Title:
DESIGNER OSTEOGENIC PROTEINS
Document Type and Number:
WIPO Patent Application WO/2012/023113
Kind Code:
A3
Abstract:
The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
Inventors:
BERASI STEPHEN PETER (US)
BROWN CHRISTOPHER TODD (US)
CAIN MICHAEL JOHN (US)
CALABRO VALERIE PERRINE (FR)
JUO ZONG SEAN (US)
MARTINEZ ROBERT VINCENT PAUL (US)
SEEHERMAN HOWARD JOEL (US)
WOZNEY JOHN MARTIN (US)
BROWN CHRISTOPHER TODD (US)
CAIN MICHAEL JOHN (US)
CALABRO VALERIE PERRINE (FR)
JUO ZONG SEAN (US)
MARTINEZ ROBERT VINCENT PAUL (US)
SEEHERMAN HOWARD JOEL (US)
WOZNEY JOHN MARTIN (US)
Application Number:
PCT/IB2011/053638
Publication Date:
April 12, 2012
Filing Date:
August 17, 2011
Export Citation:
Assignee:
WYETH LLC (US)
BERASI STEPHEN PETER (US)
BROWN CHRISTOPHER TODD (US)
CAIN MICHAEL JOHN (US)
CALABRO VALERIE PERRINE (FR)
JUO ZONG SEAN (US)
MARTINEZ ROBERT VINCENT PAUL (US)
SEEHERMAN HOWARD JOEL (US)
WOZNEY JOHN MARTIN (US)
BERASI STEPHEN PETER (US)
BROWN CHRISTOPHER TODD (US)
CAIN MICHAEL JOHN (US)
CALABRO VALERIE PERRINE (FR)
JUO ZONG SEAN (US)
MARTINEZ ROBERT VINCENT PAUL (US)
SEEHERMAN HOWARD JOEL (US)
WOZNEY JOHN MARTIN (US)
International Classes:
C07K14/51; A61K38/18
Domestic Patent References:
| WO2009086131A1 | 2009-07-09 | |||
| WO2008051526A2 | 2008-05-02 |
Foreign References:
| EP1571159A1 | 2005-09-07 |
Attorney, Agent or Firm:
BENSON, Gregg C. (Eastern Point Road MS 911, Groton CT, US)
Download PDF: