Title:
DETERMINATION OF THE QUALITY OF THE SEAL OF SEALED CAPSULES USING A MICROWAVE RESONATOR AND RELATED EQUIPMENT FOR IN-LINE INSPECTION
Document Type and Number:
WIPO Patent Application WO/2011/058475
Kind Code:
A3
Abstract:
The invention relates to a method of inspection of a filled hard capsule sealed with a solvent sealing agent, including a process for determining the quality of the seal, said process comprising - supplying a filled hard capsule (1) sealed with a solvent sealing agent; - supplying a microwave resonator (27) wherein a measuring field characterized by a resonance curve is generated; - directing said capsule through the measuring field; - measuring characteristics related to the modification of the resonance curve produced by the presence of the capsule (1 ) in the measuring field, in comparison with a reference resonance curve corresponding to an empty state of the resonator; and - using the measured characteristics to determine a value associated with the quality of the seal. The invention also relates to a method for sorting capsules on the basis of the result of the inspection method and to an associated equipment able to carry out such methods.
Inventors:
HERRMANN HANS-RAINER (DE)
HUYSMANS TOM REGINA AUGUSTINUS (BE)
SCHLEMM UDO (DE)
HUYSMANS TOM REGINA AUGUSTINUS (BE)
SCHLEMM UDO (DE)
Application Number:
PCT/IB2010/054931
Publication Date:
August 11, 2011
Filing Date:
November 01, 2010
Export Citation:
Assignee:
PFIZER (US)
HERRMANN HANS-RAINER (DE)
HUYSMANS TOM REGINA AUGUSTINUS (BE)
SCHLEMM UDO (DE)
HERRMANN HANS-RAINER (DE)
HUYSMANS TOM REGINA AUGUSTINUS (BE)
SCHLEMM UDO (DE)
International Classes:
A61J3/07; A61K9/48; B07C5/34; B07C5/344; G01N22/04; G01N33/15
Domestic Patent References:
| WO2004005903A1 | 2004-01-15 |
Foreign References:
| EP1669755A1 | 2006-06-14 | |||
| EP1467191A1 | 2004-10-13 | |||
| EP0889321A1 | 1999-01-07 | |||
| US6316946B2 | 2001-11-13 | |||
| GB2149377A | 1985-06-12 | |||
| EP1547570A1 | 2005-06-29 | |||
| JPH0826229A | 1996-01-30 |
Other References:
COLE E T: "Liquid filled and sealed hard gelatin capsules", BULLETIN TECHNIQUE GATTEFOSSE REPORT, GATTEFOSSE, SAINT-PRIEST, FR, no. 92, 1 January 1999 (1999-01-01), pages 1 - 12, XP002341036, ISSN: 1149-0306
EWART T. COLE: "CHALLENGES AND OPPORTUNITIES IN THE ENCAPSULATION OF LIQUID AND SEMI SOLID FORMULATIONS INTO GELATIN AND NON-GELATIN CAPSULES", AAPS WORKSHOP: PRODUCT DEVELOPMENT CONSIDERATIONS, 5 March 2007 (2007-03-05) - 6 March 2007 (2007-03-06), Bethesda, pages 61 - 65, XP002631312, Retrieved from the Internet [retrieved on 20110401]
KLAUS KUPFER: "Electromagnetic Aquametry - Electromagnetic Wave Interaction with Water and Moist Substances", 3 December 2004, SPRINGER, Weimar, Germany, ISBN: 3540222227, article KLAUS KUPFER: "Methods of Density-Independent Moisture Measurement", pages: 135 - 168, XP002639588
MENKE F ET AL: "NEW DENSITY-INDEPENDENT MOISTURE MEASUREMENT METHODS USING FREQUENCY-SWEPT MICROWAVE TRANSMISSION", 1996 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST. SAN FRANCISCO, JUNE 17 - 21, 1996; [IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST], NEW YORK, IEEE, UI, 17 June 1996 (1996-06-17), pages 1415 - 1418, XP000720611, ISBN: 978-0-7803-3247-8, DOI: DOI:10.1109/MWSYM.1996.512201
A. KRASZEWSKI, S. KULINSKI AND Z. STOSIO: "A Preliminary Study on Microwave Monitoring of Moisture Content in Wheat", JOURNAL OF MICROWAVE POWER, vol. 12, no. 3, 1977, pages 241 - 252, XP002639589
H. BLATES, W.GÖPEL, J. HESSE (EDITORS): "Sensors Update - Special Topic: RF & Microwave Sensing of Moist Materials", vol. 7, 2000, WILEY-VCH, Weinheim, Germany, ISBN: 3-527-29821-5, article K. KUPFER: "Microwave Moisture Measurement Systems and Their Applications", pages: 343 - 376, XP002639590
EBBE NYFORS AND PERTTI VAINIKAINEN: "INDUSTRIAL MICROWAVE SENSORS", INDUSTRIAL MICROWAVE SENSORS, 1 January 1989 (1989-01-01), XP002334964
EWART T. COLE: "CHALLENGES AND OPPORTUNITIES IN THE ENCAPSULATION OF LIQUID AND SEMI SOLID FORMULATIONS INTO GELATIN AND NON-GELATIN CAPSULES", AAPS WORKSHOP: PRODUCT DEVELOPMENT CONSIDERATIONS, 5 March 2007 (2007-03-05) - 6 March 2007 (2007-03-06), Bethesda, pages 61 - 65, XP002631312, Retrieved from the Internet
KLAUS KUPFER: "Electromagnetic Aquametry - Electromagnetic Wave Interaction with Water and Moist Substances", 3 December 2004, SPRINGER, Weimar, Germany, ISBN: 3540222227, article KLAUS KUPFER: "Methods of Density-Independent Moisture Measurement", pages: 135 - 168, XP002639588
MENKE F ET AL: "NEW DENSITY-INDEPENDENT MOISTURE MEASUREMENT METHODS USING FREQUENCY-SWEPT MICROWAVE TRANSMISSION", 1996 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST. SAN FRANCISCO, JUNE 17 - 21, 1996; [IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST], NEW YORK, IEEE, UI, 17 June 1996 (1996-06-17), pages 1415 - 1418, XP000720611, ISBN: 978-0-7803-3247-8, DOI: DOI:10.1109/MWSYM.1996.512201
A. KRASZEWSKI, S. KULINSKI AND Z. STOSIO: "A Preliminary Study on Microwave Monitoring of Moisture Content in Wheat", JOURNAL OF MICROWAVE POWER, vol. 12, no. 3, 1977, pages 241 - 252, XP002639589
H. BLATES, W.GÖPEL, J. HESSE (EDITORS): "Sensors Update - Special Topic: RF & Microwave Sensing of Moist Materials", vol. 7, 2000, WILEY-VCH, Weinheim, Germany, ISBN: 3-527-29821-5, article K. KUPFER: "Microwave Moisture Measurement Systems and Their Applications", pages: 343 - 376, XP002639590
EBBE NYFORS AND PERTTI VAINIKAINEN: "INDUSTRIAL MICROWAVE SENSORS", INDUSTRIAL MICROWAVE SENSORS, 1 January 1989 (1989-01-01), XP002334964
Attorney, Agent or Firm:
DROUIN, Stephane et al. (Ramsgate Road, Sandwich Kent CT13 9NJ, GB)
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