Title:
DETERMINATION AGENT AND DETERMINATION METHOD FOR TAUOPATHY AND DEMENTIA-RELATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/157634
Kind Code:
A1
Abstract:
The present invention provides a kit which is used to determine tauopathy and dementia-related diseases (here, Alzheimer's disease is excluded), and which comprises an antibody that recognizes a polypeptide consisting of: (1) the amino acid sequence represented by SEQ ID NO: 1; or (2) an amino acid sequence obtained by substituting, deleting, adding, or inserting one or more amino acids in the amino acid sequence represented by SEQ ID NO: 1.
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Inventors:
ONO ATSUSHI (JP)
NAGATA HIDETAKA (JP)
HASHIMOTO MASAKAZU (JP)
NAGATA HIDETAKA (JP)
HASHIMOTO MASAKAZU (JP)
Application Number:
PCT/JP2021/004018
Publication Date:
August 12, 2021
Filing Date:
February 04, 2021
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K45/00; A61K31/13; A61K31/27; A61K31/445; A61K31/473; A61K31/55; A61P25/00; A61P25/16; A61P25/28; C07K14/565; C07K16/18; C07K16/28; C12N9/12; C12N9/16; C12N9/99; C12N15/12; C12N15/13; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| WO2012091138A1 | 2012-07-05 |
Foreign References:
| JP2017506068A | 2017-03-02 | |||
| JP2003521499A | 2003-07-15 | |||
| JP2017113004A | 2017-06-29 | |||
| JP2017042172A | 2017-03-02 | |||
| US20060122377A1 | 2006-06-08 | |||
| JP2020018249A | 2020-02-06 |
Other References:
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495
KARLIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES, vol. 25, 1997, pages 3389 - 3402
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
MYERSMILLER, CABIOS, vol. 4, 1988, pages 11 - 17
PEARSON ET AL., PROC. NATL. ACAD., vol. 85, 1988, pages 2444 - 2448
BOWIE ET AL., SCIENCE, vol. 247, 1990, pages 1306 - 1310
HASHIMOTO-GOTOH, TMIZUNO, TOGASAHARA, YNAKAGAWA, M.: "An oligodeoxyribonucleotide-directed dual amber method for site-directed mutagenesis", GENE, vol. 152, 1995, pages 271 - 275, XP004042690, DOI: 10.1016/0378-1119(94)00750-M
ZOLLER, MJSMITH, M: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500, XP001088749, DOI: 10.1016/0076-6879(83)00074-9
KRAMER, WDRUTSA, VJANSEN, HWKRAMER, BPFLUGFELDER, MFRITZ, HJ: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCLEIC ACIDS RES, vol. 12, 1984, pages 9441 - 9456, XP002026371
KRAMER WFRITZ HJ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL, vol. 154, 1987, pages 350 - 367
KUNKEL, TA: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC NAT1 ACAD SCI USA, vol. 82, 1985, pages 488 - 492, XP002052322, DOI: 10.1073/pnas.82.2.488
MOL IMMUNOL, vol. 44, no. 11, April 2007 (2007-04-01), pages 3049 - 60
"Radioimmunoassay", 1974, KODANSHA
"radioimmunoassay", 1979, KODANSHA
"Enzyme Immunoassay", 1987, IGAKU-SHOIN
"Immunochemical Techniques (Part I: Hybridoma Technology and Monoclonal Antibodies", vol. 121, ACADEMIC PRESS, article "Methods in ENZYMOLOGY"
See also references of EP 4101465A4
KARLIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES, vol. 25, 1997, pages 3389 - 3402
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
MYERSMILLER, CABIOS, vol. 4, 1988, pages 11 - 17
PEARSON ET AL., PROC. NATL. ACAD., vol. 85, 1988, pages 2444 - 2448
BOWIE ET AL., SCIENCE, vol. 247, 1990, pages 1306 - 1310
HASHIMOTO-GOTOH, TMIZUNO, TOGASAHARA, YNAKAGAWA, M.: "An oligodeoxyribonucleotide-directed dual amber method for site-directed mutagenesis", GENE, vol. 152, 1995, pages 271 - 275, XP004042690, DOI: 10.1016/0378-1119(94)00750-M
ZOLLER, MJSMITH, M: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500, XP001088749, DOI: 10.1016/0076-6879(83)00074-9
KRAMER, WDRUTSA, VJANSEN, HWKRAMER, BPFLUGFELDER, MFRITZ, HJ: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCLEIC ACIDS RES, vol. 12, 1984, pages 9441 - 9456, XP002026371
KRAMER WFRITZ HJ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL, vol. 154, 1987, pages 350 - 367
KUNKEL, TA: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC NAT1 ACAD SCI USA, vol. 82, 1985, pages 488 - 492, XP002052322, DOI: 10.1073/pnas.82.2.488
MOL IMMUNOL, vol. 44, no. 11, April 2007 (2007-04-01), pages 3049 - 60
"Radioimmunoassay", 1974, KODANSHA
"radioimmunoassay", 1979, KODANSHA
"Enzyme Immunoassay", 1987, IGAKU-SHOIN
"Immunochemical Techniques (Part I: Hybridoma Technology and Monoclonal Antibodies", vol. 121, ACADEMIC PRESS, article "Methods in ENZYMOLOGY"
See also references of EP 4101465A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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