Title:
DESALANINEBENANOMICIN A DERIVATIVE AND PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/1994/017085
Kind Code:
A1
Abstract:
Amino acid derivatives of desalaninebenanomicin A, represented by general formula (Ia), are produced by the condensation of various amino acids with the carboxyl group at the 2-position of desalaninebenanomicin A prepared from benanomicin A by chemical conversion. In said formula (Ia), Ra represents hydrogen, C1-C5 alkyl, C1-C5 hydroxylakyl, carboxy or lower alkoxycarbonyl. Among various antifungal derivatives represented by the above formula (Ia), those wherein Ra represents C2-C5 alkyl, C2-C5 hydroxyalkyl, carboxy or lower alkoxycarbonyl are novel semisynthetic antibiotics having an antifungal activity.
Inventors:
TAKEUCHI TOMIO (JP)
KONDO SHINICHI (JP)
IKEDA DAISHIRO (JP)
NISHIZUKA TOSHIO (JP)
KONDO SHINICHI (JP)
IKEDA DAISHIRO (JP)
NISHIZUKA TOSHIO (JP)
Application Number:
PCT/JP1993/000082
Publication Date:
August 04, 1994
Filing Date:
January 22, 1993
Export Citation:
Assignee:
ZAIDAN HOJIN BISEIBUTSU (JP)
TAKEUCHI TOMIO (JP)
KONDO SHINICHI (JP)
IKEDA DAISHIRO (JP)
NISHIZUKA TOSHIO (JP)
TAKEUCHI TOMIO (JP)
KONDO SHINICHI (JP)
IKEDA DAISHIRO (JP)
NISHIZUKA TOSHIO (JP)
International Classes:
C07H15/24; A01N43/16; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61P31/04; A61P31/10; C07H1/00; C07H15/244; (IPC1-7): C07H15/24
Foreign References:
| JPH01121293A | 1989-05-12 | |||
| JPH03294289A | 1991-12-25 | |||
| JPH0256432A | 1990-02-26 | |||
| EP0277621A1 | 1988-08-10 | |||
| EP0479175A1 | 1992-04-08 |
Other References:
H. KAWAKAMI et al., Journal of Antibiotics, 45(9), p. 1518-25, (1992).
See also references of EP 0684253A4
See also references of EP 0684253A4
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