Title:
DEUTERATED AMMONIA PREPARATION METHOD AND DEUTERATION REACTION INVOLVING SAME AS DEUTERIUM SOURCE
Document Type and Number:
WIPO Patent Application WO/2023/283974
Kind Code:
A1
Abstract:
A deuterated ammonia preparation method and a rapid deuterated reaction involving same as a deuterium source, which belong to the technical field of organic synthesis. The deuterated ammonia preparation method comprises the following steps: passing a nitrile compound through the action of a catalyst under a deuterium source atmosphere to obtain a deuterated amine. In the deuterated ammonia preparation method, a target product can be obtained in one step under mild conditions by means of a simple organic reaction, and the operation is simple; the produced deuterated ammonia can be directly used as a deuterium source, and undergoes a rapid hydrogen-deuterium exchange reaction with active hydrogen to synthesize a corresponding deuterated compound. An active hydrogen-containing compound comprises a hydroxyl compound, a thiol compound, an alkynyl compound, a phenolic compound, a silicon-hydrogen compound or an amino compound. The preparation method has mild reaction conditions and low operation costs and has good universality.
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Inventors:
LANG JIANPING (CN)
GU HONGWEI (CN)
ZHU FENGYUAN (CN)
NIU ZHENG (CN)
GU HONGWEI (CN)
ZHU FENGYUAN (CN)
NIU ZHENG (CN)
Application Number:
PCT/CN2021/107245
Publication Date:
January 19, 2023
Filing Date:
July 20, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C01C1/08; C07B59/00
Foreign References:
| GB120034A | 1919-04-03 | |||
| CN103950952A | 2014-07-30 | |||
| GB870452A | 1961-06-14 | |||
| GB152011A | 1921-10-20 | |||
| CN101970386A | 2011-02-09 | |||
| US20160250358A1 | 2016-09-01 |
Other References:
MCALLISTER MAIRI I., BOULHO CÉDRIC, GILPIN LAUREN F., MCMILLAN LIAM, BRENNAN COLIN, LENNON DAVID: "Hydrogenation of Benzonitrile over Supported Pd Catalysts: Kinetic and Mechanistic Insight", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 5, 17 May 2019 (2019-05-17), US , pages 977 - 989, XP093023743, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.9b00058
"Isotope Organic Chemistry", 31 October 1994, ZHEJIANG EDUCATION PRESS, CN, ISBN: 7-5338-1261-1, article SHENG, HUAIYU ET AL.: "3.1.1 The synthetic method of gram generation compound", pages: 63 - 66, XP009542978
"Isotope Organic Chemistry", 31 October 1994, ZHEJIANG EDUCATION PRESS, CN, ISBN: 7-5338-1261-1, article SHENG, HUAIYU ET AL.: "3.1.1 The synthetic method of gram generation compound", pages: 63 - 66, XP009542978
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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