Title:
DETECTING MARKER FOR GASTRIC CANCER AND DETECTING METHOD USING THE SAME MARKER
Document Type and Number:
WIPO Patent Application WO/2011/078443
Kind Code:
A1
Abstract:
A composition for detecting gastric cancer including an agent for detecting the expression level of mRNA of one or more gene(s) selected from a group consisting of TXN and TXNIP or protein thereof is disclosed. Also, a detection kit, a detecting method and a screening method are disclosed. The composition allows effective detection of the incidence of gastric cancer and may be widely applicable, for example, as an agent for treating gastric cancer.
Inventors:
CHO JAE-YONG (KR)
LIM JAE YUN (KR)
LIM JAE YUN (KR)
Application Number:
PCT/KR2010/002416
Publication Date:
June 30, 2011
Filing Date:
April 19, 2010
Export Citation:
Assignee:
CHO JAE-YONG (KR)
LIM JAE YUN (KR)
LIM JAE YUN (KR)
International Classes:
C12Q1/68; C12N15/11; G01N33/574
Other References:
NODA N. ET AL: "Detection of thioredoxin in gastric cancer: association with histological type", ANTIOXIDANTS AND REDOX SIGNALING, vol. 2, no. 3, September 2000 (2000-09-01), pages 519 - 528
GROGAN T.M.: "Thioredoxin, a putative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival", HUMAN PATHOLOGY, vol. 31, no. 4, April 2000 (2000-04-01), pages 475 - 481
KAIMUL A.M. ET AL: "Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome", FREE RADICAL BIOLOGY AND MEDICINE, vol. 43, no. 6, 6 June 2007 (2007-06-06), pages 861 - 868
SINHA P. ET AL: "Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells", JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 37, no. 3, 18 November 1998 (1998-11-18), pages 105 - 116
GROGAN T.M.: "Thioredoxin, a putative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival", HUMAN PATHOLOGY, vol. 31, no. 4, April 2000 (2000-04-01), pages 475 - 481
KAIMUL A.M. ET AL: "Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome", FREE RADICAL BIOLOGY AND MEDICINE, vol. 43, no. 6, 6 June 2007 (2007-06-06), pages 861 - 868
SINHA P. ET AL: "Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells", JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 37, no. 3, 18 November 1998 (1998-11-18), pages 105 - 116
Attorney, Agent or Firm:
KIM, Sun-young (10th Floor 80-6,Susong-Dong, Chongro-Ku, Seoul 110-727, KR)
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