Title:
DETERMINATION METHOD USING GENETIC POLYMORPHISM
Document Type and Number:
WIPO Patent Application WO/2023/085036
Kind Code:
A1
Abstract:
The present invention provides a method for predicting reocclusion of an intracranial cerebral blood vessel, the method comprising: detecting whether or not a subject has a RNF213 p.R4810K polymorphism by using a sample collected from the subject; and determining that, when the subject has the RNF213 p.R4810K polymorphism and after an endovascular therapy is performed on occlusion of the intracranial cerebral blood vessel, there is a high probability of reocclusion occurring in the blood vessel that has undergone the endovascular therapy.
Inventors:
IHARA MASAFUMI (JP)
YOSHIMOTO TAKESHI (JP)
KAWAKAMI DAISUKE (JP)
YOSHIMOTO TAKESHI (JP)
KAWAKAMI DAISUKE (JP)
Application Number:
PCT/JP2022/039152
Publication Date:
May 19, 2023
Filing Date:
October 20, 2022
Export Citation:
Assignee:
SHIMADZU CORP (JP)
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
International Classes:
C12Q1/6883; C12N15/12; C12Q1/686
Domestic Patent References:
| WO2021085505A1 | 2021-05-06 |
Foreign References:
| JP2021090390A | 2021-06-17 |
Other References:
YOSHIMOTO. TAKESHI EL AL.: "OD3-2 A case of gene RNF213p.R4810K polymorphism-positive large vessel occlusion in acute stroke that repeated re-obstruction after endovascular thrombectomy", NEUROLOGICAL THERAPEUTICS, vol. 37, no. 6, 2020, pages 229, XP009546241
Attorney, Agent or Firm:
FUKAMI PATENT OFFICE, P.C. (JP)
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