Title:
DEVICE AND METHOD FOR DETERMINING THE CONCENTRATION OF A TRACER IN BLOOD
Document Type and Number:
WIPO Patent Application WO2005044311
Kind Code:
A3
Abstract:
The invention relates to device and a method for determining the concentration of a PET tracer in the blood of a patient (1). With the aid of an X-ray CT (5, 6), first of all the spatial position (r) of a volume element (2) that is filled with blood is determined, which for example can be a part of the aorta or of the left ventricle of the heart. Subsequently, a TOF PET unit that comprises two detector elements (3a, 3b) is set in such a way that it establishes the concentration of the tracer in this volume element (2) and thus in the blood. This value can for example be used within the framework of pharmaco-kinetic examinations which are carried out on the patient (1) with the aid of a three-dimensional PET unit (4).
Inventors:
BRAESS HENNING (DE)
Application Number:
PCT/IB2004/052299
Publication Date:
July 07, 2005
Filing Date:
November 04, 2004
Export Citation:
Assignee:
PHILIPS INTELLECTUAL PROPERTY (DE)
KONINKL PHILIPS ELECTRONICS NV (NL)
BRAESS HENNING (DE)
KONINKL PHILIPS ELECTRONICS NV (NL)
BRAESS HENNING (DE)
International Classes:
A61B5/0275; A61B6/00; A61B6/03; G01T1/29; (IPC1-7): G01T1/29; A61B6/03
Foreign References:
| FR2717909A1 | 1995-09-29 |
Other References:
PAANS A. M. J. AND VAALBURG W.: "Positron Emission Tomography in Drug Development and Drug Evaluation", CURRENT PHARMACEUTICAL DESIGN, vol. 6, November 2000 (2000-11-01), pages 1583 - 1591, XP002326926
SALEM K A ET AL: "X-RAY COMPUTED TOMOGRAPHY METHODS FOR IN VIVO EVALUATION OF LOCAL DRUG RELEASE SYSTEMS", IEEE TRANSACTIONS ON MEDICAL IMAGING, IEEE INC. NEW YORK, US, vol. 21, no. 10, October 2002 (2002-10-01), pages 1310 - 1316, XP001163372, ISSN: 0278-0062
MOSES W. W.: "Time of flight in PET revisited", IEEE TRANSACTIONS ON NUCLEAR SCIENCE, vol. 50, no. 5, 5 October 2003 (2003-10-05), pages 1325 - 1330, XP002326927
BECKMANN N. ET AL.: "From anatomy to the target: contributions of magnetic resonance imaging to preclinical pharmaceutical research", THE ANATOMICAL RECORD (NEW ANAT.), vol. 165, 15 April 2001 (2001-04-15), pages 85 - 100, XP002326928
TRICHARD C. ET AL: "Binding of antipsychotic drugs to cortical 5-HT2A receptors: a PET study of Chlorpromazine, clozapine, and amisulpride in schizophrenic patients", AMERICAN JOURNAL OF PSYCHIATRY, vol. 155, no. 4, 4 April 1998 (1998-04-04), pages 505 - 508, XP002326929
SALEM K A ET AL: "X-RAY COMPUTED TOMOGRAPHY METHODS FOR IN VIVO EVALUATION OF LOCAL DRUG RELEASE SYSTEMS", IEEE TRANSACTIONS ON MEDICAL IMAGING, IEEE INC. NEW YORK, US, vol. 21, no. 10, October 2002 (2002-10-01), pages 1310 - 1316, XP001163372, ISSN: 0278-0062
MOSES W. W.: "Time of flight in PET revisited", IEEE TRANSACTIONS ON NUCLEAR SCIENCE, vol. 50, no. 5, 5 October 2003 (2003-10-05), pages 1325 - 1330, XP002326927
BECKMANN N. ET AL.: "From anatomy to the target: contributions of magnetic resonance imaging to preclinical pharmaceutical research", THE ANATOMICAL RECORD (NEW ANAT.), vol. 165, 15 April 2001 (2001-04-15), pages 85 - 100, XP002326928
TRICHARD C. ET AL: "Binding of antipsychotic drugs to cortical 5-HT2A receptors: a PET study of Chlorpromazine, clozapine, and amisulpride in schizophrenic patients", AMERICAN JOURNAL OF PSYCHIATRY, vol. 155, no. 4, 4 April 1998 (1998-04-04), pages 505 - 508, XP002326929
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