Title:
DEVELOPMENT OF SYNTHETIC PSEUDAMINIC ACID-BASED ANTIBACTERIAL VACCINES AGAINST ACINETOBACTER BAUMANNII
Document Type and Number:
WIPO Patent Application WO/2023/024676
Kind Code:
A1
Abstract:
Provided are compositions comprising chemically synthesized pseudaminic acid (Pse) conjugated to a carrier protein using the OPA chemistry, methods of using said compositions to stimulate immune responses in subjects and protect the vaccinated subjects from infections caused by Pse-producing A. baumannii.
Inventors:
LI XUECHEN (CN)
WEI RUOHAN (CN)
LI HAN (CN)
CHEN SHENG (CN)
YANG XUEMEI (CN)
WEI RUOHAN (CN)
LI HAN (CN)
CHEN SHENG (CN)
YANG XUEMEI (CN)
Application Number:
PCT/CN2022/100131
Publication Date:
March 02, 2023
Filing Date:
June 21, 2022
Export Citation:
Assignee:
VERSITECH LTD (CN)
UNIV CITY HONG KONG (CN)
UNIV CITY HONG KONG (CN)
International Classes:
C07H5/06; A61K31/7008; A61K39/02; A61P31/04
Domestic Patent References:
| WO2018009906A1 | 2018-01-11 |
Foreign References:
| US20200179503A1 | 2020-06-11 |
Other References:
WEI RUOHAN, YANG XUEMEI, LIU HAN, WEI TONGYAO, CHEN SHENG, LI XUECHEN: "Synthetic Pseudaminic-Acid-Based Antibacterial Vaccine Confers Effective Protection against Acinetobacter baumannii Infection", ACS CENTRAL SCIENCE, vol. 7, no. 9, 22 September 2021 (2021-09-22), pages 1535 - 1542, XP093039027, ISSN: 2374-7943, DOI: 10.1021/acscentsci.1c00656
LEE I-MING, YANG FENG-LING, CHEN TE-LI, LIAO KUO-SHIANG, REN CHIEN-TAI, LIN NIEN-TSUNG, CHANG YU-PEI, WU CHUNG-YI, WU SHIH-HSIUNG: "Pseudaminic Acid on Exopolysaccharide of Acinetobacter baumannii Plays a Critical Role in Phage-Assisted Preparation of Glycoconjugate Vaccine with High Antigenicity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 140, no. 28, 18 July 2018 (2018-07-18), pages 8639 - 8643, XP055865690, ISSN: 0002-7863, DOI: 10.1021/jacs.8b04078
LEE I-MING, YANG FENG-LING, CHEN TE-LI, LIAO KUO-SHIANG, REN CHIEN-TAI, LIN NIEN-TSUNG, CHANG YU-PEI, WU CHUNG-YI, WU SHIH-HSIUNG: "Pseudaminic Acid on Exopolysaccharide of Acinetobacter baumannii Plays a Critical Role in Phage-Assisted Preparation of Glycoconjugate Vaccine with High Antigenicity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 140, no. 28, 18 July 2018 (2018-07-18), pages 8639 - 8643, XP055865690, ISSN: 0002-7863, DOI: 10.1021/jacs.8b04078
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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