ ynolidinon-1-1 c clo ro yl 2gs8 uas=s=. auyaro. 4u ; °y, 2-. oliaiuion-1-1 CF3 28 9 4, 4-diod"-Nfo-7, 3-ddWd-1, 4-be-fliiw7-yi 3-methylisoxazol-5-yl methyl 2870 4>4a-db2o3y~i94u3bDe7 71 3-melhylisoxazol-5-yl i-propyl 2871 4, 44iodd-8-Me-2, 3-d&yd-44-m-OT-7-yl 3-methylisoxazol-5-yl cylloprop-y-l 2872 4' Ma-° y1 3-methylisoxazol-5-1 CF3 Compound A N CC) 2873 3 4, 4-dioddl ; 8-Mc, 2 ; 3 W4%-'7-yl 2-NOr4-SO7. MePh H A methyl 2875 4, 4--% 3. d4-beMth 2-NOr4-SG'2MePhi-ptopyi 29$0 4, 4 d. $iirk-7-yl 2-CI4 2877 4<8-di, 4-<hii-yt 2'-MOz-4-S02MePhCFg -CFRH 2878 4, 44e3t3dEMiFUidoj, tiS7-yl Ei _ '2879 A, +d, ;,'dEa &, y 8 meG rneiyl _ 28, 80 4~P E 2-CI94-$O2Me i-propyl "28'82'"4, 4s. 2, 3-aa4-tst XGl-SOzMePhCFg 2882 i, WioBw33 g1 4-S02MèPh C1y3 2883 4, d-aid-&zvz-yd. yt 2=1p2-q. _CF. 3p 2884 4, 4i} de 8+ » 6°2 ; CFß meiyl 2885-4, 4di « » ndWiM+< » ~> i-propyl 2886 4, 4 dimW, 3+gVUW 2AN () 24Xh cyclopropyl _ 2887 4, 4-diod&S-b*-2, 3-di4ydm-l,",,, NO2Ph H 2888"4cmde-8-K) hydl, 4-Mtt-yt 2-N024-C : P. bH 2889 ~ 2-E02r441Ph methyl _... 2995 4, 4-&oxWo-g-Me-2., 34&yko-1, 4-bmum#iifii-7--yl 2-CI-4-NO2Ph i-propyl 2-Cl-NO2 ? h C-Yolopropyl 2892 2-Cl-4-NO2Ph CF3 2893 a., a. auxiae=s=nrs-2"3. ya, l, 4rr-yi 2-Cl NOZPh 2894 ; 4 ? 44o 8-*2, 3&yde] *7. 7l B4j90vPh methyl _ 2895 4, 44hexiae+*2, 3+1 » iw 2-CI-4-N02Ph i-propyl 2896 4-F-3-NO2Ph i-propyl 2897 a ; 4-aioxid-s-Me-z, s aYa- ; 4-tm-y1 2-Cl-4 2OaPh 2898 4, 4-dioxide sWv Js 2, 4-(NO2 ? 2Ph H 2899 4, 4diZ34WisW3ii>7yí 2, 4-(NO232Ph methyl _ 2900 4, 4-dioxtd>8-Mi2, 3u14b-7 yl 2, 4-(NO2) 2Ph i-propyl _ 2901 4, 4-djoxtdew8-W2, 3*de _ Yl 2, 4-(NO2) 2Ph 0 cyclopropyl _ 2902 44-dionds8S2, 3+l, 46 2, 4-(NO232Ph 7 = CF3 _ 2903 5- (CF3) 2P I : PLO 2904 474^aioxtdoag-Mi273 4.-F-3-NO2Ph methyl. 2905 4, 4dima » Ms2, 3~d] 4-F-3-NO2Ph i-propyl. 2906 4, 4 dioxidMi2, 34wdl, w 7-yl 4-F-3-NO2Ph cyclopropyl 2907 4, 4ditid>8-S*2, $4 t 4-E-3-NO2Ph CF3 2908 4, 46dss8-Mc-2, 3wliisydY 3, 5-(CFn Ph H 2911 3, 5- (CF 2Ph cyclopropyl 2910 d2-daI, 4-) m 3, 5- (CF3) 2Ph i-propyi 29,', 13-, 2-SOiMe-4-CF3Ph 2912 4 ; 1-aiodo-8 Mo-2, 3-drydro-1, 4-bematliT=yi 3, 5- (CFs) al't 2912 = 3, 5-(CF3) 2Ph CF3 2913 4, 4dicxt ß-Mi2, 34d 7-yl. 2-S02MeU4-CF3Ph H 2914 4, 4 dioadF 2, 3 dñ*1, 4-benzoxa*7 yl 2-S02Me-4-CF3Ph methyl _ 2915 2-SO, 2Me-4-CF3Ph.. i-propyl 2916 4, 4*dio ndc ; 8-Mi2, 3~dflydm~d-7-yl 2-SO2Me4-l : : P3Ph _ cyclõpropyl 2917 4, 4 dixd>8 MS2f34 4benzzaiiin 7-yl 2-SOzMe4-CF3Ph CF3 Compound A N, CQ 2918 2'-Cl-4-S02MePh2tnBuoromeQiyl-l, 3, 4-tbiadiazol-5-yl cyclopropyi 3 2919 2-Cl-4-SO2MePh 1, l-dioXidcS-3-oxo-1, 2-benzisothiazol-2 (3H)-yl cyclopropyl 2920 41-Ph 2-utyM, 3, 4-oxadiazol-yICF3 166 2921 X-Me-e-CFgpyrtdin-S-yl2-melhyltetrazol-5-ylcyclopropyi 2922 2- [ (2-methoethoxy) methy-CF3 2-'methyKet)'azol-5-yl cyclopropyi < pyndm-3-yi 2923 2-Ct-4-S02MePh 2, 5-dioxopyrrolidin-1-yl cyclopropyl. 2924 2-C1-4 SOPh 2 osopyridibl (w)-yl cyclopxopyl 2925 2-Cl.-4-S02MePh2-oxoqUMiolm-l (2S)-yIcyclopropyi 2926 2-Cl-4-SOzMePb1, 2-benzlsoxazol--ylcyclopropyi 2927 2-C !--4'-SOMePh2-oxo-l, 3benzoxazol-3 (2H)-yl cyclopropyi 2928 2-Cl-4-SO2MePh 3-oxo-273 H-1, 4-benzoxazin 4-yl cyclopropyl 2CI-4-S02MePh -oxop innid. n.-1-yl cyclopxo 1 2930 2-Cl-4-SO2MePh lH-1, 2, 3-benzot ol-l-yl cycTopropyl 2931 2-N02-4-S02MePh2, 5-dioxopyrrolidin-l-ylcyclopropyi 2932 2-NQ2-4-SO2MePh 2-oxopyridin-1 (2H)-yl cyclopropyl 2933 2-NO2-4-S OXePh 2-oxoquinolin-1 (2$-yl cyclopropyl 2934 2 « 62-4 SWePh 1, 2-benzisoxazol-3-yl cyclopropyl 2935 2-nez 2-oxo-1, 3-benzoxazol-3 (2H)-yl cycloproDyl 2936 202-4-S02MePh3-oxo-2, 3-dihydro'4-l, 4-benzoxazm-4-. yl cyclopropyi 2937 2-NO2-4-S02MePh 2-oxopyrimidin-1 (2H)-yl c clopropyl 2938 2-NO2-4-SO2MePh lH-1, 2, 3-benzotriazol-lyl c clo ro 1

EXAMPLE 31 Determination of the herbicidal activity and phyto- toxicity in pre-emergence.

The herbicidal activity of the compounds of the invention in pre-emergence was evaluated according to the following operative procedures.

The plant species of interest (weeds or crops) were sown in pots with an upper diameter of 10 cm, a height of 10 cm and containing sandy soil. 10 pots were used for each plant species.

Water was added to each pot in such a quantity as to germinate the seeds. The pots were divided into two groups, each containing 5 pots for each weed or crop.

After one day from the sowing, the first set of pots was treated with a hydro-acetonic dispersion containing acetone at 10% in volume, the product under evaluation at the desired concentration and Tween 20 at 0. 5%.

The second set was treated with a hydro-acetonic solution only, containing acetone at 10% in volume and Tween 20 at 0. 5%, and was used as comparison (blank).

All pots were kept under observation in a conditioned environment under the following conditions: - temperature : 24°C ; - relative humidity: 60% ; - photoperiod : 16 hours;

- light intensity: 10000 lux.

The pots were uniformly watered in order to ensure a sufficient humidity degree for a good development of the plants.

Fifteen days after the treatment, the herbicidal activity was evaluated on the basis of the following values, which refer to the damage percentage tested on the treated plants, with respect to the non-treated plants (blank) : - = 0-10 % damage; - 1 = 11 - 30 % damage; - = 31-50 % damage; - = 51-70 % damage; - 4-71-90 % damage; - = 91 % damage - death of the plant.

Table 3 shows the results obtained by treating the plant species listed below with compounds 6,7 and 11 with a dosage of 500 g/ha: Abutilon theofrasti (AT); Amaranthus retroflexus (AR) ; Chenopodium album (CA); Galium aparine (GA) ; Ipomea purpura (IP); Portulaca oleracea (PO); Solanum nigrum (SN) ; Stellaria media (SM).

Table 3: Pre-emergence herbicidal activity at rate of 500 g/ha Plant species: AT AR CA GA IP PO SN SM Compound N° 6: 5 5 5 5 5 5 5 5 Compound N° 7: 5 5 5--5 5 5 Compound N° 11 : 5-5-5 5-- EXAMPLE 32 Determination of the herbicidal activity and phyto- toxicity in post-emergence.

The herbicidal activity of the compounds of the invention in post-emergence was evaluated according to the following operative procedures.

The plant species of interest (weeds or crops) were sown in pots with an upper diameter of 10 cm, a height of 10 cm and containing sandy soil. 10 pots were used for each plant species.

Water was added to each pot in such a quantity as to germinate the seeds. The pots were divided into two groups, each containing 5 pots for each weed or crop.

Fifteen days after sowing (ten, in the case of wheat), when the weeds and crops, according to the species, were 10-15 cm high, the first set of pots was treated with a hydro-acetonic dispersion containing

acetone at 10% in volume, the product under evaluation at the desired concentration and Tween 20 at 0. 5%.

The second set was treated with a hydro-acetonic solution only, containing acetone at 10% in volume and Tween 20 at 0. 5%, and was used as comparison (blank).

All pots were kept under observation in a conditioned environment under the following conditions: - temperature : 24°C ; - relative humidity: 60% ; - photo-period : 16 hours; - light intensity: 10000 lux.

The pots were uniformly watered every other day so as to ensure a humidity degree sufficient for a good development of the plants.

The herbicidal activity was evaluated fifteen days after the treatment, on the basis of the following values which refer to the percentage of damage tested on the treated plants with respect to the non-treated plants (blank) - = 0-10 % damage ; - = 11-30 % damage; - = 31-50 % damage; - 3= 51-70% damage ; - = 71-90 % damage; - = 91 % damage-death of the plant.

TabLe 4 shows the results obtained by treating the plant species listed below with compounds 6 and 11 with a dosage of 500 g/ha: Abutilon theofrasti (AT); Chenopodium album (CA); Galium aparine (GA); Portulaca oleracea (PO) ; Solanum nigrum (SN) ; Stellaria media (SM).

Table 4: Post-emergence herbicidal activity at rate of 500 g/ha Plant species : AT CA GA PO SN SM Compound N° 6 : 5 5 5 5 5 5 Compound N° 11: 5 5--5-