Title:
DEUTERATED NUCLEOSIDE COMPOUNDS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/222055
Kind Code:
A1
Abstract:
Disclosed are a series of deuterated nucleoside compounds and a use thereof. Specifically disclosed are compounds represented by formula (IV), and stereoisomers or pharmaceutically acceptable salts thereof.
Inventors:
LI PENG (CN)
LI XIAOLIN (CN)
YANG YAXUN (CN)
LUO ZHI (CN)
HE HAIYING (CN)
CHEN SHUHUI (CN)
LI XIAOLIN (CN)
YANG YAXUN (CN)
LUO ZHI (CN)
HE HAIYING (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2023/094871
Publication Date:
November 23, 2023
Filing Date:
May 17, 2023
Export Citation:
Assignee:
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D487/04; A61K31/53; A61P31/14
Domestic Patent References:
| WO2021213288A1 | 2021-10-28 |
Foreign References:
| CN113735862A | 2021-12-03 | |||
| CN112778310A | 2021-05-11 | |||
| US20220081462A1 | 2022-03-17 | |||
| CN114292272A | 2022-04-08 | |||
| CN113698405A | 2021-11-26 | |||
| CN113292567A | 2021-08-24 | |||
| CN113999237A | 2022-02-01 | |||
| US20220227776A1 | 2022-07-21 | |||
| US20230024722A1 | 2023-01-26 | |||
| CN111961057A | 2020-11-20 | |||
| CN202210548373A | 2022-05-17 | |||
| CN202210695557A | 2022-06-15 | |||
| CN202211002496A | 2022-08-19 | |||
| CN202310213459A | 2023-03-07 |
Other References:
LI JIAPENG, LIU SHUHAN, SHI JIAN, WANG XINWEN, XUE YANLING, ZHU HAO-JIE: "Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy", ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, vol. 4, no. 2, 9 April 2021 (2021-04-09), pages 870 - 887, XP055948009, ISSN: 2575-9108, DOI: 10.1021/acsptsci.1c00016
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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