DESHYDROXY VANCOMYCIN, THE PREPARATION, PHARMACEUTICAL COMPOSITION AND THE USE

Title:

DESHYDROXY VANCOMYCIN, THE PREPARATION, PHARMACEUTICAL COMPOSITION AND THE USE

Document Type and Number:

WIPO Patent Application WO/2009/046618

Kind Code:

A1

Abstract:

A deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy vancomycin and the use of the said composition in the preparation of drugs for the treatment of susceptible bacteria infections. The method includes the following steps: (1) A concentrated vancomycin solution used to prepare the deshydroxy vancomycin is produced by fermentation of Amycolatopsis orientalis CGMCC No. 1183. (2) An ancomycin hydrochloride straining filtrate comprising the deshydroxy vancomycin is obtained by separating and purifying the concentrated vancomycin solution bycolumn chromatography. And (3) The deshydroxy vancomycin is obtained by separating and purifying the said filtrate by chromatograph. In which, the column chromatography process is processed in a gel chromatographic column comprising salt-water mobile phase; the chromatography process is processed in a macropore polymeric adsorbent chromatographic column comprising buffer-methanol mobile phase.

Inventors:

XU BINGXIANG (CN)
XIE HAISONG (CN)
YU HUAN (CN)
MAO WEI (CN)
YE WEIDONG (CN)

Application Number:

PCT/CN2008/001524

Publication Date:

April 16, 2009

Filing Date:

August 25, 2008

Export Citation:

Click for automatic bibliography generation Help

Assignee:

ZHEJIANG MEDICINE CO LTD (CN)
XU BINGXIANG (CN)
XIE HAISONG (CN)
YU HUAN (CN)
MAO WEI (CN)
YE WEIDONG (CN)

International Classes:

A61K35/74; C07K9/00; A61K38/14; A61P31/04; C12N1/20; C12P21/02

Foreign References:

EP0159180A2	1985-10-23
EP0265071A1	1988-04-27
CN1415758A	2003-05-07
CN1657601A	2005-08-24
EP0159180A2	1985-10-23

Other References: