The present invention relates to a device for conditioning the metabolism, 5 the circadian rhythms and the cell viability that influences these aspects of its user.

It is known that metabolism is the set of chemical reactions dedicated to the maintenance of life within living organisms. These reactions allow organisms to grow and reproduce, to preserve their structures and to 10 respond to the stresses of the surrounding environment.

Since the environments where most organisms live are in constant evolution, metabolic reactions are subject to constant changes and imbalances, and must be precisely regulated to maintain a constant series of conditions inside the cells, called homeostasis. Moreover, the metabolic 15 regulation allows organisms to respond to signals, and it actively interacts with the environments of organisms. In order to understand how metabolic pathways are controlled, two closely related concepts need to be understood. First, an enzyme regulates a pathway by increasing or decreasing its activity in response to signals. Secondly, the control exerted 20 by this enzyme is the result of the effects that these changes have on the pathway on which the enzyme itself interacts. For example, one enzyme may show large variations in activity, but if these changes have little effect on the flux of a metabolic pathway, then that enzyme is not involved in controlling the pathway.

25 There are several levels of metabolic regulation. In intrinsic regulation, the metabolic pathway self-regulates to respond to changes in the levels of substrates or products; for example, a decrease in the amount of product can increase the metabolic pathway to compensate. This type of regulation often involves an allosteric regulation in the activity of several enzymes in 30 the pathway. Extrinsic control involves a cell in a multicellular organism changing its metabolism in response to signals received from other cells. Generally, these signals are in the form of soluble messengers, such as hormones and growth factors, and are detected by specific receptors present on the cell surface. These signals are then transmitted inside the cell by a second messenger system that often involves the phosphorylation of proteins.

The object of the present invention is to provide a device for conditioning the metabolism, the circadian rhythms and the cell viability, allowing to obtain the therapeutic results previously described.

A further purpose of this invention, called a device for conditioning the metabolism, the circadian rhythms and the cell viability, can be achieved with considerably low costs, as far as both production and management costs are concerned.

Finally yet importantly, another purpose of this invention is to offer a device for conditioning the metabolism, the circadian rhythms and the cell viability that can be simple, safe and reliable.

Therefore, a device for conditioning the metabolism, the circadian rhythms and the cell viability constitutes the very object of the present invention, characterized by being configured as a wristwatch, on which the 24 hours of the day are arranged in a circle, following a counterclockwise direction, in the position of the circle arranged vertically above the center of the circle being positioned the number 1 , which indicates 1 :00 a.m., the minutes and the seconds are arranged on the same circle or on one or two different circles, following a counterclockwise order, on the circle of minutes being reported 120 minutes, that is, the minutes making up two hours, in the position of the circle arranged vertically above the center of the circle being positioned the number 0, which indicates the beginning of the minute circle, and/or the number 120, which indicates the end of the minute circle, the first half of the minute circle representing the minutes that make up the odd hours and the second half of the minute circle representing the minutes that make up the even hours; on the second circle being reported 120 seconds, that is, the seconds contained in two minutes, in the position of the circle arranged vertically above the center of the circle being positioned the number 0, which indicates the beginning of the second circle, and/or the number 120, which indicates the end of the second circle, the first half of the second circle representing the seconds that make up the odd minutes and the second half displays the seconds that make up the even minutes.

The invention will be described below by way of (not limiting) example, with particular reference to some illustrative cases and to the figures of the attached drawings. Let us see it in details:

- Figure 1 shows the quadrant of a device for conditioning the metabolism, the circadian rhythms and the cell viability, based on a preferred form of the invention;

- Figure 2 shows a first example of how to read the time by using the quadrant of Figure 1 ;

- Figure 3 shows a second example of how to read the time by using the quadrant of Figure 1 ;

- Figure 4 shows a third example of how to read the time by using the quadrant of Figure 1 ;

- Figure 5 shows an illustrative graph of the variation of vitality of the blood in the four groups used in the experimentation of the device for conditioning the metabolism, the circadian rhythms and the cell viability based on the present invention. It considers the analyses performed in moment‘minus one’,‘zero’,‘one’, or‘two’, which is a one-year period.

- Figure 6 shows a demonstrative graph of the changes of the circadian rhythms in the four groups used in the experimentation of the device for conditioning the metabolism, the circadian rhythms and the cell viability based on the present invention. The results range from moment‘zero’ to‘two’ (the graph examines a parameter ranging from 0 to 6 showing the changes that occurred over a one-year period).

The device for conditioning the metabolism, the circadian rhythms and the cell viability based on the present invention consists of a wristwatch (a commonly used instrument) with characteristics different from those of the typical wristwatches. Indeed, it is conceived with the aim of reshaping metabolism and circadian rhythms that regulate the biological rhythms of living beings by means of an alternative division of time, whose effectiveness has been verified on a group of volunteers.

This division of time and its subsequent representation departs from the hypothesis that time is a form of universal, linear and modulated language, built on the basis of a mathematical-alphabetic order and hidden in the passage of time itself. This mathematical-alphabetical system derives from certain pairs of numbers, contained in the twenty-four hours and called (based on the present invention) ‘golden’ or ‘synchronic series’. They consist of five sequences per hour, for a total of 120 series in a day (e.g. 00:00, 9:09 10:10, 1 1 :1 1 , 12:22, 17:33, 22:22, etc.). The series are listed in ascending order and compose a code, called‘prime code’ or‘golden Logos’; they all express a ratio of golden proportion, on the basis of which the device for conditioning the metabolism, the circadian rhythms and the cell viability based on the present invention has been created. For these reasons, the device can also be called ‘golden wristwatch’. This code has been deciphered based on the present invention by translating the number into letters by applying gematria.

According to the theory underlying (but not limiting) the present invention, time can be divided into two categories:‘absolute’ or‘golden’ time, on which the wristwatch that constitutes the subject of the present invention is conceptually and functionally set (for this reason also called‘golden clock’); and the‘relative’ or‘cyclical time’, on which common clocks are based. This division highlights substantial differences between the different types of time, showing that there are two different timelines.

In particular, the timeline that characterizes relative time, on which the scanning of common clocks is set, is circular and regulates the events that occur as a continuous cycle (or loop), even if the subjects involved and the circumstances vary. On the other hand, the timeline that characterizes absolute time, on which the watch based on the present invention is based, is shaped as a spiral. According to the theory underlying (but not limiting) the present invention, in this spiral the events follow a synchronic order, which develops through a succession of non-random events interconnected with each other and implemented by ever-changing subjects and circumstances which remain consistent nevertheless over the years. A further element of distinction between the two temporal types is the kind of movement that time itself determines, which regulates the movement of stars and planets in the universe, as well as the unfolding of events; this movement is counterclockwise in absolute time, and clockwise in the relative time. This factor influences biological cycles and naturally adapts to the type of time, to its movement and measurement.

Again according to the theory underlying (but not limiting) the present invention, absolute time is deduced from the cyclical time, even if it is the original temporal measure. As previously mentioned, it follows a spiral timeline, traced by the passing of synchronic times, the golden series that, arranged in ascending order from 00:00 to 23:55, reconstruct the golden Logos, bringing to light the first code, which expresses the original pattern of the entire human genome. According to the theory underlying the present invention, the DNA is built by maintaining the same numerical order, which is divided into 24 elements, as a day is fragmented in 24 hours: the nucleus and 23 pairs of chromosomes, which contain the 120 golden series and store the fundamental information for understanding human and universal architecture. Since it is created through the same system and stores that very code, the genetic code recognizes the golden pattern but maintains the same content in the genes. Its mapping shows the fundamental characteristics common to all human beings, whose genome is built by following the same time code. In the golden series, which are identical in the human genome, every hour conserves the primary numerical building blocks that define the skeletal structure of the cosmos, as of human DNA itself. They trace the mathematical constants that govern the spiral stair of the genetic code, bringing to evidence (according to the theory) the substantial elements that define the basic characteristics by which humans are made humans.

This special code, which is fundamental for the realization of the watch based on the present invention, is built on the concept of synchronism, which expresses the non-randomness of events and considers reality as the expression of a plan governed by a prime order regulating experience. Synchronism is a principle partially expressed in 1950 by C. Gustav Jung, who affirmed that Case does not exist as such, but rather as a series of non- random connections that determine interconnected events occurring simultaneously. According to the theory underlying the present invention, these events follow their own timeline and have a logic that ignore the ordinary consciousness. The synchronic event places the individual experiencing it in a proportionally perfect period, which is marked by synchronic times that follows the natural simultaneity inherent in the cosmos, and adapts the experience to the best circumstance for the user.

According to the theory underlying (but not limiting) the present invention, the structure of the watch highlights the constants that allowed the multi universe to manifest itself, and explains the intrinsic order in the cosmos. Given by the union of the synchronic series in one day classified in ascending order, this enumeration allows us to analyze the‘formulas’ of space-time, as well as the numerical foundations that govern the entire existence, whether the this belongs to the single individual or to the whole creation. It eventually provides a cipher that offers the opportunity to understand the architecture of macro-, medium- and micro-cosmos.

Again according to the theory underlying (but not limiting) the present invention, we can summarize the golden code in Table 1 :

In this table, we sum the ciphers that make up the number in each box, and we obtain Table 2: Table 2

We can give two possible mathematical interpretations, in matrix and geometric form, respectively.

According to the matrix form interpretation, Table 2, which will also be called Table C from now on, is made up of 24 rows and 6 columns, and has the following characteristics: considering the first row, formed by the numerical sequence {0, 2, 4, 6, 8, 10}, and the first column, made up of the numerical sequence {0, 1 , 2, 3, 4, 5, 6.. . 23} respectively as the row and the column of place 0, the number of rows, indicated with the letter m, will belong to the set {0, 1 , 2, 3... 23}, while the number of columns, indicated with the letter n, will belong to the set {0, 1 , 2, 3, 4, 5}.

Both row and column 0 are two arithmetic progressions with common difference of 2 and 1 , respectively, namely:

- For row 0 it is:

a _n =ao=0 if n=0, while a _n =a _n -i+2 if n<º {1 , 2, 3, 4, 5}

- Whereas for column 0 it is:

bm=bo=0 if m=0, while bm=bm-i+1 if m<º {1 , 2, 3, ..., 23}

Furthermore, all the rows, besides row 0, are arithmetic progressions with common difference of 2; all columns, besides column 0, are arithmetic progressions with common difference of 1 , the numerical sequence {0, 3, 6, 9, 12, 15} and all the analogue sequences are arithmetic progressions with common difference of 3.

Table C turns out to be a rectangular matrix of m rows and n columns, which can be indicated with

C=(Cmn)

with me {1 , 2, 3, ..., 23} and ne {1 , 2, 3, 4, 5}, and with the element c _mn of place mn defined as follows:

Cmn=0 if m=n=0

Cmn=a _n if m=0 and n<º {1 , 2, 3, 4, 5}

Cmn=bm if n=0 and m<º {1 , 2, 3, ..., 23}

which explains the structure of the cosmos through a system of numerical progressions with common difference of 1 , 2, 3.

According to the geometric interpretation, Table 1 is composed of numbers representing the sides of many rectangles, all of which are congruent with each other and having at least one side in common. Starting from the rectangle placed in the second row, second column, it can be stated that it is a rectangle formed by two congruent squares, also called oblong quadrilateral, in which it is possible to define a height h with a value of 1 , and a base b with a value of 2. The oblong quadrilateral with these dimensions has an area equal to 2, and a diagonal c/that can be calculated with the Pythagorean theorem: d=V(b ² +h ² )=V(2 ² +1 ² )=V5=2, 2360679...

This value is used in the formula that defines the golden number:

<p=(1 +V5)/2=1 ,6180339

Referring to Table 1 , it is possible to notice that all the fields of this table represent oblong quadrilaterals with measure of 2x1 , area equal to 2 and diagonal equal to 5. In addition, if we consider the adjacent fields positioned in the second and third row and in the second and third columns, they define a second oblong rectangle, formed by four rectangles equal to the base rectangle, of height 2 and base 4, which has an area equal to 8 and a diagonal equal 2L/5.

Considering the fields of the third row and the third column, we define an oblong rectangle, consisting of 9 rectangles equal to the base rectangle, and with a height equal to 3, base equal to 6, area equal to 18 and diagonal equal to 3L/5. Furthermore, considering the fields of the fourth row and the fourth column, we define an oblong rectangle formed by 16 rectangles equal to the base rectangle, with a height equal to 4, a base equal to 8, an area equal to 32 and a diagonal equal to 4L/5. Finally, considering the fields of the fifth row and the fifth column, another oblong rectangle is defined, consisting of 25 rectangles equal to the base rectangle, with a height equal to 5, a base equal to 10, an area equal to 50 and a diagonal equal to 5L/5.

The data above can be summarized in the following Table 3:

Table 3

The procedure of geometric representation can restart from the following row, and is repeated every 5 rows, thus allowing to reproduce the entire Table 1 , along with its representation of the cosmos. It is a perfect mathematical and geometric system based on a relationship of progressive golden progression, representative of a sort of gradual evolution.

According to the theory underlying (but not limiting) the present invention, the mathematical interpretation of the representative table of the golden code can thus be summarized in the following formula:

(An+1 )x(An+2)xC/t

and in the inverse formula:

(An+1 )x(An+2)xt/C

where A _n represents the coefficients, and the bracketed expressions (An+1 ) and (A _n +2) are the arithmetic progressions of the Table 1 , which multiply with each other and gradually increase by +1 moving from one line to the next, and +2 going from one column to the next, thus resulting in the values of the diagonals and the extension area.

According to the theory underlying the invention, in order to represent the cosmos, it is then necessary to multiply these coefficients by C (the speed of light) and divide by the time t. Dimensionally, the formula expresses a value in meters per second squared, that is, a length divided by the square of the time, i.e. acceleration, and therefore constant expansion. As the coefficients (An) change, the speed varies in a given time span. The displacement to the right is as greater as higher are the coefficients.

The second formula figures a time squared over a length that is multiplied by the coefficients, thus defining a deceleration of the advancement of matter, meaning a slower time span and a longer duration. Therefore, the formulas represent a universe in constant mutation, whose creative process experiences a perennial state of evolution and involution, of creation and destruction, of clockwise expansion and counterclockwise decrease, depending on whether it is in its acceleration or deceleration phase.

The project of the device for conditioning the metabolism, the circadian rhythms and the cell viability based on the present invention follows the same system, formulating a radically new scan of time, which uses the original golden pattern to reshape the circadian rhythms that regulate the biological rhythms of living beings, naturally aligning them with the hours of darkness and light, and with the synchrony of creation. According to the aforementioned theory, the watch proposed based on the present invention constitutes a means to provide a different and innovative reading of time, capable of representing the primary information contained in time itself through a scheme that communicates the perfection of the split of opposites, and the perfect proportional relationship inscribed in synchronic time. This scheme totally converts the sense of common watches, and offers an innovative concept of time based, as said, on the synchrony of events.

The movement of the clock hands in the present invention is, precisely for this reason, designed to be leftward, that is, to go from right to left. Indeed, the counterclockwise trend is determined by the desire to ideologically align the time on the watch of the present invention in order to propose to its user the aforementioned Inverse Formula:

(An+1 )x(An+2)xt/C

This formula determines a deceleration of time, which instead normally accelerates according to the variation of the coefficients, as the following Formula expresses:

(An+1 )x(An+2)xC/t

Therefore, the slowdown of cellular aging can be obtained.

This movement is also designed to align the time marked by the watch based on the present invention with the motion of the Milky Way that rotates in the cosmos in an anticlockwise movement, just as the Earth does in its revolution around the Sun; conversely, the common watch follows the movement of rotation. This modification is applied in such a way as to allow the time defined by the watch based on the present invention to align with the annual solar cycle, and not with the daily terrestrial cycle.

According to the theory underlying the present invention, supported by the evidence of the experimentation carried out on a prototype over the course of a year, the time on the watch based on the present invention determines a natural change of the user’s circadian rhythms. These new rhythms naturally tend to tune to the new temporal scan and align in its evolution and duration with the solar flux and metabolism based on these rhythms, with consequent positive effects on cellular aging. According to the theory underlying (but not limiting) the present invention, cells recognize the time code and adapt to the information provided by the new scan, aligning the individual’s biological rhythms with the new way of measuring time. As demonstrated in the 1970s, the mutation of an‘unknown gene’ could disrupt the natural circadian rhythm, thereby attesting that circadian rhythms have a genetic basis. In 1984, that particular gene previously discovered was identified and named PER. It was lately discovered that PER, the encoded protein of that gene, accumulates overnight and is degraded during the day. Therefore, PER protein levels fluctuate over a twenty-four hour cycle, in sync with the circadian rhythm. Being these interconnected factors, changing the scan of time and informing the genes of the original code, it is then possible to modify the very circadian rhythms.

The use of the watch based on the present invention also facilitates the formation of laminin. Laminin is a family of glycoproteins consisting of three different polypeptide chains linked by disulfide bridges. According to the theory underlying (but not limiting) the present invention, laminin affects embryonic transhumance, cell growth, and diversification by mediating through the bloodstream the movement of primorquadrant reproductive cells; it affects, for example, the embryonic yolk sac and the development of the gonads, which result in the production of sperm or ovules. The entire procreative process takes place through particularly large areas of these molecules, since the original germ cells have on their surface some proteins that bind these components to the extracellular matrix (ECM).

Moreover, laminin is essential in the production of collagen. It gives organic fabrics strength and elasticity.

According to the theory underlying (but not limiting) the present invention, it is believed that the use of the watch subject of the present invention facilitates the formation of laminin. This is due to the fact that, since laminin is a substantial component of metabolism and depends on the suprachiasmatic cell nucleus, it is influenced by the Golden Code transmitted by the conditioning device, as well as the production of melatonin and serotonin. Thanks to the use of the conditioning device of the invention, the body can naturally produce laminin is naturally produced by the body without any limit of age, while it is usually produced easily by the body system only up to forty years of age, but then its formation slows down drastically, until it almost completely disappears.

The watch based on the present invention, structured on the basis of the primitive enumeration order that builds the entire genome, acts as a natural modulator for its user who, having inscribed in his own genetic code the same temporal scheme, would make the contents underlying the series inscribed in the DNA emerge, awakening memory, adapting their rhythms to the natural light and to the information received.

The quadrant, designed specifically to recompose the golden pattern, has a predetermined design that cannot be changed in any form, since the simple movement of a single element would result in a different reading of it all. In fact, according to the theory underlying the present invention, the time system is a basic, mathematical and univocal language, whose contents vary according to the numerical juxtaposition, the relative assonance produced, and the sequences (and relative frequencies) thus determined, visually expressed in the vertical, horizontal and oblique axes of the quadrant on which the numbers are arranged.

Referring to Figure 1 , the watch based on the present invention has the function of communicating to its user an ideal harmonic composition that reveals, thanks to the arrangement of the numbers on the same axes (vertical, horizontal, oblique) their only sum, which shows the special figures that dictate the order of absolute perfection, highlighting the golden series (1 , 3, 5, 7, 9, 2, 4, 6, 8, 1 , 3, 5, ... 2, 4 , 6, 8, 1 , 3, 5, 7, 9, 2, 4, 6, 8 ..) and the fundamental numbers of creation: 26, 5, 2, 8.

This system, which communicates with its user at various levels, also affects the subconscious and determines an elaboration of individual thought, which is reformatted according to the canons of beauty and to the golden completeness, and so of harmony and well-being. This happens both for the visual communication emitted by the quadrant and for how the passing of time is conceived. Thanks to the use of the proportional separation of the odd hours from the even ones, the watch based on the present invention marks the aforementioned passing of time by tending to relate the two cerebral hemispheres, making both work in an equal way, in order to determine a thread that naturally leads to the order and harmony of opposites.

According to the theory underlying (but not limiting) the present invention, the individual who uses this form of communication brings the archetype of the perfect human being back to the memory of the unconscious. In this way, by simply observing and using the watch based on the present invention, it is possible to bring out precious information contained in the human DNA itself, in order to restore its contents and qualities and make them accessible to everyone. This language, which can be deciphered and converted into a letter by respecting the numerical value, is an emitter of frequencies that are transmitted to its user, who absorbs the intrinsic message. This concept is at the basis of any types of communication in which the archetype is applied, be it a number, letter or symbol; it is an element that makes it clear how fundamental it is to receive correct subliminal information, since it influences the human psyche and the genome.

Referring to Figures 1 -4, it is shown how the watch based on the present invention is designed to copy, thanks to its particular temporal scan and its visual language, expressed by the quadrant, the scheme of absolute time, in order to offer, in this way, to its user, a precious tool with which to fix the temporal reading on the golden perfection and adapt the time lived by its user, to the synchrony that is naturally expressed in the universe.

In particular, on quadrant (10) of the watch based on the present invention, two concentric circles are represented, respectively an external circle, indicated with the number 1 1 , on which, following an increasing counterclockwise trend, the hours from 1 to 24 are reported, indicated by a hour hand (12), which runs in a counterclockwise verse, and an internal circle (13), concentric to the external circle (1 1 ) and on which, again with an increasing counterclockwise trend, the minutes and the seconds from 1 to 120; the minutes being indicated by a minute hand (14) and the seconds being indicated by a second hand (15). In particular, referring to figures 1 -4, the 24 hours of the day are arranged on the external circle (1 1 ) and follow a counterclockwise direction, in the position of the external circle (1 1 ) arranged vertically above the center of the external circle (1 1 ) being positioned the number 1 , which indicates 1 :00 a.m., and the minutes and the seconds are arranged on the internal circle (13), in the position of the internal circle (13) arranged vertically above the center of the circle being positioned the number 0, which indicates the beginning of the minute circle, or the beginning of the second circle, and/or the number 120, which indicates the end of the minute circle, or the end of the second circle, the first half of the internal circle (13) indicating the minutes that make up the odd hours and the second half of the minute circle representing the minutes that make up the even hours and the first half of the second circle representing the seconds that make up the odd minutes and the second half of the second circle representing the seconds that make up the even minutes. Furthermore, the second half of the internal circle (13) can also represent again the numbers from 0 to 60, to indicate the minutes that make up the even hours and the seconds that make up the even minutes.

Starting from 2:00 in alignment with hour 24:00, the arrangement of the hours on the circle (1 1 ) presents the feature making the sum of all the horizontal axes result in the number 26, whose figures are in turn summed in number 8 (e.g. (24 + 2) = 26 = 8, (23+ 3) = 26 = 8, (22+ 4) = 26 = 8 etc.).

Numbers 8 and 26 are fundamental and traditionally considered sacred, since the Kabbalistic and Gnostic tradition recognizes in them the name of God and the Law.

The number 26 is also remarkable in its mathematical attributes, since it is located between two numbers: one squared (25 = 5x5) and the other cubed (27 = 3x3x3). Renaissance mathematician Pierre de Fermat showed that there is no other number between a square and a cube, which made him say that“the number 26 is a unique number in the entire mathematical universe”.

The number 8, in its main meanings, represents the Sacred Law, balance, justice, and infinity. It is a number of fundamental importance, as it conveys an inherent order that equates male and female, and relates the matter with the Spirit. The number 8 is universally considered the number of the cosmic balance. Considered sacred since ancient times, it embodies the innumerable quantity, immense and indefinable.

The vertical axes of the circle of the hours divide the quadrant into two portions: on the left, the result of the sum is the number 14, whose figures are summed in 5, and on the right, the number 38, 1 1 and 2. All these numbers also have a meaning, which is linked to phenomena and effects with a positive influence on the human being in the kabbalist tradition.

From the set of these numbers (26 = 8, 14 = 5, 38 = 2) showed on the hour circle of the quadrant of the device based on the present invention, it is possible to detect the sequence and the relative frequency 528. This is considered capable of opening people to the possibility of deep spiritual experiences or spiritual enlightenment, but also to regenerate and harmonize DNA.

The different scan of time determined by the watch based on the present invention allows a numerical mapping that subliminally communicates the perfect proportion, so evoking both in the operation of the watch based on the present invention and in the graphic expression of the quadrant (10) the first code mapped in DNA, in order to stimulate its contents. It considers the temporal scan by considering the whole day, which is divided into twelve bi hours (marked in Figure 1 in red), twelve daytime hours (1 : 00-12: 59) and twelve night hours (13:00-24:59), with a further distinction between even and odd hours. The first hour of the new day is one o’clock, which also expresses the first bi-hour of the quadrant (10).

Each bi-hour lasts 120 minutes and is made up of two hours, one odd and one even, which is the time for the minute hand to make a 360 ° turn on the quadrant, marking two identical portions of sixty minutes each. For example, the first bi-hour, which corresponds to the number one marked on the quadrant, contains the time span ranging from 1 :00:00 to 2:59:59. The first hour of this portion of time is odd (1 :00:00-1 :59:59) and coincides with the numbering of the first bi-hour. The second is even and covers the time span from 2:00:00 to 2:59:59. The second bi-hour corresponds to the number three, and as with the previous example, it includes a time span of 120 minutes going in this case from 3:00:00 to 4:59:59. This temporal fragment is split into two hours an odd one that coincides with the beginning of the second bi-hour, and an even one. The same procedure is applied to the entire scan of the daily cycle, which follows this division into twelve bi hours, twelve odd and twelve even hours, for a total of twenty-four hours.

This is a substantial conceptual distinction, which re-evaluates the ordinary conception of time and creates a series of innovative information contained in the same temporal scan. First, the odd hours of the day (1 , 3, 5, 7, 9, 1 1 , 13, 15, 17, 19, 21 , 23), which coincide in the mapping on the quadrant with the principle of the bi-hours, and highlight the active time frames, energy flows with positive polarity. From them come the golden sequence 1 , 3, 5, 7, 9, 2, 4, 6, 8, 1 , 3, 5; this is the basic series of the Golden Code, which expresses the divine proportion according to which the universe and the genetic code is developed. The even hours (i.e. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) define the time spans of the day which have negative polarity, and map passive energy flows. They define the sequence that duplicates matter (2, 4, 6, 8, 1 , 3, 5, 7, 9, 2, 4, 6, 8). This separation is essential to understand better the human and cosmic architecture based on the natural contrast of opposites, and to define the function of the cosmic energy flows that arrive on Earth by following the hourly pattern, thus making evident the opposite polarities (+ and -) that determine the motion of the entire galaxy.

As regards the functioning of the watch based on the present invention, the day is divided into 12 bi-hours (24 hours of which 12 odd and 12 even), 720 bi-minutes (1440 minutes), 43200 bi-seconds (86400 seconds). In the individual who uses this scan, it brings to light the awareness that the absolute and perfect time is the one equated with its contrast. The 12 hour hand moves counterclockwise starting from one o’clock, that is, the first bi hour (1 :00-2:59), gradually tracing them on the external circle (1 1 ) divided into 24 portions (as shown in Figure 1 ). It advances by one notch per hour, while the minute hand (14), marked in the internal circle (13), divided into 120 portions of one minute-second, performs a half-turn of 180 ° in the same period, which identifies the first half of the quadrant, on the left, on which the 60 minutes of all odd hours and all bi-hours are counted. The minute hand (14) completes its turn and rotates another 180° in the following hour, that is, from 2:00 to2:59, identifying the second half of the quadrant on the right, which always counts the 60 minutes of the even hours. The minute hand (14) runs through the entire quadrant in a bi-hour, two hours, an odd and an even one, 120 prime minutes, marked on the two half quadrants, left and right.

In the third hour (3:00-3:59), the hour hand (12) restarts from zero, in sync with the minute hand (14) and it moves one notch per hour as in the first bi-hour, while the minute hand (14) completes the first 180 ° half-turn on the left half-quadrant. As before, it concludes the entire lap with another 180 ° turn in the following hour (4:00-4:59) by tracing the minutes of the intermediate hour on the right half-quadrant.

This operation develops for all the twenty-four hours, which always count their 60 minutes on the left half-quadrant if odd, on the right half-quadrant if even, respectively.

Besides the minutes, the second half of the internal circle (13) marks the bi-seconds with the second hand (15), as shown in Figure 1 . Bi-seconds are 120 per quadrant, equivalent to 2 minutes, and are marked and read by the hand in 120 portions of a second each. Therefore, the full timetable is read with hours, minutes and bi-seconds, as in the example shown in Figure 2, which tells the hours 3, 33 minutes and 75 bi-seconds.

Therefore, the watch based on the present invention divides a day according to the following scheme:

12 bi-hours:

- 1 :00:00-2:59:59; 3:00:00^:59:59; 5:00:00-6:59:59; 7:00:00-8:59:59;

9:00:00-10:59:59; 1 1 :00:00-12:59:59; 13:00:00-14:49:49; 15:00:00- 16:59:00; 17:00:00-18:59:59; 19:00:00-20:59:59; 21 :00:00-21 :59:59; 23:00:00-24:59:59;

12 odd hours:

- 1 , 3, 5, 7, 9, 1 1 , 13, 15, 17, 19, 21 , 23;

12 even hours: - 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24;

1440 minutes;

720 bi-minutes;

43200 bi-seconds;

86400 seconds.

The day is equally divided into 12 daytime hours and 12 nighttime hours.

Daytime hours are 1 :00-12:59; night hours are 13:00-24:59.

Referring to Figure 3, an example of reading an odd bi-hour or hour is reported, which specifically tells the hours 5, 45 minutes and 75 bi- seconds; on the other hand, referring to Figure 4, an example of an even hour reading is reported: 6 hours, 45 minutes and 75 bi-seconds.

The watch based on the present invention is designed to improve the quality of life of those who use it, and to transfer to its user, in a subliminal way, new information that communicates with the individual who wears it and check it regularly (by following the instructions listed below in the methods of use), with the arrangement of the twenty-four hours, the setting of the numbers on the quadrant and the different way of marking time.

This time language, which brings to light the Golden Code (starting point of this project), is a universal language that communicates with all the cells of the body. The genetic code, in fact, is structured on the basis of the same golden code, and naturally adapts to the golden pattern, recognizing it as the first model. Once the genetic code becomes aware of this model thanks to the use of the watch based on the present invention, it autonomously reprograms the information contained in the cells, updating it according to the Golden Code.

Therefore, the human DNA that responds to the recognized information is influenced by the temporal language marked by the watch based on the present invention, and is consequently harmonized on the basis of the new notions communicated. It then models the cells and the entire body system, according to the original code and well-being.

Informed of the existence of the golden code received through the use and observation of the watch based on the present invention, the body then aligns with the original code: in this way, the cells that interact naturally with this code adapt their own structure, dissonant in case of illness, to the perfect harmony marked by the new time system.

The watch based on the present invention acts on the individual according to the Resonance Principle, which establishes a link between the communication emitted and contained by the cells and that imposed by the surrounding environment. The information contained in the cells, on which the health of the individual depends, according to this principle, is affected by the environment in which the subject interacts, and above all by the emissive devices of the archetypal language, consisting of numbers (or letters) like the watch.

A further substantial element to determine very important benefits for the individual who uses the watch based on the present invention is the counterclockwise movement of the hands. Being leftward (going from right to left), it is designed to align the time marked by the watch based on present invention to the motion of revolution that makes the Earth orbit the Sun in a year, differently from the common clock that follows the rotation movement. This modification is applied in a way that allows the time defined by the watch based on the present invention to align with the solar cycle of annual duration, and not with the terrestrial cycle of daily duration. This results in a radical change in circadian rhythms, which naturally tend to tune to the new temporal scan and align with the solar flux in their evolution and duration. Based on these rhythms precisely determined by the time scan, the human metabolism adapts to the new information defined by the time marked by the watch based on the present invention, adapting its systems to the cycle of the Sun, the epicenter of our solar system that most planets orbit counterclockwise.

The cells, which recognize the temporal information, adapt to the notions determined by the new scan; they also adapt the rhythms of their growth and consequent deterioration to the new measure aligned with the annual cycle. In this way, as they are governed by the temporal information, they naturally tend to follow the new scan, thus slowing down their aging and extending their life span. Consequently, metabolism adapts its physiological and biological rhythms, setting the organism on the new solar cycle. This mechanism leads the subject to follow the hours of darkness and light determined by the rising and setting of the Sun, thus bringing the individual to wake up and sleep ‘earlier’, in a way that makes the most of the natural time cycle of light. It also makes the time between wakefulness and sleep equivalent, which produces an indispensable regeneration of the organism.

Examples of usage of the device for conditioning the metabolism, the circadian rhythms and the cell viability. Tested case studies

Twenty wristwatch and twenty wall clock prototypes were made of the device for conditioning the metabolism, the circadian rhythms and the cell viability based on the present invention, which served to test the instrument on people and environments.

The double-blind scientific experiment was carried out on four groups, for a total of seventy patients:

- Group 1 or control, 10 patients who do not use any clock;

- Group 2, a group of 20 patients who tested the device for conditioning the metabolism, the circadian rhythms and the cell viability in its wristwatch form;

- Group 3, a group of 20 patients who used the device for conditioning the metabolism, the circadian rhythms and the cell viability in its wall clock form;

- Group 4, a group of 20 patients who used a common mechanical watch. The anticipated and previously explained benefits were consolidated by a case study of seventy subjects, men and women aged between 25 and 70, who spontaneously underwent the experiment.

The tests were carried out at the holistic research and experimentation center 7 Segreti di Sophia. Centro Alchemico per il benessere e I’evoluzione Umana’ in Lecce. They started on 9 December 2016, in the presence of researcher and creator of the present project Claudia Pellegrino, microbiologist and virologist Serena Mumolo, engineer Cesare Taurino and the seventy volunteers, who witnessed the clinical analyses carried out before, after and during the use, and its results.

The analyses listed below were carried out with the aim of demonstrating the beneficial effects on health for using the device for conditioning the metabolism, the circadian rhythms and the cell viability based on the present invention compared to the use of a common mechanical watch.

The experiment was carried out in order to evaluate the real physiological and psychological changes that occur in a patient subjected to the influence of a common mechanical watch, differently from a patient influenced by the device for conditioning the metabolism, the circadian rhythms and the cell viability, and consequently to establish a scientific and reproducible methodology.

In order to have parameters to compare, about ten days before the start of the scientific experimentation, all seventy volunteers underwent autonomously basic hematological analyses carried out at time minus one, such as CBC, Hematocrit, Homocysteine, Transaminase, Total bilirubin, Urine Analysis, Turbidity, Ketone bodies and epH. These analyses were provided on 9 December 2016 and proved the patients’ previous health status. On the same day, the first Darkfield Microscopy { DFM) or Brightfield Microscopy on live blood was performed on the participants at time zero, with the use of a brightfield reflected light microscope. It is known that the DFM allows a high-contrast representation of a live capillary blood sample that is illuminated obliquely by the reflected light of the microscope.

These time-zero analyses represent the official start of the scientific experimentation. They revealed the starting health conditions of the participants and the detailed blood morphology and vitality. These analyses were carried out according to the method of G. Enderlein under a brightfield microscope with live blood taken at the time. They were specifically used to evaluate the size and shape of the erythrocytes, the oxygenation of the red cells, the presence of symbiotic microorganisms or parasites, the vital resistance of the blood, the presence of metabolic toxins, the presence of acute or chronic inflammatory states due to fungi and bacteria, the electromagnetic pollution of the blood.

As there were no significant differences between the groups at the start date of the trial, the results of the first analyses, both those carried out at time minus one and those at time zero, were compared in a single average.

Analysis at time minus one:

Types of analysis: CBC, Hematocrit, Homocysteine, Transaminase G.O.T, G.P.T, Total Bilirubin, Urine Analysis, Turbidity, Ketone bodies and epH.

Results of the basic hematological analyses provided by the 70 patients:

- Group 1 or total control of 10 patients;

- Group 2, group of 20 patients with wristwatch based on the present invention;

- Group 3, group of 20 patients with wall clock based on the present invention;

- Group 4, group of 20 patients with common mechanical watch.

Blood count: Values detected in male patients between 39 and 59%, on average equal to 40%; in female patients between 36 and 47%, on average equal to 38%.

Hematocrit: Values detected in male patients between 35 and 50%, on average equal to 39%; in female patients between 34 and 40%, on average equal to 35%.

Homocysteine: Values detected in patients between 4 and 12 micromoles per liter (4-12pmol/L), on average equal to 10 pmol/L.

Transaminases: ALT values detected in male patients between 7 and 55, average value found 30; for women measured values between 7 and 45, average value found 28. AST values detected in adult men, between 8 and 48 U/L, average value found 28 U/L; values found in women between 8 and 43 U/L, average value found 20; in female patients between 36 and 47%, on average equal to 38%.

Bilirubin: Values detected in patients between 0.5 and 1 .1 mg/dL, on average equal to 8.

Urine Analysis:

Ketone bodies: Values found in patients between 0.6 and 1 .5 pmol/L, measured on average at 1 .2 pmol/L.

pH: Values detected in patients between 4.6 and 6.5 acid pH on averagely set at 5.5/6.0.

Time-zero analyses performed on site at the time in brightfield reflected light microscopy on the 70 patients undergoing the experiment:

- Group 1 or total control of 10 patients;

- Group 2, group of 20 patients with wristwatch based on the present invention;

- Group 3, group of 20 patients with wall clock based on the present invention;

- Group 4, group of 20 patients with common mechanical watch.

Results of brightfield microscopy analyses carried out on 70 patients.

The values report the average of the health status of the blood, evaluating the value of the Zeta Potential, a colloidal particle suspended in the blood that indicates the negative or positive ionic charge around the colloid.

If the Zeta Potential is low, there will be a high presence of metabolic toxins that cannot be eliminated, and nutrients cannot be absorbed and conducted to the cell.

- Red blood cell oxygenation: medium-low in 80% of patients, low in 19% of patients, high in 1 % of patients;

- Presence of symbiotic microorganisms: poor oxygenation, acidosis state of the tissue matrix in 80% of patients, low in 19% of patients, high in 1 % of patients;

- Vital blood resistance: still blood, poor resistance in 80% of patients, low in 19% of patients, high in 1 % of patients;

- Presence of metabolic toxins: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients;

- Presence of acute or chronic inflammatory states due to fungi and bacteria: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients;

- Electromagnetic pollution of the blood: high presence of electromagnetic pollution found on 28 patients out of 70.

Physiological and biological rhythm detection through questionnaire

On the same date, thanks to a questionnaire specifically designed and administered to the participants:

- Personal sleep-wake cycles;

- Intestinal regularity;

- The predominant emotional state.

In addition, information on the last three menstrual cycles was collected in women.

The first questionnaire included 14 questions for men and 18 for women, through which the 70 patients provided basic information regarding their biological and physiological rhythms, and their prevalent emotional state.

The patients answered the questions by crossing‘Yes’,‘No’, or Other’ on an answer sheet. In the case of an "Other" response, they had to specify the alternative.

Required questions for men and women:

1 ) Do you wake up in the morning between 5:00 and 6:00?

2) Do you wake up in the morning between 6:00 and 7:00?

3) Do you set the alarm to get up?

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.?

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.?

6) Do you rest well?

7) Do you suffer from insomnia?

8) Do you wake up rested?

9) Do you defecate on a daily basis?

10) Do you defecate less than four times a week?

11 )Do you have attacks of anger or incidents of violence?

12) Do you regularly have negative thoughts?

13) Do you feel satisfied with your life?

14) Do you think you are happy?

Questions planned for women: 1 ) Do you have regular 28-day menses?

2) Is your flow abundant?

3) Do you have pain during the menses?

4) Do they last four/five days?

Results of the questionnaire

The results were measured on the basis of the percentage of‘Yes’,‘No’, and Other’.

As in the previous tests, since there were no significant changes at time zero among the groups, they were compared by applying a single average that adds up the results of the 70 patients.

- Group 1 or total control of 10 patients;

- Group 2, group of 20 patients with wristwatch based on the present invention;

- Group 3, group of 20 patients with wall clock based on the present invention;

- Group 4, group of 20 patients with common mechanical watch.

The patients answered questions in actual number:

1 ) Do you wake up in the morning between 5:00 and 6:00? 5 YES, 57 NO, 7 OTHER

2) Do you wake up in the morning between 6:00 and 7:00? 51 YES, 10 NO, 9 OTHER

3) Do you set the alarm to get up? 40 YES, 20 NO, 10 OTHER

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.? 0 YES, 64 NO 6 OTHER

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.? 50 YES, 10, NO, 10 OTHER

6) Do you rest well? 28 YES, 43 NO, 9 OTHER

7) Do you suffer from insomnia? 15 YES, 38 NO, 17 OTHER

8) Do you wake up rested? 20 YES, 33 NO, 18 OTHER

9) Do you defecate on a daily basis? 18 YES, 47 NO, 5 OTHER

10)Do you defecate less than four times a week? 27 YES, 34 NO, 9 OTHER

11 )Do you have attacks of anger or incidents of violence? 32 YES, 13 NO, 25 OTHER

12) Do you regularly have negative thoughts? 44 YES, 1 1 NO, 15 OTHER

13) Do you feel satisfied with your life? 5 YES, 59 NO, 6 OTHER

14)Do you think you are happy? 3 YES, 20 NO, 47 OTHER

Questions for the 38 women present in the experiment:

1 ) Do you have regular 28-day menses? 19 YES, 1 1 NO, 8 OTHER

2) Is your flow abundant? 15 YES, 18 NO, 5 OTHER

3) Do you have pain during the menses? 20 YES, 9 NO, 1 1 OTHER

4) Do they last four/five days? 23 YES, 9 NO, 7 OTHER

Initial considerations revealed by the questionnaire

At Time Zero, most subjects’ sleep-wake cycles are synchronized on a wake-up time between 6:00 and 7:00 a.m., and sleep between 1 1 :00 p.m. and 1 :00 a.m.

In most patients, sleep turns out to be unrewarding, and intestinal regularity is absent. The predominant emotional state reveals considerable dissatisfaction in their lives, and in different subjects, episodes violence and anger. All subjects underwent blood pressure (BP) measurements with the mercury sphygmomanometer.

As in the previous tests, since there were no significant changes at time zero among the groups, they were compared by applying a single average that adds up the results of the 70 patients.

Results:

- Group 1 or total control of 10 patients;

- Group 2, group of 20 patients with wristwatch based on the present invention;

- Group 3, group of 20 patients with wall clock based on the present invention;

- Group 4, group of 20 patients with common mechanical watch.

Data collected

2 patients show a pressure between 50/90 and 60/100; 23 patients show a pressure between 60/100 and 60/120;

39 patients show a pressure between 70/130 and 70/140;

5 patients showed pressure between 80/140 and 80/160.

Patients’ pressure data showed a tendency to high pressure, with the optimal values corresponding to 70-80/1 10 for women and 70-80/120 for men.

Prototype delivery

On the same date, at the beginning of the scientific experimentation, the prototypes were delivered to the participants, who were instructed to activate them with battery support at midnight of that day.

Every subject has followed the instructions for use provided by the creator. They inserted the watch based on the present invention into their daily life gradually, as indicated in the program (specified below in the Models of use).

Following Time-One analyses

The following analyses were carried out at Time One, that is, six months after the experiment, on 6 June 2017. Always in the presence of all the subjects listed above. On this date, the seventy participants provided the first verification analyses, carried out independently in the preceding days. The following were checked again: CBC, Hematocrit, Homocysteine, Transaminase, Bilirubin, Urine Analysis, Ketone bodies and epH.

Results:

The results of the analyses submitted were determined as a single sum for each group:

- Group 1 or total control of 10 patients;

Blood analysis:

CBC: Values detected in male patients between 39 and 59%, on average equal to 40%; in female patients between 36 and 47%, on average equal to 38%.

Hematocrit: Values detected in male patients between 35 and 50%, on average equal to 39%; in female patients between 34 and 40%, on average equal to 35%.

Homocysteine: Values detected in patients between 4 and 12 micromoles per liter (4-12 pmol/L), on average equal to 10 pmol/L.

Transaminases: ALT values detected in male patients between 7 and 55, average value found 30; for women, values between 7 and 45, average value found 28. AST values detected in adult men, between 8 and 48 U/L, average value found 28 U/L; values found in women between 8 and 43 U/L, average value found 20; in female patients between 36 and 47%, on average equal to 38%.

Bilirubin: Values detected by patients between 0.5 and 1.1 mg/dL, on average equal to 8.

Urine Analysis:

Ketone bodies: Values found in patients between 0.6 and 3.0 pmol/L, measured on average at 1.5 pmol/L.

pH: Values measured in patients between 4.0 to 6.0, acid pH on average set at 5.

- Group 2, group of 20 patients with wristwatch based on the present invention;

Blood analysis:

Blood count: Values detected in male patients between 39 and 59%, on average equal to 45%; in female patients between 36 and 47%, on average equal to 39%.

Hematocrit: Values detected in male patients between 37 and 47%, on average equal to 40%; in female patients between 34 and 40%, on average equal to 36%.

Homocysteine: Values detected by patients between 6 and 12 micromoles per liter (6-12pmol/L), on average equal to 8 pmol/L.

Transaminases: ALT values detected in male patients between 5 and 45, average value found 20; for women, values between 2 and 20, average value found 7. AST values detected in adult men between 8 and 40 U/L, average value found 15 U/L; values found in women between 8 and 38 U/L, average value found 11. Total bilirubin: Values detected by patients between 0.3 and 1 .0 img/dL, on average equal to 0.7.

Urine Analysis:

Ketone bodies: Values found in patients between 0.6 and 3.0 pmol/L, measured on average at 0.8 pmol/L

pH: Values measured in patients between 6.0 and 8.5, on average set at 7.

- Group 3, group of 20 patients with wall clock based on the present invention;

Blood analysis:

Blood count: Values detected in male patients between 39 and 59%, on average equal to 42%; in female patients between 36 and 47%, on average equal to 38%.

Hematocrit: Values detected in male patients between 35 and 50%, on average equal to 39%; in female patients between 34 and 40%, on average equal to 35%.

Homocysteine: Values detected by patients between 4 and 12 micromoles per liter (4-12pmol/L), on average equal to 10 pmol/L.

Transaminases: ALT values detected in male patients between 7 and 55, average value found 30; for women, values measured between 7 and 45, average value found 20. AST values detected in adult men between 8 and 48 U/L, average value found 28 U/L; values found in women between 8 and 43 U/L, average value found 20, in female patients between 36 and 47%, on average equal to 38%.

Bilirubin: Values detected by patients between 0.5 and 1 .1 mg/dL, on average equal to 0.7.

Urine Analysis:

Ketone bodies: Values found in patients between 0.6 and 3.0 pmol/L, measured on average at 0.9 pmol/L.

pH: Values measured in patients between 4.6 and 7.5 on average set at 6.

- Group 4, group of 20 patients with common mechanical watch.

Blood analysis:

Blood count: Values detected in male patients between 39 and 59%, on average equal to 40%; in female patients between 36 and 47%, on average equal to 38%.

Hematocrit: Values detected in male patients between 35 and 50%, on average equal to 39%; in female patients between 34 and 40%, on average equal to 35%.

Homocysteine: Values detected in patients between 4 and 12 micromoles per liter (4-12pmol/L), on average equal to 10 pmol/L.

Transaminases: ALT values detected in male patients between 7 and 55, average value found 30; for women, values measured between 7 and 45, average value found 28. AST values detected in adult men, between 8 and 48 U/L, average value found 28 U/L; values found in women between 8-43 U/L, average value found 20, in female patients between 36 and 47%, on average equal to 38%.

Bilirubin: Values detected by patients between 0.5 and 1 .1 mg/dL, on average equal to 8.

Urine Analysis:

Ketone bodies: Values found in patients between 0.6 and 1 .5 pmol/L, measured on average at 1 .5 pmol/L

pH: Values measured in patients between 4.0 to 6.0, acid pH on average set at 5.

The analyses with brightfield reflected light microscopy were repeated on the spot, six months after the beginning of the on-site experimentation.

The values report the average of the blood state of health, and estimate the value of the Zeta Potential, a colloidal particle suspended in blood indicating the negative or positive ionic charge around the colloid.

If the Zeta potential is low, there will be a high presence of metabolic toxins that cannot be eliminated, and nutrients cannot be absorbed and conducted to the cell.

- Group 1 or total control of 10 patients;

- Red blood cell oxygenation: medium low in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Presence of symbiotic microorganisms: poor oxygenation, acidosis state of the tissue matrix in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Vital resistance of the blood: still blood, poor resistance in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Presence of metabolic toxins: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients.

- Presence of acute or chronic inflammatory states due to fungi and bacteria: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients.

- Electromagnetic pollution of the blood: high presence of electromagnetic pollution found on 4 out of 10 patients.

- Group 2, group of 20 patients with wristwatch based on the present invention;

- Red blood cell oxygenation: medium low in 15% of patients, low in 15% of patients, high in 70% of patients.

- Presence of symbiotic microorganisms: poor oxygenation, acidosis state of the tissue matrix in 15% of patients, low in 15% of patients, high in 70% of patients.

- Vital blood resistance: still blood, poor resistance in 20% of patients, low in 10% of patients, high in 70% of patients.

- Presence of metabolic toxins: high presence of metabolic toxins in 10% of patients, medium presence of metabolic toxins in 10% of patients, low presence of metabolic toxins in 80% of patients.

- Presence of acute or chronic inflammatory states due to fungi and bacteria: high presence of metabolic toxins in 20% of patients, medium presence of metabolic toxins in 10% of patients, low presence of metabolic toxins in 70% of patients.

- Electromagnetic pollution of the blood: high presence of electromagnetic pollution found in 2 out of 20 patients.

- Group 3, group of 20 patients with wall clock based on the present invention; - Red blood cell oxygenation: medium low in 25% of patients, low in 25% of patients, high in 50% of patients

- Presence of symbiotic microorganisms: poor oxygenation, acidosis state of the tissue matrix in 25% of patients, low in 25% of patients, high in 50% of patients.

- Vital blood resistance: still blood, low resistance in 20% of patients, low in 20% of patients, high in 60% of patients.

- Presence of metabolic toxins: high presence of metabolic toxins in 20% of patients, medium presence of metabolic toxins in 20% of patients, low presence of metabolic toxins in 60% of patients.

- Presence of acute or chronic inflammatory states due to fungi and bacteria: high presence of metabolic toxins in 30% of patients, medium presence of metabolic toxins in 15% of patients, low presence of metabolic toxins in 55% of patients.

- Electromagnetic pollution of the blood: high presence of electromagnetic pollution found in 2 out of 20 patients.

- Group 4, group of 20 patients with common mechanical watch;

- Red blood cell oxygenation: medium low in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Presence of symbiotic microorganisms: poor oxygenation, acidosis state of the tissue matrix in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Vital blood resistance: still blood, poor resistance in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Presence of metabolic toxins: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients.

- Presence of acute or chronic inflammatory states due to fungi and bacteria: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients

- Electromagnetic pollution of the blood: high presence of electromagnetic pollution found on 4 out of 10 patients.

All subjects underwent blood pressure (BP) measurements with mercury sphygmomanometer.

They were then compared by applying a single average for each group.

Results:

- Group 1 or total control of 10 patients;

The 10 patients maintain an average pressure between 70/150;

- Group 2, group of 20 patients with wristwatch based on the present invention;

The 20 patients who used the wristwatch based on the present invention for six months maintain an average pressure between 70/120;

- Group 3, group of 20 patients with wall clock based on the present invention;

The 20 patients who used the wall clock based on the present invention for six months maintain an average pressure between 70/130;

- Group 4, group of 20 patients with common mechanical watch;

The 20 patients who used the common mechanical watch average pressure between 60/140.

During the meeting, the questionnaire was repeated, this time asking also personal considerations regarding the changes noted concerning one’s daily, biological and physiological rhythms, as well as any emotional variations.

Results of the questionnaire

The results were measured on the basis of the percentage of ‘Yes’,‘No’, and Other’.

- Group 1 or total control of 10 patients;

Patients answered questions in real numbers:

1 ) Do you wake up in the morning between 5:00 and 6:00? 1 YES, 7 NO, 2 OTHER

2) Do you wake up in the morning between 6:00 and 7:00? 5 YES, 4 NO, 1 OTHER 3) Do you set the alarm to get up? 7 YES, 2 NO, 1 OTHER

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.? 0 YES, 8 NO 2 OTHER

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.? 7 YES, 2, NO, 1 OTHER

6) Can you rest well? 2 YES, 6 NO, 2 OTHER

7) Do you suffer from insomnia? 1 YES, 6 NO, 3 OTHER

8) Do you wake up rested? 2 YES, 3 NO, 5 OTHER

9) Do you defecate on a daily basis? 2 YES, 6 NO, 2 OTHER

10) Do you defecate less than four times a week? 2 YES, 4 NO, 6 OTHER 11 )Do you have attacks of anger or incidents of violence? 3 YES, 3 NO, 4

OTHER

12)Do you regularly have negative thoughts? 4 YES, 1 NO, 5 OTHER

13)Do you feel satisfied with your life? 1 YES, 8 NO, 1 OTHER

14)Do you think you are happy? 0 YES, 6 NO, 4 OTHER

15) Have you noticed any changes in your physiological rhythms in the past 6 months? 0 YES, 5 NO, 0 OTHER

16) Have you noticed any changes in mood in the past 6 months? 0 YES, 5 NO, 0 OTHER

17) Have you noticed a change in sleep-wake rhythms? 0 YES, 5 NO, 0 OTHER

18) Have you noticed a greater centering in the last 6 months? 0 YES, 5 NO, 0 OTHER

19) Have you noticed any different predisposition to physical activity in the last 6 months? 0 YES, 5 NO, 0 OTHER

Questions provided for the 5 women present in the experiment:

1 ) Do you have regular 28-day menses? 2 YES, 2 NO, 1 OTHER

2) Is your flow abundant? 1 YES, 3 NO, 1 OTHER

3) Do you have pain during the menses? 2 YES, 2 NO, 1 OTHER

4) Do they last four/five days? 2 YES, 1 NO, 2 OTHER

- Group 2, group of 20 patients with wristwatch based on the present invention;

Patients answered questions in real numbers: 1 ) Do you wake up in the morning between 5:00 and 6:00? 12 YES, 5 NO, 3 OTHER

2) Do you wake up in the morning between 6:00 and 7:00? 5 YES, 12 NO, 3 OTHER

3) Do you set the alarm to get up? 2 YES, 14 NO, 4 OTHER

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.? 8 YES, 6 NO 6 OTHER

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.? 5 YES, 8, NO, 7 OTHER

6) Can you rest well? 14 YES, 3 NO, 3 OTHER

7) Do you suffer from insomnia? 0 YES, 18 NO, 2 OTHER

8) Do you wake up rested? 16 YES, 2 NO, 2 OTHER

9) Do you defecate on a daily basis? 18 YES, 1 NO, 1 OTHER

10) Do you defecate less than four times a week? 0 YES, 1 NO, 1 OTHER

11 )Do you have attacks of anger or incidents of violence? 2 YES, 13 NO,

5 OTHER

12)Do you regularly have negative thoughts? 4 YES, 11 NO, 5 OTHER

13)Do you feel satisfied with your life? 10 YES, 5 NO, 5 OTHER

14)Do you think you are happy? 9 YES, 3 NO, 8 OTHER

15) Have you noticed any changes in your physiological rhythms in the past

6 months? 16 YES, 2 NO, 2 OTHER

16) Have you noticed any changes in mood in the past 6 months? 14 YES, 3 NO, 3 OTHER

17) Have you noticed a change in sleep-wake rhythms? 14 YES, 4 NO, 2 OTHER

18) Have you noticed a greater centering in the last 6 months? 14 YES, 3 NO, 3 OTHER

19) Have you noticed any different predisposition to physical activity in the last 6 months? 13 YES, 3 NO, 4 OTHER

Questions provided for the 1 1 women present in the experiment:

1 ) Do you have regular 28-day menses? 7 YES, 2 NO, 2 OTHER

2) Is your flow abundant? 6 YES, 4 NO, 1 OTHER

3) Do you have pain during the menses? 2 YES, 8 NO, 1 OTHER 4) Do they last four/five days? 6 YES, 3 NO, 2 OTHER

- Group 3, group of 20 patients with wall clock based on the present invention;

Patients answered questions in real numbers:

1 ) Do you wake up in the morning between 5:00 and 6:00? 5 YES, 7 NO, 8 OTHER

2) Do you wake up in the morning between 6:00 and 7:00? 8 YES, 5 NO,

7 OTHER

3) Do you set the alarm to get up? 6 YES, 10 NO, 4 OTHER

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.?

8 YES, 8 NO 4 OTHER

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.? 10 YES, 7 NO, 3 OTHER

6) Can you rest well? 1 1 YES, 3 NO, 6 OTHER

7) Do you suffer from insomnia? 1 YES, 17 NO, 2 OTHER

8) Do you wake up rested? 14 YES, 3 NO, 3 OTHER

9) Do you defecate on a daily basis? 14 YES, 4 NO, 1 OTHER

10) Do you defecate less than four times a week? 2 YES, 14 NO, 4 OTHER

11 )Do you have attacks of anger or incidents of violence? 2 YES, 13 NO,

5 OTHER

12)Do you regularly have negative thoughts? 4 YES, 11 NO, 5 OTHER

13)Do you feel satisfied with your life? 6 YES, 5 NO, 9 OTHER

14)Do you think you are happy? 6 YES, 5 NO, 9 OTHER

15) Have you noticed any changes in your physiological rhythms in the past

6 months? 12 YES, 5 NO, 3 OTHER

16) Have you noticed any changes in mood in the past 6 months? 1 1 YES, 5 NO, 4 OTHER

17) Have you noticed a change in sleep-wake rhythms? 12 YES, 5 NO, 7 OTHER

18) Have you noticed a greater centering in the last 6 months? 9 YES, 5 NO, 6 OTHER

19) Have you noticed any different predisposition to physical activity in the last 6 months? 9 YES, 5 NO, 6 OTHER Questions provided for the 1 1 women present in the experiment:

1 ) Do you have regular 28-day menses? 7 YES, 5 NO, 8 OTHER

2) Is your flow abundant? 1 1 YES, 8 NO, 1 OTHER

3) Do you have pain during the menses? 3 YES, 9 NO, 8 OTHER

4) Do they last four/five days? YES, 9 NO, 7 OTHER

- Group 4, group of 20 patients with common mechanical watch;

Patients answered questions in real numbers:

1 ) Do you wake up in the morning between 5:00 and 6:00? 1 YES, 15 NO,

4 OTHER

2) Do you wake up in the morning between 6:00 and 7:00? 11 YES, 4 NO,

5 OTHER

3) Do you set the alarm to get up? 17 YES, 2 NO, 1 OTHER

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.? 0 YES, 18 NO 2 OTHER

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.? 15 YES, 2 NO, 3 OTHER

6) Can you rest well? 2 YES, 14 NO, 4 OTHER

7) Do you suffer from insomnia? 7 YES, 8 NO, 5 OTHER

8) Do you wake up rested? 6 YES, 10 NO, 4 OTHER

9) Do you defecate on a daily basis? 7 YES, 10 NO, 3 OTHER

10) Do you defecate less than four times a week? 8 YES, 8 NO, 4 OTHER 11 )Do you have attacks of anger or incidents of violence? 8 YES, 3 NO, 9

OTHER

12)Do you regularly have negative thoughts? 1 1 YES, 5 NO, 4 OTHER

13)Do you feel satisfied with your life? 2 YES, 14 NO, 4 OTHER

14)Do you think you are happy? 1 YES, 17 NO, 2 OTHER

15) Have you noticed any changes in your physiological rhythms in the past

6 months? 0 YES, 20 NO, 0 OTHER

16) Have you noticed any changes in mood in the past 6 months? 0 YES, 20 NO, 0 OTHER

17) Have you noticed a change in sleep-wake rhythms? 0 YES, 20 NO, 0 OTHER

18) Have you noticed a greater centering in the last 6 months? 0 YES, 5 NO, 0 OTHER

19) Have you noticed any different predisposition to physical activity in the last 6 months? 0 YES, 5 NO, 0 OTHER

Questions provided for the 1 1 women present in the experiment:

1 ) Do you have regular 28-day menses? 4 YES, 7 NO, 9 OTHER

2) Is your flow abundant? 10 YES, 8 NO, 2 OTHER

3) Do you have pain during the menses? 16 YES, 2 NO, 2 OTHER

4) Do they last four/five days? 3 YES, 9 NO, 8 OTHER

The comparison between the time-minus-one and the time-zero tests, compared to the time-one tests, show a considerable variation in the four groups.

Six-month results:

- Group 1 or control: from the various tests carried out, it is possible to detect that the patients’ health has remained unchanged;

- Group 2: the group of 20 patients who tested the wristwatch based on the present invention showed:

- Gradual improvement of the emotional state measured by questionnaire;

- Greater ability to be assertive or centered, measured by the answers to the questionnaire;

- Greater propensity to physical activity, measured by answers of the questionnaire;

- Intestinal regularity, measured by the answers to the questionnaire;

- General well-being, measured by the comparison of hematological analyses of blood and brightfield reflected light microscopy;

- Adaptation of the circadian rhythms to the passing of day and night, measured by the answers to the questionnaire;

- Increase in the hours of night rest, measured by the answers to the questionnaire;

- Synchronization of one’s own biological alarm clock with the sunrise, measured by the answers to the questionnaire;

- pH improvement from 4.5-6.0 to 7.0-8.5, measured by the comparison of the urine analyses.

- Group 3: the group of 20 patients who tested the wall clock based on the present invention in their own houses showed a difference in results, based on how long the patient stayed in the room with the wall clock, observing it for at least twenty minutes daily.

Of these twenty patients, the best results on the state of health depended on the amount of time spent observing the watch based to the present invention.

Five patients observed the watch based on the present invention for twenty minutes during the day;

Five patients observed the watch based on the present invention for thirty forty minutes during the day;

Five patients observed the watch based on the present invention for fifty minutes during the day;

Five patients observed the watch based on the present invention for over an hour during the day.

The longer they observed, the better the state of health resulted from the tests.

In the optimal cases tested to observe the mechanism at different times during the day for over an hour, the following changes were observed, just as for the group of subjects with wristwatch:

- Gradual improvement of the emotional state, measured by the questionnaire;

- Greater ability to be assertive or centered, measured by the answers to the questionnaire;

- Greater propensity to physical activity, measured by the answers to the questionnaire;

- Intestinal regularity, measured by the answers to the questionnaire;

- General well-being, measured by the comparison of hematological analyses of blood and brightfield reflected light microscopy;

- Adaptation of one’s circadian rhythms to the passing of day and night, measured by the answers to the questionnaire;

- Increase in the hours of night rest, measured by the answers to the questionnaire;

- Synchronization of the biological alarm clock with the sunrise, measured by the answers to the questionnaire;

- pH improvement from 4.5-6.0 to 7.0-8.5, measured by the comparison of the urine analyses.

All time-one clinical analyses, both those carried out autonomously and those carried out on site with brightfield microscopy, demonstrated a considerable improvement from the previous state of health in 76% of the patients who used the wristwatch or the wall clock based on the present invention.

From the data, the blood of 30 patients taking part in the experiment, after a six-month period using the watch based on the present invention, is hydrated, oxygenated, free of harmful microorganisms and metabolic toxins; a decrease in viscosity was found, in favor of a greater increase in blood flow and a pH adjustment around 6-8.5.

In about three months, the chronic inflammatory states decreased and then disappeared completely in the remaining three months. A restoration of the intestinal bacterial flora was noted, as well.

In addition, it was possible to find in the same subjects a considerable change in the duration of the vitality of the blood (on a microscope slide), which after a six-month use of the watch based on the present invention, either in its wristwatch or wall clock form, was significantly increased.

- Group 4, a group of twenty patients who used the common mechanical watch: from the analyses, the state of health did not reveal any changes.

The remaining thirty subjects belonging to Group 1 and Group 4, namely, twenty patients who used the common mechanical watch, and ten patients who do not wear any watch, had no change in the blood values found by the analyses.

Time-two analyses, results after one year

One year after the start of the scientific experimentation, on 16 December 2017, the final, time-two analyses on the subjects were carried out. As before, they independently provided the basic analyses with the repetition of the same exams carried out previously, a few days before the meeting.

On this date, the latest verification analyses, carried out independently in the preceding days, were provided on the four groups of participants. The following aspects were checked: CBC; Hematocrit; Homocysteine, Transaminase, Total Bilirubin, Urine Analysis: Ketone Bodies and pH.

Results

The results of the analyses submitted were determined as a single sum for each group:

- Group 1 or total control of 10 patients;

Blood analysis:

CBC: Values detected in male patients between 39 and 59%, on average equal to 40%; in female patients between 36 and 47%, on average equal to 38%.

Hematocrit: Values detected in male patients, detected between 35 and 50%, on average equal to 39%; in female patients between 34 and 40%, on average equal to 35%.

Homocysteine: Values detected in patients between 4 and 12 micromoles per liter (4-12pmol/L), on average equal to 10 pmol/L.

Transaminases: ALT values detected in male patients between 7 and 55, average value found 30; for women, values measured between 7 and 45, average value found 28. AST values detected in adult men, between 8 and 48 U/L, average value found 28 U/L; Values found in women between 8 and 43 U/L, average value found 20, in female patients between 36 and 47%, on average equal to 38%.

Bilirubin: Values detected by patients between 0.5 and 1 .1 mg/dL, on average equal to 8.

Urine Analysis:

Ketone bodies: Values found in patients between 0.6 and 1 .5 pmol/L, measured on average at 1 .2 pmol/L.

pH: Values measured in patients between 4.0 to 6.0, acid pH on average set at 5. - Group 2, group of 20 patients with wristwatch based on the present invention;

Blood analysis:

CBC: Values detected in male patients between 39 and 59%, on average equal to 45%; in female patients between 36 and 47%, on average equal to 39%.

Hematocrit: Values detected in male patients between 37 and 47%, on average equal to 40%; in female patients between 34 and 40%, on average equal to 36%.

Homocysteine: Values detected in patients between 6 and 12 micromoles per liter (6-12pmol/L), on average equal to 8 pmol/L.

Transaminases: ALT values detected in male patients between 5 and 45, average value found 20; for women, values measured between 2 and 20, average value found 7. AST values detected in adult men between 8 and 40 U/L, average value found 15 U/L; Values found in women between 8 and 38 U/L, average value found 1 1.

Bilirubin: Values detected by patients between 0.5 and 1.1 mg/dL, on average equal to 0.8

Urine Analysis:

Ketone bodies: Values found in patients between 0.6 and 1.5 pmol/L, measured on average at 0.8 pmol/L

pH: Values measured in patients between 7.0 and 8.5

- Group 3, group of 20 patients with wall clock based on the present invention;

Blood analysis:

Blood count: Values detected in male patients between 39 and 59%, on average equal to 45%; in female patients between 36 and 47%, on average equal to 39%.

Hematocrit: Values detected in male patients between 37 and 47%, on average equal to 40%; in female patients between 34 and 40%, on average equal to 36%.

Homocysteine: Values detected by patients between 6 and 12 micromoles per liter (6-12pmol/L), on average equal to 8 pmol/L.

Transaminases: ALT values detected in male patients between 5 and 45, average value found 20; for women values measured between 2 and 20, average value found 7.

AST values detected in adult men between 8 and 40 U/L, average value found 15 U/L; Values found in women between 8 and 38 U/L, average value found 11.

Bilirubin: Values detected by patients between 0.5 and 1.1 mg/dL, on average equal to 0.8

Urine Analysis:

Ketone bodies: Values found in patients between 0.6 and 3.0 pmol/L, measured on average at 0.8 pmol/L

pH: Values measured in patients between 6.0 and 8.5 on average set at 7.0

- Group 4, group of 20 patients with common mechanical watch;

Blood analysis:

Blood count: Values detected in male patients between 39 and 59%, on average equal to 40%; in female patients between 36 and 47%, on average equal to 38%.

Hematocrit: Values detected in male patients between 35 and 50%, on average equal to 39%; in female patients between 34 and 40%, on average equal to 35%.

Homocysteine: Values detected by patients between 4 and 12 micromoles per liter (4-12pmol/L), on average equal to 10 pmol/L.

Transaminases: ALT values detected in male patients between 7-55, average value found 30; for women values measured between 7-45, average value found 28. AST values detected in adult men, between 8- 48 U/L, average value found 28 U/L; Values found in women between 8-43 U/L, average value found 20, in female patients between 36 and 47%, on average equal to 38%.

Bilirubin: Values detected by patients between 0.5 and 1.1 mg/dL, on average equal to 8.

Urine Analysis: Ketone bodies: Values found in patients between 0.6 and 1.5 pmol/L, measured on average at 1.2 pmol/L

pH: Values measured in patients between 4.6 to 6.0, acid pH on average set at 5.

The analyses with brightfield reflected light microscopy were repeated on the spot, six months after the beginning of the on-site experimentation.

- Group 1 or total control of 10 patients;

- Red blood cell oxygenation: medium low in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Presence of symbiotic microorganisms: poor oxygenation, acidosis state of the tissue matrix in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Vital blood resistance: still blood, poor resistance in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Presence of metabolic toxins: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients

- Presence of acute or chronic inflammatory states due to fungi and bacteria: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients.

- Electromagnetic pollution of the blood: high presence of electromagnetic pollution found on 4 out of 10 patients.

- Group 2, group of 20 patients with wristwatch based on the present invention;

- Red blood cell oxygenation: medium low in 15% of patients, low in 15% of patients, high in 70% of patients.

- Presence of symbiotic microorganisms: poor oxygenation, acidosis state of the tissue matrix in 10% of patients, low in 10% of patients, high in 80% of patients.

- Vital blood resistance: still blood, poor resistance in 10% of patients, low in 10% of patients, high in 80% of patients.

- Presence of metabolic toxins: high presence of metabolic toxins in 5% of patients, medium presence of metabolic toxins in 10% of patients, low presence of metabolic toxins in 85% of patients.

- Presence of acute or chronic inflammatory states due to fungi and bacteria: high presence of metabolic toxins in 10% of patients, medium presence of metabolic toxins in 10% of patients, low presence of metabolic toxins in 80% of patients.

- Electromagnetic pollution of the blood: high presence of electromagnetic pollution found on 0 patients out of 20.

- Group 3, group of 20 patients with wall clock based on the present invention;

- Red blood cell oxygenation: medium low in 20% of patients, low in 20% of patients, high in 60% of patients.

- Presence of symbiotic microorganisms: poor oxygenation, acidosis state of the tissue matrix in 20% of patients, low in 20% of patients, high in 60% of patients.

- Vital blood resistance: still blood, poor resistance in 10% of patients, low in 15% of patients, high in 75% of patients.

- Presence of metabolic toxins: high presence of metabolic toxins in 20% of patients, medium presence of metabolic toxins in 20% of patients, low presence of metabolic toxins in 60% of patients.

- Presence of acute or chronic inflammatory states due to fungi and bacteria: high presence of metabolic toxins in 20% of patients, medium presence of metabolic toxins in 15% of patients, low presence of metabolic toxins in 65% of patients.

- Electromagnetic pollution of the blood: high presence of electromagnetic pollution found on 0 patients out of 20.

- Group 4, group of 20 patients with common mechanical watch;

- Red blood cell oxygenation: medium low in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Presence of symbiotic microorganisms: poor oxygenation, acidosis state of the tissue matrix in 80% of patients, low in 19% of patients, high in 1 % of patients. - Vital resistance of the blood: still blood, poor resistance in 80% of patients, low in 19% of patients, high in 1 % of patients.

- Presence of metabolic toxins: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients

- Presence of acute or chronic inflammatory states due to fungi and bacteria: high presence of metabolic toxins in 70% of patients, medium presence of metabolic toxins in 18% of patients, low presence of metabolic toxins in 2% of patients

- Electromagnetic pollution of the blood: high presence of electromagnetic pollution found on 4 out of 10 patients.

All the subjects underwent blood pressure (BP) measurements with mercury sphygmomanometer. They were also compared by applying a single average for each group.

Results:

- Group 1 or total control of 10 patients;

The 10 patients maintain an average pressure between 70/150.

- Group 2, group of 20 patients with wristwatch based on the present invention;

The 20 patients who have been using the wristwatch based on the present invention for six months maintain an average pressure between 70/120.

- Group 3, group of 20 patients with wall clock based on the present invention;

The 20 patients who have been using the wall clock based on the present invention for six months maintain an average pressure between 70/130.

- Group 4, group of 20 patients with common mechanical watch;

The 20 patients who used the common mechanical watch maintain an average pressure between 60/140.

During the meeting, the questionnaire was reformulated, expanded on personal considerations regarding the changes noted about one’s daily rhythms, both biological and physiological, and about any emotional variations. Results of the questionnaire

The results were measured based on the percentage of ‘Yes’,‘No’, and Other’.

- Group 1 or total control of 10 patients;

Patients answered the questions in actual numbers:

1 ) Do you wake up in the morning between 5:00 and 6:00? 1 YES, 7 NO, 2 OTHER

2) Do you wake up in the morning between 6:00 and 7:00? 5 YES, 4 NO, 1 OTHER

3) Do you set the alarm to get up? 7 YES, 2 NO, 1 OTHER

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.? 0 YES, 8 NO 2 OTHER

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.? 7 YES, 2, NO, 1 OTHER

6) Can you rest well? 2 YES, 6 NO, 2 OTHER

7) Do you suffer from insomnia? 1 YES, 6 NO, 3 OTHER

8) Do you wake up rested? 2 YES, 3 NO, 5 OTHER

9) Do you defecate on a daily basis? 2 YES, 6 NO, 2 OTHER

10) Do you defecate less than four times a week? 2 YES, 4 NO, 6 OTHER

11 )Do you have attacks of anger or incidents of violence? 3 YES, 3 NO, 4 OTHER

12)Do you regularly have negative thoughts? 4 YES, 1 NO, 5 OTHER

13)Do you feel satisfied with your life? 1 YES, 8 NO, 1 OTHER

14)Do you think you are happy? 0 YES, 6 NO, 4 OTHER

15) Have you noticed any changes in your physiological rhythms in the past 6 months? 0 YES, 5 NO, 0 OTHER

16) Have you noticed any changes in mood in the past 6 months? 0 YES, 5 NO, 0 OTHER

17) Have you noticed a change in sleep-wake rhythms? 0 YES, 5 NO, 0

OTHER

18) Have you noticed a greater centering in the last 6 months? 0 YES, 5 NO, 0 OTHER 19) Have you noticed any different predisposition to physical activity in the last 6 months? 0 YES, 5 NO, 0 OTHER

Questions provided for the 5 women present in the experiment:

1 ) Do you have regular 28-day menses? 2 YES, 2 NO, 1 OTHER

2) Is your flow abundant? 1 YES, 3 NO, 1 OTHER

3) Do you have pain during the menses? 2 YES, 2 NO, 1 OTHER

4) Do they last four/five days? 2 YES, 1 NO, 2 OTHER

- Group 2, group of 20 patients with wristwatch based on the present invention;

Patients answered questions in real numbers:

1 ) Do you wake up in the morning between 5:00 and 6:00? 15 YES, 3 NO, 2 OTHER

2) Do you wake up in the morning between 6:00 and 7:00? 4 YES, 14 NO,

2 OTHER

3) Do you set the alarm to get up? 0 YES, 17 NO, 3 OTHER

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.? 14 YES, 3 NO 3 OTHER

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.? 1 YES, 15, NO, 4 OTHER

6) Can you rest well? 17 YES, 1 NO, 2 OTHER

7) Do you suffer from insomnia? 0 YES, 18 NO, 2 OTHER

8) Do you wake up rested? 18 YES, 0 NO, 2 OTHER

9) Do you defecate on a daily basis? 18 YES, 1 NO, 1 OTHER

10) Do you defecate less than four times a week? 0 YES, 17 NO, 3 OTHER

11 )Do you have attacks of anger or incidents of violence? 2 YES, 15 NO,

3 OTHER

12)Do you regularly have negative thoughts? 2 YES, 14 NO, 4 OTHER

13)Do you feel satisfied with your life? 12 YES, 3 NO, 5 OTHER

14)Do you think you are happy? 1 1 YES, 3 NO, 6 OTHER

15) Have you noticed any changes in your physiological rhythms in the past 6 months? 19 YES, 0 NO, 1 OTHER

16) Have you noticed any changes in mood in the past 6 months? 16 YES, 3 NO, 1 OTHER 17) Have you noticed a change in sleep-wake rhythms? 16 YES, 2 NO, 2 OTHER

18) Have you noticed a greater centering in the last 6 months? 15 YES, 3 NO, 2 OTHER

19)Have you noticed any different predisposition to physical activity in the last 6 months? 15 YES, 3 NO, 2 OTHER

Questions provided for the 1 1 women present in the experiment:

1 ) Do you have regular 28-day menses? 7 YES, 2 NO, 2 OTHER

2) Is your flow abundant? 6 YES, 4 NO, 1 OTHER

3) Do you have pain during the menses? 2 YES, 8 NO, 1 OTHER

4) Do they last four/five days? 6 YES, 3 NO, 2 OTHER

- Group 3, group of 20 patients with wall clock based on the present invention;

Patients answered questions in real numbers:

1 ) Do you wake up in the morning between 5:00 and 6:00? 14 YES, 3 NO, 3 OTHER

2) Do you wake up in the morning between 6:00 and 7:00? 3 YES, 14 NO, 3 OTHER

3) Do you set the alarm to get up? 3 YES, 13 NO, 4 OTHER

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.? 12 YES, 8 NO 1 OTHER

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.? 8 YES, 12 NO, 1 OTHER

6) Can you rest well? 14 YES, 3 NO, 3 OTHER

7) Do you suffer from insomnia? 1 YES, 17 NO, 2 OTHER

8) Do you wake up rested? 15 YES, 3 NO, 2 OTHER

9) Do you defecate on a daily basis? 16 YES, 2 NO, 2 OTHER

10) Do you defecate less than four times a week? 2 YES, 14 NO, 4 OTHER

11 )Do you have attacks of anger or incidents of violence? 2 YES, 13 NO, 5 OTHER

12)Do you regularly have negative thoughts? 3 YES, 12 NO, 5 OTHER

13)Do you feel satisfied with your life? 8 YES, 5 NO, 7 OTHER

14)Do you think you are happy? 6 YES, 5 NO, 9 OTHER 15) Have you noticed any changes in your physiological rhythms in the past 6 months? 15 YES, 3 NO, 2 OTHER

16) Have you noticed any changes in mood in the past 6 months? 14 YES, 2 NO, 4 OTHER

17) Have you noticed a change in sleep-wake rhythms? 12 YES, 5 NO, 7 OTHER

18) Have you noticed a greater centering in the last 6 months? 9 YES, 5 NO, 6 OTHER

19) Have you noticed any different predisposition to physical activity in the last 6 months? 9 YES, 5 NO, 6 OTHER

Questions provided for the 1 1 women present in the experiment:

1 ) Do you have regular 28-day menses? 7 YES, 5 NO, 8 OTHER

2) Is your flow abundant? 1 1 YES, 8 NO, 1 OTHER

3) Do you have pain during the menses? 3 YES, 9 NO, 8 OTHER

4) Do they last four/five days? YES, 9 NO, 7 OTHER

- Group 4, group of 20 patients with common mechanical watch;

Patients answered questions in real numbers:

1 ) Do you wake up in the morning between 5:00 and 6:00? 1 YES, 15 NO,

4 OTHER

2) Do you wake up in the morning between 6:00 and 7:00? 11 YES, 4 NO,

5 OTHER

3) Do you set the alarm to get up? 17 YES, 2 NO, 1 OTHER

4) Do you go to sleep in a time range between 8:00 p.m. and 10:00 p.m.? 0 YES, 18 NO, 2 OTHER

5) Do you go to sleep in a time band between 10:00 p.m. and 1 :00 a.m.? 15 YES, 2 NO, 3 OTHER

6) Can you rest well? 2 YES, 14 NO, 4 OTHER

7) Do you suffer from insomnia? 7 YES, 8 NO, 5 OTHER

8) Do you wake up rested? 6 YES, 10 NO, 4 OTHER

9) Do you defecate on a daily basis? 7 YES, 10 NO, 3 OTHER

10) Do you defecate less than four times a week? 8 YES, 8 NO, 4 OTHER 11 )Do you have attacks of anger or incidents of violence? 8 YES, 3 NO, 9

OTHER 12)Do you regularly have negative thoughts? 1 1 YES, 5 NO, 4 OTHER

13)Do you feel satisfied with your life? 2 YES, 14 NO, 4 OTHER

14)Do you think you are happy? 1 YES, 17 NO, 2 OTHER

15) Have you noticed any changes in your physiological rhythms in the past 6 months? 0 YES, 20 NO, 0 OTHER

16) Have you noticed any changes in mood in the past 6 months? 0 YES, 20 NO, 0 OTHER

17) Have you noticed a change in sleep-wake rhythms? 0 YES, 20 NO, 0 OTHER

18) Have you noticed a greater centering in the last 6 months? 0 YES, 5 NO, 0 OTHER

19) Have you noticed any different predisposition to physical activity in the last 6 months? 0 YES, 5 NO, 0 OTHER

Questions provided for the 1 1 women present in the experiment:

1 ) Do you have regular 28-day menses? 4 YES, 7 NO, 9 OTHER

2) Is your flow abundant? 10 YES, 8 NO, 2 OTHER

3) Do you have pain during the menses? 16 YES, 2 NO, 2 OTHER

4) Do they last four/five days? 3 YES, 9 NO, 8 OTHER

The comparison between the time-minus-one and time-zero tests, compared to the time-one tests, shows a considerable variation in the four groups.

Results after one year

- Group 1 or control: from the various tests carried out, it is possible to notice that the patients’ health has remained unchanged;

- Group 2: the group of 20 patients who tested the wristwatch based on the present invention showed:

- Further improvement of the emotional state, measured by the questionnaire;

- Greater ability to be assertive or centered, measured by the answers to the questionnaire;

- Greater propensity to physical activity, measured by the answers to the questionnaire; - Intestinal regularity, measured by the answers to the questionnaire;

- General well-being, assessed by the comparison of hematological analyses of blood and brightfield reflected light microscopy;

- Adaptation of one’s circadian rhythms to the passing of day and night, measured by the answers to the questionnaire;

- Increase in hours of night rest measured by the answers to the questionnaire;

- Synchronization of the biological alarm clock with the sunrise, measured by the answers to the questionnaire;

- pH improvement between 7.0 to 8.5, measured by the comparison of urine analyses.

- Group 3: the group of 20 patients who tested the wall clock based on the present invention in their own houses showed a difference in the results, relative to how long the patient stayed in the room with the wall clock observing it for at least twenty minutes a day.

Of these twenty patients, the best results on the state of health depended on the amount of time spent observing the watch based on the present invention.

Five patients observed the watch based on the present invention for twenty minutes during the day;

Five patients looked at the watch based on the present invention for thirty forty minutes during the day;

Five patients watched the watch based on the present invention for fifty minutes during the day;

Five patients looked at the watch based on the present invention for over an

hour during the day.

The longer they observed, the better was the state of health that resulted from the tests.

In the optimal cases tested to observe the mechanism at different times during the day for over an hour, the following changes were observed, just as for the group of subjects with wristwatch:

- Improvement of the emotional state measured by questionnaire; - Greater ability to be assertive or centered, measured by the answers to the questionnaire;

- Greater propensity to physical activity, measured by answers of the questionnaire;

- Intestinal regularity, measured by the answers to the questionnaire;

- General well-being, measured by the comparison of hematological analyses of blood and brightfield reflected light microscopy;

- Adaptation of the circadian rhythms to the passing of day and night, measured by the answers to the questionnaire;

- Increase in the hours of night rest, measured by the answers to the questionnaire;

- Synchronization of one’s own biological alarm clock with the sunrise, measured by the answers to the questionnaire;

- pH improvement from 4.5-6.0 to 7.0-8.5, measured by the comparison of the urine analyses.

All the time-two clinical analyses, both the analyses performed independently and the brightfield microscopy analyses carried out on site, demonstrated a considerable improvement from the previous state of health in 76% of the patients who used either the wristwatch or the wall clock based on the present invention.

From the data, the blood of 30 patients taking part in the experiment is hydrated, oxygenated, free of harmful microorganisms and metabolic toxins, finding a decrease in viscosity in favor of a greater increase in blood flow and a pH adjustment around 7.0-8.5, in a one-year use of the watch based on the present invention.

Chronic inflammatory states totally disappeared in most cases. A restoration of the intestinal bacterial flora was also noted.

In addition, it was possible to find in the same subjects a considerable change in the duration of the vitality of the blood (on a microscope slide), which after a six-month use of the watch based on the present invention, either in its wristwatch or wall clock form, was further increased.

- Group 4, a group of twenty patients who used the common mechanical watch: from the analyses, the state of health did not reveal any changes. The remaining thirty subjects belonging to Group 1 and Group 4, namely, twenty patients who used the common mechanical watch, and ten patients who do not wear any watch, had no change in the blood values found by the analyses.

Conclusions:

The last samples, performed in brightfield reflected light microscopy on live blood, have shown that the vital state of the thirty subjects’ (76%) blood improved in the first six months thanks to the daily use of the watch based on the present invention. Not only did it maintain the new state of health in all its values, but it even improved in oxygenation, as the homocysteine values were found to be below six pmol (micromoles).

After a one-year use of the watch based on the present invention, the 30 patients’ blood appears to be in an excellent state of hydration and health, more free from polluting agents, and with a pH that remains unchanged between 7 and 8.5.

The seventy patients’ blood viability of the four groups was compared after one year of use, and it was further increased in the thirty patients who had already seen improvements by using the wristwatch or wall clock based on the present invention in the first six months.

It was unchanged in the ten subjects belonging to Group 1 (control), or in the twenty patients of Group 4 who used the common mechanical watch.

Furthermore, it was possible to observe that in one year, all the forty patients using the wristwatch or wall clock prototypes based on the present invention adapted, with greater incidence in the patients who used the wristwatch based on the present invention, their organisms to the new temporal model. They aligned their circadian rhythms with the new temporal scan, and synchronized their biological rhythms with the natural light, greatly improving the state of health of body and mind.

From the last questionnaire administered to all the seventy subjects, it is also evident that the emotional state changed in those patients who used the wristwatch or wall clock based on the present invention for one year. It became almost free from angry or violent reactions.

In patients belonging to the control group or to Group 4 (those who used the mechanical watch), there were no emotional variations.

The liveliness of blood was obtained by comparing all the hematological tests provided by the patients and the brightfield reflected light microscopy tests performed on site.

The graph in Figure 5 shows the change in the viability of the blood in the four groups, examining the analyses performed in time minus one, time zero, time one, and time two (after one year).

The graph in figure 6 shows the changes in circadian rhythms over a determined period, represented by the abscissa graph with parameters from 1 to 6. The Y-axis represents the four groups, and the variations found on the different dates are indicated.

- Group 1 (control) remains unchanged throughout the experiment. This indicates that those who do not use any device are free of substantial changes;

- Group 2, i.e. the group of 20 patients who have been using the wristwatch based on the present invention for one year;

Measured on a parameter from 1 to 5, the vitality of the patients who used the wristwatch based on the present invention reached a score of 4 in the first six months. In one year, it reached the maximum score.

By measuring a parameter between 0 and 6, the circadian rhythms of the patients, based on the blood analysis and the answers obtained from the questionnaires, tuned to the new temporal model, reaching level 4 already in the first six months of use, and five after a year of use.

- Group 3, or the group of patients who have been using the wall clock based on the present invention for one year.

The patients’ vitality in the first six months seems to reach a score of 3; in the remaining six months, it reaches the score of 4. This shows that there is a variation regarding the service life of the watch based on the present invention and its observation.

The same patients tuned their circadian rhythms to the new temporal model on a parameter from zero to six, reaching level 2 in the first six months and 3 in the remaining six months.

- Group 4, or the group of patients who have been using the common clock. Patients’ vitality did not change, with its score sticking to level 1 . Even patients’ circadian rhythms remained unchanged, with the parameter from zero to six remaining on one.

Usage models

In order to make the most of its effectiveness, the watch based on the present invention must be used in a specific way.

Whether it is in its wristwatch or wall clock form, it must be activated for the first time by its users at the stroke of midnight, which equivalent to the Zen point - that is, the starting point - according to the theory of the creator.

If used in a house, it can continue to mark the time after its activation, and it can harmonize the surrounding environments, as well as those who observe it.

Conversely, if used as a wristwatch, it must be gradually inserted into the life of the person who intends to use it, following the indications given.

From the first switch on, for example at 12:00 a.m. of the 9 December, the user will wear the watch based on the present invention for seven hours on the first day, and will increase its use by one hour a day, until possible continuous use for 24 hours.

The minimum duration to determine the effectiveness and the benefits listed above is for at least seven consecutive daily hours, during which the subject will tend to look at the time several times for a minimum of twenty minutes. The greater the observation of the language transmitted by the watch based on the present invention, the greater the benefits reported.

The present invention has been described by way of (not limiting) example in its preferred embodiments, but it must be said that experts may make variations and/or modifications without thereby altering the scope of protection, as defined in the attached claims.