Title:
DESIGN, PREPARATION AND USE OF NOVEL MACROLIDE
Document Type and Number:
WIPO Patent Application WO/2023/226102
Kind Code:
A1
Abstract:
Design, preparation and use of a novel macrolide, which belong to the technical field of medical intermediates. The prostaglandin macrolide intermediates A-E are obtained by means of starting from Corey lactone and 5-7 steps of conversion. By means of starting from the common intermediates A-E, the intermediates are also successfully used for the preparation of Carboprost and Trvoprost products, and further popularized for the preparation of PGF2a, such as Bimattoprost, Tafluprost, Latanprost and Dinoprostone. The common intermediates A-E provided can be used to greatly shorten the subsequent coupling reaction step. In addition, the problem that the 5,6-double bond trans-isomer is difficult to remove during the current process is avoided in advance, and the efficiency and benefit of the PGs pharmaceutical industry are significantly improved by means of the efficient, economic and large-scale production thereof.
Inventors:
WANG FANGDAO (CN)
WANG MENG (CN)
WANG DONG (CN)
WANG MENG (CN)
WANG DONG (CN)
Application Number:
PCT/CN2022/098483
Publication Date:
November 30, 2023
Filing Date:
June 13, 2022
Export Citation:
Assignee:
CHEMVON BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D313/00; C07C405/00; C07F7/18
Foreign References:
| CN105592851A | 2016-05-18 | |||
| CN104370786A | 2015-02-25 | |||
| CN108602769A | 2018-09-28 |
Other References:
BUNDY GORDON L. ET AL.: "Synthesis and Biological Activity of Prostaglandin Lactones", JOURNAL OF MEDICINAL CHEMISTRY, vol. 26, no. 8, 31 August 1983 (1983-08-31), XP000999619, DOI: 10.1021/jm00362a001
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