Title:
DEUTERATED NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES
Document Type and Number:
WIPO Patent Application WO/2015/109017
Kind Code:
A3
Abstract:
The present invention provides deuterated NO-releasing NONOate(oxygen bound)chromene conjugates, having the structure of Formula (I): wherein Z, R1, R2, R3, R4, R5, R6, and R7 are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, or acne, using a compound of Formula (I).
Inventors:
TALLEY JOHN J (US)
MARTINEZ EDUARDO J (US)
JEROME KEVIN D (US)
MARTINEZ EDUARDO J (US)
JEROME KEVIN D (US)
Application Number:
PCT/US2015/011460
Publication Date:
November 19, 2015
Filing Date:
January 14, 2015
Export Citation:
Assignee:
EUCLISES PHARMACEUTICALS INC (US)
International Classes:
C07D311/04
Domestic Patent References:
| WO2013189121A1 | 2013-12-27 |
Foreign References:
| US7109211B2 | 2006-09-19 | |||
| US20130289003A1 | 2013-10-31 | |||
| US20130225655A1 | 2013-08-29 |
Other References:
MARTELLI ET AL.: "NO -Releasing Hybrids of Cardiovascular Drugs'.", CURRENT MEDICINAL CHEMISTRY, vol. 13, 2006, pages 609 - 625, XP009087275, DOI: doi:10.2174/092986706776055634
Attorney, Agent or Firm:
KISUK, Lee (Dickey & Pierce P.L.C.,7700 Bonhomme Avenue, Suite 40, St. Louis MO, US)
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