DETECTION OF DRUG RESISTANT ORGANISMS

WIPO Patent Application WO2000043545

A3

A method is disclosed for detecting drug resistance in a strain of an organism. In the method the presence of at least one mutation in a predetermined region within the gene of the strain is detected. The predetermined region has a multiplicity of mutations among strains of the organism that differ from a corresponding region of the wild type strain of the organism. To detect the mutation, a complex is formed comprising the predetermined region of the gene of the organism and the corresponding region of the gene of the wild type organism in double stranded form. Each member of at least one pair of non-complementary strands within the complex has a label. The association of the labels within the complex is detected wherein the association of the labels in the complex is related to the presence of the mutation. The presence of the mutation is related to the drug resistance of the strain.

LIU YEN PING
KURN NURITH

PCT/US1999/029517

October 19, 2000

December 14, 1999

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DADE BEHRING INC (US)

C12Q1/68; (IPC1-7): C12Q1/68

WO1997023646A1	1997-07-03
WO1995033074A1	1995-12-07
WO1997045558A1	1997-12-04

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COLE S T ET AL: "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 393, 11 June 1998 (1998-06-11), pages 537 - 544, XP002087941, ISSN: 0028-0836

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