Title:
DESLORATADINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/071601
Kind Code:
A1
Abstract:
Disclosed in the present application is a compound as represented by formula (A), wherein-R is-R' or -Y-(CH2)n-R', Y is O or NH, n is 1, 2, 3, 4, 5 or 6, and -R' is diethylamino, pyrrolidinyl, piperazinyl, N-morpholinyl, bis(2-methoxyethyl)amino or 4-methylpiperazinyl. Also disclosed are a synthesis method for the compound shown, and use of the compound shown in the preparation of drugs for relieving or treating or preventing allergy and related symptoms thereof.
Inventors:
YAO CHEN (CN)
Application Number:
PCT/CN2022/119480
Publication Date:
May 04, 2023
Filing Date:
September 16, 2022
Export Citation:
Assignee:
TIANJIN NEWSUN INVEST DEVELOPMENT CO LTD (CN)
International Classes:
C07D401/04; A61P11/00; A61P11/06; A61P17/00; A61P37/08
Domestic Patent References:
| WO1996005201A1 | 1996-02-22 |
Foreign References:
| US4826853A | 1989-05-02 | |||
| US5753671A | 1998-05-19 | |||
| US5721236A | 1998-02-24 |
Other References:
JAYENDRA Z. PATEL ET AL.: "Loratadine Analogues as MAGL Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, 24 February 2015 (2015-02-24), XP029148590, DOI: 10.1016/j.bmcl.2015.02.037
SERENA CUBONI ET AL.: "Loratadine and Analogues: Discovery and Preliminary Structure−Activity Relationship of Inhibitors of the Amino Acid Transporter B0AT2", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 22, 15 October 2014 (2014-10-15), pages 9473 - 9479, XP009545448
SERENA CUBONI ET AL.: "Loratadine and Analogues: Discovery and Preliminary Structure−Activity Relationship of Inhibitors of the Amino Acid Transporter B0AT2", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 22, 15 October 2014 (2014-10-15), pages 9473 - 9479, XP009545448
Attorney, Agent or Firm:
BEIJING WANHUIDA LAW FIRM (CN)
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