Title:
DERIVATIVES OF 3-HYDROXY-4-(CYCLYL-ALKYLAMINOALKYL)-5-PHENYL-1H-PYRAZOLE AS ANTAGONISTS OF THE GONADOTROPIN RELEASING HORMONE (GNRH) FOR USE IN THE TREATMENT OF SEX HORMONE RELATED CONDITIONS, SUCH AS PROSTATIC OF UTERINE CANCER
Document Type and Number:
WIPO Patent Application WO2004017961
Kind Code:
A3
Abstract:
The invention relates to a group of novel pyrazole compounds of Formula (I): wherein: R<1>, R<2>, R<3>, M and R<5> are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
Inventors:
BIRD THOMAS GEOFFREY COLERICK (FR)
HERDEMANN MATTHIAS FERDINAND (FR)
MAUDET MICKAEL LOUIS PIERRE (FR)
HERDEMANN MATTHIAS FERDINAND (FR)
MAUDET MICKAEL LOUIS PIERRE (FR)
Application Number:
PCT/GB2003/003633
Publication Date:
April 08, 2004
Filing Date:
August 19, 2003
Export Citation:
Assignee:
ASTRAZENECA AB (SE)
ASTRAZENECA UK LTD (GB)
BIRD THOMAS GEOFFREY COLERICK (FR)
HERDEMANN MATTHIAS FERDINAND (FR)
MAUDET MICKAEL LOUIS PIERRE (FR)
ASTRAZENECA UK LTD (GB)
BIRD THOMAS GEOFFREY COLERICK (FR)
HERDEMANN MATTHIAS FERDINAND (FR)
MAUDET MICKAEL LOUIS PIERRE (FR)
International Classes:
A61K31/4155; A61K31/4196; A61K31/4439; A61K31/4725; A61K31/496; A61K31/497; A61K31/506; A61K31/5377; A61K31/541; C07D231/20; C07D231/22; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D487/08; C07D491/04; C07D519/00; (IPC1-7): A61K31/4155; A61K31/4439; A61K31/4196; A61K31/496; A61K31/5377; A61K31/541; A61K31/506; A61K31/497; A61K31/4725; C07D401/12; C07D231/20; C07D403/12; C07D413/12; C07D417/12; C07D409/12; C07D491/04; C07D405/12
Domestic Patent References:
| WO2000031072A1 | 2000-06-02 | |||
| WO2000031063A1 | 2000-06-02 | |||
| WO2002048112A2 | 2002-06-20 | |||
| WO2000053602A1 | 2000-09-14 | |||
| WO2003053927A1 | 2003-07-03 |
Foreign References:
| JPH10287655A | 1998-10-27 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; O'CALLAGHAN, C. N.: "Synthesis of ethyl 3-oxo-4-pyrazolidinecarboxylates", XP002261638, retrieved from STN Database accession no. 77:61875
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOHAREB, RAFAT M. ET AL: "The reaction of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene with diethyl malonate: synthesis of coumarin, pyridine, and thiazole derivatives", XP002261639, retrieved from STN Database accession no. 135:92599
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AFRIDI, A. SULTAN ET AL: "N-Oxides and related compounds. Part 56. Preparation of NN'-linked bi(heteroaryls) from dehydroacetic acid and 2,6-dimethyl-4-pyrone", XP002261640, retrieved from STN Database accession no. 87:201414
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MUSTAFA, AHMED ET AL: "Reactions of substituted coumarins, furocoumarins, and khellinonestyryl derivatives with hydrazine and phenylhydrazine", XP002261641, retrieved from STN Database accession no. 65:20701
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOHAREB, RAFAT M. ET AL: "The reaction of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene with diethyl malonate: synthesis of coumarin, pyridine, and thiazole derivatives", XP002261639, retrieved from STN Database accession no. 135:92599
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AFRIDI, A. SULTAN ET AL: "N-Oxides and related compounds. Part 56. Preparation of NN'-linked bi(heteroaryls) from dehydroacetic acid and 2,6-dimethyl-4-pyrone", XP002261640, retrieved from STN Database accession no. 87:201414
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MUSTAFA, AHMED ET AL: "Reactions of substituted coumarins, furocoumarins, and khellinonestyryl derivatives with hydrazine and phenylhydrazine", XP002261641, retrieved from STN Database accession no. 65:20701
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